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UniProtKB - Q70LM6 (LGRB_BREPA)

Entry version 68 (23 Feb 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Linear gramicidin synthase subunit B

Gene

lgrB

Organism
Brevibacillus parabrevis
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates the 3rd to 6th amino acids (Ala, D-Leu, Ala and D-Val) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 4th (D-Leu) and the 6th (D-Val) amino acids.

Miscellaneous

Linear gramicidin is a pentadecapeptide antibiotic produced during sporulation.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 4 phosphopantetheines covalently.Curated

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.2 mM for glycine
  2. KM=1.5 mM for alanine

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase, Multifunctional enzyme
Biological processAntibiotic biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Linear gramicidin synthase subunit B
Including the following 5 domains:
ATP-dependent D-leucine adenylase
Short name:
D-LeuA
Alternative name(s):
D-leucine activase
Leucine racemase [ATP-hydrolyzing] (EC:5.1.1.-)
ATP-dependent alanine adenylase
Short name:
AlaA
Alternative name(s):
Alanine activase
ATP-dependent D-valine adenylase
Short name:
D-ValA
Alternative name(s):
D-valine activase
Valine racemase [ATP-hydrolyzing] (EC:5.1.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lgrB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrevibacillus parabrevis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri54914 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Brevibacillus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930901 – 5162Linear gramicidin synthase subunit BAdd BLAST5162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei998O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2062O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3576O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4636O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q70LM6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Large multienzyme complex composed of 4 subunits; LgrA, LgrB, LgrC and LgrD.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q70LM6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini963 – 1038Carrier 1PROSITE-ProRule annotationAdd BLAST76
Domaini2027 – 2101Carrier 2PROSITE-ProRule annotationAdd BLAST75
Domaini3541 – 3616Carrier 3PROSITE-ProRule annotationAdd BLAST76
Domaini4601 – 4675Carrier 4PROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Four module-bearing peptide synthase with a C-terminal epimerization domain. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 4 hits
3.30.300.30, 4 hits
3.30.559.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 4 hits
PF13193, AMP-binding_C, 4 hits
PF00668, Condensation, 6 hits
PF00550, PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00823, PKS_PP, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 4 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01733, AA-adenyl-dom, 4 hits
TIGR01720, NRPS-para261, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455, AMP_BINDING, 4 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q70LM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRKKVDNIY PLTPMQEGML FHSLLDEGSE SYFEQMRFTI KGLIDPAILE 
        60         70         80         90        100
QSLNALIERH DILRTVFLLE KVQKPRQIVL RERKTKVQVL DITHLSEGEQ 
       110        120        130        140        150
AAYLEDFAQK DRQASFDLAK DVLIRLTLVR TSADTHTLFW SHHHILLDGW 
       160        170        180        190        200
CIPIVLNDFF QIYQQRKGGL PVELGPVYPY STYISWLGEQ DAEEAKASWA 
       210        220        230        240        250
EYISGYEPTS FIHKQGGKNS YRQAELVFAI EQGLTDSLNK LAKQLHVTLN 
       260        270        280        290        300
NLFRAIWGLM LQRQCNTEDV VFGSVVSGRP SHLPNVEQMV GLFINTVPIR 
       310        320        330        340        350
VQAGAEQTFS ELVKQVQQEA LSLAKYHYLS LADIQGNQQL IDHILLFQNY 
       360        370        380        390        400
PMGQQFLTRL NQYNEEFTLT HLSAFEQTNY DLNVMVTPSD VITIKYIYNA 
       410        420        430        440        450
AVFSEEQLLH ISRQLTTIMT QVTNAPDILL QKLEVVDPAE KQLQLHSFND 
       460        470        480        490        500
TYRHYPTDKL IHQIFEERAE REPERIALVM GEQVLTYREL NEKANQLAKL 
       510        520        530        540        550
LRARGIGPES MVSLLTERSA EMMIAILAIF KAGGAYLPID PSHPKERIEY 
       560        570        580        590        600
ILQDSRSELL LVNHRFLGAV DFADRIIDLE AAEIYQGAAD NLECVSHANH 
       610        620        630        640        650
LAYVIYTSGS TGKPKGVMIE HASLLNIIFA LQELYPLLEN DAYLLKTTYT 
       660        670        680        690        700
FDVSVAEIFG WILGSGRLVI LDPGAEKEPA HIWETMVNHG VTHVNFVPSM 
       710        720        730        740        750
LIPFVDYVRD QQQESPLRYI FAAGEAMPSE LVGKVYEALP GVILENIYGP 
       760        770        780        790        800
TESTIYATKY SLAKDSQDVL VPIGKPLANI QTHIVNKHGQ LQPVGVPGEL 
       810        820        830        840        850
CIAGASLARG YWNNEALTNE KFVPHPFAAG QRMYRTGDLA RYRQDGNIEY 
       860        870        880        890        900
LGRIDHQVKI RGYRIELDEI RAQLIQEASI RDAVVIARTD HNGQAYLCAY 
       910        920        930        940        950
FIADKQWTVN ALREALRQTL PDYMVPSHFI QMEEFPLTSS GKIDRKALPL 
       960        970        980        990       1000
PDGRVHTGNV YLAPRNPVEE LVVRIWEEVL NVSQVGVHDN FFELGGHSLL 
      1010       1020       1030       1040       1050
ATQVLSRTAK LFHVRLPMRE IFTHQTVAEL ARRIQALRHG AEADKHSPIQ 
      1060       1070       1080       1090       1100
PSALQRADEL PLSYAQQRLW FLDRLIPDSA MYNIPVGFRL RGTVDELVLE 
      1110       1120       1130       1140       1150
RALNEIIQRH ESLRTTFVDV DGRALQVIHT DVHLSLGVTD LRDKPAAAKD 
      1160       1170       1180       1190       1200
AEWKQMAEED AATPFRLDQW PLLRAMLIRL EEQESVLWLN VHHIISDGWS 
      1210       1220       1230       1240       1250
MDVLVNELSE VYETLLKGEA LPLAALPIQY RDYAVWQREK SQDDVWKEQL 
      1260       1270       1280       1290       1300
RYWKNKLDGS EPLLPLPTDR PRAVVQSYRG DHLSFYVPGE VGQKLRELGR 
      1310       1320       1330       1340       1350
QEGATLFMTL LAAFKSFLYR YTHANDILIG TPVAGRNRQE IENLIGFFVN 
      1360       1370       1380       1390       1400
MLVLRTDLSD DPTFVELLRR VRETAFDAFA NEDVPFEKLV DELQIERSLS 
      1410       1420       1430       1440       1450
YSPLFQVLFA VQGMSTGVRE GETLAIAPDE VTLNQTTKFD LTLTMIEAAD 
      1460       1470       1480       1490       1500
NGLKGVFEYS TDLFDRTTIE RMAEHFGNLL QAIAADPGQK IVELPLLGGA 
      1510       1520       1530       1540       1550
EQSRMLVEWN QTDVAYSLDL LVHERVARIA QELPEQFAVI GEQGALTYAQ 
      1560       1570       1580       1590       1600
LDAKANQLAH ALLKRGIGSE DLVGICVERS SEMQIGQLAI LKAGAAYVPM 
      1610       1620       1630       1640       1650
DPAYPRERLA FMIKDAGMSL VLTQERLLDA LPQEAAALLC LDRDWQEIAA 
      1660       1670       1680       1690       1700
ESTAAPAIKT NADQLAYVIY TSGSTGTPKG VEIEHGSLLN LVNWHQRAYS 
      1710       1720       1730       1740       1750
VSAEDRASQI AGTAFDASVW ETWPYLTAGA TICQPREEIR LSPEKLRDWL 
      1760       1770       1780       1790       1800
VETGITISFL PTPLAENLLP LPWPTGAALR YMLTGGDTLH QYPTADVPFT 
      1810       1820       1830       1840       1850
LVNQYGPTEN TVVATAGAVP VLGERESAPT IGRPIDNVSV YVLDENRQPV 
      1860       1870       1880       1890       1900
PVGVVGELYI GGKSLARGYR NRPDLTEASF VPNPFSPIEG ARMYRTGDLV 
      1910       1920       1930       1940       1950
RYAADGSIEF IGRADDQVSI RGFRVELGEI ESALYAHPAV AESVVIVRED 
      1960       1970       1980       1990       2000
VTPGVKRLVA YAVLHEGEER QTSELRQSLK EMLPDYMVPS AIVLMEALPL 
      2010       2020       2030       2040       2050
TPNGKVDRRA LPLPDVAQTE WEGSFVEPQS DVERKLAEIW QEVLGVETIG 
      2060       2070       2080       2090       2100
VHDNFFELGG DSILTIQIVS RANQAGLQLT PKHLFDAQTL AELAASAVVL 
      2110       2120       2130       2140       2150
EKAPEMQAEQ GIVTGELPLT PIQTWFFEQD VRHVHHWNQS VMLAVREELD 
      2160       2170       2180       2190       2200
MTALTQAFAA LPRQHDALRL RFQQVNGTWQ AAHGEIADED VLLVADLSSV 
      2210       2220       2230       2240       2250
PEAEREARMR HITDELQASL DIEKGPLHRA AYFQLGAEQR LFIVIHHLVV 
      2260       2270       2280       2290       2300
DGVSWRIILE DLQTAYEQVK AGQKIAWPQK TTSFKSWAEE LTTYAEQSAV 
      2310       2320       2330       2340       2350
DEYWTGMDSE QACGLPVDHP QGKNTEGLAV QVKAKLSADE TRALLQEVPA 
      2360       2370       2380       2390       2400
AYRTQINDVL LSALTRTITD WTNKRALYVS VEGHGREPIV DGVDVSRTVG 
      2410       2420       2430       2440       2450
WFTSLYPVLL ETEPDLAWGD LLKSIKEQVR AIPDKGIGYG IHRYLSRDGQ 
      2460       2470       2480       2490       2500
TAEMLRAKPQ PEISFNYLGQ FGQGQTTDAA LFQIIPNWSA SNVSEDETRL 
      2510       2520       2530       2540       2550
YKLDVMSMVA QDQLEMSWTF SRDLYEPGTI EKLAHDYVQA LRAIIAHCRT 
      2560       2570       2580       2590       2600
EQAGGYTPSD FPLAELDQNS LDKFIGHNRL IENVYTLTPL QEGMLFHSLY 
      2610       2620       2630       2640       2650
EQAGGDYVVQ LALKLEHVNV EAFSAAWQKV VERHAILRTS FLWSGLEKPH 
      2660       2670       2680       2690       2700
QVVHAKVKTF VERLDWRHLT AAEQEAGLQT YLEQDRKRGF DLARPPLMRW 
      2710       2720       2730       2740       2750
TLIRLDASTF QFVWSFHHML LDGWSTPIVF QDWQAFYAAA SHGKEASLPA 
      2760       2770       2780       2790       2800
IPPFSAYIAW LKRQNLEEAQ QYWRDYLQGF GVPTPLGMGK SGGSAGQPKE 
      2810       2820       2830       2840       2850
YADHKLLLSE RATANLLAFA RKHQLTLNTV VQGAWALILA RYAGEAEVVF 
      2860       2870       2880       2890       2900
GTTNLGRPTD LPDAEAMVGL FINTLPVRVL FPEQTTVIDW LQSLQQAQSE 
      2910       2920       2930       2940       2950
MRQYEFTPLV DIQSWSEVPR GQSLFDSIFV FENYLSGTSV DSESGMLLGE 
      2960       2970       2980       2990       3000
VKAVEQTSYP LTLVVAPGEE LMLKLIYETG RFEQPAMDKV LAQLSSVLEA 
      3010       3020       3030       3040       3050
IMREPHEQLA DLSIITEAER HKLLVEWNAT DMPYERNLVM HQLFEAQVEA 
      3060       3070       3080       3090       3100
TPDAQALVVG TERLTYAELN KRANQLAHYL RAQGVGPEVL VAVLMERTTE 
      3110       3120       3130       3140       3150
MIVALLGIIK AGGAYVPIDP AYPQDRIGYT LDDSQAAIVL TQERLLPMLP 
      3160       3170       3180       3190       3200
EHTAQVICLD RDWACMAVQP EANVPNLAAP TNLSYVIYTS GSTGLPKGVA 
      3210       3220       3230       3240       3250
IQHSSVIAFI FWAKTVFSAE EMSGVLASTS ICFDLSVYEI FVTLSCGGKV 
      3260       3270       3280       3290       3300
ILADNALHLP SLPAAKEVTL INTVPSAAKE LVRMNAIPPS VRVVNLAGEP 
      3310       3320       3330       3340       3350
LPNTLAQSLY ALGHVQKVFN LYGPSEDTTY STYVQVTKGA KTEPTIGRPL 
      3360       3370       3380       3390       3400
ANTQAYVLDA KLQPVPLGLP GELYLGGDGL ARGYLKRPKM TAERFLPNPF 
      3410       3420       3430       3440       3450
HPDPDARMYS TGDLVRYLPD GQLEYLGRID HQVKIRGYRI ELGELEAVLR 
      3460       3470       3480       3490       3500
SHPQIKEAVV VAKEDKLGEK RLVAYITTKD GECGDRAVLT SWAKAKLPEF 
      3510       3520       3530       3540       3550
MVPSFFVWLD AMPLTPNGKI DRKQLPEPEW GQVASAAGYV APRNQTEVLV 
      3560       3570       3580       3590       3600
ASIWADVLGI EQVGVHDNFF ELGGHSLLAT RVASRLRETF AKEVPIRAIF 
      3610       3620       3630       3640       3650
ERPTVAELSE TLGAIGQNET EAQMLPVSRE AHLPLSFAQQ RLWFLDRLMP 
      3660       3670       3680       3690       3700
DSTLYNIPSA VRLLGDLDIA AWEKSLQVLI QRHESLRTTF GDVDGEAVQV 
      3710       3720       3730       3740       3750
IHSRLDGKLN VIDLRGMPAD EREAEAHRLA GLEAATPFDL SQGPLLRTTL 
      3760       3770       3780       3790       3800
IRLAEQECVF LFNLHHIIFD GWSIGIFLKE MRALYEAFVR EEAPELAEIT 
      3810       3820       3830       3840       3850
VQYADYAVWQ RKWLEGEVLA EQLAYWKEKL SGAEPLLALP TDQPRPAVQT 
      3860       3870       3880       3890       3900
HDGAMHTIKL SGELYAKLNK LSQEEGATLF MTLLAAFQVL LYRYSGQEDI 
      3910       3920       3930       3940       3950
LVGSPVAGRN RQETEPLIGF FINTLVLRTD LSGEPTFREL LARVRETAFE 
      3960       3970       3980       3990       4000
AYAHQDLPFE KLVDELELER SLSYSPLFQV MFVLQNFQLN LDEKAGIRVA 
      4010       4020       4030       4040       4050
DFEMDKHLVT SKYDLTLTMA EKQNGLFATF EYNTALFHEA TMERLSQHFI 
      4060       4070       4080       4090       4100
QLLEAIVHMP DQGIARLPLL NQSERAQLLV EWNDTTTAYP RNKRVDQLFR 
      4110       4120       4130       4140       4150
ETALLYPERL AVVAGNQTLT YAELERRANQ TANYLQQKGV RPGALVGLCV 
      4160       4170       4180       4190       4200
KRSLEMLIGM LGILKAGGAY VPLDPDYPEE RLAYMMGDAG ITVLLTQEQL 
      4210       4220       4230       4240       4250
MPGLPSGERT TIALDRDWPL IAKESEQAPD VDTTAESLAY VIYTSGSTGL 
      4260       4270       4280       4290       4300
PKGTLVVHRG IVRLVKETDY VTITEQDVFL QASTVSFDAA TFEIWGSLLN 
      4310       4320       4330       4340       4350
GAKLVLLPPE LPSLAEIGQA IQSHHVTTLW LTAGLFTLMV DHHKEYLSGV 
      4360       4370       4380       4390       4400
RQLLVGGDIV SVPHVKKALE IAGLTVINGY GPTENTTFTC CNPVTVMPES 
      4410       4420       4430       4440       4450
AHTFPIGRPI KNTTAYVLDR HMQPVPIGVT GELYIGGDGL AEGYLNRPDL 
      4460       4470       4480       4490       4500
TAERFVPNPF ATDQAARLYR TGDLVRYLPD GLIEFIGRLD NQVKIRGFRI 
      4510       4520       4530       4540       4550
ELSEVEAVLA KHPAITASVV IVHENEAGMK QLVAYAVKDA EQELGTAELR 
      4560       4570       4580       4590       4600
QHFKAHVPDY MVPAAFVMLD ALPLTPNGKV DRKALPAPVL ERSREEDAFA 
      4610       4620       4630       4640       4650
AATSHVEQTL ADIWCAVLRM DRIGIHDNFF ELGGDSILSI QIVARANKAG 
      4660       4670       4680       4690       4700
IHLTPKQLFD QQTIAELAKV AGQSTKVDAE QGNVTGEVPL LPIQTWFFEQ 
      4710       4720       4730       4740       4750
KQPTPHHWNQ SMLLQVNEPL EEECLSQAVA QLLAHHDALR LRYTFADGQW 
      4760       4770       4780       4790       4800
KQTYADVDSE VPLQVEDLSM SPPAQQARKI EKLAQQAQAS LDLQNGPLLK 
      4810       4820       4830       4840       4850
VVYFDLGYDR PGRLLMVIHH LAVDGVSWRI LIEDLQTAYG QAEKGNKIQL 
      4860       4870       4880       4890       4900
PPKTTSYKAW AEKLHKYASS ERMLVDQDYW LKAADELSGH PLPVHDWAEN 
      4910       4920       4930       4940       4950
TEANGRMWTI HLEEEETDAL LQKVPSRYRV QINDILLTAL ALAYGKWTGE 
      4960       4970       4980       4990       5000
SALLVNLEGH GREELFEDVD LSRTVGWFTS MYPLLIQLEP NTSSEDALAR 
      5010       5020       5030       5040       5050
VKEKLQQIPH KGLGYGLLRY MAQDPELVEK LKAIPQAPLS FNYLGQFHQA 
      5060       5070       5080       5090       5100
ADAKALLAYA EGERGANSGP DNRRTHLIDV VGAVTEGKLG LSFLYNGRLY 
      5110       5120       5130       5140       5150
SESHIETFAR HYTDALQSLI QAEKQSYRAE DFEDADLSQS ALNKVLARLK 
      5160 
NRKGNELHGG SH
Length:5,162
Mass (Da):577,904
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26C1F1EBDEA75BDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ566197 Genomic DNA Translation: CAD92850.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566197 Genomic DNA Translation: CAD92850.1

3D structure databases

SMRiQ70LM6
ModBaseiSearch...

Proteomic databases

PRIDEiQ70LM6

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.300.30, 4 hits
3.30.559.10, 6 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 4 hits
PF13193, AMP-binding_C, 4 hits
PF00668, Condensation, 6 hits
PF00550, PP-binding, 4 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 4 hits
SUPFAMiSSF47336, SSF47336, 4 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 4 hits
TIGR01720, NRPS-para261, 2 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 4 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLGRB_BREPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70LM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: February 23, 2022
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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