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Entry version 94 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Cytochrome c

Gene

GSU1996

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi45Iron (heme 1 axial ligand); via tele nitrogenCombined sources1
Metal bindingi45Iron (heme 3 axial ligand); via tele nitrogenCombined sources1
Metal bindingi48Iron (heme 5 axial ligand); via tele nitrogenCombined sources1
Metal bindingi48Iron (heme 9 axial ligand); via tele nitrogenCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56Heme 1 (covalent)Combined sources1
Binding sitei56Heme 3 (covalent)Combined sources1
Binding sitei59Heme 1 (covalent)Combined sources1
Binding sitei59Heme 3 (covalent)Combined sources1
Metal bindingi60Iron (heme 1 axial ligand); via tele nitrogenCombined sources1
Metal bindingi60Iron (heme 3 axial ligand); via tele nitrogenCombined sources1
Binding sitei83Heme 5 (covalent)Combined sources1
Binding sitei83Heme 9 (covalent)Combined sources1
Binding sitei86Heme 5 (covalent)Combined sources1
Binding sitei86Heme 9 (covalent)Combined sources1
Metal bindingi87Iron (heme 5 axial ligand); via tele nitrogenCombined sources1
Metal bindingi87Iron (heme 9 axial ligand); via tele nitrogenCombined sources1
Binding sitei101Heme 4 (covalent)Combined sources1
Binding sitei101Heme 6 (covalent)Combined sources1
Binding sitei104Heme 4 (covalent)Combined sources1
Binding sitei104Heme 6 (covalent)Combined sources1
Metal bindingi105Iron (heme 4 axial ligand); via tele nitrogenCombined sources1
Metal bindingi105Iron (heme 6 axial ligand); via tele nitrogenCombined sources1
Metal bindingi126Iron (heme 7 axial ligand); via tele nitrogenCombined sources1
Metal bindingi126Iron (heme 8 axial ligand); via tele nitrogenCombined sources1
Metal bindingi129Iron (heme 14 axial ligand); via tele nitrogenCombined sources1
Metal bindingi129Iron (heme 2 axial ligand); via tele nitrogenCombined sources1
Binding sitei137Heme 7 (covalent)Combined sources1
Binding sitei137Heme 8 (covalent)Combined sources1
Binding sitei140Heme 7 (covalent)Combined sources1
Binding sitei140Heme 8 (covalent)Combined sources1
Metal bindingi141Iron (heme 7 axial ligand); via tele nitrogenCombined sources1
Metal bindingi141Iron (heme 8 axial ligand); via tele nitrogenCombined sources1
Binding sitei163Heme 14 (covalent)Combined sources1
Binding sitei163Heme 2 (covalent)Combined sources1
Binding sitei166Heme 14 (covalent)Combined sources1
Binding sitei166Heme 2 (covalent)Combined sources1
Metal bindingi167Iron (heme 2 axial ligand); via tele nitrogenCombined sources1
Binding sitei179Heme 10 (covalent)Combined sources1
Binding sitei179Heme 12 (covalent)Combined sources1
Binding sitei182Heme 10 (covalent)Combined sources1
Binding sitei182Heme 12 (covalent)Combined sources1
Metal bindingi183Iron (heme 10 axial ligand); via tele nitrogenCombined sources1
Metal bindingi183Iron (heme 12 axial ligand); via tele nitrogenCombined sources1
Metal bindingi206Iron (heme 15 axial ligand); via tele nitrogenCombined sources1
Metal bindingi206Iron (heme 17 axial ligand); via tele nitrogenCombined sources1
Metal bindingi209Iron (heme 19 axial ligand); via tele nitrogenCombined sources1
Binding sitei215Heme 15 (covalent)Combined sources1
Binding sitei215Heme 17 (covalent)Combined sources1
Binding sitei218Heme 15 (covalent)Combined sources1
Binding sitei218Heme 17 (covalent)Combined sources1
Metal bindingi219Iron (heme 15 axial ligand); via tele nitrogenCombined sources1
Metal bindingi219Iron (heme 17 axial ligand); via tele nitrogenCombined sources1
Metal bindingi234Iron (heme 16 axial ligand)Combined sources1
Binding sitei243Heme 13 (covalent)Combined sources1
Binding sitei243Heme 19 (covalent)Combined sources1
Binding sitei246Heme 13 (covalent)Combined sources1
Binding sitei246Heme 19 (covalent)Combined sources1
Metal bindingi247Iron (heme 13 axial ligand); via tele nitrogenCombined sources1
Metal bindingi247Iron (heme 19 axial ligand); via tele nitrogenCombined sources1
Binding sitei259Heme 16 (covalent)Combined sources1
Binding sitei262Heme 16 (covalent)Combined sources1
Metal bindingi263Iron (heme 16 axial ligand); via tele nitrogenCombined sources1
Metal bindingi284Iron (heme 21 axial ligand); via tele nitrogenCombined sources1
Metal bindingi287Iron (heme 18 axial ligand); via tele nitrogenCombined sources1
Metal bindingi287Iron (heme 22 axial ligand); via tele nitrogenCombined sources1
Binding sitei293Heme 21 (covalent)Combined sources1
Binding sitei296Heme 21 (covalent)Combined sources1
Metal bindingi297Iron (heme 21 axial ligand); via tele nitrogenCombined sources1
Metal bindingi312Iron (heme 11 axial ligand)Combined sources1
Binding sitei321Heme 18 (covalent)Combined sources1
Binding sitei321Heme 22 (covalent)Combined sources1
Binding sitei324Heme 18 (covalent)Combined sources1
Binding sitei324Heme 22 (covalent)Combined sources1
Metal bindingi325Iron (heme 18 axial ligand); via tele nitrogenCombined sources1
Binding sitei337Heme 11 (covalent)Combined sources1
Binding sitei337Heme 20 (covalent)Combined sources1
Binding sitei340Heme 11 (covalent)Combined sources1
Binding sitei340Heme 20 (covalent)Combined sources1
Metal bindingi341Iron (heme 11 axial ligand); via tele nitrogenCombined sources1
Metal bindingi341Iron (heme 20 axial ligand); via tele nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandHemeCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GSUL243231:G1G0I-2214-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cytochrome cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:GSU1996Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243231 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000577 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243231.GSU1996

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q74BP5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q74BP5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 330MULTIHEME_CYTCInterPro annotationAdd BLAST280

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105SNX Bacteria
ENOG410XTFU LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000131970

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q74BP5

Identification of Orthologs from Complete Genome Data

More...
OMAi
RICHNAI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011031 Multihaem_cyt
IPR036280 Multihaem_cyt_sf
IPR026352 Nanowire_3heme
IPR029467 OmcB
IPR039118 QrcA

The PANTHER Classification System

More...
PANTHERi
PTHR39425 PTHR39425, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14522 Cytochrome_C7, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48695 SSF48695, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04257 nanowire_3heme, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51008 MULTIHEME_CYTC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q74BP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMRLNGVVT GIVSLVLLVA VVAMAKETKN VPFKLKNAAP VIFSHDIHLK
60 70 80 90 100
KYNNNCRICH IALFDLRKPK RYTMLDMEKG KSCGACHTGM KAFSVADDSQ
110 120 130 140 150
CVRCHSGSAR PVAYRMKGAG EAVFSHEVHV PMLEGKCRTC HSNREITGGR
160 170 180 190 200
NVTMAQMEKG KSCGACHNDK MAFTVAGNCG KCHKGMTPPK TVNFKMKGVA
210 220 230 240 250
DAAFSHEFHL GMYKCNECHT KLFAYKAGAK RFTMADMDKG KSCGACHNGK
260 270 280 290 300
DAFSSASDCG KCHPGLKPAK LTYKTSVGEA YFDHDIHLSM FKCADCHTKV
310 320 330 340
FKYRKGSAPA TMADMEKGKS CGVCHNGKDA FSVADDCVKC HNM
Length:343
Mass (Da):37,451
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC038CDDEA9FEF619
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR35372.1

NCBI Reference Sequences

More...
RefSeqi
NP_953045.1, NC_002939.5
WP_010942639.1, NC_002939.5

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAR35372; AAR35372; GSU1996

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2686130

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gsu:GSU1996

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|243231.5.peg.2032

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR35372.1
RefSeqiNP_953045.1, NC_002939.5
WP_010942639.1, NC_002939.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RWJX-ray1.70A184-265[»]
3OUEX-ray2.15A186-343[»]
3OUQX-ray2.60A26-186[»]
3OV0X-ray3.20A26-343[»]
SMRiQ74BP5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi243231.GSU1996

Genome annotation databases

EnsemblBacteriaiAAR35372; AAR35372; GSU1996
GeneIDi2686130
KEGGigsu:GSU1996
PATRICifig|243231.5.peg.2032

Phylogenomic databases

eggNOGiENOG4105SNX Bacteria
ENOG410XTFU LUCA
HOGENOMiHOG000131970
InParanoidiQ74BP5
OMAiRICHNAI

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-2214-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ74BP5

Family and domain databases

InterProiView protein in InterPro
IPR011031 Multihaem_cyt
IPR036280 Multihaem_cyt_sf
IPR026352 Nanowire_3heme
IPR029467 OmcB
IPR039118 QrcA
PANTHERiPTHR39425 PTHR39425, 1 hit
PfamiView protein in Pfam
PF14522 Cytochrome_C7, 4 hits
SUPFAMiSSF48695 SSF48695, 2 hits
TIGRFAMsiTIGR04257 nanowire_3heme, 4 hits
PROSITEiView protein in PROSITE
PS51008 MULTIHEME_CYTC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ74BP5_GEOSL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q74BP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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