Voltage-dependent calcium channel gamma-2 subunit

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium channel regulator activity Source: RGD <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.1

    "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• channel regulator activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ionotropic glutamate receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs."
    Martinez-Turrillas R., Del Rio J., Frechilla D.
    Biochem Biophys Res Commun 353:750-755(2007) [PubMed] [Europe PMC] [Abstract]
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• voltage-gated calcium channel activity Source: RGD

GO - Biological processⁱ

• eye blink reflex Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "c-Fos, Arc, and stargazin expression in rat eyeblink conditioning."
    Kim S., Thompson R.F.
    Behav Neurosci 125:117-123(2011) [PubMed] [Europe PMC] [Abstract]
• membrane depolarization Source: RGD
• membrane hyperpolarization Source: RGD
• nervous system process Source: RGD
• neuromuscular junction development Source: RGD
• neurotransmitter receptor internalization Source: RGD
• neurotransmitter receptor localization to postsynaptic specialization membrane Source: RGD
• neurotransmitter receptor transport, postsynaptic endosome to lysosome Source: RGD
• positive regulation of AMPA receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms."
    Turetsky D., Garringer E., Patneau D.K.
    J Neurosci 25:7438-7448(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein localization to basolateral plasma membrane Source: RGDInferred from direct assayⁱ
  • "The stargazin C terminus encodes an intrinsic and transferable membrane sorting signal."
    Bedoukian M.A., Whitesell J.D., Peterson E.J., Clay C.M., Partin K.M.
    J Biol Chem 283:1597-1600(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synaptic transmission, glutamatergic Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• postsynaptic neurotransmitter receptor diffusion trapping Source: RGD
• protein targeting to membrane Source: RGDInferred from direct assayⁱ
  • "The stargazin C terminus encodes an intrinsic and transferable membrane sorting signal."
    Bedoukian M.A., Whitesell J.D., Peterson E.J., Clay C.M., Partin K.M.
    J Biol Chem 283:1597-1600(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of AMPA receptor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.3

    "TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating."
    Milstein A.D., Zhou W., Karimzadegan S., Bredt D.S., Nicoll R.A.
    Neuron 55:905-918(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.4

    "AMPA receptor subunit-specific regulation by a distinct family of type II TARPs."
    Kato A.S., Siuda E.R., Nisenbaum E.S., Bredt D.S.
    Neuron 59:986-996(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.5

    "Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5."
    Soto D., Coombs I.D., Renzi M., Zonouzi M., Farrant M., Cull-Candy S.G.
    Nat. Neurosci. 12:277-285(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.7

    "Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors."
    Schwenk J., Harmel N., Zolles G., Bildl W., Kulik A., Heimrich B., Chisaka O., Jonas P., Schulte U., Fakler B., Kloecker N.
    Science 323:1313-1319(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY.
• regulation of membrane potential Source: RGD
• regulation of postsynaptic membrane neurotransmitter receptor levels Source: RGD
• response to calcium ion Source: RGDInferred from expression patternⁱ
  • "Calpain-mediated regulation of stargazin in adult rat brain."
    Yu L., Rostamiani K., Hsu Y.T., Wang Y., Bi X., Baudry M.
    Neuroscience 178:13-20(2011) [PubMed] [Europe PMC] [Abstract]
• transmission of nerve impulse Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• ionotropic glutamate receptor binding Source: RGDInferred from physical interactionⁱ
  • "Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs."
    Martinez-Turrillas R., Del Rio J., Frechilla D.
    Biochem Biophys Res Commun 353:750-755(2007) [PubMed] [Europe PMC] [Abstract]
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGLFDRGVQM LLTTVGAFAA FSLMTIAVGT DYWLYSRGVC KTKSVSENET 
        60         70         80         90        100
SKKNEEVMTH SGLWRTCCLE GNFKGLCKQI DHFPEDADYE ADTAEYFLRA 
       110        120        130        140        150
VRASSIFPIL SVILLFMGGL CIAASEFYKT RHNIILSAGI FFVSAGLSNI 
       160        170        180        190        200
IGIIVYISAN AGDPSKSDSK KNSYSYGWSF YFGALSFIIA EMVGVLAVHM 
       210        220        230        240        250
FIDRHKQLRA TARATDYLQA SAITRIPSYR YRYQRRSRSS SRSTEPSHSR 
       260        270        280        290        300
DASPVGVKGF NTLPSTEISM YTLSRDPLKA ATTPTATYNS DRDNSFLQVH 
       310        320 
NCIQKDSKDS LHANTANRRT TPV                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families