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Entry version 64 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Fructan 6-exohydrolase

Gene

6-FEH

Organism
Beta vulgaris (Sugar beet)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes levan-type beta-(2->6)-linked fructans to fructose, but not inulin-type beta-(2->1)-linked fructans.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of terminal, non-reducing (2->6)-linked beta-D-fructofuranose residues in fructans.1 Publication EC:3.2.1.154

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Not inhibited by sucrose.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=77 mM for 6-kestose1 Publication

    pH dependencei

    Optimum pH is 5.0.1 Publication

    Temperature dependencei

    Optimum temperature is 30 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei70By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.2.1.154, 836

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GH32, Glycoside Hydrolase Family 32

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Fructan 6-exohydrolaseImported (EC:3.2.1.154)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:6-FEHImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBeta vulgaris (Sugar beet)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri161934 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaeCaryophyllalesChenopodiaceaeBetoideaeBeta

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039586522 – 606Fructan 6-exohydrolaseSequence analysisAdd BLAST585

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi346N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi445 ↔ 491By similarity
    Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi585N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi593N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q70XE6

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q70XE6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyl hydrolase 32 family.Sequence analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q70XE6

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.115.10.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013320, ConA-like_dom_sf
    IPR001362, Glyco_hydro_32
    IPR013189, Glyco_hydro_32_C
    IPR013148, Glyco_hydro_32_N
    IPR023296, Glyco_hydro_beta-prop_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08244, Glyco_hydro_32C, 1 hit
    PF00251, Glyco_hydro_32N, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00640, Glyco_32, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF49899, SSF49899, 1 hit
    SSF75005, SSF75005, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q70XE6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAPNNGSWLV LSISMMLLSH GMIIIAKDQA IHHHDDDHDD MLINDHQMIN
    60 70 80 90 100
    DDDPYRTAYH FQSPKNWMND PNGPMIYKGI YHLFYQYYPY DPVWHTEIVW
    110 120 130 140 150
    GHSTSTDLIN WTQQPIALSP SEPYDINGCW SGSITILPQN KPVILYTGIN
    160 170 180 190 200
    NKNYQVQNLA LPKNLSDPYL KEWIKLPQNP LMAGTPTNNN NINASSFRDP
    210 220 230 240 250
    STAWQLSDGK WRVIVGTQQG KRGLAVLFTS DDFVKWNNTG NPLHSTEGNG
    260 270 280 290 300
    IWECPDFFPV YVGKSLGADT SIIGDDVKHV LKLSLFDTQY EYYTIGRYDI
    310 320 330 340 350
    EKDIYVPDEG SIESDLGLRY DYGKFYASKS FFDDETNRRI LWGWVNESSI
    360 370 380 390 400
    QADDIKKGWS GVQAIPRTVV LDKSGKQLVQ WPLAEVDMLR ENDVELPSQV
    410 420 430 440 450
    IKGGSLVEIS QITASQADVE ISFKIPESNY VEELDSTCTN PQILCSQKGA
    460 470 480 490 500
    SIKGRFGPFG LLTLASMGLE EYTAVFFRIF KGPNKYVVLM CSDQTRSSLN
    510 520 530 540 550
    PTTDKLSFGI FVDVDPINED LSLRILIDHS IVESFSAKGK SCITARVYPT
    560 570 580 590 600
    MAINDKAKLY VFNNGTEDVK ITKLSAWSMK KAQINLSTDN TSNMSYNSNK

    VEKEEF
    Length:606
    Mass (Da):68,496
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD19CB6816AA5E92
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ508534 mRNA Translation: CAD48404.1

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    KMT04889; KMT04889; BVRB_7g170560

    Gramene; a comparative resource for plants

    More...
    Gramenei
    KMT04889; KMT04889; BVRB_7g170560

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ag:CAD48404

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ508534 mRNA Translation: CAD48404.1

    3D structure databases

    SMRiQ70XE6
    ModBaseiSearch...

    Protein family/group databases

    CAZyiGH32, Glycoside Hydrolase Family 32

    Proteomic databases

    PRIDEiQ70XE6

    Genome annotation databases

    EnsemblPlantsiKMT04889; KMT04889; BVRB_7g170560
    GrameneiKMT04889; KMT04889; BVRB_7g170560
    KEGGiag:CAD48404

    Phylogenomic databases

    PhylomeDBiQ70XE6

    Enzyme and pathway databases

    BRENDAi3.2.1.154, 836

    Family and domain databases

    Gene3Di2.115.10.20, 1 hit
    InterProiView protein in InterPro
    IPR013320, ConA-like_dom_sf
    IPR001362, Glyco_hydro_32
    IPR013189, Glyco_hydro_32_C
    IPR013148, Glyco_hydro_32_N
    IPR023296, Glyco_hydro_beta-prop_sf
    PfamiView protein in Pfam
    PF08244, Glyco_hydro_32C, 1 hit
    PF00251, Glyco_hydro_32N, 1 hit
    SMARTiView protein in SMART
    SM00640, Glyco_32, 1 hit
    SUPFAMiSSF49899, SSF49899, 1 hit
    SSF75005, SSF75005, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei6FEH_BETVU
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70XE6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: July 5, 2004
    Last modified: December 2, 2020
    This is version 64 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
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