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Protein

Filamin-binding LIM protein 1

Gene

Fblim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Cell shape
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-446353 Cell-extracellular matrix interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Filamin-binding LIM protein 1
Short name:
FBLP-1
Alternative name(s):
CSX-associated LIM
Gene namesi
Name:Fblim1
Synonyms:Cal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1921452 Fblim1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757331 – 375Filamin-binding LIM protein 1Add BLAST375

Proteomic databases

MaxQBiQ71FD7
PaxDbiQ71FD7
PeptideAtlasiQ71FD7
PRIDEiQ71FD7

PTM databases

iPTMnetiQ71FD7
PhosphoSitePlusiQ71FD7

Expressioni

Gene expression databases

BgeeiENSMUSG00000006219 Expressed in 221 organ(s), highest expression level in heart left ventricle
CleanExiMM_FBLIM1
ExpressionAtlasiQ71FD7 baseline and differential
GenevisibleiQ71FD7 MM

Interactioni

Subunit structurei

Interacts with FERMT2, FLNA, FLNB and FLNC (By similarity). Interacts with NKX2-5.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ71FD7, 2 interactors
MINTiQ71FD7
STRINGi10090.ENSMUSP00000006381

Structurei

3D structure databases

ProteinModelPortaliQ71FD7
SMRiQ71FD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 244LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini245 – 302LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST58
Domaini303 – 372LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 84Intrinsically disorderedBy similarityAdd BLAST84
Regioni1 – 69Filamin-bindingBy similarityAdd BLAST69
Regioni278 – 375FERMT2-bindingBy similarityAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 176Pro-richAdd BLAST90

Domaini

The N-terminal region is intrinsically disordered.By similarity

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000007533
HOVERGENiHBG051561
InParanoidiQ71FD7
OMAiCYPLNNR
OrthoDBiEOG091G0CJO
TreeFamiTF320310

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q71FD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKPEKRVA SSVFITLAPP RRDVAVSEEV GQAACEARRA RPWEMLPTKT
60 70 80 90 100
PGAAVGRSPK TWTPSGKTNA SLSGVTPQLS NGGCSLPPPS LNEEDLDLPP
110 120 130 140 150
PPPPPSAYLP LPEEEPPVLP GKSLISDLEQ LHLPPPPPPP PPQAPSKGSS
160 170 180 190 200
VHPPPGHAIP SEEELPPPPE EPVTLPEREV STDVCGFCHK PVSPRELAVE
210 220 230 240 250
AMKRQYHAQC FTCRTCRRQL AGQRFYQKDG RPLCEPCYQD TLEKCGKCGE
260 270 280 290 300
VVQEHVIRAL GKAFHPPCFT CVTCARCISD ESFALDSQNQ VYCVADFYRK
310 320 330 340 350
FAPVCSICEN PIIPRDGKDA FKIECMGRNF HENCYRCEDC SVLLSVEPTD
360 370
QGCYPLNDHL FCKPCHLKRS AAGCC
Length:375
Mass (Da):41,026
Last modified:July 27, 2011 - v2
Checksum:i601DF99A8EB1BB80
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ADE7A2ADE7_MOUSE
Filamin-binding LIM protein 1
Fblim1
182Annotation score:
A2ADF3A2ADF3_MOUSE
Filamin-binding LIM protein 1
Fblim1
56Annotation score:
A2ADE5A2ADE5_MOUSE
Filamin-binding LIM protein 1
Fblim1
167Annotation score:
A2ADF2A2ADF2_MOUSE
Filamin-binding LIM protein 1
Fblim1
73Annotation score:
A2ADE9A2ADE9_MOUSE
Filamin-binding LIM protein 1
Fblim1
128Annotation score:
A2ADF4A2ADF4_MOUSE
Filamin-binding LIM protein 1
Fblim1
33Annotation score:
A2ADF1A2ADF1_MOUSE
Filamin-binding LIM protein 1
Fblim1
98Annotation score:
A2ADE6A2ADE6_MOUSE
Filamin-binding LIM protein 1
Fblim1
175Annotation score:
A2ADE8A2ADE8_MOUSE
Filamin-binding LIM protein 1
Fblim1
102Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159I → R in AAQ08090 (PubMed:14757752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513359 mRNA Translation: AAQ08090.1
AK154680 mRNA Translation: BAE32761.1
AK170151 mRNA Translation: BAE41598.1
AK170440 mRNA Translation: BAE41798.1
AL670446 Genomic DNA Translation: CAM19893.1
CH466615 Genomic DNA Translation: EDL13381.1
CH466615 Genomic DNA Translation: EDL13382.1
CH466615 Genomic DNA Translation: EDL13383.1
CH466615 Genomic DNA Translation: EDL13384.1
CH466615 Genomic DNA Translation: EDL13385.1
CH466615 Genomic DNA Translation: EDL13386.1
BC004777 mRNA Translation: AAH04777.1
CCDSiCCDS18876.1
RefSeqiNP_001156728.1, NM_001163256.1
NP_598515.3, NM_133754.5
XP_006539277.1, XM_006539214.3
XP_006539278.1, XM_006539215.3
XP_006539279.1, XM_006539216.3
UniGeneiMm.490327

Genome annotation databases

EnsembliENSMUST00000006381; ENSMUSP00000006381; ENSMUSG00000006219
ENSMUST00000105784; ENSMUSP00000101410; ENSMUSG00000006219
ENSMUST00000105785; ENSMUSP00000101411; ENSMUSG00000006219
GeneIDi74202
KEGGimmu:74202
UCSCiuc008vos.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513359 mRNA Translation: AAQ08090.1
AK154680 mRNA Translation: BAE32761.1
AK170151 mRNA Translation: BAE41598.1
AK170440 mRNA Translation: BAE41798.1
AL670446 Genomic DNA Translation: CAM19893.1
CH466615 Genomic DNA Translation: EDL13381.1
CH466615 Genomic DNA Translation: EDL13382.1
CH466615 Genomic DNA Translation: EDL13383.1
CH466615 Genomic DNA Translation: EDL13384.1
CH466615 Genomic DNA Translation: EDL13385.1
CH466615 Genomic DNA Translation: EDL13386.1
BC004777 mRNA Translation: AAH04777.1
CCDSiCCDS18876.1
RefSeqiNP_001156728.1, NM_001163256.1
NP_598515.3, NM_133754.5
XP_006539277.1, XM_006539214.3
XP_006539278.1, XM_006539215.3
XP_006539279.1, XM_006539216.3
UniGeneiMm.490327

3D structure databases

ProteinModelPortaliQ71FD7
SMRiQ71FD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ71FD7, 2 interactors
MINTiQ71FD7
STRINGi10090.ENSMUSP00000006381

PTM databases

iPTMnetiQ71FD7
PhosphoSitePlusiQ71FD7

Proteomic databases

MaxQBiQ71FD7
PaxDbiQ71FD7
PeptideAtlasiQ71FD7
PRIDEiQ71FD7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006381; ENSMUSP00000006381; ENSMUSG00000006219
ENSMUST00000105784; ENSMUSP00000101410; ENSMUSG00000006219
ENSMUST00000105785; ENSMUSP00000101411; ENSMUSG00000006219
GeneIDi74202
KEGGimmu:74202
UCSCiuc008vos.2 mouse

Organism-specific databases

CTDi54751
MGIiMGI:1921452 Fblim1

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000007533
HOVERGENiHBG051561
InParanoidiQ71FD7
OMAiCYPLNNR
OrthoDBiEOG091G0CJO
TreeFamiTF320310

Enzyme and pathway databases

ReactomeiR-MMU-446353 Cell-extracellular matrix interactions

Miscellaneous databases

ChiTaRSiFblim1 mouse
PROiPR:Q71FD7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006219 Expressed in 221 organ(s), highest expression level in heart left ventricle
CleanExiMM_FBLIM1
ExpressionAtlasiQ71FD7 baseline and differential
GenevisibleiQ71FD7 MM

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFBLI1_MOUSE
AccessioniPrimary (citable) accession number: Q71FD7
Secondary accession number(s): Q3TDK3, Q99J35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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