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Protein

Fibrinogen-like protein 1

Gene

Fgl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has hepatocyte mitogenic activity.By similarity

GO - Biological processi

  • adipose tissue development Source: MGI
  • cholesterol metabolic process Source: MGI
  • regulation of glucose metabolic process Source: MGI
  • response to stilbenoid Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen-like protein 1
Alternative name(s):
Mouse fibrinogen-related protein 1
Short name:
MFIRE-1
Gene namesi
Name:Fgl1
Synonyms:Mfire1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:102795 Fgl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000032297923 – 314Fibrinogen-like protein 1Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28InterchainPROSITE-ProRule annotation
Disulfide bondi85 ↔ 114PROSITE-ProRule annotation
Disulfide bondi250 ↔ 263PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ71KU9
PaxDbiQ71KU9
PRIDEiQ71KU9

PTM databases

iPTMnetiQ71KU9
PhosphoSitePlusiQ71KU9

Expressioni

Tissue specificityi

Liver specific.1 Publication

Gene expression databases

CleanExiMM_FGL1

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034003

Structurei

3D structure databases

ProteinModelPortaliQ71KU9
SMRiQ71KU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 308Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST233

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 62Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiQ71KU9
PhylomeDBiQ71KU9
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q71KU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKIYSFVLV AIALMMGREG WALESESCLR EQVRLRAQVH QLETRVKQQQ
60 70 80 90 100
TMIAQLLHEK EVQFLDKGSE NSFIDLGGKR QYADCSEIYN DGFKQSGFYK
110 120 130 140 150
IKPLQSLAEF SVYCDMSDGG GWTVIQRRSD GSENFNRGWN DYENGFGNFV
160 170 180 190 200
QNNGEYWLGN KNINLLTIQG DYTLKIDLTD FEKNSSFAQY QSFKVGDKKS
210 220 230 240 250
FYELNIGEYS GTAGDSLSGT FHPEVQWWAS HQRMKFSTWD RDNDNYQGNC
260 270 280 290 300
AEEEQSGWWF NRCHSANLNG VYYRGSYRAE TDNGVVWYTW HGWWYSLKSV
310
VMKIRPSDFI PNII
Length:314
Mass (Da):36,439
Last modified:March 18, 2008 - v2
Checksum:i52C16CA9C2D0386A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0E1A0A0R4J0E1_MOUSE
Fibrinogen-like protein 1
Fgl1 mCG_17732
314Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27S → N in AAQ05798 (PubMed:12528893).Curated1
Sequence conflicti80R → K in AAQ05798 (PubMed:12528893).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478470 mRNA Translation: AAQ05798.1
BC021946 mRNA Translation: AAH21946.1
CCDSiCCDS22260.1
RefSeqiNP_663569.2, NM_145594.2
XP_011240489.1, XM_011242187.1
UniGeneiMm.277955

Genome annotation databases

GeneIDi234199
KEGGimmu:234199
UCSCiuc009lnp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478470 mRNA Translation: AAQ05798.1
BC021946 mRNA Translation: AAH21946.1
CCDSiCCDS22260.1
RefSeqiNP_663569.2, NM_145594.2
XP_011240489.1, XM_011242187.1
UniGeneiMm.277955

3D structure databases

ProteinModelPortaliQ71KU9
SMRiQ71KU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034003

PTM databases

iPTMnetiQ71KU9
PhosphoSitePlusiQ71KU9

Proteomic databases

MaxQBiQ71KU9
PaxDbiQ71KU9
PRIDEiQ71KU9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi234199
KEGGimmu:234199
UCSCiuc009lnp.2 mouse

Organism-specific databases

CTDi2267
MGIiMGI:102795 Fgl1

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiQ71KU9
PhylomeDBiQ71KU9
TreeFamiTF336658

Miscellaneous databases

PROiPR:Q71KU9
SOURCEiSearch...

Gene expression databases

CleanExiMM_FGL1

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGL1_MOUSE
AccessioniPrimary (citable) accession number: Q71KU9
Secondary accession number(s): Q8VC25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: February 28, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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