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Protein

Talanin

Gene

ZNF365

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in uric acid excretion.

Miscellaneous

Isoform 4 (talanin) of ZNF365 does not exist in rodents. In primates, a canonical intron-exon structure exist, with several stop codons preventing talanin production in old world and new world monkeys. It seems therefore that isoform 4 transcript emerged during primate evolution from a noncoding genomic sequence.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

GO - Biological processi

  • gamma-tubulin complex localization Source: MGI
  • mitotic cytokinesis Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Talanin
Gene namesi
Name:ZNF365
Synonyms:KIAA0844
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138311.15
HGNCiHGNC:18194 ZNF365
MIMi607818 gene
neXtProtiNX_Q70YC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Uric acid nephrolithiasis (UAN)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of nephrolithiasis, a common multifactorial disease characterized by stones formation in the kidney and urinary tract. Nephrolithiasis is due to supersaturation of the urine by stone-forming constituents, including calcium, oxalate and uric acid. Crystals or foreign bodies can act as nidi, upon which ions from the supersaturated urine form microscopic crystalline structures. Uric acid nephrolithiasis occurs when the urine becomes overly concentrated with uric acid and accounts for 20% of all stones.
See also OMIM:605990

Organism-specific databases

DisGeNETi22891
MalaCardsiZNF365
MIMi605990 phenotype
OpenTargetsiENSG00000138311
Orphaneti2073 Narcolepsy-cataplexy
PharmGKBiPA134873576

Polymorphism and mutation databases

BioMutaiPLEK

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763781 – 216TalaninAdd BLAST216

Proteomic databases

PaxDbiQ70YC4
PRIDEiQ70YC4
ProteomicsDBi68571

Expressioni

Tissue specificityi

Isoform 4 is expressed in placenta, lung, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000138311 Expressed in 148 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_ZNF365
ExpressionAtlasiQ70YC4 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116557, 2 interactors
STRINGi9606.ENSP00000387091

Structurei

3D structure databases

ProteinModelPortaliQ70YC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH1N Eukaryota
ENOG4111IHT LUCA
GeneTreeiENSGT00530000063713
HOGENOMiHOG000154506

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 4 (identifier: Q70YC4-1) [UniParc]FASTAAdd to basket
Also known as: Talanin, ZNF365D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSALGQITIT VSRCWNTERN QTDKNPCLHG AYLQLRETVK NKSTHLKKPL
60 70 80 90 100
MKQAPPWKDH LTFQPLHPAE RKTQVWRWQS GNSSDLETTS SASPWPTGSN
110 120 130 140 150
RDVVLNTLAE SCCGLSELIT APPYAGVSIQ GFSQIWVLFP FCGGTFHHNE
160 170 180 190 200
KDVLGLQDFE RESVSTSQSR NISLLTLGQL QNCVIGKLTI IDLLTEHLLG
210
VRHGVICFPW GLPSSS
Length:216
Mass (Da):24,036
Last modified:April 3, 2007 - v2
Checksum:iA512D14205C87DA2
GO
Isoform 1 (identifier: Q70YC5-1) [UniParc]FASTAAdd to basket
Also known as: ZNF365A
The sequence of this isoform can be found in the external entry Q70YC5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:407
Mass (Da):46,542
GO
Isoform 2 (identifier: Q70YC5-2) [UniParc]FASTAAdd to basket
Also known as: ZNF365B
The sequence of this isoform can be found in the external entry Q70YC5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:333
Mass (Da):38,217
GO
Isoform 3 (identifier: Q70YC5-3) [UniParc]FASTAAdd to basket
Also known as: ZNF365C
The sequence of this isoform can be found in the external entry Q70YC5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:462
Mass (Da):52,501
GO
Isoform 5 (identifier: Q70YC5-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q70YC5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:422
Mass (Da):48,304
GO
Isoform 6 (identifier: Q70YC5-5) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q70YC5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:51
Mass (Da):5,654
GO

Polymorphismi

Thr-62 is associated with increased risk for uric acid nephrolithiasis.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02432662T → A1 PublicationCorresponds to variant dbSNP:rs7076156Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505150 mRNA Translation: CAD43729.1
AC067751 Genomic DNA No translation available.
CCDSiCCDS7265.1 [Q70YC4-1]
RefSeqiNP_955524.3, NM_199452.3
UniGeneiHs.22653

Genome annotation databases

EnsembliENST00000395251; ENSP00000378672; ENSG00000138311 [Q70YC4-1]
ENST00000614806; ENSP00000481372; ENSG00000138311 [Q70YC4-1]
GeneIDi22891
UCSCiuc001jmd.1 human [Q70YC4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505150 mRNA Translation: CAD43729.1
AC067751 Genomic DNA No translation available.
CCDSiCCDS7265.1 [Q70YC4-1]
RefSeqiNP_955524.3, NM_199452.3
UniGeneiHs.22653

3D structure databases

ProteinModelPortaliQ70YC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116557, 2 interactors
STRINGi9606.ENSP00000387091

Polymorphism and mutation databases

BioMutaiPLEK

Proteomic databases

PaxDbiQ70YC4
PRIDEiQ70YC4
ProteomicsDBi68571

Protocols and materials databases

DNASUi22891
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395251; ENSP00000378672; ENSG00000138311 [Q70YC4-1]
ENST00000614806; ENSP00000481372; ENSG00000138311 [Q70YC4-1]
GeneIDi22891
UCSCiuc001jmd.1 human [Q70YC4-1]

Organism-specific databases

CTDi22891
DisGeNETi22891
EuPathDBiHostDB:ENSG00000138311.15
GeneCardsiZNF365
HGNCiHGNC:18194 ZNF365
MalaCardsiZNF365
MIMi605990 phenotype
607818 gene
neXtProtiNX_Q70YC4
OpenTargetsiENSG00000138311
Orphaneti2073 Narcolepsy-cataplexy
PharmGKBiPA134873576
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH1N Eukaryota
ENOG4111IHT LUCA
GeneTreeiENSGT00530000063713
HOGENOMiHOG000154506

Miscellaneous databases

ChiTaRSiZNF365 human
GeneWikiiZNF365
GenomeRNAii22891
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138311 Expressed in 148 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_ZNF365
ExpressionAtlasiQ70YC4 baseline and differential

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTALAN_HUMAN
AccessioniPrimary (citable) accession number: Q70YC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: April 3, 2007
Last modified: September 12, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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