Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cystin-1

Gene

CYS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-5624138 Trafficking of myristoylated proteins to the cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Cystin-1
Alternative name(s):
Cilia-associated protein
Gene namesi
Name:CYS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000205795.4
HGNCiHGNC:18525 CYS1
neXtProtiNX_Q717R9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi192668
OpenTargetsiENSG00000205795
PharmGKBiPA38343

Polymorphism and mutation databases

BioMutaiCYS1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002611772 – 158Cystin-1Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ717R9
PeptideAtlasiQ717R9
PRIDEiQ717R9
ProteomicsDBi68591

PTM databases

iPTMnetiQ717R9
PhosphoSitePlusiQ717R9

Expressioni

Tissue specificityi

Expressed at high levels in the kidney and pancreas. Moderate expression seen in the skeletal muscle, liver and heart. A weak expression seen in the brain, lung, uterus, prostate, testis, small intestine and colon.

Developmental stagei

Fetal kidney.1 Publication

Gene expression databases

BgeeiENSG00000205795
CleanExiHS_CYS1
GenevisibleiQ717R9 HS

Interactioni

Subunit structurei

Interacts (when myristoylated) with UNC119 and UNC119B; interaction is required for localization to cilium.1 Publication

Protein-protein interaction databases

BioGridi128176, 1 interactor
STRINGi9606.ENSP00000371234

Structurei

3D structure databases

ProteinModelPortaliQ717R9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi29 – 33Ciliary targeting motifBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 16Poly-Arg4

Phylogenomic databases

eggNOGiENOG410JIWT Eukaryota
ENOG4111721 LUCA
GeneTreeiENSGT00390000016845
HOGENOMiHOG000112132
InParanoidiQ717R9
OMAiAISYDHA
OrthoDBiEOG091G0W9D
PhylomeDBiQ717R9

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q717R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGSSRSSR TLRRRRSPES LPAGPGAAAL EGGTRRRVPV AAAEVPGAAA
60 70 80 90 100
EEAPGRDPSP VAPPDGRDET LRLLDELLAE SAAWGPPEPA PRRPARLRPT
110 120 130 140 150
AVAGSAVCAE QSTEGHPGSG NVSEAPGSGR KKPERPAAIS YDHSEEGLMA

SIEREYCR
Length:158
Mass (Da):16,393
Last modified:July 5, 2004 - v1
Checksum:i9B542661E80496B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF544983 mRNA Translation: AAQ11748.1
CCDSiCCDS33145.1
RefSeqiNP_001032237.1, NM_001037160.2
UniGeneiHs.27092
Hs.720471

Genome annotation databases

EnsembliENST00000381813; ENSP00000371234; ENSG00000205795
GeneIDi192668
KEGGihsa:192668
UCSCiuc002rag.3 human

Similar proteinsi

Entry informationi

Entry nameiCYS1_HUMAN
AccessioniPrimary (citable) accession number: Q717R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health