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Entry version 88 (07 Apr 2021)
Sequence version 2 (29 Mar 2005)
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Protein

Type IV pilus biogenesis and competence protein PilQ

Gene

pilQ

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for type IV pilus biogenesis and competence. Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA (By similarity).By similarity

Miscellaneous

Present in outer membrane vesicle formulations which are used as vaccines in human.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCompetence, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
NMEN122586:G1G1B-1763-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type IV pilus biogenesis and competence protein PilQ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pilQ
Ordered Locus Names:NMB1812
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeisseria meningitidis serogroup B (strain MC58)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri122586 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000425 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...
PHI-basei
PHI:3827

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001311725 – 769Type IV pilus biogenesis and competence protein PilQAdd BLAST745

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q70M91

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homododecamer. Tetramer of trimer.

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q70M91, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1769
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q70M91

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q70M91

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006756_0_1_4

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNVPWDQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.120, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021731, AMIN_dom
IPR001775, GspD/PilQ
IPR005644, NolW-like
IPR038591, NolW-like_sf
IPR013355, Pilus_4_PilQ
IPR011662, Secretin/TonB_short_N
IPR004846, T2SS/T3SS
IPR004845, T2SS_GspD_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11741, AMIN, 1 hit
PF00263, Secretin, 1 hit
PF03958, Secretin_N, 1 hit
PF07660, STN, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00811, BCTERIALGSPD

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00965, STN, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02515, IV_pilus_PilQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00875, T2SP_D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q70M91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTKLTKIIS GLFVATAAFQ TASAGNITDI KVSSLPNKQK IVKVSFDKEI
60 70 80 90 100
VNPTGFVTSS PARIALDFEQ TGISMDQQVL EYADPLLSKI SAAQNSSRAR
110 120 130 140 150
LVLNLNKPGQ YNTEVRGNKV WIFINESDDT VSAPARPAVK AAPAAPAKQQ
160 170 180 190 200
AAAPSTKSAV SVSEPFTPAK QQAAAPFTES VVSVSAPFSP AKQQAAASAK
210 220 230 240 250
QQAAAPAKQQ AAAPAKQQAA APAKQTNIDF RKDGKNAGII ELAALGFAGQ
260 270 280 290 300
PDISQQHDHI IVTLKNHTLP TTLQRSLDVA DFKTPVQKVT LKRLNNDTQL
310 320 330 340 350
IITTAGNWEL VNKSAAPGYF TFQVLPKKQN LESGGVNNAP KTFTGRKISL
360 370 380 390 400
DFQDVEIRTI LQILAKESGM NIVASDSVNG KMTLSLKDVP WDQALDLVMQ
410 420 430 440 450
ARNLDMRQQG NIVNIAPRDE LLAKDKALLQ AEKDIADLGA LYSQNFQLKY
460 470 480 490 500
KNVEEFRSIL RLDNADTTGN RNTLISGRGS VLIDPATNTL IVTDTRSVIE
510 520 530 540 550
KFRKLIDELD VPAQQVMIEA RIVEAADGFS RDLGVKFGAT GKKKLKNDTS
560 570 580 590 600
AFGWGVNSGF GGDDKWGAET KINLPITAAA NSISLVRAIS SGALNLELSA
610 620 630 640 650
SESLSKTKTL ANPRVLTQNR KEAKIESGYE IPFTVTSIAN GGSSTNTELK
660 670 680 690 700
KAVLGLTVTP NITPDGQIIM TVKINKDSPA QCASGNQTIL CISTKNLNTQ
710 720 730 740 750
AMVENGGTLI VGGIYEEDNG NTLTKVPLLG DIPVIGNLFK TRGKKTDRRE
760
LLIFITPRIM GTAGNSLRY
Length:769
Mass (Da):82,473
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1CC24EF102DC4BC9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti203A → T in strain: CCUG 37602. 1
Natural varianti218 – 225Missing in strain: CCUG 37602. 8
Natural varianti428L → F in strain: CCUG 37602. 1
Natural varianti461R → A in strain: CCUG 37602. 1
Natural varianti475I → V in strain: CCUG 37602. 1
Natural varianti607T → P in strain: CCUG 37602. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ564200 Genomic DNA Translation: CAD91899.1
AE002098 Genomic DNA Translation: AAY52170.1

NCBI Reference Sequences

More...
RefSeqi
NP_274809.1, NC_003112.2
WP_002225652.1, NC_003112.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAY52170; AAY52170; NMB1812

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nme:NMB1812

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|122586.8.peg.2302

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564200 Genomic DNA Translation: CAD91899.1
AE002098 Genomic DNA Translation: AAY52170.1
RefSeqiNP_274809.1, NC_003112.2
WP_002225652.1, NC_003112.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AQZNMR-A224-329[»]
4AV2electron microscopy26.00A/B/C/D/E/F/G/H/I/J/K/L25-769[»]
BMRBiQ70M91
SMRiQ70M91
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ70M91, 1 interactor

Proteomic databases

PaxDbiQ70M91

Genome annotation databases

EnsemblBacteriaiAAY52170; AAY52170; NMB1812
KEGGinme:NMB1812
PATRICifig|122586.8.peg.2302

Phylogenomic databases

HOGENOMiCLU_006756_0_1_4
OMAiQNVPWDQ

Enzyme and pathway databases

BioCyciNMEN122586:G1G1B-1763-MONOMER

Miscellaneous databases

PHI-baseiPHI:3827

Family and domain databases

Gene3Di3.30.1370.120, 1 hit
InterProiView protein in InterPro
IPR021731, AMIN_dom
IPR001775, GspD/PilQ
IPR005644, NolW-like
IPR038591, NolW-like_sf
IPR013355, Pilus_4_PilQ
IPR011662, Secretin/TonB_short_N
IPR004846, T2SS/T3SS
IPR004845, T2SS_GspD_CS
PfamiView protein in Pfam
PF11741, AMIN, 1 hit
PF00263, Secretin, 1 hit
PF03958, Secretin_N, 1 hit
PF07660, STN, 1 hit
PRINTSiPR00811, BCTERIALGSPD
SMARTiView protein in SMART
SM00965, STN, 1 hit
TIGRFAMsiTIGR02515, IV_pilus_PilQ, 1 hit
PROSITEiView protein in PROSITE
PS00875, T2SP_D, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPILQ_NEIMB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70M91
Secondary accession number(s): Q4W562
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: April 7, 2021
This is version 88 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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