UniProtKB - Q70XD7 (Q70XD7_9HIV1)
Protein
Gag polyprotein
Gene
N/A
Organism
Human immunodeficiency virus 1
Status
Functioni
Catalytic activityi
- 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.ARBA annotation EC:3.1.13.2
Cofactori
Mg2+ARBA annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 1434 – 1481 | Integrase-typePROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
- exoribonuclease H activity Source: UniProtKB-EC
- RNA binding Source: UniProtKB-KW
- RNA-directed DNA polymerase activity Source: UniProtKB-KW
- RNA-DNA hybrid ribonuclease activity Source: InterPro
- structural molecule activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- DNA integration Source: UniProtKB-KW
- DNA recombination Source: UniProtKB-KW
- establishment of integrated proviral latency Source: UniProtKB-KW
- suppression by virus of host gene expression Source: UniProtKB-KW
- viral budding via host ESCRT complex Source: UniProtKB-KW
- viral entry into host cell Source: UniProtKB-KW
- viral genome integration into host DNA Source: UniProtKB-KW
- viral penetration into host nucleus Source: UniProtKB-KW
Keywordsi
Molecular function | Aspartyl proteaseARBA annotation, DNA-bindingARBA annotation, DNA-directed DNA polymeraseARBA annotation, EndonucleaseARBA annotation, Hydrolase, Multifunctional enzymeARBA annotation, Nuclease, Nucleotidyltransferase, Protease, RNA-bindingUniRule annotationARBA annotation, RNA-directed DNA polymeraseARBA annotation, Transferase, Viral nucleoproteinUniRule annotationARBA annotation |
Biological process | DNA integration, DNA recombinationARBA annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusARBA annotation, Host gene expression shutoff by virus, Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexesARBA annotation, Viral genome integrationARBA annotation, Viral penetration into host nucleusARBA annotation, Viral release from host cell, Virion maturationARBA annotation, Virus entry into host cell |
Ligand | MagnesiumARBA annotation, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Gag polyproteinUniRule annotation |
Organismi | Human immunodeficiency virus 1Imported |
Taxonomic identifieri | 11676 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Pararnavirae › Artverviricota › Revtraviricetes › Ortervirales › Retroviridae › Orthoretrovirinae › Lentivirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Cell membrane ARBA annotation; Lipid-anchor ARBA annotation
- Cytoplasm ARBA annotation
- Host cell membrane ARBA annotation; Lipid-anchor ARBA annotation
- Host cytoplasm UniRule annotationARBA annotation
- Host nucleus UniRule annotationARBA annotation
- Membrane ARBA annotation; Lipid-anchor ARBA annotation
- Nucleus ARBA annotation
- Virion UniRule annotation
- Virion UniRule annotation
- Host nucleus UniRule annotation
- Host cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
- host cell cytoplasm Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
- host cell plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: UniProtKB-SubCell
- viral nucleocapsid Source: UniProtKB-KW
Keywords - Cellular componenti
Capsid proteinUniRule annotationARBA annotation, Host cell membraneARBA annotation, Host cytoplasmUniRule annotationARBA annotation, Host membrane, Host nucleusUniRule annotationARBA annotation, Membrane, VirionPTM / Processingi
Post-translational modificationi
Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation
Keywords - PTMi
Lipoprotein, MyristateARBA annotation, PhosphoproteinARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 390 – 405 | CCHC-typeInterPro annotationAdd BLAST | 16 | |
Domaini | 412 – 427 | CCHC-typeInterPro annotationAdd BLAST | 16 | |
Domaini | 572 – 641 | Peptidase A2InterPro annotationAdd BLAST | 70 | |
Domaini | 695 – 885 | Reverse transcriptaseInterPro annotationAdd BLAST | 191 | |
Domaini | 1085 – 1208 | RNase HInterPro annotationAdd BLAST | 124 | |
Domaini | 1214 – 1255 | Integrase-typeInterPro annotationAdd BLAST | 42 | |
Domaini | 1265 – 1415 | Integrase catalyticInterPro annotationAdd BLAST | 151 | |
Domaini | 1434 – 1481 | Integrase-typeInterPro annotationAdd BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 436 – 480 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 508 – 545 | DisorderedSequence analysisAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 94 – 117 | Sequence analysisAdd BLAST | 24 | |
Coiled coili | 1366 – 1386 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 521 – 537 | PolyampholyteSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the primate lentivirus group gag polyprotein family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationFamily and domain databases
CDDi | cd05482, HIV_retropepsin_like, 1 hit |
Gene3Di | 1.10.10.200, 1 hit 1.10.1200.30, 1 hit 1.10.150.90, 1 hit 1.10.375.10, 1 hit 2.30.30.10, 1 hit 2.40.70.10, 1 hit 3.30.420.10, 2 hits 3.30.70.270, 3 hits |
InterProi | View protein in InterPro IPR001969, Aspartic_peptidase_AS IPR043502, DNA/RNA_pol_sf IPR000721, Gag_p24 IPR014817, Gag_p6 IPR017856, Integrase-like_N IPR036862, Integrase_C_dom_sf_retrovir IPR001037, Integrase_C_retrovir IPR001584, Integrase_cat-core IPR003308, Integrase_Zn-bd_dom_N IPR000071, Lentvrl_matrix_N IPR012344, Matrix_HIV/RSV_N IPR001995, Peptidase_A2_cat IPR021109, Peptidase_aspartic_dom_sf IPR034170, Retropepsin-like_cat_dom IPR018061, Retropepsins IPR008916, Retrov_capsid_C IPR008919, Retrov_capsid_N IPR010999, Retrovr_matrix IPR043128, Rev_trsase/Diguanyl_cyclase IPR012337, RNaseH-like_sf IPR002156, RNaseH_domain IPR036397, RNaseH_sf IPR000477, RT_dom IPR010659, RVT_connect IPR010661, RVT_thumb IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF00540, Gag_p17, 1 hit PF00607, Gag_p24, 1 hit PF08705, Gag_p6, 1 hit PF00552, IN_DBD_C, 1 hit PF02022, Integrase_Zn, 1 hit PF00075, RNase_H, 1 hit PF00665, rve, 1 hit PF00077, RVP, 1 hit PF00078, RVT_1, 1 hit PF06815, RVT_connect, 1 hit PF06817, RVT_thumb, 1 hit PF00098, zf-CCHC, 2 hits |
PRINTSi | PR00234, HIV1MATRIX |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 2 hits |
SUPFAMi | SSF46919, SSF46919, 1 hit SSF47836, SSF47836, 1 hit SSF47943, SSF47943, 1 hit SSF50122, SSF50122, 1 hit SSF50630, SSF50630, 1 hit SSF53098, SSF53098, 2 hits SSF56672, SSF56672, 1 hit SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50175, ASP_PROT_RETROV, 1 hit PS00141, ASP_PROTEASE, 1 hit PS50994, INTEGRASE, 1 hit PS51027, INTEGRASE_DBD, 1 hit PS50879, RNASE_H, 1 hit PS50878, RT_POL, 1 hit PS50158, ZF_CCHC, 2 hits PS50876, ZF_INTEGRASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q70XD7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGARASVLSG GKLDEWEKIR LRPGGKKKYR LKHLVWASRE LERFALNPGL
60 70 80 90 100
LETAEGCQQI MEQIQSALRT GSEELKSLYN TVATLYCVHQ RIQVKDTKEA
110 120 130 140 150
LDKIEEIQNK SKQKAQQAAA ATGNSSNVSQ NYPIVQNAQG QMVHQSISPR
160 170 180 190 200
TLNAWVKVIE EKAFSPEVIP MFSALSEGCT PQDLNMMLNI VGGHQAAMQM
210 220 230 240 250
LKDTINEEAA EWDRIHPVHA GPIPPGQMRE PRGSDIAGTT STLQEQIGWM
260 270 280 290 300
TSNPPIPVGE IYKRWIVLGL NKIVRMYSPV SILDIKQGPK EPFRDYVDRF
310 320 330 340 350
FKTLRAEQAT QEVKDWMTET LLVQNANPDC KTILRALGPG ASLEEMMTAC
360 370 380 390 400
QGVGGPSHKA RVLAEAMSQA SGANIMMQKS NFKGPKRSIK CFNCGKEGHL
410 420 430 440 450
ARNCRAPRKK GCWKCGKEGH QMKDCTERQA NFLGKIWPSN KGRPGNFPQS
460 470 480 490 500
RPEPTAPPAE SFGFGEEITP SPKQEQKEKE LYPPLASLKS LFGSDPFFRE
510 520 530 540 550
NLAFQQGEAR EFSSEQTRTN SPTRRELRVR RGDNPLPEAG AEGKGAIPSL
560 570 580 590 600
SFPQITLWQR PLVTVRIGGQ LIEALLDTGA DDTVLEEINL PGKWKPKMIG
610 620 630 640 650
GIGGFIKVRQ YDQILMEICG KRAIGTVLVG PTPVNIIGRN MLTQIGCTLN
660 670 680 690 700
FPISPIETVP VKLKPGMDGP RVKQWPLTEE KIKALTEICT EMEKEGKISK
710 720 730 740 750
IGPENPYNTP IFAIKKKDST KWRKLVDFRE LNKRTQDFWE VQLGIPHPAG
760 770 780 790 800
LKKKKSVTVL DVGDAYFSVP LDKEFRKYTA FTIPSRNNET PGIRYQYNVL
810 820 830 840 850
PQGWKGSPAI FQASMTKILE PFRTKNPEIV IYQYMDDLYV GSDLEIGQHR
860 870 880 890 900
AKIEELREHL LKWGFTTPDK KHQKEPPFLW MGYELHPDKW TVQPIQLPNK
910 920 930 940 950
DSWTVNDIQK LVGKLNWASQ IYPGIKVKQL CKLLRGAKAL TDIVPLTAEA
960 970 980 990 1000
ELELAENREI LKEPVHGVYY DPSKDLIAEI QKQGQGQWTY QIYQEPHKNL
1010 1020 1030 1040 1050
KTGKYARIKS AHTNDVKQLT EVVQKIAQES IVIWGKTPKF RLPIQKETWE
1060 1070 1080 1090 1100
IWWTEYWQAT WIPEWEFVNT PPLVKLWYQL EKDPIVGAET FYVDGAANRE
1110 1120 1130 1140 1150
TKLGKAGYVT DRGRQKVVSI TETTNQKTEL HAIHLALQDS GSEVNIVTDS
1160 1170 1180 1190 1200
QYALGIIQAQ PDRSESELVN QIIEKLIEKD KVYLSWVPAH KGIGGNEQVD
1210 1220 1230 1240 1250
KLVSSGIRKV LFLDGIDKAQ EEHERYHSNW RAMASDFNLP PIVAKEIVAS
1260 1270 1280 1290 1300
CDKCQLKGEA IHGQVDCSPG IWQLDCTHLE GKIILVAVHV ASGYIEAEVI
1310 1320 1330 1340 1350
PAETGQETAY FILKLAGRWP VKVIHTDNGS NFTSAAVKAA CWWASITQEF
1360 1370 1380 1390 1400
GIPYNPQSQG VVESMNKELK KIIGQVREQA EHLKTAVQMA VFIHNFKRKG
1410 1420 1430 1440 1450
GIGGYSAGER IIDIIASDLQ TKELQKQIIK IQNFRVYYRD SRDPIWKGPA
1460 1470 1480 1490
KLLWKGEGAV VIQDNSEIKV VPRRKAKIIR DYGKQMAGDD CVAGRQDED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ508596 Genomic DNA Translation: CAD48448.1 |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingARBA annotationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ508596 Genomic DNA Translation: CAD48448.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YPK | X-ray | 1.95 | C | 162-172 | [»] | |
2YPL | X-ray | 2.40 | C | 162-172 | [»] | |
SMRi | Q70XD7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Family and domain databases
CDDi | cd05482, HIV_retropepsin_like, 1 hit |
Gene3Di | 1.10.10.200, 1 hit 1.10.1200.30, 1 hit 1.10.150.90, 1 hit 1.10.375.10, 1 hit 2.30.30.10, 1 hit 2.40.70.10, 1 hit 3.30.420.10, 2 hits 3.30.70.270, 3 hits |
InterProi | View protein in InterPro IPR001969, Aspartic_peptidase_AS IPR043502, DNA/RNA_pol_sf IPR000721, Gag_p24 IPR014817, Gag_p6 IPR017856, Integrase-like_N IPR036862, Integrase_C_dom_sf_retrovir IPR001037, Integrase_C_retrovir IPR001584, Integrase_cat-core IPR003308, Integrase_Zn-bd_dom_N IPR000071, Lentvrl_matrix_N IPR012344, Matrix_HIV/RSV_N IPR001995, Peptidase_A2_cat IPR021109, Peptidase_aspartic_dom_sf IPR034170, Retropepsin-like_cat_dom IPR018061, Retropepsins IPR008916, Retrov_capsid_C IPR008919, Retrov_capsid_N IPR010999, Retrovr_matrix IPR043128, Rev_trsase/Diguanyl_cyclase IPR012337, RNaseH-like_sf IPR002156, RNaseH_domain IPR036397, RNaseH_sf IPR000477, RT_dom IPR010659, RVT_connect IPR010661, RVT_thumb IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF00540, Gag_p17, 1 hit PF00607, Gag_p24, 1 hit PF08705, Gag_p6, 1 hit PF00552, IN_DBD_C, 1 hit PF02022, Integrase_Zn, 1 hit PF00075, RNase_H, 1 hit PF00665, rve, 1 hit PF00077, RVP, 1 hit PF00078, RVT_1, 1 hit PF06815, RVT_connect, 1 hit PF06817, RVT_thumb, 1 hit PF00098, zf-CCHC, 2 hits |
PRINTSi | PR00234, HIV1MATRIX |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 2 hits |
SUPFAMi | SSF46919, SSF46919, 1 hit SSF47836, SSF47836, 1 hit SSF47943, SSF47943, 1 hit SSF50122, SSF50122, 1 hit SSF50630, SSF50630, 1 hit SSF53098, SSF53098, 2 hits SSF56672, SSF56672, 1 hit SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50175, ASP_PROT_RETROV, 1 hit PS00141, ASP_PROTEASE, 1 hit PS50994, INTEGRASE, 1 hit PS51027, INTEGRASE_DBD, 1 hit PS50879, RNASE_H, 1 hit PS50878, RT_POL, 1 hit PS50158, ZF_CCHC, 2 hits PS50876, ZF_INTEGRASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q70XD7_9HIV1 | |
Accessioni | Q70XD7Primary (citable) accession number: Q70XD7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |