We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q72DX8 (UVRC_DESVH)
Protein
UvrABC system protein C
Gene
uvrC
Organism
Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough)
Status
Functioni
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
UniRule annotationGO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- excinuclease ABC activity Source: UniProtKB-UniRule
GO - Biological processi
- nucleotide-excision repair Source: UniProtKB-UniRule
- SOS response Source: UniProtKB-UniRule
Keywordsi
Molecular function | Excision nuclease |
Biological process | DNA damage, DNA excision, DNA repair, SOS response |
Names & Taxonomyi
Protein namesi | Recommended name: UvrABC system protein CUniRule annotationShort name: Protein UvrCUniRule annotation Alternative name(s): Excinuclease ABC subunit CUniRule annotation |
Gene namesi | Name:uvrCUniRule annotation Ordered Locus Names:DVU_0801 |
Organismi | Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) |
Taxonomic identifieri | 882 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
- excinuclease repair complex Source: InterPro
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227428 | 1 – 688 | UvrABC system protein CAdd BLAST | 688 |
Proteomic databases
PaxDbi | Q72DX8 |
Interactioni
Subunit structurei
Interacts with UvrB in an incision complex.
UniRule annotationProtein-protein interaction databases
STRINGi | 882.DVU_0801 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 90 | GIY-YIGUniRule annotationAdd BLAST | 80 | |
Domaini | 200 – 235 | UVRUniRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the UvrC family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0322, Bacteria |
HOGENOMi | CLU_014841_3_2_7 |
OMAi | HIECFDN |
PhylomeDBi | Q72DX8 |
Family and domain databases
Gene3Di | 3.30.420.340, 1 hit 3.40.1440.10, 1 hit |
HAMAPi | MF_00203, UvrC, 1 hit |
InterProi | View protein in InterPro IPR000305, GIY-YIG_endonuc IPR035901, GIY-YIG_endonuc_sf IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif IPR010994, RuvA_2-like IPR001943, UVR_dom IPR036876, UVR_dom_sf IPR004791, UvrC IPR001162, UvrC_RNase_H_dom IPR038476, UvrC_RNase_H_dom_sf |
Pfami | View protein in Pfam PF01541, GIY-YIG, 1 hit PF02151, UVR, 1 hit PF08459, UvrC_HhH_N, 1 hit |
SMARTi | View protein in SMART SM00465, GIYc, 1 hit SM00278, HhH1, 2 hits |
SUPFAMi | SSF46600, SSF46600, 1 hit SSF47781, SSF47781, 1 hit SSF82771, SSF82771, 1 hit |
TIGRFAMsi | TIGR00194, uvrC, 1 hit |
PROSITEi | View protein in PROSITE PS50164, GIY_YIG, 1 hit PS50151, UVR, 1 hit PS50165, UVRC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q72DX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERPDLSTIP LTPGVYLYKD ESGRIIYVGK ARCLRRRVAS YFRDVSALTP
60 70 80 90 100
KTVAMLRHAV TIDTLSTTTE KEALLLEASL IKKHRPRYNI VLRDDKQYVL
110 120 130 140 150
FRIGAKHPYP RLEIVRKARR DDGRYFGPFT SASAARETWK TIHRAFPLRR
160 170 180 190 200
CSDRAFGNRV RACLYHHMGQ CLGPCVNEVP SETYAALLEQ VSLLLSGRSG
210 220 230 240 250
ELVDALRTEM EAASQGLDFE RAAVLRDRIR ALERTVERQA AVLPGGGDLD
260 270 280 290 300
VVGVVEVENG LALGVLFVRQ GVLLDGRSFF WPGLGFAEAP ELLWSFLGQF
310 320 330 340 350
YGPQATIPPR IVVPWLPDED GETGDALDGS SDAVVPVAAA TTIDASLADV
360 370 380 390 400
RTGTEVTSLI NASHAAPNVG ESTQGDTLAG ATGKGATHLM LETALAALRG
410 420 430 440 450
GIVRIALPRN PAENRLVDMA MSNAREEARR KADTPLQDLL ARALHLAGPP
460 470 480 490 500
HRIEAVDVSH TGGRNTRVGM VVFEDGKPFP EAYRTYAFED GDGDDYGTLA
510 520 530 540 550
AWAGRRVESG PPWPDLLLVD GGRGQLAAVV RAFEECGMGA AFAVASIAKA
560 570 580 590 600
RTEEGRADRR AGNVSDRIFL PGRANPLPLR AGAPELLFLQ HVRDTVHDYS
610 620 630 640 650
IGKHRRARAG AALTGELQRV EGIGPATARA LWERFDSLQA MADAGVEGLA
660 670 680
AVPGVGRARA AALHAHLVTF FGSSKQGGHA RTALQRKG
Sequence cautioni
The sequence AAS95281 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017285 Genomic DNA Translation: AAS95281.1 Different initiation. |
RefSeqi | WP_014524276.1, NC_002937.3 YP_010022.1, NC_002937.3 |
Genome annotation databases
EnsemblBacteriai | AAS95281; AAS95281; DVU_0801 |
KEGGi | dvu:DVU_0801 |
PATRICi | fig|882.5.peg.750 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017285 Genomic DNA Translation: AAS95281.1 Different initiation. |
RefSeqi | WP_014524276.1, NC_002937.3 YP_010022.1, NC_002937.3 |
3D structure databases
AlphaFoldDBi | Q72DX8 |
SMRi | Q72DX8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 882.DVU_0801 |
Proteomic databases
PaxDbi | Q72DX8 |
Genome annotation databases
EnsemblBacteriai | AAS95281; AAS95281; DVU_0801 |
KEGGi | dvu:DVU_0801 |
PATRICi | fig|882.5.peg.750 |
Phylogenomic databases
eggNOGi | COG0322, Bacteria |
HOGENOMi | CLU_014841_3_2_7 |
OMAi | HIECFDN |
PhylomeDBi | Q72DX8 |
Family and domain databases
Gene3Di | 3.30.420.340, 1 hit 3.40.1440.10, 1 hit |
HAMAPi | MF_00203, UvrC, 1 hit |
InterProi | View protein in InterPro IPR000305, GIY-YIG_endonuc IPR035901, GIY-YIG_endonuc_sf IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif IPR010994, RuvA_2-like IPR001943, UVR_dom IPR036876, UVR_dom_sf IPR004791, UvrC IPR001162, UvrC_RNase_H_dom IPR038476, UvrC_RNase_H_dom_sf |
Pfami | View protein in Pfam PF01541, GIY-YIG, 1 hit PF02151, UVR, 1 hit PF08459, UvrC_HhH_N, 1 hit |
SMARTi | View protein in SMART SM00465, GIYc, 1 hit SM00278, HhH1, 2 hits |
SUPFAMi | SSF46600, SSF46600, 1 hit SSF47781, SSF47781, 1 hit SSF82771, SSF82771, 1 hit |
TIGRFAMsi | TIGR00194, uvrC, 1 hit |
PROSITEi | View protein in PROSITE PS50164, GIY_YIG, 1 hit PS50151, UVR, 1 hit PS50165, UVRC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UVRC_DESVH | |
Accessioni | Q72DX8Primary (citable) accession number: Q72DX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | December 12, 2006 | |
Last modified: | May 25, 2022 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families