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Protein

Acetate kinase 1

Gene

ackA1

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase 1 (ackA1), Acetate kinase 2 (ackA2)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Binding sitei15ATPUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Active sitei146Proton donor/acceptorUniRule annotation1
Sitei178Transition state stabilizerUniRule annotation1
Sitei239Transition state stabilizerUniRule annotation1
Metal bindingi380MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 210ATPUniRule annotation5
Nucleotide bindingi281 – 283ATPUniRule annotation3
Nucleotide bindingi329 – 333ATPUniRule annotation5

GO - Molecular functioni

  • acetate kinase activity Source: UniProtKB-EC
  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • propionate kinase activity Source: JCVI

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00340;UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinase 1UniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
Acetokinase 1UniRule annotation
Gene namesi
Name:ackA1UniRule annotation
Ordered Locus Names:LMOf2365_1176
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075771 – 397Acetate kinase 1Add BLAST397

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ720R2
SMRiQ720R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398
KOiK00925
OMAiFMMQKEN

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q720R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHKIMAINAG SSSLKFQIFT MPGEEVLVKG LIERIGLPDA IFNMSFQNEK
60 70 80 90 100
IKEIRAINNH GEAVEILLEQ LKAHQVINDL SEITGVGHRV AHGGEDFVTS
110 120 130 140 150
CVVTDEVVKG IEAVTNLAPL HNPANIIGIK TFRELLPNAV SVAVFDTAFH
160 170 180 190 200
QTIPEENFLY ALPYELYEKH HIRKYGFHGT SHKYVAGKAA EVLEKPLEKL
210 220 230 240 250
KIISCHLGNG ASVCAIEAGK SVNTSMGFTP NAGLMMGTRS GTIDATIIPY
260 270 280 290 300
LVDELGYSLD EVMHMMSSES GVLGVSGISS DFRDIEIAAK EGNSRALLTL
310 320 330 340 350
RMFTGQICNY IGAYASAMNG CDALLFTAGV GENSPLIRQM VTEQLSYLGV
360 370 380 390
TCHVTKNNAG DMIISNDDEA VKVCIIPTNE ELMIARDVEK YAKQTIS
Length:397
Mass (Da):43,150
Last modified:July 5, 2004 - v1
Checksum:iCCD3F60C4BABF533
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA Translation: AAT03952.1
RefSeqiWP_003724707.1, NC_002973.6

Genome annotation databases

EnsemblBacteriaiAAT03952; AAT03952; LMOf2365_1176
KEGGilmf:LMOf2365_1176

Similar proteinsi

Entry informationi

Entry nameiACKA1_LISMF
AccessioniPrimary (citable) accession number: Q720R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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