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UniProtKB - Q72DX8 (UVRC_DESVH)

Entry version 106 (25 May 2022)
Sequence version 2 (12 Dec 2006)
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Protein

UvrABC system protein C

Gene

uvrC

Organism
Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:DVU_0801
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri882 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002194 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002274281 – 688UvrABC system protein CAdd BLAST688

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q72DX8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UvrB in an incision complex.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		882.DVU_0801

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q72DX8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q72DX8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 90GIY-YIGUniRule annotationAdd BLAST80
Domaini200 – 235UVRUniRule annotationAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0322, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014841_3_2_7

Identification of Orthologs from Complete Genome Data

More...OMAi		HIECFDN

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q72DX8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.420.340, 1 hit
3.40.1440.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00203, UvrC, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000305, GIY-YIG_endonuc
IPR035901, GIY-YIG_endonuc_sf
IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994, RuvA_2-like
IPR001943, UVR_dom
IPR036876, UVR_dom_sf
IPR004791, UvrC
IPR001162, UvrC_RNase_H_dom
IPR038476, UvrC_RNase_H_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01541, GIY-YIG, 1 hit
PF02151, UVR, 1 hit
PF08459, UvrC_HhH_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00465, GIYc, 1 hit
SM00278, HhH1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46600, SSF46600, 1 hit
SSF47781, SSF47781, 1 hit
SSF82771, SSF82771, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00194, uvrC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50164, GIY_YIG, 1 hit
PS50151, UVR, 1 hit
PS50165, UVRC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q72DX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERPDLSTIP LTPGVYLYKD ESGRIIYVGK ARCLRRRVAS YFRDVSALTP 
        60         70         80         90        100
KTVAMLRHAV TIDTLSTTTE KEALLLEASL IKKHRPRYNI VLRDDKQYVL 
       110        120        130        140        150
FRIGAKHPYP RLEIVRKARR DDGRYFGPFT SASAARETWK TIHRAFPLRR 
       160        170        180        190        200
CSDRAFGNRV RACLYHHMGQ CLGPCVNEVP SETYAALLEQ VSLLLSGRSG 
       210        220        230        240        250
ELVDALRTEM EAASQGLDFE RAAVLRDRIR ALERTVERQA AVLPGGGDLD 
       260        270        280        290        300
VVGVVEVENG LALGVLFVRQ GVLLDGRSFF WPGLGFAEAP ELLWSFLGQF 
       310        320        330        340        350
YGPQATIPPR IVVPWLPDED GETGDALDGS SDAVVPVAAA TTIDASLADV 
       360        370        380        390        400
RTGTEVTSLI NASHAAPNVG ESTQGDTLAG ATGKGATHLM LETALAALRG 
       410        420        430        440        450
GIVRIALPRN PAENRLVDMA MSNAREEARR KADTPLQDLL ARALHLAGPP 
       460        470        480        490        500
HRIEAVDVSH TGGRNTRVGM VVFEDGKPFP EAYRTYAFED GDGDDYGTLA 
       510        520        530        540        550
AWAGRRVESG PPWPDLLLVD GGRGQLAAVV RAFEECGMGA AFAVASIAKA 
       560        570        580        590        600
RTEEGRADRR AGNVSDRIFL PGRANPLPLR AGAPELLFLQ HVRDTVHDYS 
       610        620        630        640        650
IGKHRRARAG AALTGELQRV EGIGPATARA LWERFDSLQA MADAGVEGLA 
       660        670        680 
AVPGVGRARA AALHAHLVTF FGSSKQGGHA RTALQRKG
Length:688
Mass (Da):74,433
Last modified:December 12, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB763F7538F0F357
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAS95281 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE017285 Genomic DNA Translation: AAS95281.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		WP_014524276.1, NC_002937.3
YP_010022.1, NC_002937.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAS95281; AAS95281; DVU_0801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dvu:DVU_0801

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|882.5.peg.750

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA Translation: AAS95281.1 Different initiation.
RefSeqiWP_014524276.1, NC_002937.3
YP_010022.1, NC_002937.3

3D structure databases

AlphaFoldDBiQ72DX8
SMRiQ72DX8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi882.DVU_0801

Proteomic databases

PaxDbiQ72DX8

Genome annotation databases

EnsemblBacteriaiAAS95281; AAS95281; DVU_0801
KEGGidvu:DVU_0801
PATRICifig|882.5.peg.750

Phylogenomic databases

eggNOGiCOG0322, Bacteria
HOGENOMiCLU_014841_3_2_7
OMAiHIECFDN
PhylomeDBiQ72DX8

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203, UvrC, 1 hit
InterProiView protein in InterPro
IPR000305, GIY-YIG_endonuc
IPR035901, GIY-YIG_endonuc_sf
IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994, RuvA_2-like
IPR001943, UVR_dom
IPR036876, UVR_dom_sf
IPR004791, UvrC
IPR001162, UvrC_RNase_H_dom
IPR038476, UvrC_RNase_H_dom_sf
PfamiView protein in Pfam
PF01541, GIY-YIG, 1 hit
PF02151, UVR, 1 hit
PF08459, UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465, GIYc, 1 hit
SM00278, HhH1, 2 hits
SUPFAMiSSF46600, SSF46600, 1 hit
SSF47781, SSF47781, 1 hit
SSF82771, SSF82771, 1 hit
TIGRFAMsiTIGR00194, uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164, GIY_YIG, 1 hit
PS50151, UVR, 1 hit
PS50165, UVRC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUVRC_DESVH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q72DX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 12, 2006
Last modified: May 25, 2022
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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