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UniProtKB - Q70LM6 (LGRB_BREPA)
Protein
Linear gramicidin synthase subunit B
Gene
lgrB
Organism
Brevibacillus parabrevis
Status
Functioni
Activates the 3rd to 6th amino acids (Ala, D-Leu, Ala and D-Val) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 4th (D-Leu) and the 6th (D-Val) amino acids.
Miscellaneous
Linear gramicidin is a pentadecapeptide antibiotic produced during sporulation.
Cofactori
pantetheine 4'-phosphateCuratedNote: Binds 4 phosphopantetheines covalently.Curated
Kineticsi
- KM=2.2 mM for glycine
- KM=1.5 mM for alanine
GO - Molecular functioni
- isomerase activity Source: UniProtKB-KW
- ligase activity Source: UniProtKB-KW
- phosphopantetheine binding Source: InterPro
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase, Ligase, Multifunctional enzyme |
Biological process | Antibiotic biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Linear gramicidin synthase subunit BIncluding the following 5 domains: ATP-dependent D-leucine adenylase Short name: D-LeuA Alternative name(s): D-leucine activase Leucine racemase [ATP-hydrolyzing] (EC:5.1.1.-) ATP-dependent alanine adenylase Short name: AlaA Alternative name(s): Alanine activase ATP-dependent D-valine adenylase Short name: D-ValA Alternative name(s): D-valine activase Valine racemase [ATP-hydrolyzing] (EC:5.1.1.-) |
Gene namesi | Name:lgrB |
Organismi | Brevibacillus parabrevis |
Taxonomic identifieri | 54914 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Brevibacillus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193090 | 1 – 5162 | Linear gramicidin synthase subunit BAdd BLAST | 5162 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 998 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 2062 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 3576 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 4636 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PRIDEi | Q70LM6 |
Interactioni
Subunit structurei
Large multienzyme complex composed of 4 subunits; LgrA, LgrB, LgrC and LgrD.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 963 – 1038 | Carrier 1PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 2027 – 2101 | Carrier 2PROSITE-ProRule annotationAdd BLAST | 75 | |
Domaini | 3541 – 3616 | Carrier 3PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 4601 – 4675 | Carrier 4PROSITE-ProRule annotationAdd BLAST | 75 |
Domaini
Four module-bearing peptide synthase with a C-terminal epimerization domain. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional).
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Keywords - Domaini
RepeatFamily and domain databases
Gene3Di | 1.10.1200.10, 4 hits 3.30.300.30, 4 hits 3.30.559.10, 6 hits |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR010060, NRPS_synth IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00501, AMP-binding, 4 hits PF13193, AMP-binding_C, 4 hits PF00668, Condensation, 6 hits PF00550, PP-binding, 4 hits |
SMARTi | View protein in SMART SM00823, PKS_PP, 4 hits |
SUPFAMi | SSF47336, SSF47336, 4 hits |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 4 hits TIGR01720, NRPS-para261, 2 hits |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 4 hits PS50075, CARRIER, 4 hits PS00012, PHOSPHOPANTETHEINE, 3 hits |
i Sequence
Sequence statusi: Complete.
Q70LM6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRKKVDNIY PLTPMQEGML FHSLLDEGSE SYFEQMRFTI KGLIDPAILE
60 70 80 90 100
QSLNALIERH DILRTVFLLE KVQKPRQIVL RERKTKVQVL DITHLSEGEQ
110 120 130 140 150
AAYLEDFAQK DRQASFDLAK DVLIRLTLVR TSADTHTLFW SHHHILLDGW
160 170 180 190 200
CIPIVLNDFF QIYQQRKGGL PVELGPVYPY STYISWLGEQ DAEEAKASWA
210 220 230 240 250
EYISGYEPTS FIHKQGGKNS YRQAELVFAI EQGLTDSLNK LAKQLHVTLN
260 270 280 290 300
NLFRAIWGLM LQRQCNTEDV VFGSVVSGRP SHLPNVEQMV GLFINTVPIR
310 320 330 340 350
VQAGAEQTFS ELVKQVQQEA LSLAKYHYLS LADIQGNQQL IDHILLFQNY
360 370 380 390 400
PMGQQFLTRL NQYNEEFTLT HLSAFEQTNY DLNVMVTPSD VITIKYIYNA
410 420 430 440 450
AVFSEEQLLH ISRQLTTIMT QVTNAPDILL QKLEVVDPAE KQLQLHSFND
460 470 480 490 500
TYRHYPTDKL IHQIFEERAE REPERIALVM GEQVLTYREL NEKANQLAKL
510 520 530 540 550
LRARGIGPES MVSLLTERSA EMMIAILAIF KAGGAYLPID PSHPKERIEY
560 570 580 590 600
ILQDSRSELL LVNHRFLGAV DFADRIIDLE AAEIYQGAAD NLECVSHANH
610 620 630 640 650
LAYVIYTSGS TGKPKGVMIE HASLLNIIFA LQELYPLLEN DAYLLKTTYT
660 670 680 690 700
FDVSVAEIFG WILGSGRLVI LDPGAEKEPA HIWETMVNHG VTHVNFVPSM
710 720 730 740 750
LIPFVDYVRD QQQESPLRYI FAAGEAMPSE LVGKVYEALP GVILENIYGP
760 770 780 790 800
TESTIYATKY SLAKDSQDVL VPIGKPLANI QTHIVNKHGQ LQPVGVPGEL
810 820 830 840 850
CIAGASLARG YWNNEALTNE KFVPHPFAAG QRMYRTGDLA RYRQDGNIEY
860 870 880 890 900
LGRIDHQVKI RGYRIELDEI RAQLIQEASI RDAVVIARTD HNGQAYLCAY
910 920 930 940 950
FIADKQWTVN ALREALRQTL PDYMVPSHFI QMEEFPLTSS GKIDRKALPL
960 970 980 990 1000
PDGRVHTGNV YLAPRNPVEE LVVRIWEEVL NVSQVGVHDN FFELGGHSLL
1010 1020 1030 1040 1050
ATQVLSRTAK LFHVRLPMRE IFTHQTVAEL ARRIQALRHG AEADKHSPIQ
1060 1070 1080 1090 1100
PSALQRADEL PLSYAQQRLW FLDRLIPDSA MYNIPVGFRL RGTVDELVLE
1110 1120 1130 1140 1150
RALNEIIQRH ESLRTTFVDV DGRALQVIHT DVHLSLGVTD LRDKPAAAKD
1160 1170 1180 1190 1200
AEWKQMAEED AATPFRLDQW PLLRAMLIRL EEQESVLWLN VHHIISDGWS
1210 1220 1230 1240 1250
MDVLVNELSE VYETLLKGEA LPLAALPIQY RDYAVWQREK SQDDVWKEQL
1260 1270 1280 1290 1300
RYWKNKLDGS EPLLPLPTDR PRAVVQSYRG DHLSFYVPGE VGQKLRELGR
1310 1320 1330 1340 1350
QEGATLFMTL LAAFKSFLYR YTHANDILIG TPVAGRNRQE IENLIGFFVN
1360 1370 1380 1390 1400
MLVLRTDLSD DPTFVELLRR VRETAFDAFA NEDVPFEKLV DELQIERSLS
1410 1420 1430 1440 1450
YSPLFQVLFA VQGMSTGVRE GETLAIAPDE VTLNQTTKFD LTLTMIEAAD
1460 1470 1480 1490 1500
NGLKGVFEYS TDLFDRTTIE RMAEHFGNLL QAIAADPGQK IVELPLLGGA
1510 1520 1530 1540 1550
EQSRMLVEWN QTDVAYSLDL LVHERVARIA QELPEQFAVI GEQGALTYAQ
1560 1570 1580 1590 1600
LDAKANQLAH ALLKRGIGSE DLVGICVERS SEMQIGQLAI LKAGAAYVPM
1610 1620 1630 1640 1650
DPAYPRERLA FMIKDAGMSL VLTQERLLDA LPQEAAALLC LDRDWQEIAA
1660 1670 1680 1690 1700
ESTAAPAIKT NADQLAYVIY TSGSTGTPKG VEIEHGSLLN LVNWHQRAYS
1710 1720 1730 1740 1750
VSAEDRASQI AGTAFDASVW ETWPYLTAGA TICQPREEIR LSPEKLRDWL
1760 1770 1780 1790 1800
VETGITISFL PTPLAENLLP LPWPTGAALR YMLTGGDTLH QYPTADVPFT
1810 1820 1830 1840 1850
LVNQYGPTEN TVVATAGAVP VLGERESAPT IGRPIDNVSV YVLDENRQPV
1860 1870 1880 1890 1900
PVGVVGELYI GGKSLARGYR NRPDLTEASF VPNPFSPIEG ARMYRTGDLV
1910 1920 1930 1940 1950
RYAADGSIEF IGRADDQVSI RGFRVELGEI ESALYAHPAV AESVVIVRED
1960 1970 1980 1990 2000
VTPGVKRLVA YAVLHEGEER QTSELRQSLK EMLPDYMVPS AIVLMEALPL
2010 2020 2030 2040 2050
TPNGKVDRRA LPLPDVAQTE WEGSFVEPQS DVERKLAEIW QEVLGVETIG
2060 2070 2080 2090 2100
VHDNFFELGG DSILTIQIVS RANQAGLQLT PKHLFDAQTL AELAASAVVL
2110 2120 2130 2140 2150
EKAPEMQAEQ GIVTGELPLT PIQTWFFEQD VRHVHHWNQS VMLAVREELD
2160 2170 2180 2190 2200
MTALTQAFAA LPRQHDALRL RFQQVNGTWQ AAHGEIADED VLLVADLSSV
2210 2220 2230 2240 2250
PEAEREARMR HITDELQASL DIEKGPLHRA AYFQLGAEQR LFIVIHHLVV
2260 2270 2280 2290 2300
DGVSWRIILE DLQTAYEQVK AGQKIAWPQK TTSFKSWAEE LTTYAEQSAV
2310 2320 2330 2340 2350
DEYWTGMDSE QACGLPVDHP QGKNTEGLAV QVKAKLSADE TRALLQEVPA
2360 2370 2380 2390 2400
AYRTQINDVL LSALTRTITD WTNKRALYVS VEGHGREPIV DGVDVSRTVG
2410 2420 2430 2440 2450
WFTSLYPVLL ETEPDLAWGD LLKSIKEQVR AIPDKGIGYG IHRYLSRDGQ
2460 2470 2480 2490 2500
TAEMLRAKPQ PEISFNYLGQ FGQGQTTDAA LFQIIPNWSA SNVSEDETRL
2510 2520 2530 2540 2550
YKLDVMSMVA QDQLEMSWTF SRDLYEPGTI EKLAHDYVQA LRAIIAHCRT
2560 2570 2580 2590 2600
EQAGGYTPSD FPLAELDQNS LDKFIGHNRL IENVYTLTPL QEGMLFHSLY
2610 2620 2630 2640 2650
EQAGGDYVVQ LALKLEHVNV EAFSAAWQKV VERHAILRTS FLWSGLEKPH
2660 2670 2680 2690 2700
QVVHAKVKTF VERLDWRHLT AAEQEAGLQT YLEQDRKRGF DLARPPLMRW
2710 2720 2730 2740 2750
TLIRLDASTF QFVWSFHHML LDGWSTPIVF QDWQAFYAAA SHGKEASLPA
2760 2770 2780 2790 2800
IPPFSAYIAW LKRQNLEEAQ QYWRDYLQGF GVPTPLGMGK SGGSAGQPKE
2810 2820 2830 2840 2850
YADHKLLLSE RATANLLAFA RKHQLTLNTV VQGAWALILA RYAGEAEVVF
2860 2870 2880 2890 2900
GTTNLGRPTD LPDAEAMVGL FINTLPVRVL FPEQTTVIDW LQSLQQAQSE
2910 2920 2930 2940 2950
MRQYEFTPLV DIQSWSEVPR GQSLFDSIFV FENYLSGTSV DSESGMLLGE
2960 2970 2980 2990 3000
VKAVEQTSYP LTLVVAPGEE LMLKLIYETG RFEQPAMDKV LAQLSSVLEA
3010 3020 3030 3040 3050
IMREPHEQLA DLSIITEAER HKLLVEWNAT DMPYERNLVM HQLFEAQVEA
3060 3070 3080 3090 3100
TPDAQALVVG TERLTYAELN KRANQLAHYL RAQGVGPEVL VAVLMERTTE
3110 3120 3130 3140 3150
MIVALLGIIK AGGAYVPIDP AYPQDRIGYT LDDSQAAIVL TQERLLPMLP
3160 3170 3180 3190 3200
EHTAQVICLD RDWACMAVQP EANVPNLAAP TNLSYVIYTS GSTGLPKGVA
3210 3220 3230 3240 3250
IQHSSVIAFI FWAKTVFSAE EMSGVLASTS ICFDLSVYEI FVTLSCGGKV
3260 3270 3280 3290 3300
ILADNALHLP SLPAAKEVTL INTVPSAAKE LVRMNAIPPS VRVVNLAGEP
3310 3320 3330 3340 3350
LPNTLAQSLY ALGHVQKVFN LYGPSEDTTY STYVQVTKGA KTEPTIGRPL
3360 3370 3380 3390 3400
ANTQAYVLDA KLQPVPLGLP GELYLGGDGL ARGYLKRPKM TAERFLPNPF
3410 3420 3430 3440 3450
HPDPDARMYS TGDLVRYLPD GQLEYLGRID HQVKIRGYRI ELGELEAVLR
3460 3470 3480 3490 3500
SHPQIKEAVV VAKEDKLGEK RLVAYITTKD GECGDRAVLT SWAKAKLPEF
3510 3520 3530 3540 3550
MVPSFFVWLD AMPLTPNGKI DRKQLPEPEW GQVASAAGYV APRNQTEVLV
3560 3570 3580 3590 3600
ASIWADVLGI EQVGVHDNFF ELGGHSLLAT RVASRLRETF AKEVPIRAIF
3610 3620 3630 3640 3650
ERPTVAELSE TLGAIGQNET EAQMLPVSRE AHLPLSFAQQ RLWFLDRLMP
3660 3670 3680 3690 3700
DSTLYNIPSA VRLLGDLDIA AWEKSLQVLI QRHESLRTTF GDVDGEAVQV
3710 3720 3730 3740 3750
IHSRLDGKLN VIDLRGMPAD EREAEAHRLA GLEAATPFDL SQGPLLRTTL
3760 3770 3780 3790 3800
IRLAEQECVF LFNLHHIIFD GWSIGIFLKE MRALYEAFVR EEAPELAEIT
3810 3820 3830 3840 3850
VQYADYAVWQ RKWLEGEVLA EQLAYWKEKL SGAEPLLALP TDQPRPAVQT
3860 3870 3880 3890 3900
HDGAMHTIKL SGELYAKLNK LSQEEGATLF MTLLAAFQVL LYRYSGQEDI
3910 3920 3930 3940 3950
LVGSPVAGRN RQETEPLIGF FINTLVLRTD LSGEPTFREL LARVRETAFE
3960 3970 3980 3990 4000
AYAHQDLPFE KLVDELELER SLSYSPLFQV MFVLQNFQLN LDEKAGIRVA
4010 4020 4030 4040 4050
DFEMDKHLVT SKYDLTLTMA EKQNGLFATF EYNTALFHEA TMERLSQHFI
4060 4070 4080 4090 4100
QLLEAIVHMP DQGIARLPLL NQSERAQLLV EWNDTTTAYP RNKRVDQLFR
4110 4120 4130 4140 4150
ETALLYPERL AVVAGNQTLT YAELERRANQ TANYLQQKGV RPGALVGLCV
4160 4170 4180 4190 4200
KRSLEMLIGM LGILKAGGAY VPLDPDYPEE RLAYMMGDAG ITVLLTQEQL
4210 4220 4230 4240 4250
MPGLPSGERT TIALDRDWPL IAKESEQAPD VDTTAESLAY VIYTSGSTGL
4260 4270 4280 4290 4300
PKGTLVVHRG IVRLVKETDY VTITEQDVFL QASTVSFDAA TFEIWGSLLN
4310 4320 4330 4340 4350
GAKLVLLPPE LPSLAEIGQA IQSHHVTTLW LTAGLFTLMV DHHKEYLSGV
4360 4370 4380 4390 4400
RQLLVGGDIV SVPHVKKALE IAGLTVINGY GPTENTTFTC CNPVTVMPES
4410 4420 4430 4440 4450
AHTFPIGRPI KNTTAYVLDR HMQPVPIGVT GELYIGGDGL AEGYLNRPDL
4460 4470 4480 4490 4500
TAERFVPNPF ATDQAARLYR TGDLVRYLPD GLIEFIGRLD NQVKIRGFRI
4510 4520 4530 4540 4550
ELSEVEAVLA KHPAITASVV IVHENEAGMK QLVAYAVKDA EQELGTAELR
4560 4570 4580 4590 4600
QHFKAHVPDY MVPAAFVMLD ALPLTPNGKV DRKALPAPVL ERSREEDAFA
4610 4620 4630 4640 4650
AATSHVEQTL ADIWCAVLRM DRIGIHDNFF ELGGDSILSI QIVARANKAG
4660 4670 4680 4690 4700
IHLTPKQLFD QQTIAELAKV AGQSTKVDAE QGNVTGEVPL LPIQTWFFEQ
4710 4720 4730 4740 4750
KQPTPHHWNQ SMLLQVNEPL EEECLSQAVA QLLAHHDALR LRYTFADGQW
4760 4770 4780 4790 4800
KQTYADVDSE VPLQVEDLSM SPPAQQARKI EKLAQQAQAS LDLQNGPLLK
4810 4820 4830 4840 4850
VVYFDLGYDR PGRLLMVIHH LAVDGVSWRI LIEDLQTAYG QAEKGNKIQL
4860 4870 4880 4890 4900
PPKTTSYKAW AEKLHKYASS ERMLVDQDYW LKAADELSGH PLPVHDWAEN
4910 4920 4930 4940 4950
TEANGRMWTI HLEEEETDAL LQKVPSRYRV QINDILLTAL ALAYGKWTGE
4960 4970 4980 4990 5000
SALLVNLEGH GREELFEDVD LSRTVGWFTS MYPLLIQLEP NTSSEDALAR
5010 5020 5030 5040 5050
VKEKLQQIPH KGLGYGLLRY MAQDPELVEK LKAIPQAPLS FNYLGQFHQA
5060 5070 5080 5090 5100
ADAKALLAYA EGERGANSGP DNRRTHLIDV VGAVTEGKLG LSFLYNGRLY
5110 5120 5130 5140 5150
SESHIETFAR HYTDALQSLI QAEKQSYRAE DFEDADLSQS ALNKVLARLK
5160
NRKGNELHGG SH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ566197 Genomic DNA Translation: CAD92850.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ566197 Genomic DNA Translation: CAD92850.1 |
3D structure databases
SMRi | Q70LM6 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q70LM6 |
Family and domain databases
Gene3Di | 1.10.1200.10, 4 hits 3.30.300.30, 4 hits 3.30.559.10, 6 hits |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR010060, NRPS_synth IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00501, AMP-binding, 4 hits PF13193, AMP-binding_C, 4 hits PF00668, Condensation, 6 hits PF00550, PP-binding, 4 hits |
SMARTi | View protein in SMART SM00823, PKS_PP, 4 hits |
SUPFAMi | SSF47336, SSF47336, 4 hits |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 4 hits TIGR01720, NRPS-para261, 2 hits |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 4 hits PS50075, CARRIER, 4 hits PS00012, PHOSPHOPANTETHEINE, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LGRB_BREPA | |
Accessioni | Q70LM6Primary (citable) accession number: Q70LM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |