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Protein

40S ribosomal protein S27-like

Gene

RPS27L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 60C4-typeSequence analysisAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: UniProtKB
  • mitotic G1 DNA damage checkpoint Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • ribosomal small subunit assembly Source: GO_Central
  • translation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S27-like
Alternative name(s):
Small ribosomal subunit protein eS27-like
Gene namesi
Name:RPS27LImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000185088.13
HGNCiHGNC:18476 RPS27L
MIMi612055 gene
neXtProtiNX_Q71UM5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi51065
OpenTargetsiENSG00000185088
PharmGKBiPA38546

Polymorphism and mutation databases

BioMutaiRPS27L
DMDMi51316258

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001490541 – 8440S ribosomal protein S27-likeAdd BLAST84

Proteomic databases

EPDiQ71UM5
MaxQBiQ71UM5
PaxDbiQ71UM5
PeptideAtlasiQ71UM5
PRIDEiQ71UM5
ProteomicsDBi68634
TopDownProteomicsiQ71UM5

PTM databases

iPTMnetiQ71UM5
PhosphoSitePlusiQ71UM5
SwissPalmiQ71UM5

Expressioni

Gene expression databases

BgeeiENSG00000185088
CleanExiHS_RPS27L
ExpressionAtlasiQ71UM5 baseline and differential
GenevisibleiQ71UM5 HS

Organism-specific databases

HPAiHPA066851

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM2Q009876EBI-355126,EBI-389668

Protein-protein interaction databases

BioGridi119256, 75 interactors
IntActiQ71UM5, 43 interactors
MINTiQ71UM5
STRINGi9606.ENSP00000331019

Structurei

3D structure databases

ProteinModelPortaliQ71UM5
SMRiQ71UM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 60C4-typeSequence analysisAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1779 Eukaryota
COG2051 LUCA
GeneTreeiENSGT00390000013514
HOVERGENiHBG000252
InParanoidiQ71UM5
KOiK02978
PhylomeDBiQ71UM5
TreeFamiTF300265

Family and domain databases

HAMAPiMF_00371 Ribosomal_S27e, 1 hit
InterProiView protein in InterPro
IPR000592 Ribosomal_S27e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR11594 PTHR11594, 1 hit
PfamiView protein in Pfam
PF01667 Ribosomal_S27e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004466 Ribosomal_S27e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS01168 RIBOSOMAL_S27E, 1 hit

Sequencei

Sequence statusi: Complete.

Q71UM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA
60 70 80
QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH
Length:84
Mass (Da):9,477
Last modified:January 23, 2007 - v3
Checksum:i271CCACFBB269E38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22K → E (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070668 mRNA Translation: AAD20974.1
BC003667 mRNA Translation: AAH03667.1
CCDSiCCDS42048.1
RefSeqiNP_057004.1, NM_015920.3
UniGeneiHs.108957

Genome annotation databases

EnsembliENST00000330964; ENSP00000331019; ENSG00000185088
GeneIDi51065
KEGGihsa:51065
UCSCiuc002aly.4 human

Similar proteinsi

Entry informationi

Entry nameiRS27L_HUMAN
AccessioniPrimary (citable) accession number: Q71UM5
Secondary accession number(s): Q9BTJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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