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Entry version 134 (16 Oct 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Talin-2

Gene

Tln2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Talin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tln2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917799 Tln2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194321 – 2375Talin-2Add BLAST2375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei428PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei1024PhosphoserineBy similarity1
Modified residuei1666PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q71LX4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q71LX4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q71LX4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q71LX4

PeptideAtlas

More...
PeptideAtlasi
Q71LX4

PRoteomics IDEntifications database

More...
PRIDEi
Q71LX4

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2751

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q71LX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q71LX4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q71LX4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with PIP5K1C.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB1P05556-53EBI-2255655,EBI-7208579From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
214125, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-53098N

Protein interaction database and analysis system

More...
IntActi
Q71LX4, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039633

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q71LX4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q71LX4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini88 – 406FERMPROSITE-ProRule annotationAdd BLAST319
Domaini2205 – 2375I/LWEQPROSITE-ProRule annotationAdd BLAST171

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni312 – 406Interaction with PIP5K1CBy similarityAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi862 – 943Ala-richAdd BLAST82

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4261 Eukaryota
ENOG410XQ0V LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006734

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q71LX4

KEGG Orthology (KO)

More...
KOi
K06271

Database of Orthologous Groups

More...
OrthoDBi
9839at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit
cd12150 talin-RS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR032425 FERM_f0
IPR018979 FERM_N
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR011993 PH-like_dom_sf
IPR037438 Talin1/2-RS
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR029071 Ubiquitin-like_domsf
IPR015009 Vinculin-bd_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16511 FERM_f0, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF01608 I_LWEQ, 2 hits
PF09141 Talin_middle, 1 hit
PF08913 VBS, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM00307 ILWEQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109880 SSF109880, 1 hit
SSF109885 SSF109885, 5 hits
SSF47031 SSF47031, 1 hit
SSF47220 SSF47220, 4 hits
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50945 I_LWEQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q71LX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVALSLKICV RHCNVVKTMQ FEPSTAVYDA CRVIRERVPE AQTGQASDYG
60 70 80 90 100
LFLSDEDPRK GIWLEAGRTL DYYMLRNGDI LEYKKKQRPQ KIRMLDGSVK
110 120 130 140 150
TVMVDDSKTV GELLVTICSR IGITNYEEYS LIQETIEEKK EEGTGTLKKD
160 170 180 190 200
RTLLRDERKM EKLKAKLHTD DDLNWLDHSR TFREQGVDEN ETLLLRRKFF
210 220 230 240 250
YSDQNVDSRD PVQLNLLYVQ ARDDILNGSH PVSFEKACEF GGFQAQIQFG
260 270 280 290 300
PHVEHKHKPG FLDLKEFLPK EYIKQRGAEK RIFQEHKNCG EMSEIEAKVK
310 320 330 340 350
YVKLARSLRT YGVSFFLVKE KMKGKNKLVP RLLGITKDSV MRVDEKTKEV
360 370 380 390 400
LQEWPLTTVK RWAASPKSFT LDFGEYQESY YSVQTTEGEQ ISQLIAGYID
410 420 430 440 450
IILKKKQSKD RFGLEGDEES TMLEESVSPK KRSTILQQQF NRTGKAEHGS
460 470 480 490 500
VALPAVMRSG SSGPETFNVG SMPSPQQQVM VGQMHRGHMP PLTSAQQALM
510 520 530 540 550
GTINTSMHAV QQAQDDLSEL DSLPPLGQDM ASRVWVQNKV DESKHEIHSQ
560 570 580 590 600
VDAITAGTAS VVNLTAGDPA DTDYTAVGCA ITTISSNLTE MSKGVKLLAA
610 620 630 640 650
LMDDDVGSGE DLLRAARTLA GAVSDLLKAV QPTSGEPRQT VLTAAGSIGQ
660 670 680 690 700
ASGDLLRQIG ENETDERFQD VLMSLAKAVA NAAAMLVLKA KNVAQVAEDT
710 720 730 740 750
VLQNRVIAAA TQCALSTSQL VACAKVVSPT ISSPVCQEQL IEAGKLVDRS
760 770 780 790 800
VENCVRACQA ATSDSELLKQ VSAAASVVSQ ALHDLLQHVR QFASRGEPIG
810 820 830 840 850
RYDQATDTIM CVTESIFSSM GDAGEMVRQA RVLAQATSDL VNAMRSDAEA
860 870 880 890 900
EIDMENSKKL LAAAKLLADS TARMVEAAKG AAANPENEDQ QQRLREAAEG
910 920 930 940 950
LRVATNAAAQ NAIKKKIVNR LEVAAKQAAA AATQTIAASQ NAAISNKNPS
960 970 980 990 1000
AQQQLVQSCK AVADHIPQLV QGVRGSQAQA EDLSAQLALI ISSQNFLQPG
1010 1020 1030 1040 1050
SKMVSSAKAA VPTVSDQAAA MQLSQCAKNL ATSLAELRTA SQKAHEACGP
1060 1070 1080 1090 1100
MEIDSALNTV QTLKNELQDA KMAAAESQLK PLPGETLEKC AQDLGSTSKG
1110 1120 1130 1140 1150
VGSSMAQLLT CAAQGNEHYT GVAARETAQA LKTLAQAARG VAASTNDPEA
1160 1170 1180 1190 1200
AHAMLDSARD VMEGSAMLIQ EAKQALIAPG DTESQQRLAQ VAKAVSHSLN
1210 1220 1230 1240 1250
NCVNCLPGQK DVDVALKSIG EASKKLLVDS LPPSTKPFQE AQSELNQAAA
1260 1270 1280 1290 1300
DLNQSAGEVV HATRGQSGEL AAASGKFSDD FDEFLDAGIE MAGQAQTKED
1310 1320 1330 1340 1350
QMQVIGNLKN ISMASSKLLL AAKSLSVDPG APNAKNLLAA AARAVTESIN
1360 1370 1380 1390 1400
QLIMLCTQQA PGQKECDNAL RELETVKGML ENPNEPVSDL SYFDCIESVM
1410 1420 1430 1440 1450
ENSKVLGESM AGISQNAKTG DLPAFGECVG IASKALCGLT EAAAQAAYLV
1460 1470 1480 1490 1500
GISDPNSQAG HQGLVDPIQF ARANQAIQMA CQNLVDPGSS PSQVLSAATI
1510 1520 1530 1540 1550
VAKHTSALCN ACRIASSKTA NPVAKRHFVQ SAKEVANSTA NLVKTIKALD
1560 1570 1580 1590 1600
GDFSEDNRNK CRIATTPLIE AVENLTAFAS NPEFASIPAQ ISSEGSQAQE
1610 1620 1630 1640 1650
PILVSAKTML ESSSYLIRTA RSLAINPKDP PTWSVLAGHS HTVSDSIKSL
1660 1670 1680 1690 1700
ITSIRDKAPG QRECDYSIDG INRCIRDIEQ ASLAAVSQSL ATRDDISVEA
1710 1720 1730 1740 1750
LQEQLTSVVQ EIGHLIDPIA TAARGEAAQL GHKVTQLASY FEPLILAAVG
1760 1770 1780 1790 1800
VASKMLDHQQ QMTVLDQTKT LAESALQMLY AAKEGGGNPK AVHTAPEPKG
1810 1820 1830 1840 1850
TFVDYQTTVV KYSKAIAVTA QEMIGFQIRT RVQDLGHGCI FLVQKAGALQ
1860 1870 1880 1890 1900
VCPTDSYTKR ELIECARSVT EKVSLVLSAL QAGNKGTQAC ITAATAVSGI
1910 1920 1930 1940 1950
IADLDTTIMF ATAGTLNAEN GETFADHREN ILKTAKALVE DTKLLVSGAA
1960 1970 1980 1990 2000
STPDKLAQAA QSSAATITQL AEVVKLGAAS LGSNDPETQV VLINAIKDVA
2010 2020 2030 2040 2050
KALSDLIGAT KGAASKPADD PSMYQLKGAA KVMVTNVTSL LKTVKAVEDE
2060 2070 2080 2090 2100
ATRGTRALEA TIEYIKQELT VFQSKDIPEK TSSPEESIRM TKGITMATAK
2110 2120 2130 2140 2150
AVAAGNSCRQ EDVIATANLS RKAVSDMLIA CKQASFYPDV SEEVRTRALR
2160 2170 2180 2190 2200
YGTECTLGYL DLLEHVLVIL QKPTPELKHQ LAAFSKRVAG AVTELIQAAE
2210 2220 2230 2240 2250
AMKGTEWVDP EDPTVIAETE LLGAAASIEA AAKKLEQLKP RAKPKQADET
2260 2270 2280 2290 2300
LDFEEQILEA AKSIAAATSA LVKSASAAQR ELVAQGKVGS IPANAADDGQ
2310 2320 2330 2340 2350
WSQGLISAAR MVAAATSSLC EAANASVQGH ASEEKLISSA KQVAASTAQL
2360 2370
LVACKVKADQ DSEAMKRLQA AGNAV
Length:2,375
Mass (Da):253,621
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2264EEEC374476FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUM4E9PUM4_MOUSE
Talin-2
Tln2
2,542Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SQ51A0A1L1SQ51_MOUSE
Talin-2
Tln2
2,544Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8CDM9Q8CDM9_MOUSE
Talin-2
Tln2
1,452Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SRI1A0A1L1SRI1_MOUSE
Talin-2
Tln2
1,471Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SQP9A0A1L1SQP9_MOUSE
Talin-2
Tln2
923Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SVA8A0A1L1SVA8_MOUSE
Talin-2
Tln2
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ05019 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC34927 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102V → K in BAC34927 (PubMed:16141072).Curated1
Sequence conflicti432R → Q in AAQ05019 (Ref. 3) Curated1
Sequence conflicti447E → K in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1003M → V in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1030L → P in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1755M → I in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1775A → V in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1792V → Q in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1795A → S in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1816I → V in AAQ05019 (Ref. 3) Curated1
Sequence conflicti2047V → A in AAQ05019 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC107740 Genomic DNA No translation available.
AC107755 Genomic DNA No translation available.
AC173343 Genomic DNA No translation available.
AF467081 mRNA Translation: AAQ05019.1 Different initiation.
AK052301 mRNA Translation: BAC34927.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_001074711.2, NM_001081242.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
70549

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:70549

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107740 Genomic DNA No translation available.
AC107755 Genomic DNA No translation available.
AC173343 Genomic DNA No translation available.
AF467081 mRNA Translation: AAQ05019.1 Different initiation.
AK052301 mRNA Translation: BAC34927.1 Different initiation.
RefSeqiNP_001074711.2, NM_001081242.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G9WX-ray2.16A/B198-408[»]
SMRiQ71LX4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi214125, 2 interactors
DIPiDIP-53098N
IntActiQ71LX4, 6 interactors
STRINGi10090.ENSMUSP00000039633

PTM databases

GlyConnecti2751
iPTMnetiQ71LX4
PhosphoSitePlusiQ71LX4
SwissPalmiQ71LX4

Proteomic databases

EPDiQ71LX4
jPOSTiQ71LX4
MaxQBiQ71LX4
PaxDbiQ71LX4
PeptideAtlasiQ71LX4
PRIDEiQ71LX4

Genome annotation databases

GeneIDi70549
KEGGimmu:70549

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83660
MGIiMGI:1917799 Tln2

Phylogenomic databases

eggNOGiKOG4261 Eukaryota
ENOG410XQ0V LUCA
HOGENOMiHOG000006734
InParanoidiQ71LX4
KOiK06271
OrthoDBi9839at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tln2 mouse
EvolutionaryTraceiQ71LX4

Protein Ontology

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PROi
PR:Q71LX4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd12150 talin-RS, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR032425 FERM_f0
IPR018979 FERM_N
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR011993 PH-like_dom_sf
IPR037438 Talin1/2-RS
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR029071 Ubiquitin-like_domsf
IPR015009 Vinculin-bd_dom
PfamiView protein in Pfam
PF16511 FERM_f0, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF01608 I_LWEQ, 2 hits
PF09141 Talin_middle, 1 hit
PF08913 VBS, 2 hits
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00307 ILWEQ, 1 hit
SUPFAMiSSF109880 SSF109880, 1 hit
SSF109885 SSF109885, 5 hits
SSF47031 SSF47031, 1 hit
SSF47220 SSF47220, 4 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50945 I_LWEQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLN2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q71LX4
Secondary accession number(s): E9QM49, Q8BWK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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