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Entry version 78 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Methyltransferase Dmt

Gene

dmt

Organism
Escherichia phage P1 (Bacteriophage P1)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Methyltransferase that methylates adenine residues in the dsDNA sequence GATC. Essential for genome packaging because it methylates GATC sequences within the pac site making the latter cleavable (PubMed:3312202, PubMed:2236019).

May prevent degradation of viral DNA by the host restriction-modification antiviral defense system (PubMed:376871).

3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.9 µM for S-adenosylmethionine1 Publication

    pH dependencei

    Optimum pH is 6.9.1 Publication

    Temperature dependencei

    Optimum temperature is between 40 and 43 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei78PROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMethyltransferase, Transferase
    Biological processHost-virus interaction, Restriction-modification system evasion by virus, Viral genome packaging, Viral release from host cell
    LigandS-adenosyl-L-methionine

    Protein family/group databases

    Restriction enzymes and methylases database

    More...
    REBASEi
    7756, M.EphP1ORF2P

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Methyltransferase DmtCurated (EC:2.1.1.-3 Publications)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:dmtImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia phage P1 (Bacteriophage P1)Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10678 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraeUroviricotaCaudoviricetesCaudoviralesMyoviridaePunavirus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiEnterobacteriaceae [TaxID: 543]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000008091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004332111 – 754Methyltransferase DmtAdd BLAST754

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q71TL0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Expressed early in the viral replication cycle.1 Publication

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q71TL0

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 469SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST466

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.1020.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR023095, Ade_MeTrfase_dom_2
    IPR018117, C5_DNA_meth_AS
    IPR001525, C5_MeTfrase
    IPR002052, DNA_methylase_N6_adenine_CS
    IPR012327, MeTrfase_D12
    IPR029063, SAM-dependent_MTases

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR30481, PTHR30481, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00145, DNA_methylase, 2 hits
    PF02086, MethyltransfD12, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00505, D12N6MTFRASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53335, SSF53335, 2 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00571, dam, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00094, C5_MTASE_1, 1 hit
    PS00092, N6_MTASE, 1 hit
    PS51679, SAM_MT_C5, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q71TL0-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKELCYGSVC SGIEAASIAW EPLGMRPAWF AEIEPFPSAV LAHRWPHVAN
    60 70 80 90 100
    LGDMTKLAKK VLAGEIESPD VLVWGTPCQA FSIAGLRGGL DDERGALTLK
    110 120 130 140 150
    YVELANAIDD KRSESFLKPT VIVWENVPGV LSSADNAFGC FLAGLAGEDA
    160 170 180 190 200
    PFEPGDRPES GKSNAFWRWD GKTGCHAPKW PQCGCIYGPQ RKVAWRILDA
    210 220 230 240 250
    QYFGVAQRRR RVFVVASART DLDPATVLFE FEGVRRNIAP RRKKKEIASA
    260 270 280 290 300
    IIANGAAISG ESLNPCLHAD MPPSMKSTKA VNAFRMAAFG EYIDDETAST
    310 320 330 340 350
    VKARDFKDAT DLAVFSSTGA GFWSEGHGTL RAREQESHEH LVTLAFPERM
    360 370 380 390 400
    SGTQHAATKN TSPSLMAKNP TAVCYEVRNA EVAVRRLTPV ECERLQGFPD
    410 420 430 440 450
    GHTLIPTEKR KKVNSDELAY LRNHYPDLSE EEAAMLAADG PRYKAIGNSM
    460 470 480 490 500
    AIPVMRWIGD RITKAVCRQK EGSETKERKV KPAAEFERSI FKWAGGKFGV
    510 520 530 540 550
    LEQIFRYLPE GKRLIEPFVG GGAVFTNAGY QENLLNDVNA DLINFYKTLQ
    560 570 580 590 600
    REAHSLITLA HRFFQDYNTQ EGYLAVRNAF NKQVYDDLHR AAAFLFLNRH
    610 620 630 640 650
    CFNGLTRYNQ AGEFNVGYGK YKTPYFPLQE MEAFLGAEGR SEFVCGDFAA
    660 670 680 690 700
    VIEAAGEGDV IFCDPPYEPL PNTEGFTNYS GHDFKFEEQK RLVSLLTDAH
    710 720 730 740 750
    RRGAKVLITN SGAPNIRELY HDSGFRVEPL FARRSVSCKG DTRGVAHDVL

    GILL
    Length:754
    Mass (Da):83,628
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4201FA805A3EFBC1
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF234172 Genomic DNA Translation: AAQ14041.1

    NCBI Reference Sequences

    More...
    RefSeqi
    YP_006537.1, NC_005856.1

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2777403

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    vg:2777403

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF234172 Genomic DNA Translation: AAQ14041.1
    RefSeqiYP_006537.1, NC_005856.1

    3D structure databases

    SMRiQ71TL0
    ModBaseiSearch...

    Protein family/group databases

    REBASEi7756, M.EphP1ORF2P

    Proteomic databases

    PRIDEiQ71TL0

    Genome annotation databases

    GeneIDi2777403
    KEGGivg:2777403

    Family and domain databases

    Gene3Di1.10.1020.10, 1 hit
    InterProiView protein in InterPro
    IPR023095, Ade_MeTrfase_dom_2
    IPR018117, C5_DNA_meth_AS
    IPR001525, C5_MeTfrase
    IPR002052, DNA_methylase_N6_adenine_CS
    IPR012327, MeTrfase_D12
    IPR029063, SAM-dependent_MTases
    PANTHERiPTHR30481, PTHR30481, 1 hit
    PfamiView protein in Pfam
    PF00145, DNA_methylase, 2 hits
    PF02086, MethyltransfD12, 1 hit
    PRINTSiPR00505, D12N6MTFRASE
    SUPFAMiSSF53335, SSF53335, 2 hits
    TIGRFAMsiTIGR00571, dam, 1 hit
    PROSITEiView protein in PROSITE
    PS00094, C5_MTASE_1, 1 hit
    PS00092, N6_MTASE, 1 hit
    PS51679, SAM_MT_C5, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMT_BPP1
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q71TL0
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
    Last sequence update: July 5, 2004
    Last modified: December 2, 2020
    This is version 78 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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