UniProtKB - Q70VB1 (GPC6A_RAT)
Protein
G-protein coupled receptor family C group 6 member A
Gene
Gprc6a
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (By similarity).By similarity1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: RGD
- signaling receptor activity Source: GO_Central
GO - Biological processi
- calcium-mediated signaling Source: RGD
- G protein-coupled receptor signaling pathway Source: RGD
- response to amino acid Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-416476, G alpha (q) signalling events R-RNO-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor family C group 6 member A |
Gene namesi | Name:Gprc6a |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 735077, Gprc6a |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 594 | ExtracellularSequence analysisAdd BLAST | 574 | |
Transmembranei | 595 – 615 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 616 – 630 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 631 – 651 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 652 – 669 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 670 – 690 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 691 – 706 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 707 – 727 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 728 – 750 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 751 – 771 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 772 – 784 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 785 – 805 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 806 – 812 | ExtracellularSequence analysis | 7 | |
Transmembranei | 813 – 833 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 834 – 928 | CytoplasmicSequence analysisAdd BLAST | 95 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000043198 | 21 – 928 | G-protein coupled receptor family C group 6 member AAdd BLAST | 908 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 131 | InterchainPROSITE-ProRule annotation | ||
Glycosylationi | 332 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 555 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q70VB1 |
PRIDEi | Q70VB1 |
PTM databases
GlyGeni | Q70VB1, 2 sites |
PhosphoSitePlusi | Q70VB1 |
Expressioni
Tissue specificityi
High expression in soft palate. Weak expression in kidney, liver, lung and brain. No expression detected in heart, testis, skeletal muscle amd spleen.1 Publication
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
By similarityProtein-protein interaction databases
MINTi | Q70VB1 |
STRINGi | 10116.ENSRNOP00000000451 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00940000158416 |
HOGENOMi | CLU_005389_1_0_1 |
InParanoidi | Q70VB1 |
OMAi | VILCKQE |
OrthoDBi | 119538at2759 |
PhylomeDBi | Q70VB1 |
TreeFami | TF331269 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00592, CASENSINGR PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q70VB1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSFVFITC FMILLDTSQS CHTPDDFVAI TSPGHIMIGG LFAIHEKMLS
60 70 80 90 100
SDDHPRQPQI QKCVGFEISV FLQTLAMIHS IEMINNSSLL SGVKLGYEIY
110 120 130 140 150
DTCTEVTAAM AATLRFLSKF NCSRETVIFQ CDYSSYVPRV KAIIGAGYSE
160 170 180 190 200
ISMAVSRMLN LQLMPQVSYE STAEILSDKI RFPSFLRTVP SDFYQTKAMA
210 220 230 240 250
HLIRQSGWNW VGAITTDDDY GRLALNTFAI QAAENNVCIA FKEVLPAFLS
260 270 280 290 300
DNTIEVRINQ TLEKIIAEAQ VNVIVVFLRK FHVFNLFNKA IERKISKIWI
310 320 330 340 350
ASDNWSTAAK IITIPNVKKL GKVVGFTFRR GNMSSFHSFL QTLHMYPSDN
360 370 380 390 400
NKPLHEFAML FSACKHIKDG DLSQCISNYS QATWTYDTTK TIETHLFKRN
410 420 430 440 450
DFLWHYTEPG LIHSIQLAVL ALGHAIRDLC QDRDCQKPNA FQPWELLAVL
460 470 480 490 500
KNVTFTDGKN SFHFDAHGDL NTGYEVVLWK ETNGLMTVTK MAEYDLQHDV
510 520 530 540 550
FITTNQETKH EFRKLKQILS KCSKECIPGQ MKKATGSQHS CCYECVNCPE
560 570 580 590 600
NHYSNETDMD HCLVCNNETH WAPVRSTMCF EKEVEYLDWD DSLALLLIAL
610 620 630 640 650
SLLGIAFVLA VGIIFTRNLK TPVVKSSGGL VVCYVMLACH ALNFASTGFF
660 670 680 690 700
IGEPQDFTCK TRQTLFGVSF TLCVSCILTK SLKILLAFSF DPTLKTFLKC
710 720 730 740 750
LYRPVPIVLT CTGIQVVICT LWLVLAAPTV EENTSLPRVI ILECEEGSAL
760 770 780 790 800
AFGTMLGYIA VLAFICFVFA FKGRKLPENY NEAKFLTFGM LIYFIAWITF
810 820 830 840 850
IPVYATTFGK YLPAVEIIVI LISNYGILCC TFFPKCYIIL CKQKTNTKSV
860 870 880 890 900
FLQMVYNYSA HSVDSLALSH VSLDSASHST ATTNPRPGNK TAACQNYKHL
910 920
PVQVLAHTGM EKTMHASKTL HQKRSSSI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ535460 mRNA Translation: CAD59483.1 |
RefSeqi | NP_001258035.1, NM_001271106.1 |
Genome annotation databases
Ensembli | ENSRNOT00000000451; ENSRNOP00000000451; ENSRNOG00000000401 |
GeneIDi | 294394 |
KEGGi | rno:294394 |
UCSCi | RGD:735077, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ535460 mRNA Translation: CAD59483.1 |
RefSeqi | NP_001258035.1, NM_001271106.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
MINTi | Q70VB1 |
STRINGi | 10116.ENSRNOP00000000451 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q70VB1, 2 sites |
PhosphoSitePlusi | Q70VB1 |
Proteomic databases
PaxDbi | Q70VB1 |
PRIDEi | Q70VB1 |
Genome annotation databases
Ensembli | ENSRNOT00000000451; ENSRNOP00000000451; ENSRNOG00000000401 |
GeneIDi | 294394 |
KEGGi | rno:294394 |
UCSCi | RGD:735077, rat |
Organism-specific databases
CTDi | 222545 |
RGDi | 735077, Gprc6a |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00940000158416 |
HOGENOMi | CLU_005389_1_0_1 |
InParanoidi | Q70VB1 |
OMAi | VILCKQE |
OrthoDBi | 119538at2759 |
PhylomeDBi | Q70VB1 |
TreeFami | TF331269 |
Enzyme and pathway databases
Reactomei | R-RNO-416476, G alpha (q) signalling events R-RNO-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Miscellaneous databases
PROi | PR:Q70VB1 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00592, CASENSINGR PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPC6A_RAT | |
Accessioni | Q70VB1Primary (citable) accession number: Q70VB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries