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Entry version 67 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Linear gramicidin synthase subunit C

Gene

lgrC

Organism
Brevibacillus parabrevis
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D-Leu) and 12th (D-Leu) amino acids. The 11th (Xaa) amino acid is Trp in linear gramicidin A; Phe in linear gramicidin B and Tyr in linear gramicidin C.

Miscellaneous

Linear gramicidin is a pentadecapeptide antibiotic produced during sporulation.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 6 phosphopantetheines covalently.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase, Multifunctional enzyme
Biological processAntibiotic biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Linear gramicidin synthase subunit C
Including the following 5 domains:
ATP-dependent valine adenylase
Short name:
ValA
Alternative name(s):
Valine activase
ATP-dependent D-valine adenylase
Short name:
D-ValA
Alternative name(s):
D-valine activase
Valine racemase [ATP-hydrolyzing] (EC:5.1.1.-)
ATP-dependent tryptophan adenylase
Short name:
TrpA
Alternative name(s):
Tryptophan activase
ATP-dependent tryptophan/phenylalanine/tyrosine adenylase
Short name:
Trp/Phe/TyrA
Alternative name(s):
Tryptophan/phenylalanine/tyrosine activase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lgrC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrevibacillus parabrevis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri54914 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930911 – 7756Linear gramicidin synthase subunit CAdd BLAST7756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1012O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2077O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3592O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4656O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei6176O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei7235O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q70LM5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Large multienzyme complex composed of 4 subunits; LgrA, LgrB, LgrC and LgrD.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q70LM5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini977 – 1052Carrier 1PROSITE-ProRule annotationAdd BLAST76
Domaini2042 – 2116Carrier 2PROSITE-ProRule annotationAdd BLAST75
Domaini3557 – 3632Carrier 3PROSITE-ProRule annotationAdd BLAST76
Domaini4621 – 4695Carrier 4PROSITE-ProRule annotationAdd BLAST75
Domaini6141 – 6216Carrier 5PROSITE-ProRule annotationAdd BLAST76
Domaini7200 – 7274Carrier 6PROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Six module-bearing peptide synthase with a C-terminal epimerization domain. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 6 hits
3.30.559.10, 9 hits
3.40.50.12780, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 6 hits
PF13193, AMP-binding_C, 6 hits
PF00668, Condensation, 9 hits
PF00550, PP-binding, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 6 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 6 hits
TIGR01720, NRPS-para261, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 6 hits
PS50075, CARRIER, 6 hits
PS00012, PHOSPHOPANTETHEINE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q70LM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSMGDLTDL YTLTPLQEGM LFHSLYSEGS AYMIQTTAIL TGELDIVPFE
60 70 80 90 100
KAWKKVIQRH SILRTGFIWE ETEKPLQAVF ESVPFSIRQK DWSSYGSDEQ
110 120 130 140 150
ESMLAAFLQN EKAAGFDLSE APLMRVTIIK LGEAVHRLIW SFHHLLLDGW
160 170 180 190 200
SSPIVFQEVL DFYEAYRQGK DLRLPQARPF KDYVSWLRRQ DKTASEQFWR
210 220 230 240 250
EFLGPMENPT PIPFETHAKR TAGHEGLEKQ IGEATRALTG QVTKALAKLA
260 270 280 290 300
RTNKVTVNTI VQGAWAILLS RLSGEENVVY GVTGSGRPSD LPGVEQMVGM
310 320 330 340 350
FINTLPMKAK IEPEQSLADW FKALQEQQSK VRQYEYTSLV DIQGWTDVPR
360 370 380 390 400
GTPLFESIFV FENYPLGEED EKEVGFTISA VQHFQEVDNP LTVVGIPGDP
410 420 430 440 450
FSIKMMYATD RFEQAAIERT LDQLALILEA IVDNPERSLS ALSLLRPEER
460 470 480 490 500
QHLLVGLNDT ATNYPSDKTV HQLFAETAAR HPERIAAVAG DQQLTYAELE
510 520 530 540 550
ARANQLANYL QKQGVEAGTL VGLCVDRSLD MLIGLLAILK AGGAYVPIDP
560 570 580 590 600
AYPEERLAFM LADAKISILL TQKHLGKQWK GRKRRTVYLD RDAKKWAEES
610 620 630 640 650
PLAPDVDTTK DSLAYVIYTS GSTGTPKGVL AVHRGVVRLG QKTRTTSPIS
660 670 680 690 700
EADVFLQAST VSFDAATFEI WGALLNGAKL VLMPPDLPSL DELGEAIVQH
710 720 730 740 750
KVTTLWLTAG LFSIMVDHNA DYLRGVRQLL VGGDVVSVPH VRKVLALGGV
760 770 780 790 800
TVINGYGPTE NTTFTCCYPV TELSEDITSF PIGRPISNTT VYVLDKHKQP
810 820 830 840 850
VPYGAAGELY IGGDGLALGY LNNAELTAER FVENPFDPQK GSRLYRTGDL
860 870 880 890 900
VRYLPNGTIE FIGRIDNQVK IRGFRIELGE VEAALALHPE VSETVVMARE
910 920 930 940 950
NDRGEKHLTA YVTVAKDDAP EVADLQAWLK TKLPEYMVPS AYVFLDAMPL
960 970 980 990 1000
TANGKIDRRR LPEPEWGNRS ETKAYTEPRN QAEELIASIW SQVLGVEKVG
1010 1020 1030 1040 1050
IHDNFFELGG HSLLATRVIS RLREVFGVEQ SVRSIFEHPT IDAWSEQTAA
1060 1070 1080 1090 1100
LQLGGPGTDD SSTQIQPVPR DGALPLSFAQ QRLWFFDQLM PDNPMYNIPF
1110 1120 1130 1140 1150
ALRLQGELDV AAWEKSLQAI IARHESLRTT FTDIDGQAVQ VIHPQLDWKL
1160 1170 1180 1190 1200
DTVDLRDRSS EEKQQASARL AADDAARPFD LRQGPLMRAT MIRTEEQAHV
1210 1220 1230 1240 1250
FLINMHHIVS DGWSVGVFLR ELFAHYEAYS KGEVPQLAPM PIQYADFAAW
1260 1270 1280 1290 1300
QREWLEGEVL EQQVAYWKEK LGGAEPLLAL PTDRPRPALQ SYEGATYTTS
1310 1320 1330 1340 1350
FSHDLLAKLK KLSKEAQHDL VHDIARRFPN VLYRYSGQED IVVGSPVAGR
1360 1370 1380 1390 1400
NRQETEKLIG FFVNTLALRT SLSGDLPFTE LLARVRETAL AAYAHQDVPF
1410 1420 1430 1440 1450
EKLVDELQLE RSLSYSQLFQ VMFVLQNFPL EDVETAGLHV APVDTESHLT
1460 1470 1480 1490 1500
TSKFDLTLTM REKEDTLVAA FEYSTDLFDR TTIERMAEHL QHLLASIVTQ
1510 1520 1530 1540 1550
PEASLDQLAL LGESEWNRLV VEQNETATDY PRDKTAHQLF AETAARYPER
1560 1570 1580 1590 1600
IAAVAGDQQL TYAELDTKAN QLANYLQKQG VEAGTLVGLC VDRSLDMLVG
1610 1620 1630 1640 1650
LLAILKAGGA YVPLDPAYPE ERLAFMLADA NVSILLTQKH LGKQWKGRKR
1660 1670 1680 1690 1700
RTVYLDRDAK KWTAESPLAP AVDATKDSLA YVIYTSGSTG TPKGVLVAHR
1710 1720 1730 1740 1750
GIVRLVKNTN YVTITEEDVF LQASTVSFDA ATFEIWGALL NGAKLVLMPP
1760 1770 1780 1790 1800
DLPSLDELGE AIVQHKVTTL WLTAGLFSIM VDHNADYLRG VRQLLVGGDV
1810 1820 1830 1840 1850
VSVPHVRKVL ALDGVTVING YGPTENTTFT CCYPVTELAE EITSFPIGRP
1860 1870 1880 1890 1900
ISNTTVYVLD KNRQPVPLGV AGELYIGGDG LASGYLNNPE LTAERFVDNP
1910 1920 1930 1940 1950
FDPQKASRLY RTGDLVRYLP DGAIEFIGRI DNQVKIRGFR IELGEIETAL
1960 1970 1980 1990 2000
LRHPAVQEAF LMVREDAPGD KRLAAYLVFA GGQTVEPVEM RSYLKDKLPE
2010 2020 2030 2040 2050
YMIPSAFVQM DSFPLTPNGK VDRRALPTPE YARSEAASGY VAPATELEVK
2060 2070 2080 2090 2100
LADIWKTVLG VADVGIHDNF FELGGDSILS IQIVARANQL GIRLTPKQLF
2110 2120 2130 2140 2150
ENQTIAELLR VVADSSQLPH TKWENEQGIV TGNVPLTPIQ KWFFAADQPS
2160 2170 2180 2190 2200
LHHWNQSLLL TVQQPVDVSV LERAIASLLS HHDALRMSFS FVDGAWTQQM
2210 2220 2230 2240 2250
NGLGDHTPFR CVDLSDLSTQ EQEQAARLEE IASEVQASLN IAEGNVVQAV
2260 2270 2280 2290 2300
YFNLGEQKAG RLLLVVHHLV VDGVSWRILL EDLQHAYEQL ANHADVSFPA
2310 2320 2330 2340 2350
KTTSFKMWAE KLADYADSDA LEQEKAYWLQ QSSGGSPLPV DHPYEPNENT
2360 2370 2380 2390 2400
EAAAKQVTLS LRADETRALL HETLTAYRLQ INDVLLAALA KAMQRWTGQK
2410 2420 2430 2440 2450
TLHVHLEGHG REEIIEGADL SRTVGWFTSM YPVQLDFDQS KPWGHVLKAV
2460 2470 2480 2490 2500
KEQLRHIPQK GIGYGILQYL SNDDEWKEQL QAYTKPEISF NYLGQFDQVV
2510 2520 2530 2540 2550
SAGAKFAMAE ESRGANIAAD AIRAHLIDVN SAISGEQLHI TWMYNANIHN
2560 2570 2580 2590 2600
QETIEALARD YMESLREIME HCRSEEAGGY TPSDFPLARL DQRAIDNYVG
2610 2620 2630 2640 2650
RDRSIENVYP LTPLQEGMLF HSLYEHAGGD YVVQFSMTMH HVEVDVFQQA
2660 2670 2680 2690 2700
WQKVVDRHSI LRTSFIWDGV STPHQIVRKH VQVVVDEQDW RHVPADQQKA
2710 2720 2730 2740 2750
EWDAFLEEDR KRSFAITEPP LMRWTLLRIS DTAYRFIWSF HHVLLDGWSV
2760 2770 2780 2790 2800
PLVMKDWFAA YMALADGKDI QFGAVHPFSQ YVAWIQRQDL QAAERFWRNH
2810 2820 2830 2840 2850
LKGIYAPTQV NFGQTVQPVG ETKSYDERSI RFSAERTREL QAFARQHQVT
2860 2870 2880 2890 2900
LNTLVQSAWA MILGTYSKEA DVVFGATGSG RPADLPGVEN MVGLFINTLP
2910 2920 2930 2940 2950
IRVTLDPGKK VREWLRELQE LQVELRQYEY TPLVDIHGWS EMARNAPLFE
2960 2970 2980 2990 3000
SIFIFENYPI DESVKEVDHS FQIADVDSVE QTNYPLTVVC GPGAEFLVKI
3010 3020 3030 3040 3050
KFDQSRFDGG RIERVLEQMT LLLQSMTANP DQLLADVNMI SQSEQKQVLI
3060 3070 3080 3090 3100
EWNETKVDYP TGLCVQQAFE QQVEKTPDAV ALIYKDVELT YADLNQRANQ
3110 3120 3130 3140 3150
LAHRLLAQEV KPDTLVGICV ERSPEMIIGI FGVMKAGAAY VPIDPALPQE
3160 3170 3180 3190 3200
RIAYMVEDSQ ASILLTQQSL AELLPKTQAR VICLDGDSLA NEPVANPASE
3210 3220 3230 3240 3250
VTEQNLAYVM YTSGSTGLPK GVMVEHHSVV NLAHALIEAF RIQPSSRVLQ
3260 3270 3280 3290 3300
FTSFSFDVSV SEIVMALLAG AALVIEDREV LLPGPELISV LQQKRITTVS
3310 3320 3330 3340 3350
MVSSVLAALP AADLPDLQTL IVGGEAPSRE LVARYADRRQ FFNCYGPTEA
3360 3370 3380 3390 3400
TVCSTMMLCN AGMKSAPIGR PLANATLYVL DANQKPVPVG VPGELYIGGK
3410 3420 3430 3440 3450
GLARGYWNRP ELTAERFIAH PFGAKGERLY RTGDLVRYLP DGNLEFLGRI
3460 3470 3480 3490 3500
DTQVKIRGYR IELGEIESAL SQHPAIQEAV VIAWEQRLAA YMVAAGEAQP
3510 3520 3530 3540 3550
AAEELARYLK ETLPDYMIPA GFVFMDAIPL TVNGKVDRRA LPAPDWGILA
3560 3570 3580 3590 3600
TRQEYVAPRT PTEEMVANIW AQLLSVEKIG VHDDFFERGG HSLLATQAIS
3610 3620 3630 3640 3650
RLRQAFGVEL PLRMLFDHPT TAAISTQIAS LLQGETALRS QPIVPVPRDQ
3660 3670 3680 3690 3700
HVPLSFAQQR LWFLDRLIPN SFLYNIPSAA RLHGELDVEA WERSLKLLIQ
3710 3720 3730 3740 3750
RHESLRTTFS DRDGEAVQII HPAIEWSLGR VDLREWAEAE REAKALQLAI
3760 3770 3780 3790 3800
EDAKRPFDLE RGPLLRASLL VMAQQEYVFL LNLHHIVADG WSMNVFMEEL
3810 3820 3830 3840 3850
VTIYEALSAG ETPQLAELPL QYADYAAWQR DWLQGDVLEQ QLAYWKAKVG
3860 3870 3880 3890 3900
GAEPLLALPT DRPRPAVQSH KGAMHTITLP AERLAALKTL SREEGSTLFM
3910 3920 3930 3940 3950
TLLAAFQTLL YRYSGQSDIV VGSPVAGRNR QETESLIGFF INTLAMRTDL
3960 3970 3980 3990 4000
SGEPTFRDLL GKVRETALEA YAHQDLPFEK LVDELELERS LSYSPLFQVM
4010 4020 4030 4040 4050
FVLQNIPMDA QALSHIRLEP FHIGQEGVSA KFDITLTTVE LPAGLMATFE
4060 4070 4080 4090 4100
YNTDLFDPAT IERMAGHYAN LLAAVSVNPL QPITAIPLVS DQERKQVLFQ
4110 4120 4130 4140 4150
WNDTSVPSER DTCVHEQVAR IAQQLPNQLA VVSDEGQITY AELDAKANQV
4160 4170 4180 4190 4200
ANYLHKQGII SETLVGVCLD RSIDMLVAQL GILKAGGAYV PMDPAYPQER
4210 4220 4230 4240 4250
LAFMMQDAEM PVVLTQEHLL AQLPEARATF LCLDRDWSLI AEESDVAPVI
4260 4270 4280 4290 4300
ATNRDNLAYV IYTSGSTGTP KGVEIEHAAL LNLVSWHQRA YEVGAEDRAT
4310 4320 4330 4340 4350
QIAGTAFDAS VWEIWPYLTK GATLYLPSEE IRLVPEQLRD WLVASGITIS
4360 4370 4380 4390 4400
FLPTPLAERL LTLEWPSDAK LRYMLTGGDK LHDYPPATLP FVLANQYGPT
4410 4420 4430 4440 4450
ENAVVATAGI VPAAAGQVSA PSIGRPIDNV QVYVLDEKLQ PVPIGVAGEL
4460 4470 4480 4490 4500
YIAGDSLARG YLHRPDLTRE RFIANPYGQK AGARMYKTGD LVRYLPDGNI
4510 4520 4530 4540 4550
EFIGRADDQV SIRGFRVELG EIETALYSHP AVKETIVLVR EDMPGMKRLV
4560 4570 4580 4590 4600
AYIVQREGQE GQAVQAGDFR SYLKELLPEY MVPAAFVFMA DLPLTPNGKV
4610 4620 4630 4640 4650
DRRALPAPDL FNSEADGTYV APATELEIKL AHIWKNVLGL ADVGIHDNFF
4660 4670 4680 4690 4700
ELGGDSILSI QIVSRANQAG IRLTPKQLLA NQTIAELASV ATVTDESEAT
4710 4720 4730 4740 4750
KLPNEQGIVT GDVPLTPIQT WFFASEQPSV HHWNQSLLLT VQQPVDLAVL
4760 4770 4780 4790 4800
ERTIECLLAH HDALRMRYSR TEQGWTQRIE GLPETIPFRS VDLSAFPTTA
4810 4820 4830 4840 4850
EQEMRLEEIA SEVQASLDLT EGPVVQAVYF QLGAEQPGRL LIVAHHLVVD
4860 4870 4880 4890 4900
GVSWRILLED LQTAYEQLAK GQAVQLAAKT TSFKTWAEQL RLYATSEALR
4910 4920 4930 4940 4950
QEKAFWLEQM DEVKPLPIDR IFEPSENTEA TVKQVMLSLN AEETRALLQD
4960 4970 4980 4990 5000
TLSPYRLQIN DVLLAALTKA LHRWTGEQTV AIHLEGHGRE ELIEGADLSR
5010 5020 5030 5040 5050
TVGWFTSLYP VQLSVDPTKP WGDTLKAVKE QLRSIPNKGV GYGILRYLSE
5060 5070 5080 5090 5100
DAELQKRLAE KAQAEISFNY LGQFDQAVVP ESKFGMAQEA RGANVGQQAI
5110 5120 5130 5140 5150
RQHLLDVNSV IAGEQLHVTW MYSENIHEEA TIQQLAHNYL EALREIIAHG
5160 5170 5180 5190 5200
QSEAAGGYTP SDFPLARMDQ RALDKYLGQN RSIENVYPLS PLQGGMLFHS
5210 5220 5230 5240 5250
LYEQEGGDYV VQLAMTVEGL DVEAFEQAWQ KVVDRHSILR TSFIWEGLTE
5260 5270 5280 5290 5300
PHQVVRKQVK ACVEKIDLRH LTPDQQKAEL SEYLAADRRR SFEIAVAPLM
5310 5320 5330 5340 5350
RWTLFRLSES AYRFTWSFHH VLLDGWSIPI VLKDWFSAYL SLAEGKEVAH
5360 5370 5380 5390 5400
SFVQPFAHYV EWVQRQDLQA AEQFWREQLA GFYEPTPLAM GNSTGGRADL
5410 5420 5430 5440 5450
PKGYEEQEIR LAKDATARLQ AFVRTHQLTL NTLVQGAWAL MLGRYGGTDD
5460 5470 5480 5490 5500
VVFGATGSGR PADLPGVESM VGLFINTLPI RVALDANQSV REWLRGMQEQ
5510 5520 5530 5540 5550
QVELRQYEYT PLVDIQGWSE MTRNTALFES IFIFENYPIG ESVKDEQHQL
5560 5570 5580 5590 5600
RLSDVETIEQ TNYPLTVVCG PGEELIVKIK YEQNRFAPEQ IERVLQQMSQ
5610 5620 5630 5640 5650
LLQDMTAKPE QRLQDVSMIS ERERQQVLVD WNETSVAYPQ QLCVHQAFEQ
5660 5670 5680 5690 5700
QVEKTPDAVA LVYKDVELTY AELNERANQL AHRLLAEGVK PDELVGICVE
5710 5720 5730 5740 5750
RSPEMIVAFL GVMKAGAAYV PLDPAHPQER IAYMIEDSQA SVLLTQASLT
5760 5770 5780 5790 5800
DRLPASSRQV ICLDSDELAN EPVTNAETSV GEHNLAYVIY TSGSTGLPKG
5810 5820 5830 5840 5850
VMIEHRSVIN LAYDLIRHFQ IDATSRVLQF ISFSFDVSVS EIVMSLLAGA
5860 5870 5880 5890 5900
TLVIEDRESL LPGPELIRVL QEQRITTFAM VSSVLAALPE ADLPDLRTII
5910 5920 5930 5940 5950
VGGEAPSREL VARYATGRQF INCYGPTETT VTATLKHCQD DGKNPPIGRP
5960 5970 5980 5990 6000
IANTTVYVLD AHLQPVPIGV PGELYIGGKG VARGYWNRPE LTAERFIADP
6010 6020 6030 6040 6050
FGQADERLYR TGDLVRYLEN GELEFLGRID DQVKIRGYRI ELGEIENALR
6060 6070 6080 6090 6100
QHPAVQNVVV IARQEGAGDK RLAAYLVAAT GQQPDEAELV RYLKSTLPEY
6110 6120 6130 6140 6150
MVPAGYVWLE KIPLTVNGKV DRRALPAPDY GHAETGKAYV APRKPIEEIV
6160 6170 6180 6190 6200
ANIWAQVLSV ERVGVYDDFF ELGGHSLLAT QAVSRLKEAF GVNVPLRTLF
6210 6220 6230 6240 6250
EHPDVAGMSE KLAGLLEEQS GVTSIPLVPV PRDKQLPLSF AQQRLWFLDR
6260 6270 6280 6290 6300
LMPDSALYNI PSAVRIQGQL NIRAWERSLQ TIIERHESLR TTFTDIGGEA
6310 6320 6330 6340 6350
VQVIHEMMEW RLVEIDLRDL PDEEREAAVQ RLEKAEASQP FNLRTGPLLR
6360 6370 6380 6390 6400
ATLIQTGEED FVFLLNMHHI VSDGWSMSIF MGELATIYEA LSKGDTPQLA
6410 6420 6430 6440 6450
EMPLQYADFA AWQRDWLQGE VLEQQLAYWR EKLGAAEPML ALPTDRPRPA
6460 6470 6480 6490 6500
VQTHHGALYT TAFPLALTEK LHALSRQEGA TLFMTLLAAF QTLLYRYSGQ
6510 6520 6530 6540 6550
DDIIVGSPVA GRNKQETESM IGFFINTLAM RTDMSGAPTF RELLARVRDT
6560 6570 6580 6590 6600
ALEAYTHQDL PFEKLIDELE LERSLSYSPL FQVMFALQNF QMLTREFEGI
6610 6620 6630 6640 6650
EIVPFESKNE AVMSKYDISL TMAETQNGLV ATFDYNTDLF DHSTIVRMVN
6660 6670 6680 6690 6700
HFHQLLEGIV ARPDSSIQAL PLLATDEREQ LVSAWNNTAA AYTYEQTVHE
6710 6720 6730 6740 6750
LVAAMAEKMP EQLAVVSAEG SLTYAQLDAK ANQLANYLQQ QGITPETLVG
6760 6770 6780 6790 6800
ICVERSSEMI VGQLGILKAG GAFVPMDPAY PQERLAFMMA DTGMPFVLTQ
6810 6820 6830 6840 6850
ERLLETLPAG DAAFICLDAD WEVIAEESTQ APELAVTTDQ LAYVIYTSGS
6860 6870 6880 6890 6900
TGTPKGVEIE HRALLNLIYW HQHAYTITPD DRASQIAGTA FDAAVWEIWP
6910 6920 6930 6940 6950
YMTAGATLYL PQEEIRLIPE KLRDWLVAEG ITISFLPTPL AESMLSVDWP
6960 6970 6980 6990 7000
SHAALRYVLT GGDKLHHYPA EHVPFTLVNQ YGPTENAVVA TAGIVAVQAG
7010 7020 7030 7040 7050
QVTPPSIGRP IDNVQVYILD EQRQPVPIGV TGELYIAGSS LARGYYKRPD
7060 7070 7080 7090 7100
LTQERFVDNP FTANRGAKMY RTGDLVRYLP DGQIEFIGRS DDQVSIRGFR
7110 7120 7130 7140 7150
VELGEIESVL YQHPAVKEAI VLAREDMPGV KRLAAYVVVA EDDAEQADDL
7160 7170 7180 7190 7200
RGYLKEKLPE YMVPAAFVTL KALPLTPNGK VDRRALPVPE YTAADGEYVA
7210 7220 7230 7240 7250
PETFVEKVLA QIWKEVLGVE EVGIHDNFFE LGGDSILSIQ IVARAGQSGI
7260 7270 7280 7290 7300
RLSPKLLFEN QTIAELSHAV GDSVHICAEQ GLVTGEVPLL PIQHWFFEQK
7310 7320 7330 7340 7350
LADRNHWNQS VLLTVQPIDP EILKQAFYHL LGHHDALRLR FYHQNGAWKQ
7360 7370 7380 7390 7400
AGAEWTDIIP FYVVELGDLP ANQQVEQIEK LSGEAQASLH LADGPLLRAV
7410 7420 7430 7440 7450
YFDMGAGQEG RLLIVIHHLA VDGVSWRIIT EDLNKACNQL LQGKQVQLPP
7460 7470 7480 7490 7500
KTSSYKYWAE KLVEYAASDS LTEEADYWLS RLDTEVAALP KDYEHGQNRE
7510 7520 7530 7540 7550
LAARTVSVAL TQEETKVLLQ ELPAVYQTQI NDVLLTALAE AVFVWTGNQT
7560 7570 7580 7590 7600
TLVHLEGHGR EDIFDDVDLS RTVGWFTSMY TILLDTRGTS SLTEALQTTK
7610 7620 7630 7640 7650
EQLRSIPHKG IGYGILRYLN KETAEKFKSL PKAQISFNYL GQLDQAVRDT
7660 7670 7680 7690 7700
DSLFGFASEA RGDNFNRNSD RQHLLDFGCS VVGGQLVVSV AFSKEIYRKE
7710 7720 7730 7740 7750
TIEALADYYI TALRQLLAHA KTDKAAAPAQ SAASNLSEFG WDDEEIADLL

DLIQDK
Length:7,756
Mass (Da):866,321
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0EA2EAB6AAC5C7B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ566197 Genomic DNA Translation: CAD92851.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566197 Genomic DNA Translation: CAD92851.1

3D structure databases

SMRiQ70LM5
ModBaseiSearch...

Proteomic databases

PRIDEiQ70LM5

Family and domain databases

Gene3Di1.10.1200.10, 6 hits
3.30.559.10, 9 hits
3.40.50.12780, 6 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 6 hits
PF13193, AMP-binding_C, 6 hits
PF00668, Condensation, 9 hits
PF00550, PP-binding, 6 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 6 hits
SUPFAMiSSF47336, SSF47336, 6 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 6 hits
TIGR01720, NRPS-para261, 3 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 6 hits
PS50075, CARRIER, 6 hits
PS00012, PHOSPHOPANTETHEINE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLGRC_BREPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70LM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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