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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Wolbachia pipientis wMel
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi249Magnesium or manganese 1UniRule annotation1
Metal bindingi263Magnesium or manganese 1UniRule annotation1
Metal bindingi263Magnesium or manganese 2UniRule annotation1
Metal bindingi265Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi128 – 181ATPUniRule annotationAdd BLAST54

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:WD_0095
OrganismiWolbachia pipientis wMel
Taxonomic identifieri163164 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000008215 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003411951 – 315D-alanine--D-alanine ligaseAdd BLAST315

Interactioni

Protein-protein interaction databases

STRINGi163164.WD0095

Structurei

3D structure databases

ProteinModelPortaliQ73IQ8
SMRiQ73IQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 297ATP-graspUniRule annotationAdd BLAST197

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011592
KOiK01921
OMAiYETKYTE

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q73IQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPTIAILSG GFSCEREISL MSGKAVKKAL DSLSYNAIEI DVDSNIAEKL
60 70 80 90 100
KKINPGLAFI ALHGPYGEDG CIQGLLEILG IKYTHSGVMA SAVAINKVMS
110 120 130 140 150
KHIFRSLNID TPKGYVISRE DVLKNNIKID YPYVLKPINE GSSIGVYIIF
160 170 180 190 200
SHEDYLELKN NSSTIMEKMI VEEYIPGIEL HTAVLLDEAI GTIEVRPKNK
210 220 230 240 250
FYDYEAKYTD GFAEHIFPAK IPDNIYKMTL EHALKIHQFL GCKTISRSDF
260 270 280 290 300
RYNPKNNTLK MLEINTHPGF TELSLVPEIA KLAKGINFNE LVKIIIEDSL
310
QHKNIRDLSH VEQYY
Length:315
Mass (Da):35,482
Last modified:July 5, 2004 - v1
Checksum:i87868BA2A031C118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017196 Genomic DNA Translation: AAS13853.1

Genome annotation databases

EnsemblBacteriaiAAS13853; AAS13853; WD_0095
KEGGiwol:WD_0095

Similar proteinsi

Entry informationi

Entry nameiDDL_WOLPM
AccessioniPrimary (citable) accession number: Q73IQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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