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Entry version 62 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Aldehyde-alcohol dehydrogenase

Gene

ADHE2

Organism
Polytomella sp. Pringsheim 198.80
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationARBA annotation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.1, 14624
1.2.1.10, 14624

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldehyde-alcohol dehydrogenaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADHE2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPolytomella sp. Pringsheim 198.80Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri37502 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytacore chlorophytesChlorophyceaeCS cladeChlamydomonadalesChlamydomonadaceaePolytomellaunclassified Polytomella

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 358AldedhInterPro annotationAdd BLAST314
Domaini505 – 873Fe-ADHInterPro annotationAdd BLAST369

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08178, AAD_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.309.10, 1 hit
3.40.605.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034789, AAD_C
IPR001670, ADH_Fe/GldA
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR012079, Bifunc_Ald-ADH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00171, Aldedh, 1 hit
PF00465, Fe-ADH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000111, ALDH_ADH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53720, SSF53720, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q70YJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPTRAVSSL SRNVFARPFA NASRAYAAAP AAEQKSKSDE EGLSSLKSTL
60 70 80 90 100
NKAVAASKVF ATYSQDQVDK IFRAAAEAAN AARLPLAKMA VEETRMGVVE
110 120 130 140 150
DKVIKNHFAS EFVYSQYKNT KTCGLIAHDP ISGYSKFAEP MGVIAGIIPT
160 170 180 190 200
TNPTSTAIFK TLLALKTRNA LVICPHPRAA KCTIAAAKVV LDAAVAAGAP
210 220 230 240 250
ADIITWIDSP SSLVSGALMK APGSVLVLAT GGPGMVRAVT LPAPSLGVGA
260 270 280 290 300
GNTPALIDET ADIELAVNSV LISKTFDNGV ICASEQSIVA VDAVYDKVRA
310 320 330 340 350
EFVRRGAYFL NEEEKVKVRK GIEKDGKLNA DIVGQPVAKL AQMFGITVPA
360 370 380 390 400
GAKVLIGEVS VVGKEEPLSQ EKLSPILAMY RSSDFNTALA TTHKLIMFGG
410 420 430 440 450
AGHTSVIYTH PDNRQNIEAF QAMAKTGRIL VNSPSSQGAI GGIYNQILAP
460 470 480 490 500
SMTLGCGSWG GNIVSDNIGP LHLVNVKSVA ERRHGAGGFN VPATVLLQSG
510 520 530 540 550
GAASTFAQLS GKKVLVVADK NADVAAVSAA LAKAGAEATV FNGVGAASTL
560 570 580 590 600
AAVQAGLKAT VAFHPDTIVA VGGGAAIDAA KLIWLGYEHP ETRLDGLTIR
610 620 630 640 650
FMDMGKRVYN VPALGAKASL IAIPTAIGSG SEVTPFSSLV DEATGKSYTI
660 670 680 690 700
ADAAFFPSAA IVDPSLIAAL PKAAVAAGAF EAISHAVESF VSIAASDRTK
710 720 730 740 750
DLSREALTQI FDALPSADAE KVLYASTKAG MAYANAFLGV TQSLANKVAV
760 770 780 790 800
ACDIPVGVAA AVLLPYVIRY NATDAPFKQA IFPSYHSPRA VADYAELANA
810 820 830 840 850
LKLGGSTPVE KAENLAAAIE GLRSKAGVPS SLKAAFGSAA QDAKFLAVVD
860 870 880
KLAEEAFDDQ CSLANPRYPL IEDLKAILVA AHQGL
Length:885
Mass (Da):91,484
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1946C4CACDE7BCB8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ495765 mRNA Translation: CAD42653.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ495765 mRNA Translation: CAD42653.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Enzyme and pathway databases

BRENDAi1.1.1.1, 14624
1.2.1.10, 14624

Family and domain databases

CDDicd08178, AAD_C, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR034789, AAD_C
IPR001670, ADH_Fe/GldA
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR012079, Bifunc_Ald-ADH
PfamiView protein in Pfam
PF00171, Aldedh, 1 hit
PF00465, Fe-ADH, 1 hit
PIRSFiPIRSF000111, ALDH_ADH, 1 hit
SUPFAMiSSF53720, SSF53720, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ70YJ9_9CHLO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70YJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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