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Entry version 66 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Linear gramicidin synthase subunit B

Gene

lgrB

Organism
Brevibacillus parabrevis
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates the 3rd to 6th amino acids (Ala, D-Leu, Ala and D-Val) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 4th (D-Leu) and the 6th (D-Val) amino acids.

Miscellaneous

Linear gramicidin is a pentadecapeptide antibiotic produced during sporulation.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 4 phosphopantetheines covalently.Curated

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.2 mM for glycine
  2. KM=1.5 mM for alanine

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase, Ligase, Multifunctional enzyme
    Biological processAntibiotic biosynthesis

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Linear gramicidin synthase subunit B
    Including the following 5 domains:
    ATP-dependent D-leucine adenylase
    Short name:
    D-LeuA
    Alternative name(s):
    D-leucine activase
    Leucine racemase [ATP-hydrolyzing] (EC:5.1.1.-)
    ATP-dependent alanine adenylase
    Short name:
    AlaA
    Alternative name(s):
    Alanine activase
    ATP-dependent D-valine adenylase
    Short name:
    D-ValA
    Alternative name(s):
    D-valine activase
    Valine racemase [ATP-hydrolyzing] (EC:5.1.1.-)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:lgrB
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrevibacillus parabrevis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri54914 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930901 – 5162Linear gramicidin synthase subunit BAdd BLAST5162

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei998O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
    Modified residuei2062O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
    Modified residuei3576O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
    Modified residuei4636O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

    Keywords - PTMi

    Phosphopantetheine, Phosphoprotein

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q70LM6

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Large multienzyme complex composed of 4 subunits; LgrA, LgrB, LgrC and LgrD.

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q70LM6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini963 – 1038Carrier 1PROSITE-ProRule annotationAdd BLAST76
    Domaini2027 – 2101Carrier 2PROSITE-ProRule annotationAdd BLAST75
    Domaini3541 – 3616Carrier 3PROSITE-ProRule annotationAdd BLAST76
    Domaini4601 – 4675Carrier 4PROSITE-ProRule annotationAdd BLAST75

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Four module-bearing peptide synthase with a C-terminal epimerization domain. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional).

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.1200.10, 4 hits
    3.30.559.10, 6 hits
    3.40.50.12780, 4 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR010071, AA_adenyl_domain
    IPR036736, ACP-like_sf
    IPR025110, AMP-bd_C
    IPR020845, AMP-binding_CS
    IPR000873, AMP-dep_Synth/Lig
    IPR042099, AMP-dep_Synthh-like_sf
    IPR023213, CAT-like_dom_sf
    IPR001242, Condensatn
    IPR010060, NRPS_synth
    IPR020806, PKS_PP-bd
    IPR009081, PP-bd_ACP
    IPR006162, Ppantetheine_attach_site

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00501, AMP-binding, 4 hits
    PF13193, AMP-binding_C, 4 hits
    PF00668, Condensation, 6 hits
    PF00550, PP-binding, 4 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00823, PKS_PP, 4 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47336, SSF47336, 4 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01733, AA-adenyl-dom, 4 hits
    TIGR01720, NRPS-para261, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00455, AMP_BINDING, 4 hits
    PS50075, CARRIER, 4 hits
    PS00012, PHOSPHOPANTETHEINE, 3 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q70LM6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSRKKVDNIY PLTPMQEGML FHSLLDEGSE SYFEQMRFTI KGLIDPAILE
    60 70 80 90 100
    QSLNALIERH DILRTVFLLE KVQKPRQIVL RERKTKVQVL DITHLSEGEQ
    110 120 130 140 150
    AAYLEDFAQK DRQASFDLAK DVLIRLTLVR TSADTHTLFW SHHHILLDGW
    160 170 180 190 200
    CIPIVLNDFF QIYQQRKGGL PVELGPVYPY STYISWLGEQ DAEEAKASWA
    210 220 230 240 250
    EYISGYEPTS FIHKQGGKNS YRQAELVFAI EQGLTDSLNK LAKQLHVTLN
    260 270 280 290 300
    NLFRAIWGLM LQRQCNTEDV VFGSVVSGRP SHLPNVEQMV GLFINTVPIR
    310 320 330 340 350
    VQAGAEQTFS ELVKQVQQEA LSLAKYHYLS LADIQGNQQL IDHILLFQNY
    360 370 380 390 400
    PMGQQFLTRL NQYNEEFTLT HLSAFEQTNY DLNVMVTPSD VITIKYIYNA
    410 420 430 440 450
    AVFSEEQLLH ISRQLTTIMT QVTNAPDILL QKLEVVDPAE KQLQLHSFND
    460 470 480 490 500
    TYRHYPTDKL IHQIFEERAE REPERIALVM GEQVLTYREL NEKANQLAKL
    510 520 530 540 550
    LRARGIGPES MVSLLTERSA EMMIAILAIF KAGGAYLPID PSHPKERIEY
    560 570 580 590 600
    ILQDSRSELL LVNHRFLGAV DFADRIIDLE AAEIYQGAAD NLECVSHANH
    610 620 630 640 650
    LAYVIYTSGS TGKPKGVMIE HASLLNIIFA LQELYPLLEN DAYLLKTTYT
    660 670 680 690 700
    FDVSVAEIFG WILGSGRLVI LDPGAEKEPA HIWETMVNHG VTHVNFVPSM
    710 720 730 740 750
    LIPFVDYVRD QQQESPLRYI FAAGEAMPSE LVGKVYEALP GVILENIYGP
    760 770 780 790 800
    TESTIYATKY SLAKDSQDVL VPIGKPLANI QTHIVNKHGQ LQPVGVPGEL
    810 820 830 840 850
    CIAGASLARG YWNNEALTNE KFVPHPFAAG QRMYRTGDLA RYRQDGNIEY
    860 870 880 890 900
    LGRIDHQVKI RGYRIELDEI RAQLIQEASI RDAVVIARTD HNGQAYLCAY
    910 920 930 940 950
    FIADKQWTVN ALREALRQTL PDYMVPSHFI QMEEFPLTSS GKIDRKALPL
    960 970 980 990 1000
    PDGRVHTGNV YLAPRNPVEE LVVRIWEEVL NVSQVGVHDN FFELGGHSLL
    1010 1020 1030 1040 1050
    ATQVLSRTAK LFHVRLPMRE IFTHQTVAEL ARRIQALRHG AEADKHSPIQ
    1060 1070 1080 1090 1100
    PSALQRADEL PLSYAQQRLW FLDRLIPDSA MYNIPVGFRL RGTVDELVLE
    1110 1120 1130 1140 1150
    RALNEIIQRH ESLRTTFVDV DGRALQVIHT DVHLSLGVTD LRDKPAAAKD
    1160 1170 1180 1190 1200
    AEWKQMAEED AATPFRLDQW PLLRAMLIRL EEQESVLWLN VHHIISDGWS
    1210 1220 1230 1240 1250
    MDVLVNELSE VYETLLKGEA LPLAALPIQY RDYAVWQREK SQDDVWKEQL
    1260 1270 1280 1290 1300
    RYWKNKLDGS EPLLPLPTDR PRAVVQSYRG DHLSFYVPGE VGQKLRELGR
    1310 1320 1330 1340 1350
    QEGATLFMTL LAAFKSFLYR YTHANDILIG TPVAGRNRQE IENLIGFFVN
    1360 1370 1380 1390 1400
    MLVLRTDLSD DPTFVELLRR VRETAFDAFA NEDVPFEKLV DELQIERSLS
    1410 1420 1430 1440 1450
    YSPLFQVLFA VQGMSTGVRE GETLAIAPDE VTLNQTTKFD LTLTMIEAAD
    1460 1470 1480 1490 1500
    NGLKGVFEYS TDLFDRTTIE RMAEHFGNLL QAIAADPGQK IVELPLLGGA
    1510 1520 1530 1540 1550
    EQSRMLVEWN QTDVAYSLDL LVHERVARIA QELPEQFAVI GEQGALTYAQ
    1560 1570 1580 1590 1600
    LDAKANQLAH ALLKRGIGSE DLVGICVERS SEMQIGQLAI LKAGAAYVPM
    1610 1620 1630 1640 1650
    DPAYPRERLA FMIKDAGMSL VLTQERLLDA LPQEAAALLC LDRDWQEIAA
    1660 1670 1680 1690 1700
    ESTAAPAIKT NADQLAYVIY TSGSTGTPKG VEIEHGSLLN LVNWHQRAYS
    1710 1720 1730 1740 1750
    VSAEDRASQI AGTAFDASVW ETWPYLTAGA TICQPREEIR LSPEKLRDWL
    1760 1770 1780 1790 1800
    VETGITISFL PTPLAENLLP LPWPTGAALR YMLTGGDTLH QYPTADVPFT
    1810 1820 1830 1840 1850
    LVNQYGPTEN TVVATAGAVP VLGERESAPT IGRPIDNVSV YVLDENRQPV
    1860 1870 1880 1890 1900
    PVGVVGELYI GGKSLARGYR NRPDLTEASF VPNPFSPIEG ARMYRTGDLV
    1910 1920 1930 1940 1950
    RYAADGSIEF IGRADDQVSI RGFRVELGEI ESALYAHPAV AESVVIVRED
    1960 1970 1980 1990 2000
    VTPGVKRLVA YAVLHEGEER QTSELRQSLK EMLPDYMVPS AIVLMEALPL
    2010 2020 2030 2040 2050
    TPNGKVDRRA LPLPDVAQTE WEGSFVEPQS DVERKLAEIW QEVLGVETIG
    2060 2070 2080 2090 2100
    VHDNFFELGG DSILTIQIVS RANQAGLQLT PKHLFDAQTL AELAASAVVL
    2110 2120 2130 2140 2150
    EKAPEMQAEQ GIVTGELPLT PIQTWFFEQD VRHVHHWNQS VMLAVREELD
    2160 2170 2180 2190 2200
    MTALTQAFAA LPRQHDALRL RFQQVNGTWQ AAHGEIADED VLLVADLSSV
    2210 2220 2230 2240 2250
    PEAEREARMR HITDELQASL DIEKGPLHRA AYFQLGAEQR LFIVIHHLVV
    2260 2270 2280 2290 2300
    DGVSWRIILE DLQTAYEQVK AGQKIAWPQK TTSFKSWAEE LTTYAEQSAV
    2310 2320 2330 2340 2350
    DEYWTGMDSE QACGLPVDHP QGKNTEGLAV QVKAKLSADE TRALLQEVPA
    2360 2370 2380 2390 2400
    AYRTQINDVL LSALTRTITD WTNKRALYVS VEGHGREPIV DGVDVSRTVG
    2410 2420 2430 2440 2450
    WFTSLYPVLL ETEPDLAWGD LLKSIKEQVR AIPDKGIGYG IHRYLSRDGQ
    2460 2470 2480 2490 2500
    TAEMLRAKPQ PEISFNYLGQ FGQGQTTDAA LFQIIPNWSA SNVSEDETRL
    2510 2520 2530 2540 2550
    YKLDVMSMVA QDQLEMSWTF SRDLYEPGTI EKLAHDYVQA LRAIIAHCRT
    2560 2570 2580 2590 2600
    EQAGGYTPSD FPLAELDQNS LDKFIGHNRL IENVYTLTPL QEGMLFHSLY
    2610 2620 2630 2640 2650
    EQAGGDYVVQ LALKLEHVNV EAFSAAWQKV VERHAILRTS FLWSGLEKPH
    2660 2670 2680 2690 2700
    QVVHAKVKTF VERLDWRHLT AAEQEAGLQT YLEQDRKRGF DLARPPLMRW
    2710 2720 2730 2740 2750
    TLIRLDASTF QFVWSFHHML LDGWSTPIVF QDWQAFYAAA SHGKEASLPA
    2760 2770 2780 2790 2800
    IPPFSAYIAW LKRQNLEEAQ QYWRDYLQGF GVPTPLGMGK SGGSAGQPKE
    2810 2820 2830 2840 2850
    YADHKLLLSE RATANLLAFA RKHQLTLNTV VQGAWALILA RYAGEAEVVF
    2860 2870 2880 2890 2900
    GTTNLGRPTD LPDAEAMVGL FINTLPVRVL FPEQTTVIDW LQSLQQAQSE
    2910 2920 2930 2940 2950
    MRQYEFTPLV DIQSWSEVPR GQSLFDSIFV FENYLSGTSV DSESGMLLGE
    2960 2970 2980 2990 3000
    VKAVEQTSYP LTLVVAPGEE LMLKLIYETG RFEQPAMDKV LAQLSSVLEA
    3010 3020 3030 3040 3050
    IMREPHEQLA DLSIITEAER HKLLVEWNAT DMPYERNLVM HQLFEAQVEA
    3060 3070 3080 3090 3100
    TPDAQALVVG TERLTYAELN KRANQLAHYL RAQGVGPEVL VAVLMERTTE
    3110 3120 3130 3140 3150
    MIVALLGIIK AGGAYVPIDP AYPQDRIGYT LDDSQAAIVL TQERLLPMLP
    3160 3170 3180 3190 3200
    EHTAQVICLD RDWACMAVQP EANVPNLAAP TNLSYVIYTS GSTGLPKGVA
    3210 3220 3230 3240 3250
    IQHSSVIAFI FWAKTVFSAE EMSGVLASTS ICFDLSVYEI FVTLSCGGKV
    3260 3270 3280 3290 3300
    ILADNALHLP SLPAAKEVTL INTVPSAAKE LVRMNAIPPS VRVVNLAGEP
    3310 3320 3330 3340 3350
    LPNTLAQSLY ALGHVQKVFN LYGPSEDTTY STYVQVTKGA KTEPTIGRPL
    3360 3370 3380 3390 3400
    ANTQAYVLDA KLQPVPLGLP GELYLGGDGL ARGYLKRPKM TAERFLPNPF
    3410 3420 3430 3440 3450
    HPDPDARMYS TGDLVRYLPD GQLEYLGRID HQVKIRGYRI ELGELEAVLR
    3460 3470 3480 3490 3500
    SHPQIKEAVV VAKEDKLGEK RLVAYITTKD GECGDRAVLT SWAKAKLPEF
    3510 3520 3530 3540 3550
    MVPSFFVWLD AMPLTPNGKI DRKQLPEPEW GQVASAAGYV APRNQTEVLV
    3560 3570 3580 3590 3600
    ASIWADVLGI EQVGVHDNFF ELGGHSLLAT RVASRLRETF AKEVPIRAIF
    3610 3620 3630 3640 3650
    ERPTVAELSE TLGAIGQNET EAQMLPVSRE AHLPLSFAQQ RLWFLDRLMP
    3660 3670 3680 3690 3700
    DSTLYNIPSA VRLLGDLDIA AWEKSLQVLI QRHESLRTTF GDVDGEAVQV
    3710 3720 3730 3740 3750
    IHSRLDGKLN VIDLRGMPAD EREAEAHRLA GLEAATPFDL SQGPLLRTTL
    3760 3770 3780 3790 3800
    IRLAEQECVF LFNLHHIIFD GWSIGIFLKE MRALYEAFVR EEAPELAEIT
    3810 3820 3830 3840 3850
    VQYADYAVWQ RKWLEGEVLA EQLAYWKEKL SGAEPLLALP TDQPRPAVQT
    3860 3870 3880 3890 3900
    HDGAMHTIKL SGELYAKLNK LSQEEGATLF MTLLAAFQVL LYRYSGQEDI
    3910 3920 3930 3940 3950
    LVGSPVAGRN RQETEPLIGF FINTLVLRTD LSGEPTFREL LARVRETAFE
    3960 3970 3980 3990 4000
    AYAHQDLPFE KLVDELELER SLSYSPLFQV MFVLQNFQLN LDEKAGIRVA
    4010 4020 4030 4040 4050
    DFEMDKHLVT SKYDLTLTMA EKQNGLFATF EYNTALFHEA TMERLSQHFI
    4060 4070 4080 4090 4100
    QLLEAIVHMP DQGIARLPLL NQSERAQLLV EWNDTTTAYP RNKRVDQLFR
    4110 4120 4130 4140 4150
    ETALLYPERL AVVAGNQTLT YAELERRANQ TANYLQQKGV RPGALVGLCV
    4160 4170 4180 4190 4200
    KRSLEMLIGM LGILKAGGAY VPLDPDYPEE RLAYMMGDAG ITVLLTQEQL
    4210 4220 4230 4240 4250
    MPGLPSGERT TIALDRDWPL IAKESEQAPD VDTTAESLAY VIYTSGSTGL
    4260 4270 4280 4290 4300
    PKGTLVVHRG IVRLVKETDY VTITEQDVFL QASTVSFDAA TFEIWGSLLN
    4310 4320 4330 4340 4350
    GAKLVLLPPE LPSLAEIGQA IQSHHVTTLW LTAGLFTLMV DHHKEYLSGV
    4360 4370 4380 4390 4400
    RQLLVGGDIV SVPHVKKALE IAGLTVINGY GPTENTTFTC CNPVTVMPES
    4410 4420 4430 4440 4450
    AHTFPIGRPI KNTTAYVLDR HMQPVPIGVT GELYIGGDGL AEGYLNRPDL
    4460 4470 4480 4490 4500
    TAERFVPNPF ATDQAARLYR TGDLVRYLPD GLIEFIGRLD NQVKIRGFRI
    4510 4520 4530 4540 4550
    ELSEVEAVLA KHPAITASVV IVHENEAGMK QLVAYAVKDA EQELGTAELR
    4560 4570 4580 4590 4600
    QHFKAHVPDY MVPAAFVMLD ALPLTPNGKV DRKALPAPVL ERSREEDAFA
    4610 4620 4630 4640 4650
    AATSHVEQTL ADIWCAVLRM DRIGIHDNFF ELGGDSILSI QIVARANKAG
    4660 4670 4680 4690 4700
    IHLTPKQLFD QQTIAELAKV AGQSTKVDAE QGNVTGEVPL LPIQTWFFEQ
    4710 4720 4730 4740 4750
    KQPTPHHWNQ SMLLQVNEPL EEECLSQAVA QLLAHHDALR LRYTFADGQW
    4760 4770 4780 4790 4800
    KQTYADVDSE VPLQVEDLSM SPPAQQARKI EKLAQQAQAS LDLQNGPLLK
    4810 4820 4830 4840 4850
    VVYFDLGYDR PGRLLMVIHH LAVDGVSWRI LIEDLQTAYG QAEKGNKIQL
    4860 4870 4880 4890 4900
    PPKTTSYKAW AEKLHKYASS ERMLVDQDYW LKAADELSGH PLPVHDWAEN
    4910 4920 4930 4940 4950
    TEANGRMWTI HLEEEETDAL LQKVPSRYRV QINDILLTAL ALAYGKWTGE
    4960 4970 4980 4990 5000
    SALLVNLEGH GREELFEDVD LSRTVGWFTS MYPLLIQLEP NTSSEDALAR
    5010 5020 5030 5040 5050
    VKEKLQQIPH KGLGYGLLRY MAQDPELVEK LKAIPQAPLS FNYLGQFHQA
    5060 5070 5080 5090 5100
    ADAKALLAYA EGERGANSGP DNRRTHLIDV VGAVTEGKLG LSFLYNGRLY
    5110 5120 5130 5140 5150
    SESHIETFAR HYTDALQSLI QAEKQSYRAE DFEDADLSQS ALNKVLARLK
    5160
    NRKGNELHGG SH
    Length:5,162
    Mass (Da):577,904
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26C1F1EBDEA75BDB
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ566197 Genomic DNA Translation: CAD92850.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ566197 Genomic DNA Translation: CAD92850.1

    3D structure databases

    SMRiQ70LM6
    ModBaseiSearch...

    Proteomic databases

    PRIDEiQ70LM6

    Family and domain databases

    Gene3Di1.10.1200.10, 4 hits
    3.30.559.10, 6 hits
    3.40.50.12780, 4 hits
    InterProiView protein in InterPro
    IPR010071, AA_adenyl_domain
    IPR036736, ACP-like_sf
    IPR025110, AMP-bd_C
    IPR020845, AMP-binding_CS
    IPR000873, AMP-dep_Synth/Lig
    IPR042099, AMP-dep_Synthh-like_sf
    IPR023213, CAT-like_dom_sf
    IPR001242, Condensatn
    IPR010060, NRPS_synth
    IPR020806, PKS_PP-bd
    IPR009081, PP-bd_ACP
    IPR006162, Ppantetheine_attach_site
    PfamiView protein in Pfam
    PF00501, AMP-binding, 4 hits
    PF13193, AMP-binding_C, 4 hits
    PF00668, Condensation, 6 hits
    PF00550, PP-binding, 4 hits
    SMARTiView protein in SMART
    SM00823, PKS_PP, 4 hits
    SUPFAMiSSF47336, SSF47336, 4 hits
    TIGRFAMsiTIGR01733, AA-adenyl-dom, 4 hits
    TIGR01720, NRPS-para261, 2 hits
    PROSITEiView protein in PROSITE
    PS00455, AMP_BINDING, 4 hits
    PS50075, CARRIER, 4 hits
    PS00012, PHOSPHOPANTETHEINE, 3 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLGRB_BREPA
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70LM6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2004
    Last modified: December 11, 2019
    This is version 66 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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