UniProtKB - Q722Y7 (HIS6_LISMF)
Protein
Imidazole glycerol phosphate synthase subunit HisF
Gene
hisF
Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Functioni
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.UniRule annotation
Catalytic activityi
- 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H+ + L-glutamateUniRule annotationEC:4.3.2.10UniRule annotation
: L-histidine biosynthesis Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationProteins known to be involved in the 9 steps of the subpathway in this organism are:
- ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
- Phosphoribosyl-ATP pyrophosphatase (hisE)
- Phosphoribosyl-AMP cyclohydrolase (hisI)
- 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
- Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
- Imidazoleglycerol-phosphate dehydratase (hisB)
- Histidinol-phosphate aminotransferase (hisC)
- no protein annotated in this organism
- Histidinol dehydrogenase (hisD)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 11 | UniRule annotation | 1 | |
Active sitei | 130 | UniRule annotation | 1 |
GO - Molecular functioni
- imidazoleglycerol-phosphate synthase activity Source: UniProtKB-UniRule
- lyase activity Source: UniProtKB-KW
GO - Biological processi
- histidine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Lyase |
Biological process | Amino-acid biosynthesis, Histidine biosynthesis |
Enzyme and pathway databases
BioCyci | LMON265669:G1G0V-607-MONOMER |
UniPathwayi | UPA00031;UER00010 |
Names & Taxonomyi
Protein namesi | Recommended name: Imidazole glycerol phosphate synthase subunit HisFUniRule annotation (EC:4.3.2.10UniRule annotation)Alternative name(s): IGP synthase cyclase subunitUniRule annotation IGP synthase subunit HisFUniRule annotation ImGP synthase subunit HisFUniRule annotation Short name: IGPS subunit HisFUniRule annotation |
Gene namesi | Name:hisFUniRule annotation Ordered Locus Names:LMOf2365_0592 |
Organismi | Listeria monocytogenes serotype 4b (strain F2365) |
Taxonomic identifieri | 265669 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000142179 | 1 – 251 | Imidazole glycerol phosphate synthase subunit HisFAdd BLAST | 251 |
Interactioni
Subunit structurei
Heterodimer of HisH and HisF.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the HisA/HisF family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_048577_4_0_9 |
OMAi | KRIVPCL |
Family and domain databases
CDDi | cd04731, HisF, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01013, HisF, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR006062, His_biosynth IPR004651, HisF IPR011060, RibuloseP-bd_barrel |
Pfami | View protein in Pfam PF00977, His_biosynth, 1 hit |
SUPFAMi | SSF51366, SSF51366, 1 hit |
TIGRFAMsi | TIGR00735, hisF, 1 hit |
i Sequence
Sequence statusi: Complete.
Q722Y7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTKRIIPCL DVTAGRVVKG VNFVSLTDVG DPVEIAKAYN EAGADELVFL
60 70 80 90 100
DITATVELRQ TMIDVVERTA EQVFIPLTVG GGISSVSDMK ELLQAGADKI
110 120 130 140 150
SLNSAAIKRP ELIQEGAAKF GNQCIVVAID AKWNGTNWSV FTRGGRNDTG
160 170 180 190 200
LDAIEWAKKA VQLGAGEILL TSMDGDGTKN GYDIPLTKAI SAAVSVPVIA
210 220 230 240 250
SGGCGNAAHM AEVFEKTKAT AALAASIFHY GELSIKNVKT TLLEKGVNIR
P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017262 Genomic DNA Translation: AAT03374.1 |
RefSeqi | WP_003725465.1, NC_002973.6 |
Genome annotation databases
KEGGi | lmf:LMOf2365_0592 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017262 Genomic DNA Translation: AAT03374.1 |
RefSeqi | WP_003725465.1, NC_002973.6 |
3D structure databases
SMRi | Q722Y7 |
ModBasei | Search... |
Genome annotation databases
KEGGi | lmf:LMOf2365_0592 |
Phylogenomic databases
HOGENOMi | CLU_048577_4_0_9 |
OMAi | KRIVPCL |
Enzyme and pathway databases
UniPathwayi | UPA00031;UER00010 |
BioCyci | LMON265669:G1G0V-607-MONOMER |
Family and domain databases
CDDi | cd04731, HisF, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01013, HisF, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR006062, His_biosynth IPR004651, HisF IPR011060, RibuloseP-bd_barrel |
Pfami | View protein in Pfam PF00977, His_biosynth, 1 hit |
SUPFAMi | SSF51366, SSF51366, 1 hit |
TIGRFAMsi | TIGR00735, hisF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HIS6_LISMF | |
Accessioni | Q722Y7Primary (citable) accession number: Q722Y7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families