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UniProtKB - Q72I07 (RL2_THET2)
Protein
50S ribosomal protein L2
Gene
rplB
Organism
Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Status
Functioni
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
UniRule annotationGO - Molecular functioni
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: InterPro
- transferase activity Source: InterPro
GO - Biological processi
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L2UniRule annotation |
Gene namesi | Name:rplBUniRule annotation Ordered Locus Names:TT_C1325 |
Organismi | Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) |
Taxonomic identifieri | 262724 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000237259 | 1 – 276 | 50S ribosomal protein L2Add BLAST | 276 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit.
Forms a bridge to the 30S subunit in the 70S ribosome.
UniRule annotationProtein-protein interaction databases
IntActi | Q72I07, 4 interactors |
STRINGi | 262724.TT_C1325 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q72I07 |
SMRi | Q72I07 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q72I07 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 223 – 276 | DisorderedSequence analysisAdd BLAST | 54 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 256 – 276 | Basic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the universal ribosomal protein uL2 family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0090, Bacteria |
HOGENOMi | CLU_036235_2_1_0 |
OMAi | SCIELRP |
OrthoDBi | 961486at2 |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 2.40.50.140, 1 hit 4.10.950.10, 1 hit |
HAMAPi | MF_01320_B, Ribosomal_L2_B, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR022666, Rbsml_prot_L2_RNA-bd_dom IPR014722, Rib_L2_dom2 IPR002171, Ribosomal_L2 IPR005880, Ribosomal_L2_bac/org-type IPR022669, Ribosomal_L2_C IPR022671, Ribosomal_L2_CS IPR014726, Ribosomal_L2_dom3 IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR13691, PTHR13691, 1 hit |
Pfami | View protein in Pfam PF00181, Ribosomal_L2, 1 hit PF03947, Ribosomal_L2_C, 1 hit |
PIRSFi | PIRSF002158, Ribosomal_L2, 1 hit |
SMARTi | View protein in SMART SM01383, Ribosomal_L2, 1 hit SM01382, Ribosomal_L2_C, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR01171, rplB_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00467, RIBOSOMAL_L2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q72I07-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVKKFKPYT PSRRFMTVAD FSEITKTEPE KSLVKPLKKT GGRNNQGRIT
60 70 80 90 100
VRFRGGGHKR LYRIIDFKRW DKVGIPAKVA AIEYDPNRSA RIALLHYVDG
110 120 130 140 150
EKRYIIAPDG LQVGQQVVAG PDAPIQVGNA LPLRFIPVGT VVHAVELEPK
160 170 180 190 200
KGAKLARAAG TSAQIQGREG DYVILRLPSG ELRKVHGECY ATVGAVGNAD
210 220 230 240 250
HKNIVLGKAG RSRWLGRRPH VRGAAMNPVD HPHGGGEGRA PRGRPPASPW
260 270
GWQTKGLKTR KRRKPSSRFI IARRKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017221 Genomic DNA Translation: AAS81667.1 |
RefSeqi | WP_011173712.1, NC_005835.1 |
Genome annotation databases
EnsemblBacteriai | AAS81667; AAS81667; TT_C1325 |
GeneIDi | 3168720 |
KEGGi | tth:TT_C1325 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017221 Genomic DNA Translation: AAS81667.1 |
RefSeqi | WP_011173712.1, NC_005835.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4V4I | X-ray | 3.71 | B | 1-276 | [»] | |
4V4J | X-ray | 3.83 | B | 1-276 | [»] | |
4V63 | X-ray | 3.21 | BD/DD | 1-276 | [»] | |
4V67 | X-ray | 3.00 | BD/DD | 1-276 | [»] | |
4V7P | X-ray | 3.62 | BC/CC | 2-276 | [»] | |
4V83 | X-ray | 3.50 | BC/DC | 2-272 | [»] | |
4V84 | X-ray | 3.40 | BC/DC | 2-272 | [»] | |
4V9J | X-ray | 3.86 | BD/DD | 2-276 | [»] | |
4V9K | X-ray | 3.50 | BD/DD | 2-276 | [»] | |
4V9L | X-ray | 3.50 | BD/DD | 2-276 | [»] | |
4V9M | X-ray | 4.00 | BD/DD | 2-276 | [»] | |
4V9N | X-ray | 3.40 | BD/DD | 2-272 | [»] | |
4V9Q | X-ray | 3.40 | AD/CD | 2-272 | [»] | |
4W29 | X-ray | 3.80 | BD/DD | 2-276 | [»] | |
4XEJ | X-ray | 3.80 | AL02/BL02 | 2-272 | [»] | |
5J4D | X-ray | 3.10 | E/JB | 2-276 | [»] | |
AlphaFoldDBi | Q72I07 | |||||
SMRi | Q72I07 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q72I07, 4 interactors |
STRINGi | 262724.TT_C1325 |
Genome annotation databases
EnsemblBacteriai | AAS81667; AAS81667; TT_C1325 |
GeneIDi | 3168720 |
KEGGi | tth:TT_C1325 |
Phylogenomic databases
eggNOGi | COG0090, Bacteria |
HOGENOMi | CLU_036235_2_1_0 |
OMAi | SCIELRP |
OrthoDBi | 961486at2 |
Miscellaneous databases
EvolutionaryTracei | Q72I07 |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 2.40.50.140, 1 hit 4.10.950.10, 1 hit |
HAMAPi | MF_01320_B, Ribosomal_L2_B, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR022666, Rbsml_prot_L2_RNA-bd_dom IPR014722, Rib_L2_dom2 IPR002171, Ribosomal_L2 IPR005880, Ribosomal_L2_bac/org-type IPR022669, Ribosomal_L2_C IPR022671, Ribosomal_L2_CS IPR014726, Ribosomal_L2_dom3 IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR13691, PTHR13691, 1 hit |
Pfami | View protein in Pfam PF00181, Ribosomal_L2, 1 hit PF03947, Ribosomal_L2_C, 1 hit |
PIRSFi | PIRSF002158, Ribosomal_L2, 1 hit |
SMARTi | View protein in SMART SM01383, Ribosomal_L2, 1 hit SM01382, Ribosomal_L2_C, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR01171, rplB_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00467, RIBOSOMAL_L2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL2_THET2 | |
Accessioni | Q72I07Primary (citable) accession number: Q72I07 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families