UniProtKB - Q71UM8 (Q71UM8_HUMAN)
Protein
Submitted name:
Adenylyl cyclase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- phosphorus-oxygen lyase activity Source: InterPro
GO - Biological processi
- cyclic nucleotide biosynthetic process Source: InterPro
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | LyaseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Adenylyl cyclaseImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 33 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 40 – 58 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 78 – 96 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 163 – 308 | Guanylate cyclaseInterPro annotationAdd BLAST | 146 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 114 – 134 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OrthoDBi | 363718at2759 |
Family and domain databases
Gene3Di | 3.30.70.1230, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF00211, Guanylate_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 1 hit |
SUPFAMi | SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q71UM8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
QVAILRAQNL FFLPYFIYSC ILGLISCSVF LRVNYELKML IMMVALVGYN
60 70 80 90 100
TILLHTHAHV LGDYSQVLFE RPGIWKDLKT MGSVSLSIFF ITLLVLGRQN
110 120 130 140 150
EYYCRLDFLW KNKFKKEREE IETMENLNRV LLENVLPAHV AEHFLARSLK
160 170 180 190 200
NEELYHQSYD CVCVMFASIP DFKEFYTESD VNKEGLECLR LLNEIIADFD
210 220 230 240 250
DLLSKPKFSG VEKIKTIGST YMAATGLSAV PSQEHSQEPE RQYMHIGTMV
260 270 280 290 300
EFAFALVGKL DAINKHSFND FKLRVGINHG PVIAGVIGAQ KPQYDIWGNT
310 320 330 340 350
VNVASRMDST GVLDKIQVTE ETSLVLQTLG YTCTCRGIIN VKGKGDLKTY
360
FVNTEMSRSL SQSNVAS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF070583 mRNA Translation: AAC28647.1 |
RefSeqi | NP_065433.2, NM_020546.2 |
Genome annotation databases
GeneIDi | 108 |
KEGGi | hsa:108 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF070583 mRNA Translation: AAC28647.1 |
RefSeqi | NP_065433.2, NM_020546.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q71UM8 |
Genome annotation databases
GeneIDi | 108 |
KEGGi | hsa:108 |
Organism-specific databases
CTDi | 108 |
PharmGKBi | PA24561 |
Phylogenomic databases
OrthoDBi | 363718at2759 |
Miscellaneous databases
BioGRID-ORCSi | 108, 2 hits in 843 CRISPR screens |
GenomeRNAii | 108 |
Gene expression databases
Genevisiblei | Q71UM8, HS |
Family and domain databases
Gene3Di | 3.30.70.1230, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF00211, Guanylate_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 1 hit |
SUPFAMi | SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q71UM8_HUMAN | |
Accessioni | Q71UM8Primary (citable) accession number: Q71UM8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |