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Protein

Diacylglycerol O-acyltransferase 2

Gene

DGAT2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity).By similarity

Catalytic activityi

Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Acyl-CoA + retinol = CoA + retinyl ester.

Enzyme regulationi

Inhibited by niacin.By similarity

Pathwayi: triacylglycerol biosynthesis

This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processGlycerol metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00282

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol O-acyltransferase 2 (EC:2.3.1.20)
Alternative name(s):
Acyl-CoA retinol O-fatty-acyltransferase (EC:2.3.1.76)
Short name:
ARAT
Short name:
Retinol O-fatty-acyltransferase
Diglyceride acyltransferase 2
Gene namesi
Name:DGAT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42CytoplasmicSequence analysisAdd BLAST42
Transmembranei43 – 61HelicalSequence analysisAdd BLAST19
Topological domaini62 – 65LumenalSequence analysis4
Transmembranei66 – 85HelicalSequence analysisAdd BLAST20
Topological domaini86 – 361CytoplasmicSequence analysisAdd BLAST276

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002490441 – 361Diacylglycerol O-acyltransferase 2Add BLAST361

Proteomic databases

PaxDbiQ70VZ8
PRIDEiQ70VZ8

Interactioni

Subunit structurei

Forms multimeric complexes consisting of several DGAT2 subunits.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001536

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0831 Eukaryota
ENOG410XTG3 LUCA
HOVERGENiHBG065791
InParanoidiQ70VZ8
KOiK11160
TreeFamiTF314707

Family and domain databases

InterProiView protein in InterPro
IPR007130 DAGAT
PfamiView protein in Pfam
PF03982 DAGAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q70VZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLIAAYSG VLRGTGSSIL SALQDLFSVT WLNRAKVEKQ LQVISVLQWV
60 70 80 90 100
LSFLVLGVAC SVILMYTFCT DCWLIAVLYF TWLVFDWNTP KKGGRRSQWV
110 120 130 140 150
RNWAVWRYFR DYFPIQLVKT HNLLTSRNYI FGYHPHGIMG LGAFCNFSTE
160 170 180 190 200
ATEVSKKFPG IRPYLATLAG NFRMPVLREY LMSGGICPVN RDTIDYLLSK
210 220 230 240 250
NGSGNAIIIV VGGAAESLSS MPGKNAVTLR NRKGFVKLAL RHGADLVPTY
260 270 280 290 300
SFGENEVYKQ VIFEEGSWGR WVQKKFQKYI GFAPCIFHGR GLFSSDTWGL
310 320 330 340 350
VPYSKPITTV VGEPITIPRL ERPTQQDIDL YHAMYVQALV KLFDQHKTKF
360
GLPETEVLEV N
Length:361
Mass (Da):40,896
Last modified:July 5, 2004 - v1
Checksum:iC84BA6DF0242675A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35A → S in ABQ12972 (PubMed:16305752).Curated1
Sequence conflicti300L → P in AAT02660 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ519787 mRNA Translation: CAD58592.1
AJ534368
, AJ534369, AJ534370, AJ534371, AJ534372 Genomic DNA Translation: CAD58968.1
BT030532 mRNA Translation: ABQ12972.1
AY589091 Genomic DNA Translation: AAT02657.1
AY589092 Genomic DNA Translation: AAT02658.1
AY589093 Genomic DNA Translation: AAT02659.1
AY589094 Genomic DNA Translation: AAT02660.1
AY675174 mRNA Translation: AAT78344.1
RefSeqiNP_991362.2, NM_205793.2
UniGeneiBt.23550

Genome annotation databases

GeneIDi404129
KEGGibta:404129

Similar proteinsi

Entry informationi

Entry nameiDGAT2_BOVIN
AccessioniPrimary (citable) accession number: Q70VZ8
Secondary accession number(s): A5D9B3
, Q6B852, Q6PP93, Q6PP94, Q6PP95, Q6PP96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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