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Entry version 103 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Laccase

Gene

TT_C1370

Organism
Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi95Copper 1; via tele nitrogenCombined sources1
Metal bindingi97Copper 1Combined sources1
Metal bindingi97Copper 3; via pros nitrogenCombined sources1
Metal bindingi135Copper 3; via tele nitrogenCombined sources1
Metal bindingi137Copper 2; via tele nitrogenCombined sources1
Metal bindingi393Copper 4; via pros nitrogenCombined sources1
Metal bindingi396Copper 1; via tele nitrogenCombined sources1
Metal bindingi398Copper 1Combined sources1
Metal bindingi398Copper 2; via tele nitrogenCombined sources1
Metal bindingi444Copper 2; via tele nitrogenCombined sources1
Metal bindingi445Copper 4Combined sources1
Metal bindingi446Copper 3; via tele nitrogenCombined sources1
Metal bindingi450Copper 4; via pros nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImportedARBA annotation
LigandCopperCombined sources, Metal-bindingCombined sourcesARBA annotation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.10.3.2, 2305

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q72HW2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LaccaseImported (EC:1.10.3.2Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:TT_C1370Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri262724 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000592 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
262724.TT_C1370

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q72HW2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q72HW2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 158Plastocyanin-likeInterPro annotationAdd BLAST107
Domaini197 – 285Plastocyanin-likeInterPro annotationAdd BLAST89
Domaini348 – 461Plastocyanin-likeInterPro annotationAdd BLAST114

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2132, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009100_2_1_0

Identification of Orthologs from Complete Genome Data

More...
OMAi
PHNFHVH

Database of Orthologous Groups

More...
OrthoDBi
971126at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.420, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001117, Cu-oxidase
IPR011706, Cu-oxidase_2
IPR011707, Cu-oxidase_3
IPR002355, Cu_oxidase_Cu_BS
IPR008972, Cupredoxin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00394, Cu-oxidase, 1 hit
PF07731, Cu-oxidase_2, 1 hit
PF07732, Cu-oxidase_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503, SSF49503, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00080, MULTICOPPER_OXIDASE2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q72HW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARRSFLQA AAGSLVLGLA RAQGPSFPEP KVVRSQGGLL SLKLSATPTP
60 70 80 90 100
LALAGQRATL LTYGGSFPGP TLRVRPRDTV RLTLENRLPE PTNLHWHGLP
110 120 130 140 150
ISPKVDDPFL EIPPGESWTY EFTVPKELAG TFWYHPHLHG RVAPQLFAGL
160 170 180 190 200
LGALVVESSL DAIPELREAE EHLLVLKDLA LQGGRPAPHT PMDWMNGKEG
210 220 230 240 250
DLVLVNGALR PTLVAQKATL RLRLLNASNA RYYRLALQDH PLYLIAADGG
260 270 280 290 300
FLEEPLEVSE LLLAPGERAE VLVRLRKEGR FLLQALPYDR GAMGMMDMGG
310 320 330 340 350
MAHAMPQGPS RPETLLYLIA PKNPKPLPLP KALSPFPTLP APVVTRRLVL
360 370 380 390 400
TEDMMAARFF INGQVFDHRR VDLKGQAQTV EVWEVENQGD MDHPFHLHVH
410 420 430 440 450
PFQVLSVGGR PFPYRAWKDV VNLKAGEVAR LLVPLREKGR TVFHCHIVEH
460
EDRGMMGVLE VG
Length:462
Mass (Da):51,110
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F196A48AF3875AD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE017221 Genomic DNA Translation: AAS81712.1

NCBI Reference Sequences

More...
RefSeqi
WP_011173754.1, NC_005835.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAS81712; AAS81712; TT_C1370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tth:TT_C1370

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA Translation: AAS81712.1
RefSeqiWP_011173754.1, NC_005835.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XU9X-ray1.50A24-462[»]
2XUWX-ray1.70A24-462[»]
2XVBX-ray1.70A24-462[»]
2YAEX-ray1.80A24-462[»]
2YAFX-ray1.80A24-462[»]
2YAHX-ray1.80A24-462[»]
2YAMX-ray1.80A24-462[»]
2YAOX-ray1.80A24-462[»]
2YAPX-ray1.80A24-462[»]
2YAQX-ray1.80A24-462[»]
2YARX-ray1.80A24-462[»]
4AI7X-ray1.70A24-462[»]
5AFAX-ray2.19A24-462[»]
5G3BX-ray1.69A24-462[»]
5G3DX-ray1.78A24-462[»]
5G3EX-ray1.78A24-462[»]
5G3FX-ray1.82A24-462[»]
5JRRX-ray1.90A24-462[»]
5JX9X-ray1.60A24-462[»]
5K0DX-ray1.82A24-462[»]
5K15X-ray1.55A24-462[»]
5K3KX-ray1.64A24-462[»]
5K5KX-ray1.80A24-462[»]
5K7AX-ray1.50A24-462[»]
5K84X-ray1.78A24-462[»]
6Q29X-ray1.70A24-462[»]
6TYRX-ray1.81A24-462[»]
SMRiQ72HW2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi262724.TT_C1370

Genome annotation databases

EnsemblBacteriaiAAS81712; AAS81712; TT_C1370
KEGGitth:TT_C1370

Phylogenomic databases

eggNOGiCOG2132, Bacteria
HOGENOMiCLU_009100_2_1_0
OMAiPHNFHVH
OrthoDBi971126at2

Enzyme and pathway databases

BRENDAi1.10.3.2, 2305
SABIO-RKiQ72HW2

Miscellaneous databases

EvolutionaryTraceiQ72HW2

Family and domain databases

Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117, Cu-oxidase
IPR011706, Cu-oxidase_2
IPR011707, Cu-oxidase_3
IPR002355, Cu_oxidase_Cu_BS
IPR008972, Cupredoxin
PfamiView protein in Pfam
PF00394, Cu-oxidase, 1 hit
PF07731, Cu-oxidase_2, 1 hit
PF07732, Cu-oxidase_3, 1 hit
SUPFAMiSSF49503, SSF49503, 3 hits
PROSITEiView protein in PROSITE
PS00080, MULTICOPPER_OXIDASE2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ72HW2_THET2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q72HW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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