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Entry version 135 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Centromere protein U

Gene

CENPU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q71F23

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877, Mitotic Prometaphase
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q71F23

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centromere protein U
Short name:
CENP-U
Alternative name(s):
Centromere protein of 50 kDa
Short name:
CENP-50
Interphase centromere complex protein 24
KSHV latent nuclear antigen-interacting protein 1
MLF1-interacting protein
Polo-box-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CENPU
Synonyms:ICEN24, KLIP1, MLF1IP, PBIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000151725.11

Human Gene Nomenclature Database

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HGNCi
HGNC:21348, CENPU

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611511, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q71F23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi77S → A: Insensitive to PLK1-induced degradation. 1 Publication1
Mutagenesisi78T → A: Insensitive to PLK1-induced degradation. 1 Publication1
Mutagenesisi78T → D: Failed to enhance the PLK1-dependent degradation. 1 Publication1
Mutagenesisi78T → E: Failed to enhance the PLK1-dependent degradation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79682

Open Targets

More...
OpenTargetsi
ENSG00000151725

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134893791

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q71F23, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CENPU

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74712714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002476721 – 418Centromere protein UAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78Phosphothreonine; by PLK11 Publication1
Modified residuei98PhosphothreonineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei110PhosphothreonineCombined sources1
Modified residuei111PhosphoserineCombined sources1
Modified residuei116PhosphoserineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei136PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei190PhosphoserineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q71F23

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q71F23

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q71F23

MaxQB - The MaxQuant DataBase

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MaxQBi
Q71F23

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q71F23

PeptideAtlas

More...
PeptideAtlasi
Q71F23

PRoteomics IDEntifications database

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PRIDEi
Q71F23

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58731
68598 [Q71F23-1]
68599 [Q71F23-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q71F23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q71F23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000151725, Expressed in testis and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q71F23, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q71F23, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000151725, Tissue enhanced (bone marrow, lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.

Interacts with MLF1.

Interacts with PLK1.

4 Publications

(Microbial infection) Interacts with the N-terminal domain of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LNA).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122805, 70 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q71F23

Database of interacting proteins

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DIPi
DIP-48539N

Protein interaction database and analysis system

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IntActi
Q71F23, 61 interactors

Molecular INTeraction database

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MINTi
Q71F23

STRING: functional protein association networks

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STRINGi
9606.ENSP00000281453

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q71F23, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q71F23

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili297 – 356Sequence analysisAdd BLAST60
Coiled coili397 – 417Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi6 – 23Nuclear localization signalSequence analysisAdd BLAST18
Motifi303 – 320Nuclear localization signalSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CENP-U/AME1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502S1IM, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000015511

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_057340_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q71F23

KEGG Orthology (KO)

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KOi
K11513

Identification of Orthologs from Complete Genome Data

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OMAi
HQDYSDI

Database of Orthologous Groups

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OrthoDBi
970617at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q71F23

TreeFam database of animal gene trees

More...
TreeFami
TF330780

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025214, CENP-U

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13097, CENP-U, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q71F23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPRGRRRPR PHRSEGARRS KNTLERTHSM KDKAGQKCKP IDVFDFPDNS
60 70 80 90 100
DVSSIGRLGE NEKDEETYET FDPPLHSTAI YADEEEFSKH CGLSLSSTPP
110 120 130 140 150
GKEAKRSSDT SGNEASEIES VKISAKKPGR KLRPISDDSE SIEESDTRRK
160 170 180 190 200
VKSAEKISTQ RHEVIRTTAS SELSEKPAES VTSKKTGPLS AQPSVEKENL
210 220 230 240 250
AIESQSKTQK KGKISHDKRK KSRSKAIGSD TSDIVHIWCP EGMKTSDIKE
260 270 280 290 300
LNIVLPEFEK THLEHQQRIE SKVCKAAIAT FYVNVKEQFI KMLKESQMLT
310 320 330 340 350
NLKRKNAKMI SDIEKKRQRM IEVQDELLRL EPQLKQLQTK YDELKERKSS
360 370 380 390 400
LRNAAYFLSN LKQLYQDYSD VQAQEPNVKE TYDSSSLPAL LFKARTLLGA
410
ESHLRNINHQ LEKLLDQG
Length:418
Mass (Da):47,522
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA99BC012EF7188F9
GO
Isoform 2 (identifier: Q71F23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-242: Missing.

Show »
Length:176
Mass (Da):20,710
Checksum:iC5731EE5F7ADCE1D
GO
Isoform 3 (identifier: Q71F23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-337: EPQLKQL → WTGAGLW
     338-418: Missing.

Show »
Length:337
Mass (Da):38,102
Checksum:i24A4BBC85B3E98E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9S4D6R9S4_HUMAN
Centromere protein U
CENPU
177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q09GN1Q09GN1_HUMAN
Centromere protein U
CENPU MLF1IP
320Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti163E → G in AAI07745 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04869216G → R. Corresponds to variant dbSNP:rs902174Ensembl.1
Natural variantiVAR_02714416G → S. Corresponds to variant dbSNP:rs902174Ensembl.1
Natural variantiVAR_027145157I → T. Corresponds to variant dbSNP:rs6552804Ensembl.1
Natural variantiVAR_027146214I → M. Corresponds to variant dbSNP:rs4616798Ensembl.1
Natural variantiVAR_048693279A → T. Corresponds to variant dbSNP:rs34007339Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0200301 – 242Missing in isoform 2. 3 PublicationsAdd BLAST242
Alternative sequenceiVSP_053526331 – 337EPQLKQL → WTGAGLW in isoform 3. 1 Publication7
Alternative sequenceiVSP_053527338 – 418Missing in isoform 3. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF469667 mRNA Translation: AAQ05290.1
AF516710 mRNA Translation: AAQ08228.1
AK027121 mRNA Translation: BAB15665.1
CR457376 mRNA Translation: CAG33657.1
DQ907910 mRNA Translation: ABI49142.1
AC079257 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04666.1
BC107744 mRNA Translation: AAI07745.1
BC031520 mRNA Translation: AAH31520.1
BC131556 mRNA Translation: AAI31557.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3838.1 [Q71F23-1]

NCBI Reference Sequences

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RefSeqi
NP_078905.2, NM_024629.3 [Q71F23-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000281453; ENSP00000281453; ENSG00000151725 [Q71F23-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79682

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79682

UCSC genome browser

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UCSCi
uc003iwq.4, human [Q71F23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469667 mRNA Translation: AAQ05290.1
AF516710 mRNA Translation: AAQ08228.1
AK027121 mRNA Translation: BAB15665.1
CR457376 mRNA Translation: CAG33657.1
DQ907910 mRNA Translation: ABI49142.1
AC079257 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04666.1
BC107744 mRNA Translation: AAI07745.1
BC031520 mRNA Translation: AAH31520.1
BC131556 mRNA Translation: AAI31557.1
CCDSiCCDS3838.1 [Q71F23-1]
RefSeqiNP_078905.2, NM_024629.3 [Q71F23-1]

3D structure databases

SMRiQ71F23
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122805, 70 interactors
CORUMiQ71F23
DIPiDIP-48539N
IntActiQ71F23, 61 interactors
MINTiQ71F23
STRINGi9606.ENSP00000281453

PTM databases

iPTMnetiQ71F23
PhosphoSitePlusiQ71F23

Polymorphism and mutation databases

BioMutaiCENPU
DMDMi74712714

Proteomic databases

EPDiQ71F23
jPOSTiQ71F23
MassIVEiQ71F23
MaxQBiQ71F23
PaxDbiQ71F23
PeptideAtlasiQ71F23
PRIDEiQ71F23
ProteomicsDBi58731
68598 [Q71F23-1]
68599 [Q71F23-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
17397, 293 antibodies

Genome annotation databases

EnsembliENST00000281453; ENSP00000281453; ENSG00000151725 [Q71F23-1]
GeneIDi79682
KEGGihsa:79682
UCSCiuc003iwq.4, human [Q71F23-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79682
DisGeNETi79682
EuPathDBiHostDB:ENSG00000151725.11

GeneCards: human genes, protein and diseases

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GeneCardsi
CENPU
HGNCiHGNC:21348, CENPU
HPAiENSG00000151725, Tissue enhanced (bone marrow, lymphoid tissue, testis)
MIMi611511, gene
neXtProtiNX_Q71F23
OpenTargetsiENSG00000151725
PharmGKBiPA134893791

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S1IM, Eukaryota
GeneTreeiENSGT00390000015511
HOGENOMiCLU_057340_1_0_1
InParanoidiQ71F23
KOiK11513
OMAiHQDYSDI
OrthoDBi970617at2759
PhylomeDBiQ71F23
TreeFamiTF330780

Enzyme and pathway databases

PathwayCommonsiQ71F23
ReactomeiR-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877, Mitotic Prometaphase
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
SIGNORiQ71F23

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79682, 38 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CENPU, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MLF1IP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79682
PharosiQ71F23, Tbio

Protein Ontology

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PROi
PR:Q71F23
RNActiQ71F23, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151725, Expressed in testis and 210 other tissues
ExpressionAtlasiQ71F23, baseline and differential
GenevisibleiQ71F23, HS

Family and domain databases

InterProiView protein in InterPro
IPR025214, CENP-U
PfamiView protein in Pfam
PF13097, CENP-U, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCENPU_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q71F23
Secondary accession number(s): A2RRD9
, Q09GN2, Q32Q71, Q9H5G1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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