We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q72LR0 (MNMG_LEPIC)
Protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Gene
mnmG
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Status
Functioni
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.
UniRule annotationCofactori
FADUniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 20 – 25 | FADUniRule annotation | 6 | |
Nucleotide bindingi | 279 – 293 | NADUniRule annotationAdd BLAST | 15 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: UniProtKB-UniRule
GO - Biological processi
- tRNA wobble uridine modification Source: InterPro
Keywordsi
Biological process | tRNA processing |
Ligand | FAD, Flavoprotein, NAD |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotationAlternative name(s): Glucose-inhibited division protein AUniRule annotation |
Gene namesi | Name:mnmGUniRule annotation Synonyms:gidAUniRule annotation Ordered Locus Names:LIC_13495 |
Organismi | Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) |
Taxonomic identifieri | 267671 [NCBI] |
Taxonomic lineagei | Bacteria › Spirochaetes › Leptospirales › Leptospiraceae › Leptospira › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000117124 | 1 – 635 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGAdd BLAST | 635 |
Proteomic databases
PaxDbi | Q72LR0 |
Interactioni
Subunit structurei
Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the MnmG family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_007831_2_2_12 |
OMAi | FRPGYAI |
Family and domain databases
Gene3Di | 1.10.150.570, 1 hit 3.50.50.60, 2 hits |
HAMAPi | MF_00129, MnmG_GidA, 1 hit |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR004416, MnmG IPR002218, MnmG-rel IPR020595, MnmG-rel_CS IPR026904, MnmG_C IPR044920, MnmG_C_subdom IPR040131, MnmG_N |
PANTHERi | PTHR11806, PTHR11806, 1 hit PTHR11806:SF0, PTHR11806:SF0, 1 hit |
Pfami | View protein in Pfam PF01134, GIDA, 1 hit PF13932, GIDA_C, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
TIGRFAMsi | TIGR00136, gidA, 1 hit |
PROSITEi | View protein in PROSITE PS01280, GIDA_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q72LR0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIESKNQSFF PNRFDCVVVG AGHAGSEAAY ISSKGGARTL LITMNLDTIG
60 70 80 90 100
QMSCNPAIGG IAKGHMVREV DALGGIMGKM IDNTGIQFKM LNTSKGPSVW
110 120 130 140 150
APRAQAEKKE YQLKVKHTLE AEKNLSIRQD TVEELIIEND QVIGVRTGRG
160 170 180 190 200
FEIFTNHVIL TTGTFLSSLV HIGTYQNENG RMCEPTVKGL SKSLAKYNLK
210 220 230 240 250
LGRLKTGTPP RIHKNSVDLS VLTIQEGDSN PSPFSFSTDK ITRKQIPCFI
260 270 280 290 300
TYTNAETHKL IHENLNLSPM YSGQIQSTGP RYCPSIEDKV VRFADRERHQ
310 320 330 340 350
VFLEPEGYET SEIYLNGVST SLPEEVQWKL VRSLKGLENA EIVRPGYAIE
360 370 380 390 400
YDYVDPTELK PTLETKKIKG LYHAGQINGT TGYEEAAAQG LVAAYSVLHS
410 420 430 440 450
LRNLTPLLFK RSESYIGVLI DDLVHKGVED PYRMFTSRAE HRLLLRQDNA
460 470 480 490 500
DQRLMKYGYD LGLVDQKSYD CMKEKYERVN SVREKIYQIP LKPSDKFQNL
510 520 530 540 550
LDQKGITNYK FGMKLDSFLK RPEIKIKDIE FMIPEVSSWS DLEKSILEME
560 570 580 590 600
IKYEGYIKRE LETIQWKNKY LDLAIPEDIN YEMIAGLKKE AIQKLKSHKP
610 620 630
MTLEKASQIS GVDPSDVDLI LYHIKGKKKQ EVEIF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016823 Genomic DNA Translation: AAS72029.1 |
RefSeqi | WP_000572985.1, NC_005823.1 |
Genome annotation databases
EnsemblBacteriai | AAS72029; AAS72029; LIC_13495 |
GeneIDi | 61143353 |
KEGGi | lic:LIC_13495 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016823 Genomic DNA Translation: AAS72029.1 |
RefSeqi | WP_000572985.1, NC_005823.1 |
3D structure databases
AlphaFoldDBi | Q72LR0 |
SMRi | Q72LR0 |
ModBasei | Search... |
Proteomic databases
PaxDbi | Q72LR0 |
Genome annotation databases
EnsemblBacteriai | AAS72029; AAS72029; LIC_13495 |
GeneIDi | 61143353 |
KEGGi | lic:LIC_13495 |
Phylogenomic databases
HOGENOMi | CLU_007831_2_2_12 |
OMAi | FRPGYAI |
Family and domain databases
Gene3Di | 1.10.150.570, 1 hit 3.50.50.60, 2 hits |
HAMAPi | MF_00129, MnmG_GidA, 1 hit |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR004416, MnmG IPR002218, MnmG-rel IPR020595, MnmG-rel_CS IPR026904, MnmG_C IPR044920, MnmG_C_subdom IPR040131, MnmG_N |
PANTHERi | PTHR11806, PTHR11806, 1 hit PTHR11806:SF0, PTHR11806:SF0, 1 hit |
Pfami | View protein in Pfam PF01134, GIDA, 1 hit PF13932, GIDA_C, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
TIGRFAMsi | TIGR00136, gidA, 1 hit |
PROSITEi | View protein in PROSITE PS01280, GIDA_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MNMG_LEPIC | |
Accessioni | Q72LR0Primary (citable) accession number: Q72LR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |