UniProtKB - Q728V0 (MURB_DESVH)
Protein
UDP-N-acetylenolpyruvoylglucosamine reductase
Gene
murB
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Status
Functioni
Cell wall formation.UniRule annotation
Catalytic activityi
- NADP+ + UDP-N-acetyl-α-D-muramate = H+ + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-α-D-glucosamineUniRule annotationEC:1.3.1.98UniRule annotation
Cofactori
FADUniRule annotation
: peptidoglycan biosynthesis Pathwayi
This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 166 | UniRule annotation | 1 | |
Active sitei | 218 | Proton donorUniRule annotation | 1 | |
Active sitei | 289 | UniRule annotation | 1 |
GO - Molecular functioni
- FAD binding Source: InterPro
- UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-UniRule
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cell wall organization Source: UniProtKB-KW
- peptidoglycan biosynthetic process Source: UniProtKB-UniRule
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
BioCyci | DVUL882:G1GT1-2571-MONOMER |
UniPathwayi | UPA00219 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)Alternative name(s): UDP-N-acetylmuramate dehydrogenaseUniRule annotation |
Gene namesi | Name:murBUniRule annotation Ordered Locus Names:DVU_2502 |
Organismi | Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303) |
Taxonomic identifieri | 882 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000224682 | 1 – 296 | UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST | 296 |
Proteomic databases
PaxDbi | Q728V0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 189 | FAD-binding PCMH-typeUniRule annotationAdd BLAST | 172 |
Sequence similaritiesi
Belongs to the MurB family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0812, Bacteria |
HOGENOMi | CLU_035304_1_1_7 |
OMAi | KMNAGMK |
PhylomeDBi | Q728V0 |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit 3.30.465.10, 1 hit 3.90.78.10, 1 hit |
HAMAPi | MF_00037, MurB, 1 hit |
InterProi | View protein in InterPro IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR003170, MurB IPR011601, MurB_C IPR036635, MurB_C_sf IPR006094, Oxid_FAD_bind_N |
PANTHERi | PTHR21071, PTHR21071, 1 hit |
Pfami | View protein in Pfam PF01565, FAD_binding_4, 1 hit PF02873, MurB_C, 1 hit |
SUPFAMi | SSF56176, SSF56176, 1 hit SSF56194, SSF56194, 1 hit |
TIGRFAMsi | TIGR00179, murB, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q728V0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKVLEGPSL AERTTLRLGG RALAEVRVTS RDALDDLPGV LQCLGGSPLM
60 70 80 90 100
LGCGSNILAA DGELPVVVVS LDMDDAPTIV GETAEGVVVR VGAATRLPRL
110 120 130 140 150
LGQLASWGLA GLEGLAGIPG SVGGAVAMNA GSYGCEFGTV LRSVEVFSPD
160 170 180 190 200
FGLADVPHEN IEYAYRHFGL KGCHGWFVVT GADIVLRRGE SAAITAAMRA
210 220 230 240 250
NYLKKKSTQP VLARSAGCVF RNPAPGVSAG RLIDQAGLRG KRIGGMAFSE
260 270 280 290
VHANFLVNEG AGRSDEAFEL LQLAQEIVKR RHGMDLTLEV KILSWL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017285 Genomic DNA Translation: AAS96974.1 |
RefSeqi | WP_010939772.1, NZ_CABHLV010000001.1 YP_011714.1, NC_002937.3 |
Genome annotation databases
EnsemblBacteriai | AAS96974; AAS96974; DVU_2502 |
KEGGi | dvu:DVU2502 |
PATRICi | fig|882.5.peg.2262 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017285 Genomic DNA Translation: AAS96974.1 |
RefSeqi | WP_010939772.1, NZ_CABHLV010000001.1 YP_011714.1, NC_002937.3 |
3D structure databases
SMRi | Q728V0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q728V0, 1 interactor |
STRINGi | 882.DVU_2502 |
Proteomic databases
PaxDbi | Q728V0 |
Genome annotation databases
EnsemblBacteriai | AAS96974; AAS96974; DVU_2502 |
KEGGi | dvu:DVU2502 |
PATRICi | fig|882.5.peg.2262 |
Phylogenomic databases
eggNOGi | COG0812, Bacteria |
HOGENOMi | CLU_035304_1_1_7 |
OMAi | KMNAGMK |
PhylomeDBi | Q728V0 |
Enzyme and pathway databases
UniPathwayi | UPA00219 |
BioCyci | DVUL882:G1GT1-2571-MONOMER |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit 3.30.465.10, 1 hit 3.90.78.10, 1 hit |
HAMAPi | MF_00037, MurB, 1 hit |
InterProi | View protein in InterPro IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR003170, MurB IPR011601, MurB_C IPR036635, MurB_C_sf IPR006094, Oxid_FAD_bind_N |
PANTHERi | PTHR21071, PTHR21071, 1 hit |
Pfami | View protein in Pfam PF01565, FAD_binding_4, 1 hit PF02873, MurB_C, 1 hit |
SUPFAMi | SSF56176, SSF56176, 1 hit SSF56194, SSF56194, 1 hit |
TIGRFAMsi | TIGR00179, murB, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MURB_DESVH | |
Accessioni | Q728V0Primary (citable) accession number: Q728V0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families