ID Q70Q12_SQUAC Unreviewed; 94 AA. AC Q70Q12; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 27-MAR-2024, entry version 73. DE RecName: Full=FXYD domain-containing ion transport regulator {ECO:0000256|RuleBase:RU364131}; GN Name=fxyd10 {ECO:0000313|EMBL:CAD88978.1}; OS Squalus acanthias (Spiny dogfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; OC Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus. OX NCBI_TaxID=7797 {ECO:0000313|EMBL:CAD88978.1}; RN [1] {ECO:0000313|EMBL:CAD88978.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12874284; DOI=10.1074/jbc.M305126200; RA Mahmmoud Y.A., Cramb G., Maunsbach A.B., Cutler C.P., Meischke L., RA Cornelius F.; RT "Regulation of Na,K-ATPase by PLMS, the phospholemman-like protein from RT shark: molecular cloning, sequence, expression, cellular distribution, and RT functional effects of PLMS."; RL J. Biol. Chem. 278:37427-37438(2003). RN [2] {ECO:0007829|PDB:2ZXE} RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 21-94. RX PubMed=19458722; DOI=10.1038/nature07939; RA Shinoda T., Ogawa H., Cornelius F., Toyoshima C.; RT "Crystal structure of the sodium-potassium pump at 2.4 A resolution."; RL Nature 459:446-450(2009). RN [3] {ECO:0007829|PDB:3A3Y} RP X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 21-94. RX PubMed=19666591; DOI=10.1073/pnas.0907054106; RA Ogawa H., Shinoda T., Cornelius F., Toyoshima C.; RT "Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound RT potassium and ouabain."; RL Proc. Natl. Acad. Sci. U.S.A. 106:13742-13747(2009). RN [4] {ECO:0007829|PDB:5AVQ, ECO:0007829|PDB:5AVR} RP X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 21-94. RX PubMed=26258479; DOI=10.1038/ncomms9004; RA Ogawa H., Cornelius F., Hirata A., Toyoshima C.; RT "Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by RT X-ray crystallography."; RL Nat. Commun. 6:8004-8004(2015). RN [5] {ECO:0007829|PDB:7Y45, ECO:0007829|PDB:7Y46} RP STRUCTURE BY ELECTRON MICROSCOPY (3.30 ANGSTROMS). RX PubMed=35747985; DOI=10.1002/1873-3468.14437; RA Kanai R., Cornelius F., Vilsen B., Toyoshima C.; RT "Cryo-electron microscopy of Na+ ,K+ -ATPase reveals how the extracellular RT gate locks in the E22K+ state. ."; RL FEBS Lett. 596:2513-2524(2022). RN [6] {ECO:0007829|PDB:7WYU, ECO:0007829|PDB:7WYV} RP STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS). RX PubMed=35380894; DOI=10.1073/pnas.2123226119; RA Kanai R., Cornelius F., Vilsen B., Toyoshima C.; RT "Cryoelectron microscopy of Na+,K+-ATPase in the two RT E2P states with and without cardiotonic steroids."; RL Proc. Natl. Acad. Sci. U.S.A. 119:e2123226119-e2123226119(2022). RN [7] {ECO:0007829|PDB:8JFZ} RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS). RX PubMed=37357620; DOI=10.1002/1873-3468.14689; RA Kanai R., Vilsen B., Cornelius F., Toyoshima C.; RT "Crystal structures of Na+ ,K+ -ATPase reveal the RT mechanism that converts the K+ -bound form to Na+ RT -bound form and opens and closes the cytoplasmic gate."; RL FEBS Lett. 597:1957-1976(2023). CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000256|ARBA:ARBA00005948, CC ECO:0000256|RuleBase:RU364131}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ556170; CAD88978.1; -; mRNA. DR PDB; 2ZXE; X-ray; 2.40 A; G=21-94. DR PDB; 3A3Y; X-ray; 2.80 A; G=21-94. DR PDB; 5AVQ; X-ray; 2.60 A; G=21-94. DR PDB; 5AVR; X-ray; 2.70 A; G=21-94. DR PDB; 5AVS; X-ray; 2.90 A; G=21-94. DR PDB; 5AVT; X-ray; 2.90 A; G=21-94. DR PDB; 5AVU; X-ray; 2.55 A; G=21-94. DR PDB; 5AVV; X-ray; 2.90 A; G=21-94. DR PDB; 5AVW; X-ray; 2.60 A; G=21-94. DR PDB; 5AVX; X-ray; 3.30 A; G=21-94. DR PDB; 5AVY; X-ray; 3.45 A; G=21-94. DR PDB; 5AVZ; X-ray; 3.20 A; G=21-94. DR PDB; 5AW0; X-ray; 3.30 A; G=21-94. DR PDB; 5AW1; X-ray; 3.35 A; G=21-94. DR PDB; 5AW2; X-ray; 3.20 A; G=21-94. DR PDB; 5AW3; X-ray; 3.35 A; G=21-94. DR PDB; 5AW4; X-ray; 2.80 A; G=21-94. DR PDB; 5AW5; X-ray; 2.90 A; G=21-94. DR PDB; 5AW6; X-ray; 2.80 A; G=21-94. DR PDB; 5AW7; X-ray; 2.90 A; G=21-94. DR PDB; 5AW8; X-ray; 2.80 A; G=21-94. DR PDB; 5AW9; X-ray; 2.80 A; G=21-94. DR PDB; 7WYU; EM; 3.40 A; E/G=1-94. DR PDB; 7WYV; EM; 3.70 A; E/G=1-94. DR PDB; 7WYW; EM; 3.80 A; E/G=1-94. DR PDB; 7WYX; EM; 3.40 A; E/G=1-94. DR PDB; 7WYY; EM; 3.90 A; E/G=1-94. DR PDB; 7WYZ; EM; 3.40 A; E/G=1-94. DR PDB; 7WZ0; EM; 3.00 A; E/G=1-94. DR PDB; 7Y45; EM; 3.30 A; E/G=1-94. DR PDB; 7Y46; EM; 7.20 A; E/G=1-94. DR PDB; 8JFZ; EM; 3.50 A; E/G=1-94. DR PDBsum; 2ZXE; -. DR PDBsum; 3A3Y; -. DR PDBsum; 5AVQ; -. DR PDBsum; 5AVR; -. DR PDBsum; 5AVS; -. DR PDBsum; 5AVT; -. DR PDBsum; 5AVU; -. DR PDBsum; 5AVV; -. DR PDBsum; 5AVW; -. DR PDBsum; 5AVX; -. DR PDBsum; 5AVY; -. DR PDBsum; 5AVZ; -. DR PDBsum; 5AW0; -. DR PDBsum; 5AW1; -. DR PDBsum; 5AW2; -. DR PDBsum; 5AW3; -. DR PDBsum; 5AW4; -. DR PDBsum; 5AW5; -. DR PDBsum; 5AW6; -. DR PDBsum; 5AW7; -. DR PDBsum; 5AW8; -. DR PDBsum; 5AW9; -. DR AlphaFoldDB; Q70Q12; -. DR EMDB; EMD-32894; -. DR EMDB; EMD-32895; -. DR EMDB; EMD-32896; -. DR EMDB; EMD-32897; -. DR EMDB; EMD-32898; -. DR EMDB; EMD-32899; -. DR EMDB; EMD-32900; -. DR EMDB; EMD-33601; -. DR EMDB; EMD-33602; -. DR EMDB; EMD-36220; -. DR SMR; Q70Q12; -. DR DIP; DIP-59759N; -. DR IntAct; Q70Q12; 1. DR TCDB; 3.A.3.1.6; the p-type atpase (p-atpase) superfamily. DR EvolutionaryTrace; Q70Q12; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro. DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW. DR GO; GO:0043269; P:regulation of monoatomic ion transport; IEA:InterPro. DR CDD; cd20328; FXYD3-like; 1. DR DisProt; DP00754; -. DR Gene3D; 1.20.5.780; Single helix bin; 1. DR InterPro; IPR047297; FXYD_motif. DR InterPro; IPR000272; Ion-transport_regulator_FXYD. DR PANTHER; PTHR14132:SF14; FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 5; 1. DR PANTHER; PTHR14132; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA; 1. DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1. DR PROSITE; PS01310; FXYD; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:2ZXE, ECO:0007829|PDB:3A3Y}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU364131}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364131}; KW Signal {ECO:0000256|RuleBase:RU364131}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU364131}; KW Transmembrane helix {ECO:0000256|RuleBase:RU364131}; KW Transport {ECO:0000256|RuleBase:RU364131}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|RuleBase:RU364131" FT CHAIN 21..94 FT /note="FXYD domain-containing ion transport regulator" FT /evidence="ECO:0000256|RuleBase:RU364131" FT /id="PRO_5011328900" FT TRANSMEM 36..61 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU364131" FT REGION 70..94 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 70..86 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 94 AA; 10186 MW; 2999C1D0C4BCF552 CRC64; MLGAATGLMV LVAVTQGVWA MDPEGPDNDE RFTYDYYRLR VVGLIVAAVL CVIGIIILLA GKCRCKFNQN KRTRSNSGTA TAQHLLQPGE ATEC //