Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-conjugating enzyme E2 R2

Gene

UBE2R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.2 Publications

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Glycyl thioester intermediate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.3.2.B6 2681
ReactomeiR-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ712K3
SIGNORiQ712K3
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 R2 (EC:2.3.2.231 Publication)
Alternative name(s):
E2 ubiquitin-conjugating enzyme R2
Ubiquitin carrier protein R2
Ubiquitin-conjugating enzyme E2-CDC34B
Ubiquitin-protein ligase R2
Gene namesi
Name:UBE2R2
Synonyms:CDC34B, UBC3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107341.4
HGNCiHGNC:19907 UBE2R2
MIMi612506 gene
neXtProtiNX_Q712K3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi93C → S: Loss of function. 1 Publication1
Mutagenesisi97L → S: Loss of function. 1 Publication1
Mutagenesisi233S → A: Abolishes phosphorylation by CK2. 1 Publication1

Organism-specific databases

DisGeNETi54926
OpenTargetsiENSG00000107341
PharmGKBiPA134946881

Polymorphism and mutation databases

BioMutaiUBE2R2
DMDMi74749761

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002805131 – 238Ubiquitin-conjugating enzyme E2 R2Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233Phosphoserine; by CK2Combined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ712K3
MaxQBiQ712K3
PaxDbiQ712K3
PeptideAtlasiQ712K3
PRIDEiQ712K3
ProteomicsDBi68590

PTM databases

iPTMnetiQ712K3
PhosphoSitePlusiQ712K3

Expressioni

Gene expression databases

BgeeiENSG00000107341 Expressed in 204 organ(s), highest expression level in sperm
CleanExiHS_UBE2R2
GenevisibleiQ712K3 HS

Organism-specific databases

HPAiHPA061000

Interactioni

Subunit structurei

When phosphorylated, interacts with beta-TrCP (BTRC).1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120266, 42 interactors
IntActiQ712K3, 16 interactors
MINTiQ712K3
STRINGi9606.ENSP00000263228

Structurei

3D structure databases

ProteinModelPortaliQ712K3
SMRiQ712K3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi200 – 238Asp/Glu-rich (acidic)Add BLAST39

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0425 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110436
HOGENOMiHOG000233454
HOVERGENiHBG063308
InParanoidiQ712K3
KOiK02207
OMAiRWSPLQG
OrthoDBiEOG091G0O9F
PhylomeDBiQ712K3
TreeFamiTF101107

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q712K3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQQQMTSSQ KALMLELKSL QEEPVEGFRI TLVDESDLYN WEVAIFGPPN
60 70 80 90 100
TLYEGGYFKA HIKFPIDYPY SPPTFRFLTK MWHPNIYENG DVCISILHPP
110 120 130 140 150
VDDPQSGELP SERWNPTQNV RTILLSVISL LNEPNTFSPA NVDASVMFRK
160 170 180 190 200
WRDSKGKDKE YAEIIRKQVS ATKAEAEKDG VKVPTTLAEY CIKTKVPSND
210 220 230
NSSDLLYDDL YDDDIDDEDE EEEDADCYDD DDSGNEES
Length:238
Mass (Da):27,166
Last modified:July 5, 2004 - v1
Checksum:iE896CF0116A56308
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39Y → H in BAA91156 (PubMed:14702039).Curated1
Sequence conflicti127V → A in BAA91156 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ240087 mRNA Translation: CAC80336.1
AK000426 mRNA Translation: BAA91156.1
CR457233 mRNA Translation: CAG33514.1
AL139113 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58479.1
CH471071 Genomic DNA Translation: EAW58480.1
BC004862 mRNA Translation: AAH04862.1
BC047584 mRNA Translation: AAH47584.1
CCDSiCCDS6546.1
RefSeqiNP_060281.2, NM_017811.3
UniGeneiHs.643648

Genome annotation databases

EnsembliENST00000263228; ENSP00000263228; ENSG00000107341
GeneIDi54926
KEGGihsa:54926
UCSCiuc003ztm.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ240087 mRNA Translation: CAC80336.1
AK000426 mRNA Translation: BAA91156.1
CR457233 mRNA Translation: CAG33514.1
AL139113 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58479.1
CH471071 Genomic DNA Translation: EAW58480.1
BC004862 mRNA Translation: AAH04862.1
BC047584 mRNA Translation: AAH47584.1
CCDSiCCDS6546.1
RefSeqiNP_060281.2, NM_017811.3
UniGeneiHs.643648

3D structure databases

ProteinModelPortaliQ712K3
SMRiQ712K3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120266, 42 interactors
IntActiQ712K3, 16 interactors
MINTiQ712K3
STRINGi9606.ENSP00000263228

PTM databases

iPTMnetiQ712K3
PhosphoSitePlusiQ712K3

Polymorphism and mutation databases

BioMutaiUBE2R2
DMDMi74749761

Proteomic databases

EPDiQ712K3
MaxQBiQ712K3
PaxDbiQ712K3
PeptideAtlasiQ712K3
PRIDEiQ712K3
ProteomicsDBi68590

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263228; ENSP00000263228; ENSG00000107341
GeneIDi54926
KEGGihsa:54926
UCSCiuc003ztm.4 human

Organism-specific databases

CTDi54926
DisGeNETi54926
EuPathDBiHostDB:ENSG00000107341.4
GeneCardsiUBE2R2
HGNCiHGNC:19907 UBE2R2
HPAiHPA061000
MIMi612506 gene
neXtProtiNX_Q712K3
OpenTargetsiENSG00000107341
PharmGKBiPA134946881
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0425 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110436
HOGENOMiHOG000233454
HOVERGENiHBG063308
InParanoidiQ712K3
KOiK02207
OMAiRWSPLQG
OrthoDBiEOG091G0O9F
PhylomeDBiQ712K3
TreeFamiTF101107

Enzyme and pathway databases

UniPathwayi
UPA00143

BRENDAi2.3.2.B6 2681
ReactomeiR-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ712K3
SIGNORiQ712K3

Miscellaneous databases

ChiTaRSiUBE2R2 human
GeneWikiiUBE2R2
GenomeRNAii54926
PROiPR:Q712K3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107341 Expressed in 204 organ(s), highest expression level in sperm
CleanExiHS_UBE2R2
GenevisibleiQ712K3 HS

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUB2R2_HUMAN
AccessioniPrimary (citable) accession number: Q712K3
Secondary accession number(s): D3DRL5, Q9NX64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again