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Entry version 140 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

Gene

PREX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8948751 Regulation of PTEN stability and activity

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q70Z35

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 proteinCurated
Short name:
P-Rex2
Short name:
PtdIns(3,4,5)-dependent Rac exchanger 2
Alternative name(s):
DEP domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PREX2Imported
Synonyms:DEPDC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000046889.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22950 PREX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612139 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q70Z35

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80243

Open Targets

More...
OpenTargetsi
ENSG00000046889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164725103

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q70Z35 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PREX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758897

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002867951 – 1606Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 proteinAdd BLAST1606

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q70Z35

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q70Z35

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q70Z35

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q70Z35

PeptideAtlas

More...
PeptideAtlasi
Q70Z35

PRoteomics IDEntifications database

More...
PRIDEi
Q70Z35

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68577 [Q70Z35-1]
68579 [Q70Z35-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q70Z35

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q70Z35

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000046889 Expressed in corpus callosum and 185 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q70Z35 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000046889 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAC1.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123199, 4 interactors

Protein interaction database and analysis system

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IntActi
Q70Z35, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000288368

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q70Z35 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11606
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q70Z35

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 214DHPROSITE-ProRule annotationAdd BLAST192
Domaini245 – 361PHPROSITE-ProRule annotationAdd BLAST117
Domaini390 – 464DEP 1PROSITE-ProRule annotationAdd BLAST75
Domaini491 – 566DEP 2PROSITE-ProRule annotationAdd BLAST76
Domaini592 – 671PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini677 – 754PDZ 2PROSITE-ProRule annotationAdd BLAST78

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42.
DH domain alone was unable to confer substrate specificity and recognition.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3519 Eukaryota
KOG4428 Eukaryota
ENOG410XRJD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155894

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003935_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q70Z35

KEGG Orthology (KO)

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KOi
K17588

Identification of Orthologs from Complete Genome Data

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OMAi
VRQYNQK

Database of Orthologous Groups

More...
OrthoDBi
24217at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q70Z35

TreeFam database of animal gene trees

More...
TreeFami
TF328639

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04439 DEP_1_P-Rex, 1 hit
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000591 DEP_dom
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037367 Rex2_DEP_1
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 2 hits
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 2 hits
SM00228 PDZ, 2 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 2 hits
SSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 2 hits
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 2 hits
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q70Z35-1) [UniParc]FASTAAdd to basket
Also known as: P-Rex2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEDSRGDSR AESAKDLEKQ LRLRVCVLSE LQKTERDYVG TLEFLVSAFL
60 70 80 90 100
HRMNQCAASK VDKNVTEETV KMLFSNIEDI LAVHKEFLKV VEECLHPEPN
110 120 130 140 150
AQQEVGTCFL HFKDKFRIYD EYCSNHEKAQ KLLLELNKIR TIRTFLLNCM
160 170 180 190 200
LLGGRKNTDV PLEGYLVTPI QRICKYPLIL KELLKRTPRK HSDYAAVMEA
210 220 230 240 250
LQAMKAVCSN INEAKRQMEK LEVLEEWQSH IEGWEGSNIT DTCTEMLMCG
260 270 280 290 300
VLLKISSGNI QERVFFLFDN LLVYCKRKHR RLKNSKASTD GHRYLFRGRI
310 320 330 340 350
NTEVMEVENV DDGTADFHSS GHIVVNGWKI HNTAKNKWFV CMAKTPEEKH
360 370 380 390 400
EWFEAILKER ERRKGLKLGM EQDTWVMISE QGEKLYKMMC RQGNLIKDRK
410 420 430 440 450
RKLTTFPKCF LGSEFVSWLL EIGEIHRPEE GVHLGQALLE NGIIHHVTDK
460 470 480 490 500
HQFKPEQMLY RFRYDDGTFY PRNEMQDVIS KGVRLYCRLH SLFTPVIRDK
510 520 530 540 550
DYHLRTYKSV VMANKLIDWL IAQGDCRTRE EAMIFGVGLC DNGFMHHVLE
560 570 580 590 600
KSEFKDEPLL FRFFSDEEME GSNMKHRLMK HDLKVVENVI AKSLLIKSNE
610 620 630 640 650
GSYGFGLEDK NKVPIIKLVE KGSNAEMAGM EVGKKIFAIN GDLVFMRPFN
660 670 680 690 700
EVDCFLKSCL NSRKPLRVLV STKPRETVKI PDSADGLGFQ IRGFGPSVVH
710 720 730 740 750
AVGRGTVAAA AGLHPGQCII KVNGINVSKE THASVIAHVT ACRKYRRPTK
760 770 780 790 800
QDSIQWVYNS IESAQEDLQK SHSKPPGDEA GDAFDCKVEE VIDKFNTMAI
810 820 830 840 850
IDGKKEHVSL TVDNVHLEYG VVYEYDSTAG IKCNVVEKMI EPKGFFSLTA
860 870 880 890 900
KILEALAKSD EHFVQNCTSL NSLNEVIPTD LQSKFSALCS ERIEHLCQRI
910 920 930 940 950
SSYKKFSRVL KNRAWPTFKQ AKSKISPLHS SDFCPTNCHV NVMEVSYPKT
960 970 980 990 1000
STSLGSAFGV QLDSRKHNSH DKENKSSEQG KLSPMVYIQH TITTMAAPSG
1010 1020 1030 1040 1050
LSLGQQDGHG LRYLLKEEDL ETQDIYQKLL GKLQTALKEV EMCVCQIDDL
1060 1070 1080 1090 1100
LSSITYSPKL ERKTSEGIIP TDSDNEKGER NSKRVCFNVA GDEQEDSGHD
1110 1120 1130 1140 1150
TISNRDSYSD CNSNRNSIAS FTSICSSQCS SYFHSDEMDS GDELPLSVRI
1160 1170 1180 1190 1200
SHDKQDKIHS CLEHLFSQVD SITNLLKGQA VVRAFDQTKY LTPGRGLQEF
1210 1220 1230 1240 1250
QQEMEPKLSC PKRLRLHIKQ DPWNLPSSVR TLAQNIRKFV EEVKCRLLLA
1260 1270 1280 1290 1300
LLEYSDSETQ LRRDMVFCQT LVATVCAFSE QLMAALNQMF DNSKENEMET
1310 1320 1330 1340 1350
WEASRRWLDQ IANAGVLFHF QSLLSPNLTD EQAMLEDTLV ALFDLEKVSF
1360 1370 1380 1390 1400
YFKPSEEEPL VANVPLTYQA EGSRQALKVY FYIDSYHFEQ LPQRLKNGGG
1410 1420 1430 1440 1450
FKIHPVLFAQ ALESMEGYYY RDNVSVEEFQ AQINAASLEK VKQYNQKLRA
1460 1470 1480 1490 1500
FYLDKSNSPP NSTSKAAYVD KLMRPLNALD ELYRLVASFI RSKRTAACAN
1510 1520 1530 1540 1550
TACSASGVGL LSVSSELCNR LGACHIIMCS SGVHRCTLSV TLEQAIILAR
1560 1570 1580 1590 1600
SHGLPPRYIM QATDVMRKQG ARVQNTAKNL GVRDRTPQSA PRLYKLCEPP

PPAGEE
Length:1,606
Mass (Da):182,622
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9E938D65CE2C7DD
GO
Isoform 3 (identifier: Q70Z35-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     906-979: FSRVLKNRAW...HDKENKSSEQ → VQASERFYNF...EMLLAERAPV
     980-1606: Missing.

Show »
Length:979
Mass (Da):112,091
Checksum:i98B38EB98ED26657
GO
Isoform 4 (identifier: Q70Z35-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-112: Missing.
     1049-1049: D → E
     1050-1606: Missing.

Show »
Length:984
Mass (Da):112,404
Checksum:i4BBF022C4AAF66B5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK024079 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14375 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG57581 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence DAA05334 differs from that shown. Non-canonical splice intron-exon junction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti158T → I in AAS82571 (Ref. 2) Curated1
Sequence conflicti158T → I in AAS82572 (Ref. 2) Curated1
Sequence conflicti1076E → V in AAS82571 (Ref. 2) Curated1
Sequence conflicti1076E → V in AK024079 (PubMed:14702039).Curated1
Sequence conflicti1268C → R in AAS82571 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032163312D → N. Corresponds to variant dbSNP:rs11784582Ensembl.1
Natural variantiVAR_035973537V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs147538692Ensembl.1
Natural variantiVAR_0359741571A → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05561248 – 112Missing in isoform 4. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_025150906 – 979FSRVL…KSSEQ → VQASERFYNFTARHAVWEHS FDLHSVSSTFPVPVTMEFLL LPPPLLGISQDGRQHCIPED LPSQEMLLAERAPV in isoform 3. 2 PublicationsAdd BLAST74
Alternative sequenceiVSP_025152980 – 1606Missing in isoform 3. 2 PublicationsAdd BLAST627
Alternative sequenceiVSP_0556131049D → E in isoform 4. 1 Publication1
Alternative sequenceiVSP_0556141050 – 1606Missing in isoform 4. 1 PublicationAdd BLAST557

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ437636 mRNA Translation: CAD26885.2
AY508996 mRNA Translation: AAS82571.1
AY508997 mRNA Translation: AAS82572.1
AC011853 Genomic DNA No translation available.
AC103783 Genomic DNA No translation available.
AC104416 Genomic DNA No translation available.
AK023049 mRNA Translation: BAB14375.1 Different initiation.
AK024079 mRNA No translation available.
AK294299 mRNA Translation: BAG57581.1 Different initiation.
BK005160 mRNA Translation: DAA05333.1
BK005161 mRNA Translation: DAA05334.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS6201.1 [Q70Z35-1]

NCBI Reference Sequences

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RefSeqi
NP_079146.2, NM_024870.3 [Q70Z35-1]
NP_079446.3, NM_025170.5 [Q70Z35-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000288368; ENSP00000288368; ENSG00000046889 [Q70Z35-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80243

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80243

UCSC genome browser

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UCSCi
uc003xxv.2 human [Q70Z35-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ437636 mRNA Translation: CAD26885.2
AY508996 mRNA Translation: AAS82571.1
AY508997 mRNA Translation: AAS82572.1
AC011853 Genomic DNA No translation available.
AC103783 Genomic DNA No translation available.
AC104416 Genomic DNA No translation available.
AK023049 mRNA Translation: BAB14375.1 Different initiation.
AK024079 mRNA No translation available.
AK294299 mRNA Translation: BAG57581.1 Different initiation.
BK005160 mRNA Translation: DAA05333.1
BK005161 mRNA Translation: DAA05334.1 Sequence problems.
CCDSiCCDS6201.1 [Q70Z35-1]
RefSeqiNP_079146.2, NM_024870.3 [Q70Z35-1]
NP_079446.3, NM_025170.5 [Q70Z35-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BNMX-ray1.90A219-377[»]
SMRiQ70Z35
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123199, 4 interactors
IntActiQ70Z35, 7 interactors
STRINGi9606.ENSP00000288368

PTM databases

iPTMnetiQ70Z35
PhosphoSitePlusiQ70Z35

Polymorphism and mutation databases

BioMutaiPREX2
DMDMi74758897

Proteomic databases

EPDiQ70Z35
MassIVEiQ70Z35
MaxQBiQ70Z35
PaxDbiQ70Z35
PeptideAtlasiQ70Z35
PRIDEiQ70Z35
ProteomicsDBi68577 [Q70Z35-1]
68579 [Q70Z35-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2764 59 antibodies

The DNASU plasmid repository

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DNASUi
80243

Genome annotation databases

EnsembliENST00000288368; ENSP00000288368; ENSG00000046889 [Q70Z35-1]
GeneIDi80243
KEGGihsa:80243
UCSCiuc003xxv.2 human [Q70Z35-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80243
DisGeNETi80243
EuPathDBiHostDB:ENSG00000046889.18

GeneCards: human genes, protein and diseases

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GeneCardsi
PREX2
HGNCiHGNC:22950 PREX2
HPAiENSG00000046889 Low tissue specificity
MIMi612139 gene
neXtProtiNX_Q70Z35
OpenTargetsiENSG00000046889
PharmGKBiPA164725103

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3519 Eukaryota
KOG4428 Eukaryota
ENOG410XRJD LUCA
GeneTreeiENSGT00940000155894
HOGENOMiCLU_003935_0_0_1
InParanoidiQ70Z35
KOiK17588
OMAiVRQYNQK
OrthoDBi24217at2759
PhylomeDBiQ70Z35
TreeFamiTF328639

Enzyme and pathway databases

ReactomeiR-HSA-8948751 Regulation of PTEN stability and activity
SIGNORiQ70Z35

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
80243 6 hits in 789 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PREX2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PREX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80243
PharosiQ70Z35 Tbio

Protein Ontology

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PROi
PR:Q70Z35
RNActiQ70Z35 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000046889 Expressed in corpus callosum and 185 other tissues
GenevisibleiQ70Z35 HS

Family and domain databases

CDDicd04439 DEP_1_P-Rex, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.10.10.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 2 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000591 DEP_dom
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037367 Rex2_DEP_1
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 2 hits
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 2 hits
SM00228 PDZ, 2 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits
SSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50186 DEP, 2 hits
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 2 hits
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPREX2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70Z35
Secondary accession number(s): B4DFX0
, Q32KL0, Q32KL1, Q6R7Q3, Q6R7Q4, Q9H805, Q9H961
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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