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UniProtKB - Q72874 (Q72874_9HIV1)
Protein
Submitted name:
Pol polyprotein
Gene
pol
Organism
Human immunodeficiency virus 1
Status
Functioni
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Aspartyl proteaseARBA annotation, Hydrolase, Protease |
Protein family/group databases
MEROPSi | A02.001 |
Names & Taxonomyi
Protein namesi | Submitted name: Pol polyproteinImported |
Gene namesi | Name:polImported |
Organismi | Human immunodeficiency virus 1Imported |
Taxonomic identifieri | 11676 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Pararnavirae › Artverviricota › Revtraviricetes › Ortervirales › Retroviridae › Orthoretrovirinae › Lentivirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Pathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL243 |
DrugBanki | DB00701, Amprenavir DB01072, Atazanavir DB04887, Brecanavir DB01264, Darunavir DB01319, Fosamprenavir DB00224, Indinavir DB01601, Lopinavir DB00503, Ritonavir DB01232, Saquinavir DB00932, Tipranavir |
DrugCentrali | Q72874 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 89 | Peptidase A2InterPro annotationAdd BLAST | 70 |
Family and domain databases
CDDi | cd05482, HIV_retropepsin_like, 1 hit |
Gene3Di | 2.40.70.10, 1 hit |
InterProi | View protein in InterPro IPR001969, Aspartic_peptidase_AS IPR001995, Peptidase_A2_cat IPR021109, Peptidase_aspartic_dom_sf IPR034170, Retropepsin-like_cat_dom IPR018061, Retropepsins |
Pfami | View protein in Pfam PF00077, RVP, 1 hit |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS50175, ASP_PROT_RETROV, 1 hit PS00141, ASP_PROTEASE, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q72874-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
PQVTLWQRPL VTIKIGGQLK EALLDTGADD TVLEEMSLPG RWKPKMIGGI
60 70 80 90
GGFIKVRQYD QILIEICGHK AIGTVLVGPT PVNIIGRNLL TQIGCTLNF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 99 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31398 Genomic DNA Translation: AAA91440.1 |
PIRi | S63716 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31398 Genomic DNA Translation: AAA91440.1 |
PIRi | S63716 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5V4Y | X-ray | 1.90 | A | 1-99 | [»] | |
7DOZ | X-ray | 1.91 | A | 1-99 | [»] | |
7DPQ | X-ray | 1.65 | A | 1-99 | [»] | |
SMRi | Q72874 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
BindingDBi | Q72874 |
ChEMBLi | CHEMBL243 |
DrugBanki | DB00701, Amprenavir DB01072, Atazanavir DB04887, Brecanavir DB01264, Darunavir DB01319, Fosamprenavir DB00224, Indinavir DB01601, Lopinavir DB00503, Ritonavir DB01232, Saquinavir DB00932, Tipranavir |
DrugCentrali | Q72874 |
Protein family/group databases
MEROPSi | A02.001 |
Family and domain databases
CDDi | cd05482, HIV_retropepsin_like, 1 hit |
Gene3Di | 2.40.70.10, 1 hit |
InterProi | View protein in InterPro IPR001969, Aspartic_peptidase_AS IPR001995, Peptidase_A2_cat IPR021109, Peptidase_aspartic_dom_sf IPR034170, Retropepsin-like_cat_dom IPR018061, Retropepsins |
Pfami | View protein in Pfam PF00077, RVP, 1 hit |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS50175, ASP_PROT_RETROV, 1 hit PS00141, ASP_PROTEASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q72874_9HIV1 | |
Accessioni | Q72874Primary (citable) accession number: Q72874 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1996 |
Last sequence update: | November 1, 1996 | |
Last modified: | January 19, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |