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Protein

L-lactate dehydrogenase 2

Gene

ldh2

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase 2 (ldh2), L-lactate dehydrogenase 1 (ldh1)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14NAD; via amide nitrogenUniRule annotation1
Binding sitei35NADUniRule annotation1
Binding sitei40NADUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Binding sitei103NADUniRule annotation1
Binding sitei145NADUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1
Binding sitei230SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi120 – 122NADUniRule annotation3

GO - Molecular functioni

  • L-lactate dehydrogenase activity Source: JCVI

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase 2UniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDH 2UniRule annotation
Gene namesi
Name:ldh2UniRule annotation
Ordered Locus Names:LMOf2365_1553
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683641 – 311L-lactate dehydrogenase 2Add BLAST311

Proteomic databases

PRIDEiQ71ZD6

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ71ZD6
SMRiQ71ZD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 125Substrate bindingUniRule annotation4
Regioni150 – 153Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213793
KOiK00016
OMAiSESCHGW

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q71ZD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPRKVMIIG AGNVGTAAAH AFVNQKFVEE LILVDLNKER VEGNRKDLAD
60 70 80 90 100
AAAFMPGKMD ITVRDASDCA DVDIAVITVT AGPLKEGQTR LDELRSTSRI
110 120 130 140 150
VSSIVPEMMK GGFNGIFLIA TNPCDIITYQ VWKLSGLPRE RVLGTGVWLD
160 170 180 190 200
TTRLRRLLAE KLDIAAQSID AFILGEHGDS QFPVWSHSSI YGKPVNEYSV
210 220 230 240 250
EKLGEALDLK QIGETARDTG FEIYHQKGCT EYGIGGTIVE ICRHIFSGSQ
260 270 280 290 300
RALTVSCVLD GEYGESGLAI GVPAVLSQNG VKEIISLKLD EKEKEAFANS
310
VAVIKKSIQS I
Length:311
Mass (Da):33,783
Last modified:July 5, 2004 - v1
Checksum:i1B288BDBDC01DC07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA Translation: AAT04328.1
RefSeqiWP_003726645.1, NC_002973.6

Genome annotation databases

EnsemblBacteriaiAAT04328; AAT04328; LMOf2365_1553
KEGGilmf:LMOf2365_1553

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA Translation: AAT04328.1
RefSeqiWP_003726645.1, NC_002973.6

3D structure databases

ProteinModelPortaliQ71ZD6
SMRiQ71ZD6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ71ZD6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT04328; AAT04328; LMOf2365_1553
KEGGilmf:LMOf2365_1553

Phylogenomic databases

HOGENOMiHOG000213793
KOiK00016
OMAiSESCHGW

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLDH2_LISMF
AccessioniPrimary (citable) accession number: Q71ZD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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