UniProtKB - Q72H91 (SP0J_THET2)
Protein
Chromosome-partitioning protein Spo0J
Gene
spo0C
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Functioni
Probably involved in chromosome partitioning. Binds to a plasmid centromere-like site parS. Stimulates the ATPase activity 10-fold of Soj; the first 20 residues may be responsible.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 137 – 156 | H-T-H motifCuratedAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- chromosome segregation Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Chromosome partition |
Names & Taxonomyi
Protein namesi | Recommended name: Chromosome-partitioning protein Spo0J |
Gene namesi | Name:spo0C Synonyms:parB Ordered Locus Names:TT_C1604 |
Organismi | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) |
Taxonomic identifieri | 262724 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › |
Proteomesi |
|
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 10 | R → A: No longer stimulates ATPase activity of Soj, in the 1-20 peptide. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422778 | 1 – 269 | Chromosome-partitioning protein Spo0JAdd BLAST | 269 |
Interactioni
Subunit structurei
Homodimer, probably via the C-terminal 46 residues. Dimerization of the N-terminal H-T-H region may require DNA-binding. Probably interacts with ATPase Soj.
1 PublicationProtein-protein interaction databases
STRINGi | 262724.TT_C1604 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q72H91 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q72H91 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | Stimulates ATPase activity of Soj by 8%Add BLAST | 20 | |
Regioni | 223 – 269 | Required for DNA-binding; may be responsible for dimerizationAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the ParB family.Curated
Phylogenomic databases
eggNOGi | COG1475, Bacteria |
HOGENOMi | CLU_023853_0_0_0 |
OMAi | IALSYQR |
OrthoDBi | 653368at2 |
Family and domain databases
InterProi | View protein in InterPro IPR041468, HTH_ParB/Spo0J IPR004437, ParB/RepB/Spo0J IPR003115, ParB/Sulfiredoxin_dom IPR036086, ParB/Sulfiredoxin_sf |
Pfami | View protein in Pfam PF17762, HTH_ParB, 1 hit PF02195, ParBc, 1 hit |
SMARTi | View protein in SMART SM00470, ParB, 1 hit |
SUPFAMi | SSF110849, SSF110849, 1 hit |
TIGRFAMsi | TIGR00180, parB_part, 1 hit |
i Sequence
Sequence statusi: Complete.
Q72H91-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRKPSGLGR GLEALLPKTG AGVVRLPLAS IRPNPRQPRK RFAEESLKEL
60 70 80 90 100
ADSIREKGLL QPLLVRPQGD GYELVAGERR YRAALMAGLQ EVPAVVKDLT
110 120 130 140 150
DREALELALV ENLQREDLSP VEEARGYQAL LEMGLTQEEV ARRVGKARST
160 170 180 190 200
VANALRLLQL PPEALEALER GEITAGHARA LLMLEPEDRL WGLKEILEKG
210 220 230 240 250
LSVRQAEALR ERLAMAPKRS AEPSPLSLEL SRHLGLPVRV VGGKKGKVVI
260
QYRSLEELEA LLRRLGYQA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017221 Genomic DNA Translation: AAS81946.1 |
RefSeqi | WP_011173975.1, NC_005835.1 |
Genome annotation databases
EnsemblBacteriai | AAS81946; AAS81946; TT_C1604 |
KEGGi | tth:TT_C1604 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017221 Genomic DNA Translation: AAS81946.1 |
RefSeqi | WP_011173975.1, NC_005835.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1VZ0 | X-ray | 2.30 | A/B/C/D/E/F/G/H | 1-222 | [»] | |
SMRi | Q72H91 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 262724.TT_C1604 |
Genome annotation databases
EnsemblBacteriai | AAS81946; AAS81946; TT_C1604 |
KEGGi | tth:TT_C1604 |
Phylogenomic databases
eggNOGi | COG1475, Bacteria |
HOGENOMi | CLU_023853_0_0_0 |
OMAi | IALSYQR |
OrthoDBi | 653368at2 |
Miscellaneous databases
EvolutionaryTracei | Q72H91 |
Family and domain databases
InterProi | View protein in InterPro IPR041468, HTH_ParB/Spo0J IPR004437, ParB/RepB/Spo0J IPR003115, ParB/Sulfiredoxin_dom IPR036086, ParB/Sulfiredoxin_sf |
Pfami | View protein in Pfam PF17762, HTH_ParB, 1 hit PF02195, ParBc, 1 hit |
SMARTi | View protein in SMART SM00470, ParB, 1 hit |
SUPFAMi | SSF110849, SSF110849, 1 hit |
TIGRFAMsi | TIGR00180, parB_part, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SP0J_THET2 | |
Accessioni | Q72H91Primary (citable) accession number: Q72H91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2013 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families