UniProtKB - Q72HB8 (RF1_THET2)
Protein
Peptide chain release factor 1
Gene
prfA
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Functioni
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.UniRule annotation
GO - Molecular functioni
- translation release factor activity, codon specific Source: UniProtKB-UniRule
Keywordsi
Biological process | Protein biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Peptide chain release factor 1UniRule annotationShort name: RF-1UniRule annotation |
Gene namesi | Name:prfAUniRule annotation Ordered Locus Names:TT_C1577 |
Organismi | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) |
Taxonomic identifieri | 262724 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000263382 | 1 – 354 | Peptide chain release factor 1Add BLAST | 354 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 230 | N5-methylglutamineUniRule annotation | 1 |
Post-translational modificationi
Methylated by PrmC. Methylation increases the termination efficiency of RF1.UniRule annotation
Keywords - PTMi
MethylationProteomic databases
PRIDEi | Q72HB8 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q72HB8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q72HB8 |
Family & Domainsi
Sequence similaritiesi
Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0216, Bacteria |
HOGENOMi | CLU_036856_0_1_0 |
OMAi | ISDHRVG |
OrthoDBi | 928964at2 |
Family and domain databases
HAMAPi | MF_00093, Rel_fac_1, 1 hit |
InterProi | View protein in InterPro IPR005139, PCRF IPR000352, Pep_chain_release_fac_I IPR004373, PrfA |
Pfami | View protein in Pfam PF03462, PCRF, 1 hit PF00472, RF-1, 1 hit |
SMARTi | View protein in SMART SM00937, PCRF, 1 hit |
TIGRFAMsi | TIGR00019, prfA, 1 hit |
PROSITEi | View protein in PROSITE PS00745, RF_PROK_I, 1 hit |
i Sequence
Sequence statusi: Complete.
Q72HB8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDKLDRLEE EYRELEALLS DPEVLKDKGR YQSLSRRYAE MGEVIGLIRE
60 70 80 90 100
YRKVLEDLEQ AESLLDDPEL KEMAKAEREA LLARKEALEK ELERHLLPKD
110 120 130 140 150
PMDERDAIVE IRAGTGGEEA ALFARDLFNM YLRFAEEMGF ETEVLDSHPT
160 170 180 190 200
DLGGFSKVVF EVRGPGAYGT FKYESGVHRV QRVPVTETQG RIHTSTATVA
210 220 230 240 250
VLPKAEEEDF ALNMDEIRID VMRASGPGGQ GVNTTDSAVR VVHLPTGIMV
260 270 280 290 300
TCQDSRSQIK NREKALMILR SRLLEMKRAE EAERLRKTRL AQIGTGERSE
310 320 330 340 350
KIRTYNFPQS RVTDHRIGFT THDLEGVLSG HLTPILEALK RADQERQLAA
LAEG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017221 Genomic DNA Translation: AAS81919.1 |
RefSeqi | WP_011173949.1, NC_005835.1 |
Genome annotation databases
EnsemblBacteriai | AAS81919; AAS81919; TT_C1577 |
GeneIDi | 3169506 |
KEGGi | tth:TT_C1577 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017221 Genomic DNA Translation: AAS81919.1 |
RefSeqi | WP_011173949.1, NC_005835.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4V63 | X-ray | 3.21 | AX/CX | 1-354 | [»] | |
4V7P | X-ray | 3.62 | AV/DV | 1-354 | [»] | |
SMRi | Q72HB8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 262724.TT_C1577 |
Proteomic databases
PRIDEi | Q72HB8 |
Genome annotation databases
EnsemblBacteriai | AAS81919; AAS81919; TT_C1577 |
GeneIDi | 3169506 |
KEGGi | tth:TT_C1577 |
Phylogenomic databases
eggNOGi | COG0216, Bacteria |
HOGENOMi | CLU_036856_0_1_0 |
OMAi | ISDHRVG |
OrthoDBi | 928964at2 |
Miscellaneous databases
EvolutionaryTracei | Q72HB8 |
Family and domain databases
HAMAPi | MF_00093, Rel_fac_1, 1 hit |
InterProi | View protein in InterPro IPR005139, PCRF IPR000352, Pep_chain_release_fac_I IPR004373, PrfA |
Pfami | View protein in Pfam PF03462, PCRF, 1 hit PF00472, RF-1, 1 hit |
SMARTi | View protein in SMART SM00937, PCRF, 1 hit |
TIGRFAMsi | TIGR00019, prfA, 1 hit |
PROSITEi | View protein in PROSITE PS00745, RF_PROK_I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RF1_THET2 | |
Accessioni | Q72HB8Primary (citable) accession number: Q72HB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families