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UniProtKB - Q70YC5 (ZN365_HUMAN)

Entry version 137 (23 Feb 2022)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
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Protein

Protein ZNF365

Gene

ZNF365

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905).

Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity).

Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166).

Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040).

By similarity3 Publications

Miscellaneous

Cells silencing ZNF365 display delayed mitotic progression and exit, due to increased replication stress, and ultimately leading to cytokinesis failure, re-duplication of centrosomes and increased aneuploidy.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri26 – 51C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurogenesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q70YC5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q70YC5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ZNF365
Alternative name(s):
DISC1-binding zinc-finger protein1 Publication
Protein su48
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF365
Synonyms:DBZ1 Publication, KIAA0844
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18194, ZNF365

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607818, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q70YC5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000138311

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		22891

MalaCards human disease database

More...MalaCardsi		ZNF365

Open Targets

More...OpenTargetsi		ENSG00000138311

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2073, Narcolepsy type 1
83465, Narcolepsy type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134873576

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q70YC5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF365

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373495

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000763741 – 407Protein ZNF365Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineBy similarity1
Modified residuei138PhosphoserineBy similarity1
Modified residuei175PhosphothreonineBy similarity1
Modified residuei369PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q70YC5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q70YC5

PeptideAtlas

More...PeptideAtlasi		Q70YC5

PRoteomics IDEntifications database

More...PRIDEi		Q70YC5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68572 [Q70YC5-1]
68573 [Q70YC5-2]
68574 [Q70YC5-3]
68575 [Q70YC5-4]
68576 [Q70YC5-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q70YC5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q70YC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed in brain. Isoform 2 is expressed in placenta and at low level in lung and liver. Isoform 3 is expressed in kidney and pancreas. Isoform 1 is expressed exclusively in brain (PubMed:17389905).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by gamma irradiation and zeocin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138311, Expressed in middle temporal gyrus and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q70YC5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q70YC5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138311, Tissue enhanced (brain, esophagus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with NDE1 and NDEL1. Does not interact with TUBG1.

Interacts with DISC1 (PubMed:17389905).

Interacts with PARP1 (PubMed:23966166).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116557, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q70YC5

Database of interacting proteins

More...DIPi		DIP-35261N

Protein interaction database and analysis system

More...IntActi		Q70YC5, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000387091

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q70YC5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q70YC5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni347 – 392DisorderedSequence analysisAdd BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili169 – 297Sequence analysisAdd BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi347 – 382Basic and acidic residuesSequence analysisAdd BLAST36

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 51C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QT88, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063713

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049609_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q70YC5

Identification of Orthologs from Complete Genome Data

More...OMAi		AMDIRAD

Database of Orthologous Groups

More...OrthoDBi		918236at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q70YC5

TreeFam database of animal gene trees

More...TreeFami		TF329439

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q70YC5-1) [UniParc]FASTAAdd to basket
Also known as: ZNF365A

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQQKAFEESR YPWQESFENV AVCLPLRCPR CGDHTRFRSL SSLRAHLEFS 
        60         70         80         90        100
HSYEERTLLT KCSLFPSLKD TDLVTSSELL KPGKLQSSGN VVKQKPSYVN 
       110        120        130        140        150
LYSISHEHSK DRKPFEVVAE RPVSYVQTYT AMDLHADSLD GTRSGPGLPT 
       160        170        180        190        200
SDTKASFEAH VREKFNRMVE AVDRTIEKRI DKLTKELAQK TAELLEVRAA 
       210        220        230        240        250
FVQLTQKKQE VQRRERALNR QVDVAVEMIA VLRQRLTESE EELLRKEEEV 
       260        270        280        290        300
VTFNHFLEAA AEKEVQGKAR LQDFIENLLQ RVELAEKQLE YYQSQQASGF 
       310        320        330        340        350
VRDLSGHVLT DISSNRKPKC LSRGHPHSVC NHPDLKAHFH PKGRNHLKKA 
       360        370        380        390        400
KDDRASMQPA KAIHEQAESS RDLCRPPKKG ELLGFGRKGN IRPKMAKKKP 

TAIVNII
Length:407
Mass (Da):46,542
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC3C25AF6A753E64
GO
Isoform 2 (identifier: Q70YC5-2) [UniParc]FASTAAdd to basket
Also known as: ZNF365B

The sequence of this isoform differs from the canonical sequence as follows:
     309-333: LTDISSNRKPKCLSRGHPHSVCNHP → SWKGAGEARLVCQNDLELEESAIVE
     334-407: Missing.

Show »
Length:333
Mass (Da):38,217
Checksum:i6C143290C74C9BA2
GO
Isoform 3 (identifier: Q70YC5-3) [UniParc]FASTAAdd to basket
Also known as: ZNF365C

The sequence of this isoform differs from the canonical sequence as follows:
     309-407: LTDISSNRKP...KKPTAIVNII → SWKGAGEARL...CFPWGLPSSS

Show »
Length:462
Mass (Da):52,501
Checksum:i52B5B9170F4C1EC5
GO
Isoform 5 (identifier: Q70YC5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTMRPPQSCEPTFRVM

Show »
Length:422
Mass (Da):48,304
Checksum:iD9ACEBDD206A5889
GO
Isoform 6 (identifier: Q70YC5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-356: Missing.

Show »
Length:51
Mass (Da):5,654
Checksum:iD16DB9DAA8FAD040
GO
Isoform 4 (identifier: Q70YC4-1) [UniParc]FASTAAdd to basket
Also known as: Talanin, ZNF365D
The sequence of this isoform can be found in the external entry Q70YC4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:216
Mass (Da):24,036
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1G1C9J1G1_HUMAN
Talanin
ZNF365
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17841 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA74867 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55E → Q in AAT27443 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024325337A → S4 PublicationsCorresponds to variant dbSNP:rs3758490Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0165961 – 356Missing in isoform 6. 1 PublicationAdd BLAST356
Alternative sequenceiVSP_0165971M → MTMRPPQSCEPTFRVM in isoform 5. 1 Publication1
Alternative sequenceiVSP_016598309 – 407LTDIS…IVNII → SWKGAGEARLVCQNDLELEI FGHINHHLSGLKDSHCLVFL QAPPVPWIILASFLWILGNP WTSSTATAGFSQIWVLFPFC GGTFHHNEKDVLGLQDFERE SVSTSQSRNISLLTLGQLQN CVIGKLTIIDLLTEHLLGVR HGVICFPWGLPSSS in isoform 3. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_016599309 – 333LTDIS…VCNHP → SWKGAGEARLVCQNDLELEE SAIVE in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_016600334 – 407Missing in isoform 2. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ505147 mRNA Translation: CAD43726.1
AJ505148 mRNA Translation: CAD43727.1
AJ505149 mRNA Translation: CAD43728.1
AB020651 mRNA Translation: BAA74867.2 Different initiation.
AK289515 mRNA Translation: BAF82204.1
AK289808 mRNA Translation: BAF82497.1
BX647904 mRNA Translation: CAI46100.1
AC024597 Genomic DNA No translation available.
AC024598 Genomic DNA No translation available.
BC017841 mRNA Translation: AAH17841.1 Sequence problems.
BC035049 mRNA Translation: AAH35049.1
BC060817 mRNA Translation: AAH60817.1
AY547355 Genomic DNA Translation: AAT27443.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31209.1 [Q70YC5-1]
CCDS41531.1 [Q70YC5-2]

NCBI Reference Sequences

More...RefSeqi		NP_055766.2, NM_014951.2 [Q70YC5-1]
NP_955522.1, NM_199450.2 [Q70YC5-2]
NP_955523.1, NM_199451.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000395254; ENSP00000378674; ENSG00000138311
ENST00000395255; ENSP00000378675; ENSG00000138311 [Q70YC5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22891

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22891

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000395254.8; ENSP00000378674.3; NM_014951.3; NP_055766.2

UCSC genome browser

More...UCSCi		uc001jlz.5, human [Q70YC5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505147 mRNA Translation: CAD43726.1
AJ505148 mRNA Translation: CAD43727.1
AJ505149 mRNA Translation: CAD43728.1
AB020651 mRNA Translation: BAA74867.2 Different initiation.
AK289515 mRNA Translation: BAF82204.1
AK289808 mRNA Translation: BAF82497.1
BX647904 mRNA Translation: CAI46100.1
AC024597 Genomic DNA No translation available.
AC024598 Genomic DNA No translation available.
BC017841 mRNA Translation: AAH17841.1 Sequence problems.
BC035049 mRNA Translation: AAH35049.1
BC060817 mRNA Translation: AAH60817.1
AY547355 Genomic DNA Translation: AAT27443.1
CCDSiCCDS31209.1 [Q70YC5-1]
CCDS41531.1 [Q70YC5-2]
RefSeqiNP_055766.2, NM_014951.2 [Q70YC5-1]
NP_955522.1, NM_199450.2 [Q70YC5-2]
NP_955523.1, NM_199451.2

3D structure databases

SMRiQ70YC5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116557, 13 interactors
CORUMiQ70YC5
DIPiDIP-35261N
IntActiQ70YC5, 4 interactors
STRINGi9606.ENSP00000387091

PTM databases

iPTMnetiQ70YC5
PhosphoSitePlusiQ70YC5

Genetic variation databases

BioMutaiZNF365
DMDMi317373495

Proteomic databases

MassIVEiQ70YC5
MaxQBiQ70YC5
PeptideAtlasiQ70YC5
PRIDEiQ70YC5
ProteomicsDBi68572 [Q70YC5-1]
68573 [Q70YC5-2]
68574 [Q70YC5-3]
68575 [Q70YC5-4]
68576 [Q70YC5-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28272, 405 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		22891

Genome annotation databases

EnsembliENST00000395254; ENSP00000378674; ENSG00000138311
ENST00000395255; ENSP00000378675; ENSG00000138311 [Q70YC5-2]
GeneIDi22891
KEGGihsa:22891
MANE-SelectiENST00000395254.8; ENSP00000378674.3; NM_014951.3; NP_055766.2
UCSCiuc001jlz.5, human [Q70YC5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22891
DisGeNETi22891

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF365
HGNCiHGNC:18194, ZNF365
HPAiENSG00000138311, Tissue enhanced (brain, esophagus)
MalaCardsiZNF365
MIMi607818, gene
neXtProtiNX_Q70YC5
OpenTargetsiENSG00000138311
Orphaneti2073, Narcolepsy type 1
83465, Narcolepsy type 2
PharmGKBiPA134873576
VEuPathDBiHostDB:ENSG00000138311

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QT88, Eukaryota
GeneTreeiENSGT00530000063713
HOGENOMiCLU_049609_0_0_1
InParanoidiQ70YC5
OMAiAMDIRAD
OrthoDBi918236at2759
PhylomeDBiQ70YC5
TreeFamiTF329439

Enzyme and pathway databases

PathwayCommonsiQ70YC5
SignaLinkiQ70YC5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22891, 5 hits in 1042 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF365, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22891
PharosiQ70YC5, Tbio
RNActiQ70YC5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138311, Expressed in middle temporal gyrus and 172 other tissues
ExpressionAtlasiQ70YC5, baseline and differential
GenevisibleiQ70YC5, HS

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN365_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70YC5
Secondary accession number(s): A8K0F0
, O94930, Q05D75, Q5HYE6, Q68SG8, Q6NSK2, Q6P9D4, Q70YC6, Q70YC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 11, 2011
Last modified: February 23, 2022
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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