ID Q70Q12_SQUAC Unreviewed; 94 AA.
AC Q70Q12;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=FXYD domain-containing ion transport regulator {ECO:0000256|RuleBase:RU364131};
GN Name=fxyd10 {ECO:0000313|EMBL:CAD88978.1};
OS Squalus acanthias (Spiny dogfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX NCBI_TaxID=7797 {ECO:0000313|EMBL:CAD88978.1};
RN [1] {ECO:0000313|EMBL:CAD88978.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12874284; DOI=10.1074/jbc.M305126200;
RA Mahmmoud Y.A., Cramb G., Maunsbach A.B., Cutler C.P., Meischke L.,
RA Cornelius F.;
RT "Regulation of Na,K-ATPase by PLMS, the phospholemman-like protein from
RT shark: molecular cloning, sequence, expression, cellular distribution, and
RT functional effects of PLMS.";
RL J. Biol. Chem. 278:37427-37438(2003).
RN [2] {ECO:0007829|PDB:2ZXE}
RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 21-94.
RX PubMed=19458722; DOI=10.1038/nature07939;
RA Shinoda T., Ogawa H., Cornelius F., Toyoshima C.;
RT "Crystal structure of the sodium-potassium pump at 2.4 A resolution.";
RL Nature 459:446-450(2009).
RN [3] {ECO:0007829|PDB:3A3Y}
RP X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 21-94.
RX PubMed=19666591; DOI=10.1073/pnas.0907054106;
RA Ogawa H., Shinoda T., Cornelius F., Toyoshima C.;
RT "Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound
RT potassium and ouabain.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:13742-13747(2009).
RN [4] {ECO:0007829|PDB:5AVQ, ECO:0007829|PDB:5AVR}
RP X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 21-94.
RX PubMed=26258479; DOI=10.1038/ncomms9004;
RA Ogawa H., Cornelius F., Hirata A., Toyoshima C.;
RT "Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by
RT X-ray crystallography.";
RL Nat. Commun. 6:8004-8004(2015).
RN [5] {ECO:0007829|PDB:7Y45, ECO:0007829|PDB:7Y46}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.30 ANGSTROMS).
RX PubMed=35747985; DOI=10.1002/1873-3468.14437;
RA Kanai R., Cornelius F., Vilsen B., Toyoshima C.;
RT "Cryo-electron microscopy of Na+ ,K+ -ATPase reveals how the extracellular
RT gate locks in the E22K+ state. .";
RL FEBS Lett. 596:2513-2524(2022).
RN [6] {ECO:0007829|PDB:7WYU, ECO:0007829|PDB:7WYV}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS).
RX PubMed=35380894; DOI=10.1073/pnas.2123226119;
RA Kanai R., Cornelius F., Vilsen B., Toyoshima C.;
RT "Cryoelectron microscopy of Na+,K+-ATPase in the two
RT E2P states with and without cardiotonic steroids.";
RL Proc. Natl. Acad. Sci. U.S.A. 119:e2123226119-e2123226119(2022).
RN [7] {ECO:0007829|PDB:8JFZ}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS).
RX PubMed=37357620; DOI=10.1002/1873-3468.14689;
RA Kanai R., Vilsen B., Cornelius F., Toyoshima C.;
RT "Crystal structures of Na+ ,K+ -ATPase reveal the
RT mechanism that converts the K+ -bound form to Na+
RT -bound form and opens and closes the cytoplasmic gate.";
RL FEBS Lett. 597:1957-1976(2023).
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000256|ARBA:ARBA00005948,
CC ECO:0000256|RuleBase:RU364131}.
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DR EMBL; AJ556170; CAD88978.1; -; mRNA.
DR PDB; 2ZXE; X-ray; 2.40 A; G=21-94.
DR PDB; 3A3Y; X-ray; 2.80 A; G=21-94.
DR PDB; 5AVQ; X-ray; 2.60 A; G=21-94.
DR PDB; 5AVR; X-ray; 2.70 A; G=21-94.
DR PDB; 5AVS; X-ray; 2.90 A; G=21-94.
DR PDB; 5AVT; X-ray; 2.90 A; G=21-94.
DR PDB; 5AVU; X-ray; 2.55 A; G=21-94.
DR PDB; 5AVV; X-ray; 2.90 A; G=21-94.
DR PDB; 5AVW; X-ray; 2.60 A; G=21-94.
DR PDB; 5AVX; X-ray; 3.30 A; G=21-94.
DR PDB; 5AVY; X-ray; 3.45 A; G=21-94.
DR PDB; 5AVZ; X-ray; 3.20 A; G=21-94.
DR PDB; 5AW0; X-ray; 3.30 A; G=21-94.
DR PDB; 5AW1; X-ray; 3.35 A; G=21-94.
DR PDB; 5AW2; X-ray; 3.20 A; G=21-94.
DR PDB; 5AW3; X-ray; 3.35 A; G=21-94.
DR PDB; 5AW4; X-ray; 2.80 A; G=21-94.
DR PDB; 5AW5; X-ray; 2.90 A; G=21-94.
DR PDB; 5AW6; X-ray; 2.80 A; G=21-94.
DR PDB; 5AW7; X-ray; 2.90 A; G=21-94.
DR PDB; 5AW8; X-ray; 2.80 A; G=21-94.
DR PDB; 5AW9; X-ray; 2.80 A; G=21-94.
DR PDB; 7WYU; EM; 3.40 A; E/G=1-94.
DR PDB; 7WYV; EM; 3.70 A; E/G=1-94.
DR PDB; 7WYW; EM; 3.80 A; E/G=1-94.
DR PDB; 7WYX; EM; 3.40 A; E/G=1-94.
DR PDB; 7WYY; EM; 3.90 A; E/G=1-94.
DR PDB; 7WYZ; EM; 3.40 A; E/G=1-94.
DR PDB; 7WZ0; EM; 3.00 A; E/G=1-94.
DR PDB; 7Y45; EM; 3.30 A; E/G=1-94.
DR PDB; 7Y46; EM; 7.20 A; E/G=1-94.
DR PDB; 8JFZ; EM; 3.50 A; E/G=1-94.
DR PDBsum; 2ZXE; -.
DR PDBsum; 3A3Y; -.
DR PDBsum; 5AVQ; -.
DR PDBsum; 5AVR; -.
DR PDBsum; 5AVS; -.
DR PDBsum; 5AVT; -.
DR PDBsum; 5AVU; -.
DR PDBsum; 5AVV; -.
DR PDBsum; 5AVW; -.
DR PDBsum; 5AVX; -.
DR PDBsum; 5AVY; -.
DR PDBsum; 5AVZ; -.
DR PDBsum; 5AW0; -.
DR PDBsum; 5AW1; -.
DR PDBsum; 5AW2; -.
DR PDBsum; 5AW3; -.
DR PDBsum; 5AW4; -.
DR PDBsum; 5AW5; -.
DR PDBsum; 5AW6; -.
DR PDBsum; 5AW7; -.
DR PDBsum; 5AW8; -.
DR PDBsum; 5AW9; -.
DR AlphaFoldDB; Q70Q12; -.
DR EMDB; EMD-32894; -.
DR EMDB; EMD-32895; -.
DR EMDB; EMD-32896; -.
DR EMDB; EMD-32897; -.
DR EMDB; EMD-32898; -.
DR EMDB; EMD-32899; -.
DR EMDB; EMD-32900; -.
DR EMDB; EMD-33601; -.
DR EMDB; EMD-33602; -.
DR EMDB; EMD-36220; -.
DR SMR; Q70Q12; -.
DR DIP; DIP-59759N; -.
DR IntAct; Q70Q12; 1.
DR TCDB; 3.A.3.1.6; the p-type atpase (p-atpase) superfamily.
DR EvolutionaryTrace; Q70Q12; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0043269; P:regulation of monoatomic ion transport; IEA:InterPro.
DR CDD; cd20328; FXYD3-like; 1.
DR DisProt; DP00754; -.
DR Gene3D; 1.20.5.780; Single helix bin; 1.
DR InterPro; IPR047297; FXYD_motif.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR PANTHER; PTHR14132:SF14; FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 5; 1.
DR PANTHER; PTHR14132; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA; 1.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR PROSITE; PS01310; FXYD; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:2ZXE, ECO:0007829|PDB:3A3Y};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU364131};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364131};
KW Signal {ECO:0000256|RuleBase:RU364131};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364131};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364131};
KW Transport {ECO:0000256|RuleBase:RU364131}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|RuleBase:RU364131"
FT CHAIN 21..94
FT /note="FXYD domain-containing ion transport regulator"
FT /evidence="ECO:0000256|RuleBase:RU364131"
FT /id="PRO_5011328900"
FT TRANSMEM 36..61
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364131"
FT REGION 70..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 94 AA; 10186 MW; 2999C1D0C4BCF552 CRC64;
MLGAATGLMV LVAVTQGVWA MDPEGPDNDE RFTYDYYRLR VVGLIVAAVL CVIGIIILLA
GKCRCKFNQN KRTRSNSGTA TAQHLLQPGE ATEC
//