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Protein

Protein ZNF365

Gene

ZNF365

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040).By similarity3 Publications

Miscellaneous

Cells silencing ZNF365 display delayed mitotic progression and exit, due to increased replication stress, and ultimately leading to cytokinesis failure, re-duplication of centrosomes and increased aneuploidy.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 51C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cerebellar molecular layer morphogenesis Source: UniProtKB
  • dendrite arborization Source: UniProtKB
  • dendritic spine morphogenesis Source: UniProtKB
  • negative regulation of neuron projection development Source: UniProtKB
  • positive regulation of oligodendrocyte differentiation Source: UniProtKB
  • regulation of DNA strand resection involved in replication fork processing Source: UniProtKB
  • regulation of double-strand break repair via homologous recombination Source: UniProtKB
  • telomere maintenance Source: UniProtKB

Keywordsi

Biological processNeurogenesis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZNF365
Alternative name(s):
DISC1-binding zinc-finger protein1 Publication
Protein su48
Gene namesi
Name:ZNF365
Synonyms:DBZ1 Publication, KIAA0844
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138311.15
HGNCiHGNC:18194 ZNF365
MIMi607818 gene
neXtProtiNX_Q70YC5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi22891
MalaCardsiZNF365
OpenTargetsiENSG00000138311
PharmGKBiPA134873576

Polymorphism and mutation databases

BioMutaiCACNA1A
DMDMi317373495

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763741 – 407Protein ZNF365Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineBy similarity1
Modified residuei138PhosphoserineBy similarity1
Modified residuei175PhosphothreonineBy similarity1
Modified residuei369PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ70YC5
PeptideAtlasiQ70YC5
PRIDEiQ70YC5
ProteomicsDBi68572
68573 [Q70YC5-2]
68574 [Q70YC5-3]
68575 [Q70YC5-4]
68576 [Q70YC5-5]

PTM databases

iPTMnetiQ70YC5
PhosphoSitePlusiQ70YC5

Expressioni

Tissue specificityi

Isoform 1 is expressed in brain. Isoform 2 is expressed in placenta and at low level in lung and liver. Isoform 3 is expressed in kidney and pancreas. Isoform 1 is expressed exclusively in brain (PubMed:17389905).2 Publications

Inductioni

Induced by gamma irradiation and zeocin.1 Publication

Gene expression databases

BgeeiENSG00000138311
CleanExiHS_ZNF365
ExpressionAtlasiQ70YC5 baseline and differential
GenevisibleiQ70YC5 HS

Organism-specific databases

HPAiHPA052446

Interactioni

Subunit structurei

Homodimer. Interacts with NDE1 and NDEL1. Does not interact with TUBG1. Interacts with DISC1 (PubMed:17389905). Interacts with PARP1 (PubMed:23966166).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NDE1Q9NXR13EBI-941182,EBI-941227

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi116557, 2 interactors
CORUMiQ70YC5
DIPiDIP-35261N
IntActiQ70YC5, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ70YC5
SMRiQ70YC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili169 – 297Sequence analysisAdd BLAST129

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 51C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00530000063713
HOVERGENiHBG094181
InParanoidiQ70YC5
KOiK16737
OMAiTHFHPKG
OrthoDBiEOG091G0BHK
PhylomeDBiQ70YC5
TreeFamiTF329439

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q70YC5-1) [UniParc]FASTAAdd to basket
Also known as: ZNF365A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQKAFEESR YPWQESFENV AVCLPLRCPR CGDHTRFRSL SSLRAHLEFS
60 70 80 90 100
HSYEERTLLT KCSLFPSLKD TDLVTSSELL KPGKLQSSGN VVKQKPSYVN
110 120 130 140 150
LYSISHEHSK DRKPFEVVAE RPVSYVQTYT AMDLHADSLD GTRSGPGLPT
160 170 180 190 200
SDTKASFEAH VREKFNRMVE AVDRTIEKRI DKLTKELAQK TAELLEVRAA
210 220 230 240 250
FVQLTQKKQE VQRRERALNR QVDVAVEMIA VLRQRLTESE EELLRKEEEV
260 270 280 290 300
VTFNHFLEAA AEKEVQGKAR LQDFIENLLQ RVELAEKQLE YYQSQQASGF
310 320 330 340 350
VRDLSGHVLT DISSNRKPKC LSRGHPHSVC NHPDLKAHFH PKGRNHLKKA
360 370 380 390 400
KDDRASMQPA KAIHEQAESS RDLCRPPKKG ELLGFGRKGN IRPKMAKKKP

TAIVNII
Length:407
Mass (Da):46,542
Last modified:January 11, 2011 - v3
Checksum:iCC3C25AF6A753E64
GO
Isoform 2 (identifier: Q70YC5-2) [UniParc]FASTAAdd to basket
Also known as: ZNF365B

The sequence of this isoform differs from the canonical sequence as follows:
     309-333: LTDISSNRKPKCLSRGHPHSVCNHP → SWKGAGEARLVCQNDLELEESAIVE
     334-407: Missing.

Show »
Length:333
Mass (Da):38,217
Checksum:i6C143290C74C9BA2
GO
Isoform 3 (identifier: Q70YC5-3) [UniParc]FASTAAdd to basket
Also known as: ZNF365C

The sequence of this isoform differs from the canonical sequence as follows:
     309-407: LTDISSNRKP...KKPTAIVNII → SWKGAGEARL...CFPWGLPSSS

Show »
Length:462
Mass (Da):52,501
Checksum:i52B5B9170F4C1EC5
GO
Isoform 5 (identifier: Q70YC5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTMRPPQSCEPTFRVM

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):48,304
Checksum:iD9ACEBDD206A5889
GO
Isoform 6 (identifier: Q70YC5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-356: Missing.

Note: No experimental confirmation available.
Show »
Length:51
Mass (Da):5,654
Checksum:iD16DB9DAA8FAD040
GO
Isoform 4 (identifier: Q70YC4-1) [UniParc]FASTAAdd to basket
Also known as: Talanin, ZNF365D
The sequence of this isoform can be found in the external entry Q70YC4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:216
Mass (Da):24,036
GO

Sequence cautioni

The sequence AAH17841 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA74867 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55E → Q in AAT27443 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024325337A → S4 PublicationsCorresponds to variant dbSNP:rs3758490Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0165961 – 356Missing in isoform 6. 1 PublicationAdd BLAST356
Alternative sequenceiVSP_0165971M → MTMRPPQSCEPTFRVM in isoform 5. 1 Publication1
Alternative sequenceiVSP_016598309 – 407LTDIS…IVNII → SWKGAGEARLVCQNDLELEI FGHINHHLSGLKDSHCLVFL QAPPVPWIILASFLWILGNP WTSSTATAGFSQIWVLFPFC GGTFHHNEKDVLGLQDFERE SVSTSQSRNISLLTLGQLQN CVIGKLTIIDLLTEHLLGVR HGVICFPWGLPSSS in isoform 3. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_016599309 – 333LTDIS…VCNHP → SWKGAGEARLVCQNDLELEE SAIVE in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_016600334 – 407Missing in isoform 2. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505147 mRNA Translation: CAD43726.1
AJ505148 mRNA Translation: CAD43727.1
AJ505149 mRNA Translation: CAD43728.1
AB020651 mRNA Translation: BAA74867.2 Different initiation.
AK289515 mRNA Translation: BAF82204.1
AK289808 mRNA Translation: BAF82497.1
BX647904 mRNA Translation: CAI46100.1
AC024597 Genomic DNA No translation available.
AC024598 Genomic DNA No translation available.
BC017841 mRNA Translation: AAH17841.1 Sequence problems.
BC035049 mRNA Translation: AAH35049.1
BC060817 mRNA Translation: AAH60817.1
AY547355 Genomic DNA Translation: AAT27443.1
CCDSiCCDS31209.1 [Q70YC5-1]
CCDS41531.1 [Q70YC5-2]
CCDS7264.1 [Q70YC5-3]
RefSeqiNP_055766.2, NM_014951.2 [Q70YC5-1]
NP_955522.1, NM_199450.2 [Q70YC5-2]
NP_955523.1, NM_199451.2 [Q70YC5-3]
UniGeneiHs.22653

Genome annotation databases

EnsembliENST00000395254; ENSP00000378674; ENSG00000138311 [Q70YC5-1]
ENST00000395255; ENSP00000378675; ENSG00000138311 [Q70YC5-2]
ENST00000410046; ENSP00000387091; ENSG00000138311 [Q70YC5-3]
GeneIDi22891
KEGGihsa:22891
UCSCiuc001jlz.5 human [Q70YC5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN365_HUMAN
AccessioniPrimary (citable) accession number: Q70YC5
Secondary accession number(s): A8K0F0
, O94930, Q05D75, Q5HYE6, Q68SG8, Q6NSK2, Q6P9D4, Q70YC6, Q70YC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 11, 2011
Last modified: July 18, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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