We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q719I0 (AHSA2_HUMAN)
Protein
Putative activator of 90 kDa heat shock protein ATPase homolog 2
Gene
AHSA2P
Organism
Homo sapiens (Human)
Status
Functioni
Co-chaperone that stimulates HSP90 ATPase activity.
By similarityCaution
Could be the product of a pseudogene.Curated
GO - Molecular functioni
- ATPase activator activity Source: GO_Central
- chaperone binding Source: InterPro
- Hsp90 protein binding Source: InterPro
GO - Biological processi
- positive regulation of ATPase activity Source: GO_Central
- protein folding Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Enzyme and pathway databases
PathwayCommonsi | Q719I0 |
SignaLinki | Q719I0 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative activator of 90 kDa heat shock protein ATPase homolog 2CuratedAlternative name(s): Activator of HSP90 ATPase homolog 2 pseudogeneImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20437, AHSA2P |
neXtProti | NX_Q719I0 |
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA134913389 |
Miscellaneous databases
Pharosi | Q719I0, Tdark |
Genetic variation databases
BioMutai | AHSA2 |
DMDMi | 166198353 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315605 | 1 – 299 | Putative activator of 90 kDa heat shock protein ATPase homolog 2Add BLAST | 299 |
Proteomic databases
jPOSTi | Q719I0 |
MassIVEi | Q719I0 |
PaxDbi | Q719I0 |
PeptideAtlasi | Q719I0 |
PRIDEi | Q719I0 |
ProteomicsDBi | 68594 [Q719I0-1] 68595 [Q719I0-2] 68596 [Q719I0-3] |
PTM databases
iPTMneti | Q719I0 |
PhosphoSitePlusi | Q719I0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173209, Expressed in left lobe of thyroid gland and 230 other tissues |
Genevisiblei | Q719I0, HS |
Interactioni
Binary interactionsi
Q719I0
With | #Exp. | IntAct |
---|---|---|
MEOX2 [P50222] | 3 | EBI-9361704,EBI-748397 |
GO - Molecular functioni
- chaperone binding Source: InterPro
- Hsp90 protein binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 126261, 5 interactors |
IntActi | Q719I0, 3 interactors |
STRINGi | 9606.ENSP00000377970 |
Miscellaneous databases
RNActi | Q719I0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the AHA1 family.Curated
Phylogenomic databases
eggNOGi | KOG2936, Eukaryota |
InParanoidi | Q719I0 |
PhylomeDBi | Q719I0 |
Family and domain databases
Gene3Di | 3.15.10.20, 1 hit 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR036338, Aha1 IPR039981, AHSA-like IPR015310, AHSA1_N IPR023393, START-like_dom_sf |
PANTHERi | PTHR13009, PTHR13009, 2 hits |
Pfami | View protein in Pfam PF09229, Aha1_N, 1 hit |
SMARTi | View protein in SMART SM01000, Aha1_N, 1 hit |
SUPFAMi | SSF103111, SSF103111, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q719I0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKWGQGNPH WIVEEREDGT NVNNWRWTER DATSLSKGKF QELLVGIVVE
60 70 80 90 100
NDAGRGEINE LKQVEGEASC SSRKGKLIFF YEWNIKLGWK GIVKESGVKH
110 120 130 140 150
KGLIEIPNLS EENEVDDTEV SLSKKKGDGV ILKDLMKTAG TAKVREALGD
160 170 180 190 200
YLKALKTEFT TGMILPTKAM ATQELTVKRK LSGNTLQVQA SSPVALGVRI
210 220 230 240 250
PTVALHMMEL FDTTVEQLYS IFTVKELTNK KIIMKWRCGN WPEEHYAMVA
260 270 280 290
LNFVPTLGQT ELQLKEFLSI CKEENMKFCW QKQHFEEIKG SLQLTPLNG
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038256 | 248 | M → T in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030569 | 1 – 162 | Missing in isoform 3. 3 PublicationsAdd BLAST | 162 | |
Alternative sequenceiVSP_030570 | 1 – 153 | Missing in isoform 2. 1 PublicationAdd BLAST | 153 | |
Alternative sequenceiVSP_030571 | 154 – 157 | ALKT → MTLP in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF542548 mRNA Translation: AAQ09531.1 AK092817 mRNA Translation: BAG52613.1 AL833813 mRNA Translation: CAD38676.1 AC016747 Genomic DNA Translation: AAY14686.1 CH471053 Genomic DNA Translation: EAX00003.1 CH471053 Genomic DNA Translation: EAX00006.1 CH471053 Genomic DNA Translation: EAX00008.1 BC113671 mRNA Translation: AAI13672.1 BC117278 mRNA Translation: AAI17279.1 |
RefSeqi | NP_001308229.1, NM_001321300.1 NP_689605.1, NM_152392.4 |
Genome annotation databases
UCSCi | uc002sbb.4, human [Q719I0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF542548 mRNA Translation: AAQ09531.1 AK092817 mRNA Translation: BAG52613.1 AL833813 mRNA Translation: CAD38676.1 AC016747 Genomic DNA Translation: AAY14686.1 CH471053 Genomic DNA Translation: EAX00003.1 CH471053 Genomic DNA Translation: EAX00006.1 CH471053 Genomic DNA Translation: EAX00008.1 BC113671 mRNA Translation: AAI13672.1 BC117278 mRNA Translation: AAI17279.1 |
RefSeqi | NP_001308229.1, NM_001321300.1 NP_689605.1, NM_152392.4 |
3D structure databases
SMRi | Q719I0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126261, 5 interactors |
IntActi | Q719I0, 3 interactors |
STRINGi | 9606.ENSP00000377970 |
PTM databases
iPTMneti | Q719I0 |
PhosphoSitePlusi | Q719I0 |
Genetic variation databases
BioMutai | AHSA2 |
DMDMi | 166198353 |
Proteomic databases
jPOSTi | Q719I0 |
MassIVEi | Q719I0 |
PaxDbi | Q719I0 |
PeptideAtlasi | Q719I0 |
PRIDEi | Q719I0 |
ProteomicsDBi | 68594 [Q719I0-1] 68595 [Q719I0-2] 68596 [Q719I0-3] |
Protocols and materials databases
DNASUi | 130872 |
Genome annotation databases
UCSCi | uc002sbb.4, human [Q719I0-1] |
Organism-specific databases
GeneCardsi | AHSA2P |
HGNCi | HGNC:20437, AHSA2P |
neXtProti | NX_Q719I0 |
PharmGKBi | PA134913389 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2936, Eukaryota |
InParanoidi | Q719I0 |
PhylomeDBi | Q719I0 |
Enzyme and pathway databases
PathwayCommonsi | Q719I0 |
SignaLinki | Q719I0 |
Miscellaneous databases
BioGRID-ORCSi | 130872, 11 hits in 1038 CRISPR screens |
ChiTaRSi | AHSA2, human |
GenomeRNAii | 130872 |
Pharosi | Q719I0, Tdark |
PROi | PR:Q719I0 |
RNActi | Q719I0, protein |
Gene expression databases
Bgeei | ENSG00000173209, Expressed in left lobe of thyroid gland and 230 other tissues |
Genevisiblei | Q719I0, HS |
Family and domain databases
Gene3Di | 3.15.10.20, 1 hit 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR036338, Aha1 IPR039981, AHSA-like IPR015310, AHSA1_N IPR023393, START-like_dom_sf |
PANTHERi | PTHR13009, PTHR13009, 2 hits |
Pfami | View protein in Pfam PF09229, Aha1_N, 1 hit |
SMARTi | View protein in SMART SM01000, Aha1_N, 1 hit |
SUPFAMi | SSF103111, SSF103111, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AHSA2_HUMAN | |
Accessioni | Q719I0Primary (citable) accession number: Q719I0 Secondary accession number(s): B3KS51, D6W5E0, Q8NDU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families