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Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9ATPUniRule annotation1
Binding sitei57ATPUniRule annotation1
Binding sitei85ATPUniRule annotation1
Binding sitei91ATPUniRule annotation1
Binding sitei102ATPUniRule annotation1
Binding sitei112ATPUniRule annotation1
Active sitei115Pros-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE262724:G1G0N-1843-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:TT_C1798
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001370661 – 137Nucleoside diphosphate kinaseAdd BLAST137

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ72GQ0

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi262724.TTC1798

Structurei

3D structure databases

ProteinModelPortaliQ72GQ0
SMRiQ72GQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UGX Bacteria
COG0105 LUCA
KOiK00940
OMAiKIVAMKM

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit

Sequencei

Sequence statusi: Complete.

Q72GQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTFVMIKP DGVRRGLVGE ILARFERKGF RIAALKLMRI SQELAERHYA
60 70 80 90 100
EHREKPFFPG LVRFITSGPV VAMVLEGPGV VAEVRKMMGA THPKDALPGT
110 120 130
IRGDFATTID ENVIHGSATL EDAQREIALF FRPEELL
Length:137
Mass (Da):15,372
Last modified:July 5, 2004 - v1
Checksum:iE53165C37B34D1EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA Translation: AAS82140.1
RefSeqiWP_011174154.1, NC_005835.1

Genome annotation databases

EnsemblBacteriaiAAS82140; AAS82140; TT_C1798
KEGGitth:TT_C1798

Similar proteinsi

Entry informationi

Entry nameiNDK_THET2
AccessioniPrimary (citable) accession number: Q72GQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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