UniProtKB - Q73XZ5 (HRCA_MYCPA)
Protein
Heat-inducible transcription repressor HrcA
Gene
hrcA
Organism
Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) (Mycobacterium paratuberculosis)
Status
Functioni
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.UniRule annotation
GO - Molecular functioni
- DNA binding Source: InterPro
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB-UniRule
Keywordsi
Molecular function | Repressor |
Biological process | Stress response, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Heat-inducible transcription repressor HrcAUniRule annotation |
Gene namesi | Name:hrcAUniRule annotation Ordered Locus Names:MAP_2163c |
Organismi | Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) (Mycobacterium paratuberculosis) |
Taxonomic identifieri | 262316 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) › |
Proteomesi |
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PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000182508 | 1 – 343 | Heat-inducible transcription repressor HrcAAdd BLAST | 343 |
Family & Domainsi
Sequence similaritiesi
Belongs to the HrcA family.UniRule annotation
Phylogenomic databases
eggNOGi | COG1420, Bacteria |
HOGENOMi | CLU_050019_2_0_11 |
OMAi | DYPGTMG |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.390.60, 1 hit 3.30.450.40, 1 hit |
HAMAPi | MF_00081, HrcA, 1 hit |
InterProi | View protein in InterPro IPR029016, GAF-like_dom_sf IPR002571, HrcA IPR021153, HrcA_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf IPR023120, WHTH_transcript_rep_HrcA_IDD |
PANTHERi | PTHR34824, PTHR34824, 1 hit |
Pfami | View protein in Pfam PF01628, HrcA, 1 hit |
PIRSFi | PIRSF005485, HrcA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR00331, hrcA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q73XZ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSADERRFE VLRAIVADFV ATKEPIGSKT LVERHNLGVS SATVRNDMAV
60 70 80 90 100
LEAEGYITQP HTSSGRVPTE KGYREFVDRL DDVKPLSAAE RRAIQNFLES
110 120 130 140 150
GVDLDDVLRR AVRLLAQLTR QVAIVQYPTL SSSTVRHLEV IALTPARLLM
160 170 180 190 200
VVITDSGRVD QRIVELGDVI DDHELSRLRE MLGQALVGKK LSAASVAVAD
210 220 230 240 250
LAEQLRSPDG LGDAVGRSAT VLLESLVEHS EERLLMGGTA NLTRNAADFG
260 270 280 290 300
GSLRSILEAL EEQVVVLRLL AAQQEAGKVT VRIGHETAAE QMVGTSMVTT
310 320 330 340
AYGTSDTVYG GMGVLGPTRM DYPGTIASVA AVAMYIGEVL GAR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016958 Genomic DNA Translation: AAS04480.1 |
RefSeqi | WP_003878336.1, NC_002944.2 |
Genome annotation databases
EnsemblBacteriai | AAS04480; AAS04480; MAP_2163c |
GeneIDi | 2719107 |
KEGGi | mpa:MAP_2163c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016958 Genomic DNA Translation: AAS04480.1 |
RefSeqi | WP_003878336.1, NC_002944.2 |
3D structure databases
SMRi | Q73XZ5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 262316.MAP_2163c |
Genome annotation databases
EnsemblBacteriai | AAS04480; AAS04480; MAP_2163c |
GeneIDi | 2719107 |
KEGGi | mpa:MAP_2163c |
Phylogenomic databases
eggNOGi | COG1420, Bacteria |
HOGENOMi | CLU_050019_2_0_11 |
OMAi | DYPGTMG |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.390.60, 1 hit 3.30.450.40, 1 hit |
HAMAPi | MF_00081, HrcA, 1 hit |
InterProi | View protein in InterPro IPR029016, GAF-like_dom_sf IPR002571, HrcA IPR021153, HrcA_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf IPR023120, WHTH_transcript_rep_HrcA_IDD |
PANTHERi | PTHR34824, PTHR34824, 1 hit |
Pfami | View protein in Pfam PF01628, HrcA, 1 hit |
PIRSFi | PIRSF005485, HrcA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR00331, hrcA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HRCA_MYCPA | |
Accessioni | Q73XZ5Primary (citable) accession number: Q73XZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families