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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Activity regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase (upp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei775-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei1025-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei192Uracil; via amide nitrogenUniRule annotation1
Binding sitei1985-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
LigandGTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAVI262316:G1G0E-3598-MONOMER
UniPathwayi
UPA00574;UER00636

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:MAP_3431c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000000580 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001208541 – 257Uracil phosphoribosyltransferaseAdd BLAST257

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP3431c

Structurei

3D structure databases

ProteinModelPortaliQ73UD7
SMRiQ73UD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 1375-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation9
Regioni197 – 199Uracil bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ5 Bacteria
COG0035 LUCA
KOiK00761
OMAiRICGYEI
OrthoDBiPOG091H02GN

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit

Sequencei

Sequence statusi: Complete.

Q73UD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVCVIDHPL AAARLTVLRD ERTDTAGFRA ALRDLTLMLV YEASRDAPRK
60 70 80 90 100
SVRIRTPVAA AAGTRLVNPP LLVPVLRAGL GMVDPAQAAL PEAEVGFVGV
110 120 130 140 150
ARDEQTHRPV PYLAALPDKL AGRPVMVLDP MLATGGSMAH TLGLLQRRGA
160 170 180 190 200
TDITVLCVVA APEGLAAVGE TAPDARVFTA AVDKGLNKAA YIVPGLGDAG
210 220 230 240 250
DRQFGPNLFT SSAPSRPEAP AGRGRAAAKT PGRRSARSES PSSTSPSARS

RKAAPPA
Length:257
Mass (Da):26,629
Last modified:July 5, 2004 - v1
Checksum:iF9F8C5C45311DC1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA Translation: AAS05981.1
RefSeqiWP_010949958.1, NC_002944.2

Genome annotation databases

EnsemblBacteriaiAAS05981; AAS05981; MAP_3431c
GeneIDi31477859
KEGGimpa:MAP_3431c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA Translation: AAS05981.1
RefSeqiWP_010949958.1, NC_002944.2

3D structure databases

ProteinModelPortaliQ73UD7
SMRiQ73UD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262316.MAP3431c

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS05981; AAS05981; MAP_3431c
GeneIDi31477859
KEGGimpa:MAP_3431c

Phylogenomic databases

eggNOGiENOG4105CZ5 Bacteria
COG0035 LUCA
KOiK00761
OMAiRICGYEI
OrthoDBiPOG091H02GN

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00636

BioCyciMAVI262316:G1G0E-3598-MONOMER

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPP_MYCPA
AccessioniPrimary (citable) accession number: Q73UD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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