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UniProtKB - Q70LM6 (LGRB_BREPA)

Entry version 66 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Linear gramicidin synthase subunit B

Gene

lgrB

Organism
Brevibacillus parabrevis
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates the 3rd to 6th amino acids (Ala, D-Leu, Ala and D-Val) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 4th (D-Leu) and the 6th (D-Val) amino acids.

Miscellaneous

Linear gramicidin is a pentadecapeptide antibiotic produced during sporulation.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 4 phosphopantetheines covalently.Curated

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.2 mM for glycine
  2. KM=1.5 mM for alanine

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase, Ligase, Multifunctional enzyme
    Biological processAntibiotic biosynthesis

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Linear gramicidin synthase subunit B
    Including the following 5 domains:
    ATP-dependent D-leucine adenylase
    Short name:
    D-LeuA
    Alternative name(s):
    D-leucine activase
    Leucine racemase [ATP-hydrolyzing] (EC:5.1.1.-)
    ATP-dependent alanine adenylase
    Short name:
    AlaA
    Alternative name(s):
    Alanine activase
    ATP-dependent D-valine adenylase
    Short name:
    D-ValA
    Alternative name(s):
    D-valine activase
    Valine racemase [ATP-hydrolyzing] (EC:5.1.1.-)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:lgrB
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrevibacillus parabrevis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri54914 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Brevibacillus

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930901 – 5162Linear gramicidin synthase subunit BAdd BLAST5162

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei998O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
    Modified residuei2062O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
    Modified residuei3576O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
    Modified residuei4636O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

    Keywords - PTMi

    Phosphopantetheine, Phosphoprotein

    Proteomic databases

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q70LM6

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Large multienzyme complex composed of 4 subunits; LgrA, LgrB, LgrC and LgrD.

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q70LM6

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini963 – 1038Carrier 1PROSITE-ProRule annotationAdd BLAST76
    Domaini2027 – 2101Carrier 2PROSITE-ProRule annotationAdd BLAST75
    Domaini3541 – 3616Carrier 3PROSITE-ProRule annotationAdd BLAST76
    Domaini4601 – 4675Carrier 4PROSITE-ProRule annotationAdd BLAST75

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Four module-bearing peptide synthase with a C-terminal epimerization domain. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional).

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the ATP-dependent AMP-binding enzyme family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.1200.10, 4 hits
    3.30.559.10, 6 hits
    3.40.50.12780, 4 hits

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR010071, AA_adenyl_domain
    IPR036736, ACP-like_sf
    IPR025110, AMP-bd_C
    IPR020845, AMP-binding_CS
    IPR000873, AMP-dep_Synth/Lig
    IPR042099, AMP-dep_Synthh-like_sf
    IPR023213, CAT-like_dom_sf
    IPR001242, Condensatn
    IPR010060, NRPS_synth
    IPR020806, PKS_PP-bd
    IPR009081, PP-bd_ACP
    IPR006162, Ppantetheine_attach_site

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00501, AMP-binding, 4 hits
    PF13193, AMP-binding_C, 4 hits
    PF00668, Condensation, 6 hits
    PF00550, PP-binding, 4 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00823, PKS_PP, 4 hits

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF47336, SSF47336, 4 hits

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR01733, AA-adenyl-dom, 4 hits
    TIGR01720, NRPS-para261, 2 hits

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00455, AMP_BINDING, 4 hits
    PS50075, CARRIER, 4 hits
    PS00012, PHOSPHOPANTETHEINE, 3 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q70LM6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSRKKVDNIY PLTPMQEGML FHSLLDEGSE SYFEQMRFTI KGLIDPAILE 
            60         70         80         90        100
    QSLNALIERH DILRTVFLLE KVQKPRQIVL RERKTKVQVL DITHLSEGEQ 
           110        120        130        140        150
    AAYLEDFAQK DRQASFDLAK DVLIRLTLVR TSADTHTLFW SHHHILLDGW 
           160        170        180        190        200
    CIPIVLNDFF QIYQQRKGGL PVELGPVYPY STYISWLGEQ DAEEAKASWA 
           210        220        230        240        250
    EYISGYEPTS FIHKQGGKNS YRQAELVFAI EQGLTDSLNK LAKQLHVTLN 
           260        270        280        290        300
    NLFRAIWGLM LQRQCNTEDV VFGSVVSGRP SHLPNVEQMV GLFINTVPIR 
           310        320        330        340        350
    VQAGAEQTFS ELVKQVQQEA LSLAKYHYLS LADIQGNQQL IDHILLFQNY 
           360        370        380        390        400
    PMGQQFLTRL NQYNEEFTLT HLSAFEQTNY DLNVMVTPSD VITIKYIYNA 
           410        420        430        440        450
    AVFSEEQLLH ISRQLTTIMT QVTNAPDILL QKLEVVDPAE KQLQLHSFND 
           460        470        480        490        500
    TYRHYPTDKL IHQIFEERAE REPERIALVM GEQVLTYREL NEKANQLAKL 
           510        520        530        540        550
    LRARGIGPES MVSLLTERSA EMMIAILAIF KAGGAYLPID PSHPKERIEY 
           560        570        580        590        600
    ILQDSRSELL LVNHRFLGAV DFADRIIDLE AAEIYQGAAD NLECVSHANH 
           610        620        630        640        650
    LAYVIYTSGS TGKPKGVMIE HASLLNIIFA LQELYPLLEN DAYLLKTTYT 
           660        670        680        690        700
    FDVSVAEIFG WILGSGRLVI LDPGAEKEPA HIWETMVNHG VTHVNFVPSM 
           710        720        730        740        750
    LIPFVDYVRD QQQESPLRYI FAAGEAMPSE LVGKVYEALP GVILENIYGP 
           760        770        780        790        800
    TESTIYATKY SLAKDSQDVL VPIGKPLANI QTHIVNKHGQ LQPVGVPGEL 
           810        820        830        840        850
    CIAGASLARG YWNNEALTNE KFVPHPFAAG QRMYRTGDLA RYRQDGNIEY 
           860        870        880        890        900
    LGRIDHQVKI RGYRIELDEI RAQLIQEASI RDAVVIARTD HNGQAYLCAY 
           910        920        930        940        950
    FIADKQWTVN ALREALRQTL PDYMVPSHFI QMEEFPLTSS GKIDRKALPL 
           960        970        980        990       1000
    PDGRVHTGNV YLAPRNPVEE LVVRIWEEVL NVSQVGVHDN FFELGGHSLL 
          1010       1020       1030       1040       1050
    ATQVLSRTAK LFHVRLPMRE IFTHQTVAEL ARRIQALRHG AEADKHSPIQ 
          1060       1070       1080       1090       1100
    PSALQRADEL PLSYAQQRLW FLDRLIPDSA MYNIPVGFRL RGTVDELVLE 
          1110       1120       1130       1140       1150
    RALNEIIQRH ESLRTTFVDV DGRALQVIHT DVHLSLGVTD LRDKPAAAKD 
          1160       1170       1180       1190       1200
    AEWKQMAEED AATPFRLDQW PLLRAMLIRL EEQESVLWLN VHHIISDGWS 
          1210       1220       1230       1240       1250
    MDVLVNELSE VYETLLKGEA LPLAALPIQY RDYAVWQREK SQDDVWKEQL 
          1260       1270       1280       1290       1300
    RYWKNKLDGS EPLLPLPTDR PRAVVQSYRG DHLSFYVPGE VGQKLRELGR 
          1310       1320       1330       1340       1350
    QEGATLFMTL LAAFKSFLYR YTHANDILIG TPVAGRNRQE IENLIGFFVN 
          1360       1370       1380       1390       1400
    MLVLRTDLSD DPTFVELLRR VRETAFDAFA NEDVPFEKLV DELQIERSLS 
          1410       1420       1430       1440       1450
    YSPLFQVLFA VQGMSTGVRE GETLAIAPDE VTLNQTTKFD LTLTMIEAAD 
          1460       1470       1480       1490       1500
    NGLKGVFEYS TDLFDRTTIE RMAEHFGNLL QAIAADPGQK IVELPLLGGA 
          1510       1520       1530       1540       1550
    EQSRMLVEWN QTDVAYSLDL LVHERVARIA QELPEQFAVI GEQGALTYAQ 
          1560       1570       1580       1590       1600
    LDAKANQLAH ALLKRGIGSE DLVGICVERS SEMQIGQLAI LKAGAAYVPM 
          1610       1620       1630       1640       1650
    DPAYPRERLA FMIKDAGMSL VLTQERLLDA LPQEAAALLC LDRDWQEIAA 
          1660       1670       1680       1690       1700
    ESTAAPAIKT NADQLAYVIY TSGSTGTPKG VEIEHGSLLN LVNWHQRAYS 
          1710       1720       1730       1740       1750
    VSAEDRASQI AGTAFDASVW ETWPYLTAGA TICQPREEIR LSPEKLRDWL 
          1760       1770       1780       1790       1800
    VETGITISFL PTPLAENLLP LPWPTGAALR YMLTGGDTLH QYPTADVPFT 
          1810       1820       1830       1840       1850
    LVNQYGPTEN TVVATAGAVP VLGERESAPT IGRPIDNVSV YVLDENRQPV 
          1860       1870       1880       1890       1900
    PVGVVGELYI GGKSLARGYR NRPDLTEASF VPNPFSPIEG ARMYRTGDLV 
          1910       1920       1930       1940       1950
    RYAADGSIEF IGRADDQVSI RGFRVELGEI ESALYAHPAV AESVVIVRED 
          1960       1970       1980       1990       2000
    VTPGVKRLVA YAVLHEGEER QTSELRQSLK EMLPDYMVPS AIVLMEALPL 
          2010       2020       2030       2040       2050
    TPNGKVDRRA LPLPDVAQTE WEGSFVEPQS DVERKLAEIW QEVLGVETIG 
          2060       2070       2080       2090       2100
    VHDNFFELGG DSILTIQIVS RANQAGLQLT PKHLFDAQTL AELAASAVVL 
          2110       2120       2130       2140       2150
    EKAPEMQAEQ GIVTGELPLT PIQTWFFEQD VRHVHHWNQS VMLAVREELD 
          2160       2170       2180       2190       2200
    MTALTQAFAA LPRQHDALRL RFQQVNGTWQ AAHGEIADED VLLVADLSSV 
          2210       2220       2230       2240       2250
    PEAEREARMR HITDELQASL DIEKGPLHRA AYFQLGAEQR LFIVIHHLVV 
          2260       2270       2280       2290       2300
    DGVSWRIILE DLQTAYEQVK AGQKIAWPQK TTSFKSWAEE LTTYAEQSAV 
          2310       2320       2330       2340       2350
    DEYWTGMDSE QACGLPVDHP QGKNTEGLAV QVKAKLSADE TRALLQEVPA 
          2360       2370       2380       2390       2400
    AYRTQINDVL LSALTRTITD WTNKRALYVS VEGHGREPIV DGVDVSRTVG 
          2410       2420       2430       2440       2450
    WFTSLYPVLL ETEPDLAWGD LLKSIKEQVR AIPDKGIGYG IHRYLSRDGQ 
          2460       2470       2480       2490       2500
    TAEMLRAKPQ PEISFNYLGQ FGQGQTTDAA LFQIIPNWSA SNVSEDETRL 
          2510       2520       2530       2540       2550
    YKLDVMSMVA QDQLEMSWTF SRDLYEPGTI EKLAHDYVQA LRAIIAHCRT 
          2560       2570       2580       2590       2600
    EQAGGYTPSD FPLAELDQNS LDKFIGHNRL IENVYTLTPL QEGMLFHSLY 
          2610       2620       2630       2640       2650
    EQAGGDYVVQ LALKLEHVNV EAFSAAWQKV VERHAILRTS FLWSGLEKPH 
          2660       2670       2680       2690       2700
    QVVHAKVKTF VERLDWRHLT AAEQEAGLQT YLEQDRKRGF DLARPPLMRW 
          2710       2720       2730       2740       2750
    TLIRLDASTF QFVWSFHHML LDGWSTPIVF QDWQAFYAAA SHGKEASLPA 
          2760       2770       2780       2790       2800
    IPPFSAYIAW LKRQNLEEAQ QYWRDYLQGF GVPTPLGMGK SGGSAGQPKE 
          2810       2820       2830       2840       2850
    YADHKLLLSE RATANLLAFA RKHQLTLNTV VQGAWALILA RYAGEAEVVF 
          2860       2870       2880       2890       2900
    GTTNLGRPTD LPDAEAMVGL FINTLPVRVL FPEQTTVIDW LQSLQQAQSE 
          2910       2920       2930       2940       2950
    MRQYEFTPLV DIQSWSEVPR GQSLFDSIFV FENYLSGTSV DSESGMLLGE 
          2960       2970       2980       2990       3000
    VKAVEQTSYP LTLVVAPGEE LMLKLIYETG RFEQPAMDKV LAQLSSVLEA 
          3010       3020       3030       3040       3050
    IMREPHEQLA DLSIITEAER HKLLVEWNAT DMPYERNLVM HQLFEAQVEA 
          3060       3070       3080       3090       3100
    TPDAQALVVG TERLTYAELN KRANQLAHYL RAQGVGPEVL VAVLMERTTE 
          3110       3120       3130       3140       3150
    MIVALLGIIK AGGAYVPIDP AYPQDRIGYT LDDSQAAIVL TQERLLPMLP 
          3160       3170       3180       3190       3200
    EHTAQVICLD RDWACMAVQP EANVPNLAAP TNLSYVIYTS GSTGLPKGVA 
          3210       3220       3230       3240       3250
    IQHSSVIAFI FWAKTVFSAE EMSGVLASTS ICFDLSVYEI FVTLSCGGKV 
          3260       3270       3280       3290       3300
    ILADNALHLP SLPAAKEVTL INTVPSAAKE LVRMNAIPPS VRVVNLAGEP 
          3310       3320       3330       3340       3350
    LPNTLAQSLY ALGHVQKVFN LYGPSEDTTY STYVQVTKGA KTEPTIGRPL 
          3360       3370       3380       3390       3400
    ANTQAYVLDA KLQPVPLGLP GELYLGGDGL ARGYLKRPKM TAERFLPNPF 
          3410       3420       3430       3440       3450
    HPDPDARMYS TGDLVRYLPD GQLEYLGRID HQVKIRGYRI ELGELEAVLR 
          3460       3470       3480       3490       3500
    SHPQIKEAVV VAKEDKLGEK RLVAYITTKD GECGDRAVLT SWAKAKLPEF 
          3510       3520       3530       3540       3550
    MVPSFFVWLD AMPLTPNGKI DRKQLPEPEW GQVASAAGYV APRNQTEVLV 
          3560       3570       3580       3590       3600
    ASIWADVLGI EQVGVHDNFF ELGGHSLLAT RVASRLRETF AKEVPIRAIF 
          3610       3620       3630       3640       3650
    ERPTVAELSE TLGAIGQNET EAQMLPVSRE AHLPLSFAQQ RLWFLDRLMP 
          3660       3670       3680       3690       3700
    DSTLYNIPSA VRLLGDLDIA AWEKSLQVLI QRHESLRTTF GDVDGEAVQV 
          3710       3720       3730       3740       3750
    IHSRLDGKLN VIDLRGMPAD EREAEAHRLA GLEAATPFDL SQGPLLRTTL 
          3760       3770       3780       3790       3800
    IRLAEQECVF LFNLHHIIFD GWSIGIFLKE MRALYEAFVR EEAPELAEIT 
          3810       3820       3830       3840       3850
    VQYADYAVWQ RKWLEGEVLA EQLAYWKEKL SGAEPLLALP TDQPRPAVQT 
          3860       3870       3880       3890       3900
    HDGAMHTIKL SGELYAKLNK LSQEEGATLF MTLLAAFQVL LYRYSGQEDI 
          3910       3920       3930       3940       3950
    LVGSPVAGRN RQETEPLIGF FINTLVLRTD LSGEPTFREL LARVRETAFE 
          3960       3970       3980       3990       4000
    AYAHQDLPFE KLVDELELER SLSYSPLFQV MFVLQNFQLN LDEKAGIRVA 
          4010       4020       4030       4040       4050
    DFEMDKHLVT SKYDLTLTMA EKQNGLFATF EYNTALFHEA TMERLSQHFI 
          4060       4070       4080       4090       4100
    QLLEAIVHMP DQGIARLPLL NQSERAQLLV EWNDTTTAYP RNKRVDQLFR 
          4110       4120       4130       4140       4150
    ETALLYPERL AVVAGNQTLT YAELERRANQ TANYLQQKGV RPGALVGLCV 
          4160       4170       4180       4190       4200
    KRSLEMLIGM LGILKAGGAY VPLDPDYPEE RLAYMMGDAG ITVLLTQEQL 
          4210       4220       4230       4240       4250
    MPGLPSGERT TIALDRDWPL IAKESEQAPD VDTTAESLAY VIYTSGSTGL 
          4260       4270       4280       4290       4300
    PKGTLVVHRG IVRLVKETDY VTITEQDVFL QASTVSFDAA TFEIWGSLLN 
          4310       4320       4330       4340       4350
    GAKLVLLPPE LPSLAEIGQA IQSHHVTTLW LTAGLFTLMV DHHKEYLSGV 
          4360       4370       4380       4390       4400
    RQLLVGGDIV SVPHVKKALE IAGLTVINGY GPTENTTFTC CNPVTVMPES 
          4410       4420       4430       4440       4450
    AHTFPIGRPI KNTTAYVLDR HMQPVPIGVT GELYIGGDGL AEGYLNRPDL 
          4460       4470       4480       4490       4500
    TAERFVPNPF ATDQAARLYR TGDLVRYLPD GLIEFIGRLD NQVKIRGFRI 
          4510       4520       4530       4540       4550
    ELSEVEAVLA KHPAITASVV IVHENEAGMK QLVAYAVKDA EQELGTAELR 
          4560       4570       4580       4590       4600
    QHFKAHVPDY MVPAAFVMLD ALPLTPNGKV DRKALPAPVL ERSREEDAFA 
          4610       4620       4630       4640       4650
    AATSHVEQTL ADIWCAVLRM DRIGIHDNFF ELGGDSILSI QIVARANKAG 
          4660       4670       4680       4690       4700
    IHLTPKQLFD QQTIAELAKV AGQSTKVDAE QGNVTGEVPL LPIQTWFFEQ 
          4710       4720       4730       4740       4750
    KQPTPHHWNQ SMLLQVNEPL EEECLSQAVA QLLAHHDALR LRYTFADGQW 
          4760       4770       4780       4790       4800
    KQTYADVDSE VPLQVEDLSM SPPAQQARKI EKLAQQAQAS LDLQNGPLLK 
          4810       4820       4830       4840       4850
    VVYFDLGYDR PGRLLMVIHH LAVDGVSWRI LIEDLQTAYG QAEKGNKIQL 
          4860       4870       4880       4890       4900
    PPKTTSYKAW AEKLHKYASS ERMLVDQDYW LKAADELSGH PLPVHDWAEN 
          4910       4920       4930       4940       4950
    TEANGRMWTI HLEEEETDAL LQKVPSRYRV QINDILLTAL ALAYGKWTGE 
          4960       4970       4980       4990       5000
    SALLVNLEGH GREELFEDVD LSRTVGWFTS MYPLLIQLEP NTSSEDALAR 
          5010       5020       5030       5040       5050
    VKEKLQQIPH KGLGYGLLRY MAQDPELVEK LKAIPQAPLS FNYLGQFHQA 
          5060       5070       5080       5090       5100
    ADAKALLAYA EGERGANSGP DNRRTHLIDV VGAVTEGKLG LSFLYNGRLY 
          5110       5120       5130       5140       5150
    SESHIETFAR HYTDALQSLI QAEKQSYRAE DFEDADLSQS ALNKVLARLK 
          5160 
    NRKGNELHGG SH
    Length:5,162
    Mass (Da):577,904
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26C1F1EBDEA75BDB
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AJ566197 Genomic DNA Translation: CAD92850.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AJ566197 Genomic DNA Translation: CAD92850.1

    3D structure databases

    SMRiQ70LM6
    ModBaseiSearch...

    Proteomic databases

    PRIDEiQ70LM6

    Family and domain databases

    Gene3Di1.10.1200.10, 4 hits
    3.30.559.10, 6 hits
    3.40.50.12780, 4 hits
    InterProiView protein in InterPro
    IPR010071, AA_adenyl_domain
    IPR036736, ACP-like_sf
    IPR025110, AMP-bd_C
    IPR020845, AMP-binding_CS
    IPR000873, AMP-dep_Synth/Lig
    IPR042099, AMP-dep_Synthh-like_sf
    IPR023213, CAT-like_dom_sf
    IPR001242, Condensatn
    IPR010060, NRPS_synth
    IPR020806, PKS_PP-bd
    IPR009081, PP-bd_ACP
    IPR006162, Ppantetheine_attach_site
    PfamiView protein in Pfam
    PF00501, AMP-binding, 4 hits
    PF13193, AMP-binding_C, 4 hits
    PF00668, Condensation, 6 hits
    PF00550, PP-binding, 4 hits
    SMARTiView protein in SMART
    SM00823, PKS_PP, 4 hits
    SUPFAMiSSF47336, SSF47336, 4 hits
    TIGRFAMsiTIGR01733, AA-adenyl-dom, 4 hits
    TIGR01720, NRPS-para261, 2 hits
    PROSITEiView protein in PROSITE
    PS00455, AMP_BINDING, 4 hits
    PS50075, CARRIER, 4 hits
    PS00012, PHOSPHOPANTETHEINE, 3 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLGRB_BREPA
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70LM6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2004
    Last modified: December 11, 2019
    This is version 66 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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