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Protein

La-related protein 4

Gene

LARP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • poly(A) binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • regulation of cell morphogenesis Source: UniProtKB
  • translation Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 4
Alternative name(s):
La ribonucleoprotein domain family member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LARP4
ORF Names:PP13296
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000161813.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24320 LARP4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q71RC2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15L → A: Nearly abolishes interaction with PABPC1; when associated with A-22. 1 Publication1
Mutagenesisi22W → A: Nearly abolishes interaction with PABPC1; when associated with A-15. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
113251

Open Targets

More...
OpenTargetsi
ENSG00000161813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671566

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LARP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189047131

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076111 – 724La-related protein 4Add BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei368Omega-N-methylarginineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei505PhosphoserineCombined sources1
Modified residuei578PhosphothreonineCombined sources1
Modified residuei579PhosphothreonineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei649PhosphothreonineCombined sources1
Modified residuei686Omega-N-methylarginineCombined sources1
Modified residuei722PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q71RC2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q71RC2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q71RC2

PeptideAtlas

More...
PeptideAtlasi
Q71RC2

PRoteomics IDEntifications database

More...
PRIDEi
Q71RC2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68610
68611 [Q71RC2-2]
68612 [Q71RC2-3]
68613 [Q71RC2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q71RC2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q71RC2

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q71RC2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161813 Expressed in 230 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_LARP4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q71RC2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q71RC2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039306
HPA039673

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminal region) with PABPC1 (PubMed:27615744, PubMed:21098120). Interacts with RACK1 (PubMed:21098120).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125238, 28 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q71RC2

Protein interaction database and analysis system

More...
IntActi
Q71RC2, 23 interactors

Molecular INTeraction database

More...
MINTi
Q71RC2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381490

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1724
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q71RC2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q71RC2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q71RC2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 202HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST90
Domaini203 – 281RRMAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni13 – 22Interaction with PABPC11 Publication10
Regioni111 – 303Interaction with the poly-A tract of mRNA1 PublicationAdd BLAST193

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2591 Eukaryota
ENOG410XTHK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154409

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000004803

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055137

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q71RC2

KEGG Orthology (KO)

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KOi
K18763

Identification of Orthologs from Complete Genome Data

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OMAi
WTIANME

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03E9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q71RC2

TreeFam database of animal gene trees

More...
TreeFami
TF321960

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12707 RRM_LARP4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006630 La_HTH
IPR034903 LARP4_RRM
IPR035979 RBD_domain_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05383 La, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00715 LA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50961 HTH_LA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q71RC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLFVEQVAS KGTGLNPNAK VWQEIAPGNT DATPVTHGTE SSWHEIAATS
60 70 80 90 100
GAHPEGNAEL SEDICKEYEV MYSSSCETTR NTTGIEESTD GMILGPEDLS
110 120 130 140 150
YQIYDVSGES NSAVSTEDLK ECLKKQLEFC FSRENLSKDL YLISQMDSDQ
160 170 180 190 200
FIPIWTVANM EEIKKLTTDP DLILEVLRSS PMVQVDEKGE KVRPSHKRCI
210 220 230 240 250
VILREIPETT PIEEVKGLFK SENCPKVISC EFAHNSNWYI TFQSDTDAQQ
260 270 280 290 300
AFKYLREEVK TFQGKPIMAR IKAINTFFAK NGYRLMDSSI YSHPIQTQAQ
310 320 330 340 350
YASPVFMQPV YNPHQQYSVY SIVPQSWSPN PTPYFETPLA PFPNGSFVNG
360 370 380 390 400
FNSPGSYKTN AAAMNMGRPF QKNRVKPQFR SSGGSEHSTE GSVSLGDGQL
410 420 430 440 450
NRYSSRNFPA ERHNPTVTGH QEQTYLQKET STLQVEQNGD YGRGRRTLFR
460 470 480 490 500
GRRRREDDRI SRPHPSTAES KAPTPKFDLL ASNFPPLPGS SSRMPGELVL
510 520 530 540 550
ENRMSDVVKG VYKEKDNEEL TISCPVPADE QTECTSAQQL NMSTSSPCAA
560 570 580 590 600
ELTALSTTQQ EKDLIEDSSV QKDGLNQTTI PVSPPSTTKP SRASTASPCN
610 620 630 640 650
NNINAATAVA LQEPRKLSYA EVCQKPPKEP SSVLVQPLRE LRSNVVSPTK
660 670 680 690 700
NEDNGAPENS VEKPHEKPEA RASKDYSGFR GNIIPRGAAG KIREQRRQFS
710 720
HRAIPQGVTR RNGKEQYVPP RSPK
Length:724
Mass (Da):80,596
Last modified:May 20, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93B8C2D8CB3CDAEF
GO
Isoform 2 (identifier: Q71RC2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-7: Missing.
     97-194: Missing.
     593-612: Missing.

Note: No experimental confirmation available.
Show »
Length:605
Mass (Da):67,280
Checksum:i8BBA0DFC9487ACD1
GO
Isoform 3 (identifier: Q71RC2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-7: Missing.

Note: May be due to competing acceptor splice site. No experimental confirmation available.
Show »
Length:723
Mass (Da):80,468
Checksum:i3FD2F26A384908DB
GO
Isoform 4 (identifier: Q71RC2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-55: E → EVSVFNT

Note: No experimental confirmation available.
Show »
Length:730
Mass (Da):81,244
Checksum:i0E1FED65589E925A
GO
Isoform 5 (identifier: Q71RC2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-339: Missing.

Note: No experimental confirmation available.
Show »
Length:653
Mass (Da):72,400
Checksum:iD425781E3C7E9015
GO
Isoform 6 (identifier: Q71RC2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     374-444: Missing.

Note: No experimental confirmation available.
Show »
Length:653
Mass (Da):72,734
Checksum:iF31AAD0535BF93B1
GO
Isoform 7 (identifier: Q71RC2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-724: Missing.

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):49,952
Checksum:iE1E0BF43FCEAC2B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96J85Q96J85_HUMAN
C-Mpl binding protein
LARP4
375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RLN4X6RLN4_HUMAN
La-related protein 4
LARP4
491Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8TBL5Q8TBL5_HUMAN
LARP4 protein
LARP4
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VY40F8VY40_HUMAN
La-related protein 4
LARP4
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1I4F8W1I4_HUMAN
La-related protein 4
LARP4
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1Z5F8W1Z5_HUMAN
La-related protein 4
LARP4
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHZ8E5RHZ8_HUMAN
La-related protein 4
LARP4
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTL9A0A087WTL9_HUMAN
La-related protein 4
LARP4
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZ60F8VZ60_HUMAN
La-related protein 4
LARP4
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VSA9F8VSA9_HUMAN
La-related protein 4
LARP4
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC86052 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti422E → G in BX647457 (PubMed:17974005).Curated1
Sequence conflicti529D → G in BX647457 (PubMed:17974005).Curated1
Sequence conflicti639R → Q in BAF84435 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055936351F → L. Corresponds to variant dbSNP:rs17124706Ensembl.1
Natural variantiVAR_055937502N → T1 PublicationCorresponds to variant dbSNP:rs17124715Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0338117Missing in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_03381255E → EVSVFNT in isoform 4. 1 Publication1
Alternative sequenceiVSP_01461197 – 194Missing in isoform 2. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_045677269 – 339Missing in isoform 5. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_046780374 – 444Missing in isoform 6. CuratedAdd BLAST71
Alternative sequenceiVSP_046781446 – 724Missing in isoform 7. CuratedAdd BLAST279
Alternative sequenceiVSP_014612593 – 612Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055521 mRNA Translation: BAB70940.1
AK125113 mRNA Translation: BAC86052.1 Different initiation.
AK291746 mRNA Translation: BAF84435.1
AF370416 mRNA Translation: AAQ15252.1
BX647457 mRNA No translation available.
CR936626 mRNA Translation: CAI56769.1
AC090058 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58146.1
CH471111 Genomic DNA Translation: EAW58148.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41782.1 [Q71RC2-1]
CCDS44879.2 [Q71RC2-3]
CCDS44880.1 [Q71RC2-5]
CCDS53789.1 [Q71RC2-7]
CCDS53790.1 [Q71RC2-6]
CCDS81690.1 [Q71RC2-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001164279.1, NM_001170808.1 [Q71RC2-6]
NP_001317344.1, NM_001330415.1 [Q71RC2-4]
NP_443111.4, NM_052879.4 [Q71RC2-1]
NP_954658.2, NM_199188.2 [Q71RC2-3]
NP_954660.1, NM_199190.2 [Q71RC2-5]
XP_005268670.1, XM_005268613.2
XP_011536140.1, XM_011537838.2
XP_011536141.1, XM_011537839.2
XP_011536142.1, XM_011537840.2
XP_011536143.1, XM_011537841.2
XP_016874240.1, XM_017018751.1
XP_016874241.1, XM_017018752.1
XP_016874242.1, XM_017018753.1
XP_016874243.1, XM_017018754.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.26613

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000293618; ENSP00000293618; ENSG00000161813 [Q71RC2-6]
ENST00000347328; ENSP00000340901; ENSG00000161813 [Q71RC2-5]
ENST00000398473; ENSP00000381490; ENSG00000161813 [Q71RC2-1]
ENST00000429001; ENSP00000415464; ENSG00000161813 [Q71RC2-4]
ENST00000518444; ENSP00000429077; ENSG00000161813 [Q71RC2-3]
ENST00000522085; ENSP00000429781; ENSG00000161813 [Q71RC2-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113251

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:113251

UCSC genome browser

More...
UCSCi
uc001rwm.4 human [Q71RC2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055521 mRNA Translation: BAB70940.1
AK125113 mRNA Translation: BAC86052.1 Different initiation.
AK291746 mRNA Translation: BAF84435.1
AF370416 mRNA Translation: AAQ15252.1
BX647457 mRNA No translation available.
CR936626 mRNA Translation: CAI56769.1
AC090058 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58146.1
CH471111 Genomic DNA Translation: EAW58148.1
CCDSiCCDS41782.1 [Q71RC2-1]
CCDS44879.2 [Q71RC2-3]
CCDS44880.1 [Q71RC2-5]
CCDS53789.1 [Q71RC2-7]
CCDS53790.1 [Q71RC2-6]
CCDS81690.1 [Q71RC2-4]
RefSeqiNP_001164279.1, NM_001170808.1 [Q71RC2-6]
NP_001317344.1, NM_001330415.1 [Q71RC2-4]
NP_443111.4, NM_052879.4 [Q71RC2-1]
NP_954658.2, NM_199188.2 [Q71RC2-3]
NP_954660.1, NM_199190.2 [Q71RC2-5]
XP_005268670.1, XM_005268613.2
XP_011536140.1, XM_011537838.2
XP_011536141.1, XM_011537839.2
XP_011536142.1, XM_011537840.2
XP_011536143.1, XM_011537841.2
XP_016874240.1, XM_017018751.1
XP_016874241.1, XM_017018752.1
XP_016874242.1, XM_017018753.1
XP_016874243.1, XM_017018754.1
UniGeneiHs.26613

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQKNMR-A113-200[»]
3PKNX-ray1.80B13-26[»]
ProteinModelPortaliQ71RC2
SMRiQ71RC2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125238, 28 interactors
ELMiQ71RC2
IntActiQ71RC2, 23 interactors
MINTiQ71RC2
STRINGi9606.ENSP00000381490

PTM databases

iPTMnetiQ71RC2
PhosphoSitePlusiQ71RC2

Polymorphism and mutation databases

BioMutaiLARP4
DMDMi189047131

Proteomic databases

EPDiQ71RC2
MaxQBiQ71RC2
PaxDbiQ71RC2
PeptideAtlasiQ71RC2
PRIDEiQ71RC2
ProteomicsDBi68610
68611 [Q71RC2-2]
68612 [Q71RC2-3]
68613 [Q71RC2-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
113251
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293618; ENSP00000293618; ENSG00000161813 [Q71RC2-6]
ENST00000347328; ENSP00000340901; ENSG00000161813 [Q71RC2-5]
ENST00000398473; ENSP00000381490; ENSG00000161813 [Q71RC2-1]
ENST00000429001; ENSP00000415464; ENSG00000161813 [Q71RC2-4]
ENST00000518444; ENSP00000429077; ENSG00000161813 [Q71RC2-3]
ENST00000522085; ENSP00000429781; ENSG00000161813 [Q71RC2-7]
GeneIDi113251
KEGGihsa:113251
UCSCiuc001rwm.4 human [Q71RC2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
113251
DisGeNETi113251
EuPathDBiHostDB:ENSG00000161813.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LARP4
HGNCiHGNC:24320 LARP4
HPAiHPA039306
HPA039673
neXtProtiNX_Q71RC2
OpenTargetsiENSG00000161813
PharmGKBiPA142671566

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2591 Eukaryota
ENOG410XTHK LUCA
GeneTreeiENSGT00940000154409
HOGENOMiHOG000004803
HOVERGENiHBG055137
InParanoidiQ71RC2
KOiK18763
OMAiWTIANME
OrthoDBiEOG091G03E9
PhylomeDBiQ71RC2
TreeFamiTF321960

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LARP4 human
EvolutionaryTraceiQ71RC2

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LARP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
113251
PMAP-CutDBiQ71RC2

Protein Ontology

More...
PROi
PR:Q71RC2

Gene expression databases

BgeeiENSG00000161813 Expressed in 230 organ(s), highest expression level in liver
CleanExiHS_LARP4
ExpressionAtlasiQ71RC2 baseline and differential
GenevisibleiQ71RC2 HS

Family and domain databases

CDDicd12707 RRM_LARP4, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006630 La_HTH
IPR034903 LARP4_RRM
IPR035979 RBD_domain_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
SMARTiView protein in SMART
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLARP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q71RC2
Secondary accession number(s): A8K6T1
, E9PDG5, G3XAA8, G5E976, Q5CZ97, Q6ZV14, Q96NF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 20, 2008
Last modified: December 5, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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