UniProtKB - Q717C1 (TS1R3_GORGO)
Protein
Taste receptor type 1 member 3
Gene
TAS1R3
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Functioni
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity).By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- detection of chemical stimulus involved in sensory perception of sweet taste Source: GOC
- sensory perception of sweet taste Source: GO_Central
- sensory perception of umami taste Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Taste receptor type 1 member 3Alternative name(s): Sweet taste receptor T1R3 |
Gene namesi | Name:TAS1R3 Synonyms:T1R3 |
Organismi | Gorilla gorilla gorilla (Western lowland gorilla) |
Taxonomic identifieri | 9595 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 570 | ExtracellularSequence analysisAdd BLAST | 550 | |
Transmembranei | 571 – 591 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 592 – 603 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 604 – 624 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 625 – 639 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 640 – 660 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 661 – 682 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 683 – 703 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 704 – 729 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 730 – 750 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 751 – 762 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 763 – 783 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 784 – 791 | ExtracellularSequence analysis | 8 | |
Transmembranei | 792 – 812 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 813 – 852 | CytoplasmicSequence analysisAdd BLAST | 40 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000012960 | 21 – 852 | Taste receptor type 1 member 3Add BLAST | 832 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 130 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 264 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 285 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 380 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 411 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 432 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 475 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
By similarityProtein-protein interaction databases
STRINGi | 9593.ENSGGOP00000023446 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
InParanoidi | Q717C1 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q717C1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGPAVLGLS LWALLQPGAG APLCLSQQLR MKGDYMLGGL FPLGEAEEAG
60 70 80 90 100
FRSRTRPSSP VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF
110 120 130 140 150
DTCSEPVVAM KPSLMFLAKA GSRDIAAYCN YTQYQPRVLA VIGPHSSELA
160 170 180 190 200
MVTGKFFSFF LMPQVSYGAS MELLSARETF PSFFRTVPSD RVQLTAAAEL
210 220 230 240 250
LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE GLVPLPRADD
260 270 280 290 300
SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS
310 320 330 340 350
EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALAADPAF
360 370 380 390 400
CSALGEREQG LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV
410 420 430 440 450
AQALHNTLQC NASGCPAQDP VKPWQLLENM YNLTFHAGGL MLRFDSSGNV
460 470 480 490 500
DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT ERLKIRWHTS DNQKPVSRCS
510 520 530 540 550
RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDVTCTS CGQDEWSPER
560 570 580 590 600
STRCFHRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ
610 620 630 640 650
ASGGPLACFG LVCLGLVCLS VLLFPGQPSP AQCLAQQPLS HLPLTGCLST
660 670 680 690 700
LFLQAAEIFV ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL
710 720 730 740 750
VAFPPEVVTD WHMLPTEALV HCRTRSWVSF GLAHATNATL AFLCFLGTFL
760 770 780 790 800
VRSQPGRYNR ARGLTFAMLA YFITWVSFVP LLANVQVVLR PAVQMGALLL
810 820 830 840 850
CVLGILAAFH LPRCYLLIRQ PGLNTPEFFL GGGPGDAQGR NDGDTGNQGK
HE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF545574 Genomic DNA Translation: AAQ11897.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF545574 Genomic DNA Translation: AAQ11897.1 |
3D structure databases
SMRi | Q717C1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9593.ENSGGOP00000023446 |
Protein family/group databases
GPCRDBi | Search... |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
InParanoidi | Q717C1 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TS1R3_GORGO | |
Accessioni | Q717C1Primary (citable) accession number: Q717C1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families