Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:TT_C0427
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001132201 – 302Aspartate carbamoyltransferaseAdd BLAST302

Proteomic databases

PRIDEiQ72KU0

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC0427

Structurei

3D structure databases

ProteinModelPortaliQ72KU0
SMRiQ72KU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT Bacteria
COG0540 LUCA
KOiK00609
OMAiWCDVANM

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q72KU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLLDFQGW SRTEVESLLD TARVMREVLE RPIKKVPALQ GFTVATVFFE
60 70 80 90 100
PSTRTRISFE LAARRMSADV VSFAAQTSSL QKGESYKDTL LTLEAMGVDA
110 120 130 140 150
YVIRADSAGV PHQATRWVKG AVINGGDGRR AHPTQALLDA YTLLEALGTL
160 170 180 190 200
EGKKVAIVGD ILHSRVARSG AELLSLLGAQ VFCAGPPSLL PQSLPGAHLT
210 220 230 240 250
PRLEEALEEA DAVMVLRLQK ERMEAGLVHL EDYVARYQVT EKRLALAKPQ
260 270 280 290 300
APLLHPGPMN RDVELEGTLA DSARSLVNRQ VQNGVAVRMA VLYHLLVGRE

KA
Length:302
Mass (Da):33,015
Last modified:July 5, 2004 - v1
Checksum:i630EFD0E2237B709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA Translation: AAS80775.1
RefSeqiWP_011172874.1, NC_005835.1

Genome annotation databases

EnsemblBacteriaiAAS80775; AAS80775; TT_C0427
KEGGitth:TT_C0427

Similar proteinsi

Entry informationi

Entry nameiPYRB_THET2
AccessioniPrimary (citable) accession number: Q72KU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health