UniProtKB - Q72J47 (RPIA_THET2)
Protein
Ribose-5-phosphate isomerase A
Gene
rpiA
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Functioni
Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. Can also act on D-ribose-5-diphosphate and D-ribose-5-triphosphate as substrate.1 Publication
Catalytic activityi
- EC:5.3.1.6UniRule annotation
Kineticsi
Kcat is 1072 sec(-1) for ribose-5-phosphate.
- KM=1.63 mM for ribose-5-phosphate (at 50 degrees Celsius)1 Publication
: pentose phosphate pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Ribose-5-phosphate isomerase A (rpiA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 108 | Proton acceptorUniRule annotation1 Publication | 1 | |
Binding sitei | 126 | Substrate | 1 |
GO - Molecular functioni
- ribose-5-phosphate isomerase activity Source: UniProtKB-UniRule
GO - Biological processi
- pentose-phosphate shunt, non-oxidative branch Source: UniProtKB-UniRule
Keywordsi
Molecular function | Isomerase |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00412 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)Alternative name(s): Phosphoriboisomerase AUniRule annotation Short name: PRIUniRule annotation |
Gene namesi | Name:rpiAUniRule annotation Ordered Locus Names:TT_C0932 |
Organismi | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) |
Taxonomic identifieri | 262724 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000158486 | 1 – 227 | Ribose-5-phosphate isomerase AAdd BLAST | 227 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotation1 PublicationProtein-protein interaction databases
STRINGi | 262724.TT_C0932 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q72J47 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q72J47 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 33 | Substrate binding | 4 | |
Regioni | 86 – 89 | Substrate binding | 4 | |
Regioni | 99 – 104 | Substrate binding | 6 |
Sequence similaritiesi
Belongs to the ribose 5-phosphate isomerase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0120, Bacteria |
HOGENOMi | CLU_056590_1_0_0 |
OMAi | VAPMAYV |
OrthoDBi | 1681738at2 |
Family and domain databases
CDDi | cd01398, RPI_A, 1 hit |
HAMAPi | MF_00170, Rib_5P_isom_A, 1 hit |
InterProi | View protein in InterPro IPR037171, NagB/RpiA_transferase-like IPR020672, Ribose5P_isomerase_typA_subgr IPR004788, Ribose5P_isomerase_type_A |
Pfami | View protein in Pfam PF06026, Rib_5-P_isom_A, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00021, rpiA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q72J47-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERPLESYKK EAAHAAIAYV QDGMVVGLGT GSTARYAVLE LARRLREGEL
60 70 80 90 100
KGVVGVPTSR ATEELAKREG IPLVDLPPEG VDLAIDGADE IAPGLALIKG
110 120 130 140 150
MGGALLREKI VERAAKEFIV IADHTKKVPV LGRGPVPVEI VPFGYRATLK
160 170 180 190 200
AIADLGGEPE LRMDGDEFYF TDGGHLIADC RFGPIGDPLG LHRALLEIPG
210 220
VVETGLFVGM ATRALVAGPF GVEELLP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017221 Genomic DNA Translation: AAS81276.1 |
RefSeqi | WP_011173356.1, NC_005835.1 |
Genome annotation databases
EnsemblBacteriai | AAS81276; AAS81276; TT_C0932 |
KEGGi | tth:TT_C0932 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017221 Genomic DNA Translation: AAS81276.1 |
RefSeqi | WP_011173356.1, NC_005835.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UJ4 | X-ray | 1.80 | A | 1-227 | [»] | |
1UJ5 | X-ray | 2.00 | A | 1-227 | [»] | |
1UJ6 | X-ray | 1.74 | A | 1-227 | [»] | |
SMRi | Q72J47 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 262724.TT_C0932 |
Genome annotation databases
EnsemblBacteriai | AAS81276; AAS81276; TT_C0932 |
KEGGi | tth:TT_C0932 |
Phylogenomic databases
eggNOGi | COG0120, Bacteria |
HOGENOMi | CLU_056590_1_0_0 |
OMAi | VAPMAYV |
OrthoDBi | 1681738at2 |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00412 |
Miscellaneous databases
EvolutionaryTracei | Q72J47 |
Family and domain databases
CDDi | cd01398, RPI_A, 1 hit |
HAMAPi | MF_00170, Rib_5P_isom_A, 1 hit |
InterProi | View protein in InterPro IPR037171, NagB/RpiA_transferase-like IPR020672, Ribose5P_isomerase_typA_subgr IPR004788, Ribose5P_isomerase_type_A |
Pfami | View protein in Pfam PF06026, Rib_5-P_isom_A, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00021, rpiA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPIA_THET2 | |
Accessioni | Q72J47Primary (citable) accession number: Q72J47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families