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Protein
Submitted name:

Reverse transcriptase/RNaseH

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi443ManganeseCombined sources1
Metal bindingi478ManganeseCombined sources1
Metal bindingi498ManganeseCombined sources1

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed DNA polymeraseSAAS annotationImported, Transferase
LigandManganeseCombined sources, Metal-bindingCombined sourcesSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Reverse transcriptase/RNaseHImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL247
DrugBankiDB07935 5-[(5-fluoro-3-methyl-1H-indazol-4-yl)oxy]benzene-1,3-dicarbonitrile
DB01048 Abacavir
DB11799 Bictegravir
DB00705 Delavirdine
DB00900 Didanosine
DB00625 Efavirenz
DB00879 Emtricitabine
DB00709 Lamivudine
DB00238 Nevirapine
DB08864 Rilpivirine
DB11365 Sennosides
DB00649 Stavudine
DB09299 Tenofovir alafenamide
DB00300 Tenofovir disoproxil
DB00943 Zalcitabine
DB00495 Zidovudine

Interactioni

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

IntActiQ72547, 1 interactor
MINTiQ72547

Structurei

3D structure databases

ProteinModelPortaliQ72547
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72547

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 234Reverse transcriptaseInterPro annotationAdd BLAST191
Domaini434 – 557RNase HInterPro annotationAdd BLAST124

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
PfamiView protein in Pfam
PF00075 RNase_H, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit
PS50878 RT_POL, 1 hit

Sequencei

Sequence statusi: Fragment.

Q72547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PISPIETVPV KLKPGMDGPK VKQWPLTEEK IKALVEICTE MEKEGKISKI
60 70 80 90 100
GPENPYNTPV FAIKKKDSTK WRKLVDFREL NKRTQDFWEV QLGIPHPAGL
110 120 130 140 150
KKRKSVTVLD VGDAYFSVPL DEDFRKYTAF TIPSINNETP GIRYQYNVLP
160 170 180 190 200
QGWKGSPAIF QSSMTKILEP FRKQNPDIVI YQYMDDLYVG SDLEIGQHRT
210 220 230 240 250
KIEELRQHLL RWGLTTPDKK HQKEPPFLWM GYELHPDKWT VQPIVLPEKD
260 270 280 290 300
SWTVNDIQKL VGKLNWASQI YPGIRVRQLC KLLRGTKALT EVIPLTEEAE
310 320 330 340 350
LELAENREIL KEPVHGVYYD PSKDLIAEIQ KQGQGQWTYQ IYQEPFKNLR
360 370 380 390 400
TGKYARMRGA HTNDVKQLTE AVQKITTESI VIWGKTPKFK LPIQKETWET
410 420 430 440 450
WWTEYWQATW IPEWEFVNTP PLVKLWYQLE KEPIVGAETF YVDGAANRET
460 470 480 490 500
KLGKAGYVTN RGRQKVVTLT DTTNQKTELQ AIYLALQDSG LEVNIVTDSQ
510 520 530 540 550
YALGIIQAQP DQSESELVNQ IIEQLIKKEK VYLAWVPAHK GIGGNEQVDK
560
LVSAGIRKVL FLDGID
Length:566
Mass (Da):65,224
Last modified:November 1, 1996 - v1
Checksum:iAA4B9287ECC4E5C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei566Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28646 Genomic DNA Translation: AAA93161.1
PIRiA47330
B47330
C47330
D47330
E47330
F47330
S32132

Similar proteinsi

Entry informationi

Entry nameiQ72547_9HIV1
AccessioniPrimary (citable) accession number: Q72547
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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