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Protein

Inhibitor of nuclear factor kappa-B kinase-interacting protein

Gene

IKBIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Target of p53/TP53 with pro-apoptotic function.1 Publication

Miscellaneous

Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • response to X-ray Source: BHF-UCL

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inhibitor of nuclear factor kappa-B kinase-interacting protein
Short name:
I kappa-B kinase-interacting protein
Short name:
IKBKB-interacting protein
Short name:
IKK-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IKBIP
Synonyms:IKIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166130.14

Human Gene Nomenclature Database

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HGNCi
HGNC:26430 IKBIP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609861 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q70UQ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei46 – 62HelicalSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000166130

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA165512948

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IKBIP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74712656

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003422611 – 350Inhibitor of nuclear factor kappa-B kinase-interacting proteinAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi144N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi328N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. Isoform 4 is glycosylated at Asn-154.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q70UQ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q70UQ0

PeptideAtlas

More...
PeptideAtlasi
Q70UQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q70UQ0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68566
68567 [Q70UQ0-2]
68568 [Q70UQ0-3]
68569 [Q70UQ0-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1398

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q70UQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q70UQ0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q70UQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By X-ray irradiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166130 Expressed in 186 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q70UQ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038677
HPA038678
HPA061541

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125730, 77 interactors

Protein interaction database and analysis system

More...
IntActi
Q70UQ0, 32 interactors

Molecular INTeraction database

More...
MINTi
Q70UQ0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q70UQ0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q70UQ0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili184 – 217Sequence analysisAdd BLAST34

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00500000045001

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113024

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080784

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q70UQ0

Identification of Orthologs from Complete Genome Data

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OMAi
YNLENKG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G09QS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q70UQ0

TreeFam database of animal gene trees

More...
TreeFami
TF331715

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024152 Inh_kappa-B_kinase-int

The PANTHER Classification System

More...
PANTHERi
PTHR21734 PTHR21734, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q70UQ0-1) [UniParc]FASTAAdd to basket
Also known as: IKIP2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEVKSRKKS GPKGAPAAEP GKRSEGGKTP VARSSGGGGW ADPRTCLSLL
60 70 80 90 100
SLGTCLGLAW FVFQQSEKFA KVENQYQLLK LETNEFQQLQ SKISLISEKW
110 120 130 140 150
QKSEAIMEQL KSFQIIAHLK RLQEEINEVK TWSNRITEKQ DILNNSLTTL
160 170 180 190 200
SQDITKVDQS TTSMAKDVGL KITSVKTDIR RISGLVTDVI SLTDSVQELE
210 220 230 240 250
NKIEKVEKNT VKNIGDLLSS SIDRTATLRK TASENSQRIN SVKKTLTELK
260 270 280 290 300
SDFDKHTDRF LSLEGDRAKV LKTVTFANDL KPKVYNLKKD FSRLEPLVND
310 320 330 340 350
LTLRIGRLVT DLLQREKEIA FLSEKISNLT IVQAEIKDIK DEIAHISDMN
Length:350
Mass (Da):39,309
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98BDA498C7BA1D0A
GO
Isoform 2 (identifier: Q70UQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:244
Mass (Da):27,769
Checksum:iB79E47CAF0588F29
GO
Isoform 3 (identifier: Q70UQ0-3) [UniParc]FASTAAdd to basket
Also known as: IKIP3

The sequence of this isoform differs from the canonical sequence as follows:
     60-70: WFVFQQSEKFA → CGRNLKLSWNN
     71-350: Missing.

Show »
Length:70
Mass (Da):7,141
Checksum:iB6627F6EBF24973C
GO
Isoform 4 (identifier: Q70UQ0-4) [UniParc]FASTAAdd to basket
Also known as: IKIP1

The sequence of this isoform differs from the canonical sequence as follows:
     100-350: WQKSEAIMEQ...DEIAHISDMN → LESTESILQE...IENKGIGGDF

Show »
Length:377
Mass (Da):43,084
Checksum:i405E03A48B3FEF09
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051067265G → S. Corresponds to variant dbSNP:rs1048906Ensembl.1
Isoform 4 (identifier: Q70UQ0-4)
Natural varianti122Q → H. Corresponds to variant dbSNP:rs12322444Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0344071 – 106Missing in isoform 2. 2 PublicationsAdd BLAST106
Alternative sequenceiVSP_03440860 – 70WFVFQQSEKFA → CGRNLKLSWNN in isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_03440971 – 350Missing in isoform 3. 2 PublicationsAdd BLAST280
Alternative sequenceiVSP_034410100 – 350WQKSE…ISDMN → LESTESILQEATSSMSLMTQ FEQEVSNLQDIMHDIQNNEE VLTQRMQSLNEKFQNITDFW KRSLEEMNINTDIFKSEAKH IHSQVTVQINSAEQEIKLLT ERLKDLEDSTLRNIRTVKRQ EEEDLLRVEEQLGSDTKAIE KLEEEQHALFARDEDLTNKL SDYEPKVEECKTHLPTIESA IHSVLRVSQDLIETEKKMED LTMQMFNMEDDMLKAVSEIM EMQKTLEGIQYDNSILKMQN ELDILKEKVHDFIAYSSTGE KGTLKEYNIENKGIGGDF in isoform 4. 3 PublicationsAdd BLAST251

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ539425 mRNA Translation: CAD62380.1
AJ539426 mRNA Translation: CAD62381.1
AJ539427 mRNA Translation: CAD62382.1
AJ539427 mRNA Translation: CAD62383.1
AK055613 mRNA Translation: BAB70970.1
AK123069 mRNA Translation: BAC85528.1
CH471054 Genomic DNA Translation: EAW97601.1
BC029415 mRNA Translation: AAH29415.2
BC051372 mRNA Translation: AAH51372.2
BC058933 mRNA Translation: AAH58933.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41822.1 [Q70UQ0-3]
CCDS9067.1 [Q70UQ0-1]
CCDS9068.1 [Q70UQ0-4]

NCBI Reference Sequences

More...
RefSeqi
NP_710154.1, NM_153687.3 [Q70UQ0-4]
NP_963906.1, NM_201612.2 [Q70UQ0-1]
NP_963907.1, NM_201613.2 [Q70UQ0-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.252543

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299157; ENSP00000299157; ENSG00000166130 [Q70UQ0-4]
ENST00000342502; ENSP00000343471; ENSG00000166130 [Q70UQ0-1]
ENST00000393042; ENSP00000376762; ENSG00000166130 [Q70UQ0-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
121457

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:121457

UCSC genome browser

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UCSCi
uc001tfv.5 human [Q70UQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ539425 mRNA Translation: CAD62380.1
AJ539426 mRNA Translation: CAD62381.1
AJ539427 mRNA Translation: CAD62382.1
AJ539427 mRNA Translation: CAD62383.1
AK055613 mRNA Translation: BAB70970.1
AK123069 mRNA Translation: BAC85528.1
CH471054 Genomic DNA Translation: EAW97601.1
BC029415 mRNA Translation: AAH29415.2
BC051372 mRNA Translation: AAH51372.2
BC058933 mRNA Translation: AAH58933.1
CCDSiCCDS41822.1 [Q70UQ0-3]
CCDS9067.1 [Q70UQ0-1]
CCDS9068.1 [Q70UQ0-4]
RefSeqiNP_710154.1, NM_153687.3 [Q70UQ0-4]
NP_963906.1, NM_201612.2 [Q70UQ0-1]
NP_963907.1, NM_201613.2 [Q70UQ0-3]
UniGeneiHs.252543

3D structure databases

ProteinModelPortaliQ70UQ0
SMRiQ70UQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125730, 77 interactors
IntActiQ70UQ0, 32 interactors
MINTiQ70UQ0

PTM databases

GlyConnecti1398
iPTMnetiQ70UQ0
PhosphoSitePlusiQ70UQ0
SwissPalmiQ70UQ0

Polymorphism and mutation databases

BioMutaiIKBIP
DMDMi74712656

Proteomic databases

EPDiQ70UQ0
MaxQBiQ70UQ0
PeptideAtlasiQ70UQ0
PRIDEiQ70UQ0
ProteomicsDBi68566
68567 [Q70UQ0-2]
68568 [Q70UQ0-3]
68569 [Q70UQ0-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
121457
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299157; ENSP00000299157; ENSG00000166130 [Q70UQ0-4]
ENST00000342502; ENSP00000343471; ENSG00000166130 [Q70UQ0-1]
ENST00000393042; ENSP00000376762; ENSG00000166130 [Q70UQ0-3]
GeneIDi121457
KEGGihsa:121457
UCSCiuc001tfv.5 human [Q70UQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
121457
EuPathDBiHostDB:ENSG00000166130.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IKBIP
HGNCiHGNC:26430 IKBIP
HPAiHPA038677
HPA038678
HPA061541
MIMi609861 gene
neXtProtiNX_Q70UQ0
OpenTargetsiENSG00000166130
PharmGKBiPA165512948

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00500000045001
HOGENOMiHOG000113024
HOVERGENiHBG080784
InParanoidiQ70UQ0
OMAiYNLENKG
OrthoDBiEOG091G09QS
PhylomeDBiQ70UQ0
TreeFamiTF331715

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
121457

Protein Ontology

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PROi
PR:Q70UQ0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166130 Expressed in 186 organ(s), highest expression level in blood
GenevisibleiQ70UQ0 HS

Family and domain databases

InterProiView protein in InterPro
IPR024152 Inh_kappa-B_kinase-int
PANTHERiPTHR21734 PTHR21734, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIKIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70UQ0
Secondary accession number(s): Q6ZWH4
, Q70UP9, Q86V91, Q96ND2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: December 5, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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