UniProtKB - Q70YC5 (ZN365_HUMAN)
Protein ZNF365
ZNF365
Functioni
Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905).
Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity).
Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166).
Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040).
By similarity3 PublicationsMiscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 26 – 51 | C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cerebellar molecular layer morphogenesis Source: UniProtKB
- dendrite arborization Source: UniProtKB
- dendritic spine morphogenesis Source: UniProtKB
- negative regulation of neuron projection development Source: UniProtKB
- positive regulation of oligodendrocyte differentiation Source: UniProtKB
- regulation of DNA strand resection involved in replication fork processing Source: UniProtKB
- regulation of double-strand break repair via homologous recombination Source: UniProtKB
- regulation of neuron projection development Source: GO_Central
- telomere maintenance Source: UniProtKB
Keywordsi
Biological process | Neurogenesis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q70YC5 |
SignaLinki | Q70YC5 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein ZNF365Alternative name(s): DISC1-binding zinc-finger protein1 Publication Protein su48 |
Gene namesi | Name:ZNF365 Synonyms:DBZ1 Publication, KIAA0844 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18194, ZNF365 |
MIMi | 607818, gene |
neXtProti | NX_Q70YC5 |
VEuPathDBi | HostDB:ENSG00000138311 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Note: localizes to the centrosome at all stages of the cell cycle.1 Publication
Cytoskeleton
- centriolar satellite Source: HPA
- centrosome Source: CACAO
Other locations
- cytoplasm Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 22891 |
MalaCardsi | ZNF365 |
OpenTargetsi | ENSG00000138311 |
Orphaneti | 2073, Narcolepsy type 1 83465, Narcolepsy type 2 |
PharmGKBi | PA134873576 |
Miscellaneous databases
Pharosi | Q70YC5, Tbio |
Genetic variation databases
BioMutai | ZNF365 |
DMDMi | 317373495 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076374 | 1 – 407 | Protein ZNF365Add BLAST | 407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | PhosphoserineBy similarity | 1 | |
Modified residuei | 138 | PhosphoserineBy similarity | 1 | |
Modified residuei | 175 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 369 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q70YC5 |
MaxQBi | Q70YC5 |
PeptideAtlasi | Q70YC5 |
PRIDEi | Q70YC5 |
ProteomicsDBi | 68572 [Q70YC5-1] 68573 [Q70YC5-2] 68574 [Q70YC5-3] 68575 [Q70YC5-4] 68576 [Q70YC5-5] |
PTM databases
iPTMneti | Q70YC5 |
PhosphoSitePlusi | Q70YC5 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000138311, Expressed in middle temporal gyrus and 172 other tissues |
ExpressionAtlasi | Q70YC5, baseline and differential |
Genevisiblei | Q70YC5, HS |
Organism-specific databases
HPAi | ENSG00000138311, Tissue enhanced (brain, esophagus) |
Interactioni
Subunit structurei
Binary interactionsi
Q70YC5
With | #Exp. | IntAct |
---|---|---|
NDE1 [Q9NXR1] | 3 | EBI-941182,EBI-941227 |
ZNF365 - isoform 1 [Q70YC5-1]
With | #Exp. | IntAct |
---|---|---|
itself | 4 | EBI-15580061,EBI-15580061 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 116557, 13 interactors |
CORUMi | Q70YC5 |
DIPi | DIP-35261N |
IntActi | Q70YC5, 4 interactors |
STRINGi | 9606.ENSP00000387091 |
Miscellaneous databases
RNActi | Q70YC5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 347 – 392 | DisorderedSequence analysisAdd BLAST | 46 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 169 – 297 | Sequence analysisAdd BLAST | 129 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 347 – 382 | Basic and acidic residuesSequence analysisAdd BLAST | 36 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 26 – 51 | C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QT88, Eukaryota |
GeneTreei | ENSGT00530000063713 |
HOGENOMi | CLU_049609_0_0_1 |
InParanoidi | Q70YC5 |
OMAi | AMDIRAD |
OrthoDBi | 918236at2759 |
PhylomeDBi | Q70YC5 |
TreeFami | TF329439 |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQQKAFEESR YPWQESFENV AVCLPLRCPR CGDHTRFRSL SSLRAHLEFS
60 70 80 90 100
HSYEERTLLT KCSLFPSLKD TDLVTSSELL KPGKLQSSGN VVKQKPSYVN
110 120 130 140 150
LYSISHEHSK DRKPFEVVAE RPVSYVQTYT AMDLHADSLD GTRSGPGLPT
160 170 180 190 200
SDTKASFEAH VREKFNRMVE AVDRTIEKRI DKLTKELAQK TAELLEVRAA
210 220 230 240 250
FVQLTQKKQE VQRRERALNR QVDVAVEMIA VLRQRLTESE EELLRKEEEV
260 270 280 290 300
VTFNHFLEAA AEKEVQGKAR LQDFIENLLQ RVELAEKQLE YYQSQQASGF
310 320 330 340 350
VRDLSGHVLT DISSNRKPKC LSRGHPHSVC NHPDLKAHFH PKGRNHLKKA
360 370 380 390 400
KDDRASMQPA KAIHEQAESS RDLCRPPKKG ELLGFGRKGN IRPKMAKKKP
TAIVNII
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J1G1 | C9J1G1_HUMAN | Talanin | ZNF365 | 53 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | E → Q in AAT27443 (Ref. 7) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024325 | 337 | A → S4 PublicationsCorresponds to variant dbSNP:rs3758490Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016596 | 1 – 356 | Missing in isoform 6. 1 PublicationAdd BLAST | 356 | |
Alternative sequenceiVSP_016597 | 1 | M → MTMRPPQSCEPTFRVM in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_016598 | 309 – 407 | LTDIS…IVNII → SWKGAGEARLVCQNDLELEI FGHINHHLSGLKDSHCLVFL QAPPVPWIILASFLWILGNP WTSSTATAGFSQIWVLFPFC GGTFHHNEKDVLGLQDFERE SVSTSQSRNISLLTLGQLQN CVIGKLTIIDLLTEHLLGVR HGVICFPWGLPSSS in isoform 3. 1 PublicationAdd BLAST | 99 | |
Alternative sequenceiVSP_016599 | 309 – 333 | LTDIS…VCNHP → SWKGAGEARLVCQNDLELEE SAIVE in isoform 2. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_016600 | 334 – 407 | Missing in isoform 2. 1 PublicationAdd BLAST | 74 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ505147 mRNA Translation: CAD43726.1 AJ505148 mRNA Translation: CAD43727.1 AJ505149 mRNA Translation: CAD43728.1 AB020651 mRNA Translation: BAA74867.2 Different initiation. AK289515 mRNA Translation: BAF82204.1 AK289808 mRNA Translation: BAF82497.1 BX647904 mRNA Translation: CAI46100.1 AC024597 Genomic DNA No translation available. AC024598 Genomic DNA No translation available. BC017841 mRNA Translation: AAH17841.1 Sequence problems. BC035049 mRNA Translation: AAH35049.1 BC060817 mRNA Translation: AAH60817.1 AY547355 Genomic DNA Translation: AAT27443.1 |
CCDSi | CCDS31209.1 [Q70YC5-1] CCDS41531.1 [Q70YC5-2] |
RefSeqi | NP_055766.2, NM_014951.2 [Q70YC5-1] NP_955522.1, NM_199450.2 [Q70YC5-2] NP_955523.1, NM_199451.2 |
Genome annotation databases
Ensembli | ENST00000395254; ENSP00000378674; ENSG00000138311 ENST00000395255; ENSP00000378675; ENSG00000138311 [Q70YC5-2] |
GeneIDi | 22891 |
KEGGi | hsa:22891 |
MANE-Selecti | ENST00000395254.8; ENSP00000378674.3; NM_014951.3; NP_055766.2 |
UCSCi | uc001jlz.5, human [Q70YC5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ505147 mRNA Translation: CAD43726.1 AJ505148 mRNA Translation: CAD43727.1 AJ505149 mRNA Translation: CAD43728.1 AB020651 mRNA Translation: BAA74867.2 Different initiation. AK289515 mRNA Translation: BAF82204.1 AK289808 mRNA Translation: BAF82497.1 BX647904 mRNA Translation: CAI46100.1 AC024597 Genomic DNA No translation available. AC024598 Genomic DNA No translation available. BC017841 mRNA Translation: AAH17841.1 Sequence problems. BC035049 mRNA Translation: AAH35049.1 BC060817 mRNA Translation: AAH60817.1 AY547355 Genomic DNA Translation: AAT27443.1 |
CCDSi | CCDS31209.1 [Q70YC5-1] CCDS41531.1 [Q70YC5-2] |
RefSeqi | NP_055766.2, NM_014951.2 [Q70YC5-1] NP_955522.1, NM_199450.2 [Q70YC5-2] NP_955523.1, NM_199451.2 |
3D structure databases
SMRi | Q70YC5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116557, 13 interactors |
CORUMi | Q70YC5 |
DIPi | DIP-35261N |
IntActi | Q70YC5, 4 interactors |
STRINGi | 9606.ENSP00000387091 |
PTM databases
iPTMneti | Q70YC5 |
PhosphoSitePlusi | Q70YC5 |
Genetic variation databases
BioMutai | ZNF365 |
DMDMi | 317373495 |
Proteomic databases
MassIVEi | Q70YC5 |
MaxQBi | Q70YC5 |
PeptideAtlasi | Q70YC5 |
PRIDEi | Q70YC5 |
ProteomicsDBi | 68572 [Q70YC5-1] 68573 [Q70YC5-2] 68574 [Q70YC5-3] 68575 [Q70YC5-4] 68576 [Q70YC5-5] |
Protocols and materials databases
Antibodypediai | 28272, 405 antibodies from 20 providers |
DNASUi | 22891 |
Genome annotation databases
Ensembli | ENST00000395254; ENSP00000378674; ENSG00000138311 ENST00000395255; ENSP00000378675; ENSG00000138311 [Q70YC5-2] |
GeneIDi | 22891 |
KEGGi | hsa:22891 |
MANE-Selecti | ENST00000395254.8; ENSP00000378674.3; NM_014951.3; NP_055766.2 |
UCSCi | uc001jlz.5, human [Q70YC5-1] |
Organism-specific databases
CTDi | 22891 |
DisGeNETi | 22891 |
GeneCardsi | ZNF365 |
HGNCi | HGNC:18194, ZNF365 |
HPAi | ENSG00000138311, Tissue enhanced (brain, esophagus) |
MalaCardsi | ZNF365 |
MIMi | 607818, gene |
neXtProti | NX_Q70YC5 |
OpenTargetsi | ENSG00000138311 |
Orphaneti | 2073, Narcolepsy type 1 83465, Narcolepsy type 2 |
PharmGKBi | PA134873576 |
VEuPathDBi | HostDB:ENSG00000138311 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT88, Eukaryota |
GeneTreei | ENSGT00530000063713 |
HOGENOMi | CLU_049609_0_0_1 |
InParanoidi | Q70YC5 |
OMAi | AMDIRAD |
OrthoDBi | 918236at2759 |
PhylomeDBi | Q70YC5 |
TreeFami | TF329439 |
Enzyme and pathway databases
PathwayCommonsi | Q70YC5 |
SignaLinki | Q70YC5 |
Miscellaneous databases
BioGRID-ORCSi | 22891, 5 hits in 1042 CRISPR screens |
ChiTaRSi | ZNF365, human |
GenomeRNAii | 22891 |
Pharosi | Q70YC5, Tbio |
RNActi | Q70YC5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138311, Expressed in middle temporal gyrus and 172 other tissues |
ExpressionAtlasi | Q70YC5, baseline and differential |
Genevisiblei | Q70YC5, HS |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | ZN365_HUMAN | |
Accessioni | Q70YC5Primary (citable) accession number: Q70YC5 Secondary accession number(s): A8K0F0 Q70YC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot