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Entry version 73 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Linear gramicidin synthase subunit D

Gene

lgrD

Organism
Brevibacillus parabrevis
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates the 13th to the 16th (Trp, D-Leu, Trp and Gly) amino acids in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 14th (D-Leu) amino acid. It also catalyzes the NAD(P)H-dependent reduction of the C-terminal glycine residue of the N-formylated 16-mer peptide, that binds to the peptidyl carrier domain of the terminal module of this protein, to form a peptidyl-aldehyde intermediate that is released from the enzyme complex.

Miscellaneous

Linear gramicidin is a pentadecapeptide antibiotic produced during sporulation.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 4 phosphopantetheines covalently.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase, Multifunctional enzyme, Oxidoreductase
Biological processAntibiotic biosynthesis
LigandNAD, NADP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Linear gramicidin synthase subunit D
Including the following 5 domains:
ATP-dependent D-leucine adenylase
Short name:
D-LeuA
Alternative name(s):
D-leucine activase
Leucine racemase [ATP-hydrolyzing] (EC:5.1.1.-)
ATP-dependent tryptophan adenylase
Short name:
TrpA
Alternative name(s):
Tryptophan activase
ATP-dependent glycine adenylase
Short name:
GlyA
Alternative name(s):
Glycine activase
Linear gramicidin--PCP reductase (EC:1.-.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lgrD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrevibacillus parabrevis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri54914 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930921 – 5085Linear gramicidin synthase subunit DAdd BLAST5085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei997O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2058O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3579O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4636O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q70LM4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Large multienzyme complex composed of 4 subunits; LgrA, LgrB, LgrC and LgrD.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q70LM4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini962 – 1037Carrier 1PROSITE-ProRule annotationAdd BLAST76
Domaini2023 – 2097Carrier 2PROSITE-ProRule annotationAdd BLAST75
Domaini3544 – 3619Carrier 3PROSITE-ProRule annotationAdd BLAST76
Domaini4601 – 4676Carrier 4PROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Four module-bearing peptide synthase with a C-terminal epimerization domain. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional). Contains a reductase domain at the C-terminus.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05235, SDR_e1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR013120, Male_sterile_NAD-bd
IPR036291, NAD(P)-bd_dom_sf
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR010080, Thioester_reductase-like_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 4 hits
PF13193, AMP-binding_C, 4 hits
PF00668, Condensation, 5 hits
PF07993, NAD_binding_4, 1 hit
PF00550, PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 4 hits
SSF51735, SSF51735, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 4 hits
TIGR01720, NRPS-para261, 1 hit
TIGR01746, Thioester-redct, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 4 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q70LM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNIETYYPV TPLQQGLIFH SLLEPESGAY IVQMGLKLQG PLNIPLFEQA
60 70 80 90 100
WQCLVDRHAI FRTRFVGGKV KEYVQVVLKD LKISLVEHDL IHLSSSEQEA
110 120 130 140 150
FLHHFAKEDR KRGFDIEQAP LMRLNVFHLN SETVHFLWTL HHVLIDGWSM
160 170 180 190 200
PLVFGEVFAA YEMLSKGQPL SLPPVRAYRD YIVWLKKQDL QQAEAFWRTY
210 220 230 240 250
MQGFTEATPL SFGRAYKNPY LDQKQYRELD LTVSEQTSKA LQTLARQHRL
260 270 280 290 300
TVNTIVQGAW ALLLNRYSGQ DDIVFGATVS GRPADLPGVE TMIGLFINTL
310 320 330 340 350
PVRVQVNAEE SVINWLKTLQ QQQADFRQYE YTPLVEIQGW SDVPRGQSLF
360 370 380 390 400
ESILVFENMP VGKSGGGESA ISIVDVYSEE QTNYPFTLVA ASGKTIDIKV
410 420 430 440 450
KFDESQFELA AIERVVDQLH SLLSSIAKNA KQRIGDLSLI SESERQQVLV
460 470 480 490 500
EWNQTAEDYP SGLCIHQAFE QQAEKTPDAV AVAYKNRELT YAQLNERANQ
510 520 530 540 550
LAHRLIRKGV KPDTLVGICL ERSPEMIIGI LGVMKAGAAY VPIDPAHPQE
560 570 580 590 600
RIAYMVADSQ ASALLTQQSL LEILPVTAAH VICLDSDLLA DEPVDNASSE
610 620 630 640 650
VTEQNLAYVI YTSGSTGLPK GVMIEHHSAI NLAYALIDAF DIQPTSRVLQ
660 670 680 690 700
FTSFSFDVSV SEVVMALLAG ATLVIEDRES LLPGPELIQV LQEQRITTVS
710 720 730 740 750
MVSSVLAALP DADLPDLHTL IVGGEAPSRE LVARYAPGRQ FFNCYGPTEA
760 770 780 790 800
TVCSTMMLCQ AGMNNPPIGR PIANATVYVL DANLNPVPVG VPGELYIGGK
810 820 830 840 850
GLARGYWNRP ELTAESFIPH PFGTAGERLY RTGDLVRYRQ DGNLEFLGRI
860 870 880 890 900
DHQVKIRGYR IELGEIENAI RQHPAVQEAV VIAREEKAGD KRLAAYLVAA
910 920 930 940 950
GKAQPPAEEI ALFLKETLPE YMVPAGVVWL DAIPLTVNGK VDRRALPVPD
960 970 980 990 1000
WGQLSTKREY VAPRTPTEEM VANIWSQVLS VERVGSFDDF FELGGHSLLA
1010 1020 1030 1040 1050
TQTVSRLKEA FGVDLPLRVL FECSTVNKLS EWIAAAGEDK SGLSRIPLVP
1060 1070 1080 1090 1100
VSRDRHLPLS FAQQRLWFFD RLMPNSALYN IPTAVRLQGE LDMDALEQSL
1110 1120 1130 1140 1150
QTIIQRHESL RTTFTDHNGE AVSVIHPEID WKLERIDLRE RSEEMRNEAG
1160 1170 1180 1190 1200
LRLAKEEANR PFDLVTGPLM RATIIQTDER DFIFLLNVHH IIADGWSAGI
1210 1220 1230 1240 1250
LIRELFHCYQ AFAKAEAPQL AELPIQYADY AYWQREWLTS DVLDEQLSYW
1260 1270 1280 1290 1300
RAKLGGAEPL LALPTDRPRP AVQSYAGSSI SLLFDDELRA NLLALSKREG
1310 1320 1330 1340 1350
TTLFMTLLAA FQVFLYRYTG QDDILVGTPE AGRSRQETEG LIGFFINTLV
1360 1370 1380 1390 1400
MRTDLSGEPS FKEVLARVRE TALGAYAHQD LPFEKLVDEL NVERSLSYSP
1410 1420 1430 1440 1450
LFQVMFVLQN IPVQADALDG IRILPLEGSQ QVETTKFDLT LTMAEAANGL
1460 1470 1480 1490 1500
AATFEYNTAL FERNTVERMI GHFSSLLKAV AANANQAITA LPLMSEVEEQ
1510 1520 1530 1540 1550
QLVLEWNDTA VAYSTEQLVH ELVAQVARDM PDQPAVVTRD QLLTYGQLEA
1560 1570 1580 1590 1600
KANQLAHYLQ KQGVGRGSLV GICVERSVEM VIGQLAIMKA GAAYIPMDPA
1610 1620 1630 1640 1650
YPKERLAFMM HDASMAIVLT QAKLRQKLPA DTSRLICLDA DWETIAQEPT
1660 1670 1680 1690 1700
AALVNTTAAS DLAYVIYTSG STGTPKGVEI EHAALLNLIF WHQRAYDVTA
1710 1720 1730 1740 1750
TDRASQIAGT AFDASVWEIW PYVTKGATLY LPEEEIRLVP EKLRDWLVAS
1760 1770 1780 1790 1800
NITVSFLPTP LTESMLALEW PGDTALRYML TGGDKLHHYP SEKIPFTLVN
1810 1820 1830 1840 1850
QYGPTENTVV ATAGIVPKEA GQTAAPTIGR PIDNVQVYIL DAHRQPVPVG
1860 1870 1880 1890 1900
VSGELYIGGS SLARGYLNRP DLTQERFVAH PFTEKAGARL YRTGDLVRSL
1910 1920 1930 1940 1950
PDGSIEFIGR ADDQTSIRGF RVELGEVETA IVALPAVKEA VVTVCTDKQG
1960 1970 1980 1990 2000
TKRLAAYLVL EEGAALATGD IRKALKETLP DYMVPAFFTQ LAYLPLTPNG
2010 2020 2030 2040 2050
KVDRKNLPAP DFQRPELEGE FVSPSTEKER RLAAIWKDVL GIEQIGIHDN
2060 2070 2080 2090 2100
FFELGGDSIL SIQIVSRANQ AGLSLAPKQL FEYQTIAELA EIVEEKAAVQ
2110 2120 2130 2140 2150
AEQGAVTGEL PLLPIQKWFF RLPLANRDHW NQSVLLSIQA GIDPAALKQA
2160 2170 2180 2190 2200
VGQLMFQHDA FRMRYTQSES GWLQAMDAPS ETIPFRVEDL SQLAPEEQSS
2210 2220 2230 2240 2250
AIEAIANETQ TQLSLRAGQV VQTIYFHLGK EVPGRLLIVA HHLVVDGVSW
2260 2270 2280 2290 2300
RIILEDLQHA YQQIAAGQEV KLPAKTTSYK EWAQELERYA HSEAFKHEKS
2310 2320 2330 2340 2350
YWLSKSSVHS TELPADMPDS AENTEATVKS VHFSLTVEET KALLQQVPQA
2360 2370 2380 2390 2400
YRTQINDVLL AALAKALGQW TGKRSVFVNV EGHGREELAE HLDLSRTVGW
2410 2420 2430 2440 2450
FTSMYPVHLQ WDETFSVRRA LLTTKEELRA IPNKGLGYGV LRYLHAEQEI
2460 2470 2480 2490 2500
VDAISRIQAD VLFNYMGKID QIVGSDSLFG SAPESSGANL CPSAQRHHLL
2510 2520 2530 2540 2550
DVNSVVAGEQ LHVTWRYSEK LQRESTIAAV AESFMAALRE IVAHCTLPEA
2560 2570 2580 2590 2600
GGYSPSDFPL AVLEQKQIDK HIGFDRQIED VYTLSPLQQG MLFHSLYNQD
2610 2620 2630 2640 2650
SGDYVVQFAV TFQNLDVSVL EKAWQNVLDR HSILRTHFVW EGLSEPHQVV
2660 2670 2680 2690 2700
RKDVKVTLTK EDWRHLQADV QDEMLAAFLE EDRRRSFDIA QAPLSRWVVF
2710 2720 2730 2740 2750
QTKDEEYRFV WSFHHVLLDG WSVPIVLNEL LAHYAAISEG REGKLVPSQP
2760 2770 2780 2790 2800
FSQYIAWLKR QDREKAKPFW TDQLKGFHEP TSLGMGKNVA ASQQKQYKEQ
2810 2820 2830 2840 2850
SVLLSEEATE HLQSFTREHQ LTLNTLVQGA WGWILGSYSG EEEVLFGATG
2860 2870 2880 2890 2900
SGRPADLPGV ETMVGSFINT LPVRVPLQTD ATLLAWLKDL QRRQLEIREY
2910 2920 2930 2940 2950
EYTPLFDIQG WSELPRGSAL FESILVFENY PTVQAAKKGE DEAASATSGV
2960 2970 2980 2990 3000
SLEIHDVAAV EQTNYPLTLV AAPGKQVAFK LKYDQDRFDD AMIERVLNQM
3010 3020 3030 3040 3050
TRLMVYMSKS PELRLNDVAL MDEDERKQVL IDWNRTEKEY PRELCLHHAF
3060 3070 3080 3090 3100
EQQAAKTPEN IALEYKEQSL SYAGLNERAN QLAHLLIAQG VKPDTTVAIC
3110 3120 3130 3140 3150
VERSMEMIIG ILGVLKAGAA YVPIDPAHPE ERIAYMLDDS QAVVVLTQAG
3160 3170 3180 3190 3200
LADKFTQAAA PVICLGEKLF ADRAHVDVDN IQTDVASTNL AYVIYTSGTT
3210 3220 3230 3240 3250
GLPKGVAVEH RSAMNMVQAY IAYFGLDESS RVLQFTSFSF DVSVSEIWQA
3260 3270 3280 3290 3300
LLSGGTLVIE DRESLLPGPD LVRTLRERRI SKVSMASSLL ASLPVAEYPD
3310 3320 3330 3340 3350
LAVLEVGGDA CSRELVARYA TGRKFFNCYG PTEATVGTVI KQLTLDDDTP
3360 3370 3380 3390 3400
TIGRPFPNTK LYVLDQNRKP VPVGVPGELY IGGECLARGY WNRPELTAER
3410 3420 3430 3440 3450
FVANPFGQPG ERLYRTGDLV RYLPDGNVDY LGRFDDQVKI RGYRIELGEI
3460 3470 3480 3490 3500
AEALRQHAAI REAVVLAREV RPGDKRLAAY LTSAAEQELS VDEIKQWLKE
3510 3520 3530 3540 3550
KLPDYMVPAS YTWLPAIPLN VNGKVDRKAL PAPDWGQITA AYVAPRNPLE
3560 3570 3580 3590 3600
EMIANVFAEV LAVEKVGIDD NFFELGGHSL LATQTVSRLR EIVGVELQLR
3610 3620 3630 3640 3650
TLFEHPTVAG LGEQLELLTK QSSRKLAPPI GKVSRKEPLP LSFTQQRLWF
3660 3670 3680 3690 3700
LEQFTQNSSI NNIPSFLRIQ GELDVAAWEA SFSAIILRHE SLRTSFEVRD
3710 3720 3730 3740 3750
GRPVQVIQPH GDWAMTRIDL RALEPAEREA EIKRLAEQAI VQPFDLTKGL
3760 3770 3780 3790 3800
LLRASLVQLD ANDFVFLFVM HHIASDGWSM GILLSELMTN YKAFRQGEAS
3810 3820 3830 3840 3850
PLGELPIQYA DFAVWQREWL SGEVLAEQLG YWREKLKGSE PLLQLPTDRP
3860 3870 3880 3890 3900
RPPVQTYEGE KMSVQFGAEL LKQLQSLSRK EGATLFMTLF AAFQTLLYRY
3910 3920 3930 3940 3950
TNQDDILVGT PIAGRNKQET EQLIGYFINT LVLRTDMSGH PSFRELLARV
3960 3970 3980 3990 4000
RETALEAYAH QDVPFEKLLD ELQLERSMSY SPLFQVMFIL QNIPVQAEPA
4010 4020 4030 4040 4050
GDIQLSSFDL ELGAVTSKFD MTVTMVETPD GLLATLEYNK ALFDSSTITR
4060 4070 4080 4090 4100
MVEHFHKLME EIVANPDQSI TLLPLMREEE EQLLITEWNR TEVPYSREKC
4110 4120 4130 4140 4150
VHEMIEEMVS KAPDSIALIV GEQRVTYGEL NRQANQLAHY LRKQGVGPEV
4160 4170 4180 4190 4200
LVGICAERTV EMMIGLLAIL KAGGAYVPID PAYPAERIAY IIGHSQIPVL
4210 4220 4230 4240 4250
LTQEHLLPTL PEHQAKVICL DRDWATVAVE SEENPGKLAT SDNLIYVIYT
4260 4270 4280 4290 4300
SGSTGNPKGV ALEHRSVIYF LSWAHDTYTP EEMSGVLFST SICFDLSVYE
4310 4320 4330 4340 4350
MFATLTMGGK VIMAENALQL PALPAADQVT LVNTVPSAAT ELVRMKGIPA
4360 4370 4380 4390 4400
SVRVINLCGE PLSNRLAQEL YAFPHVEKVF NLYGPTEDTV YSTHAIVTKG
4410 4420 4430 4440 4450
ATNEPLIGRP QFNTHVFVLD SHRKPVPVGV PGELYLSGSG LARGYLHRPD
4460 4470 4480 4490 4500
LTAERFVQNP FREPGARMYR TGDLVRYLPD GNLQFVGRVD YQVKIRGYRI
4510 4520 4530 4540 4550
ELGEIESVLN RFPGVKEVVL LAREDREGDK CLVAYIVFEA DCTSKIHDLN
4560 4570 4580 4590 4600
HFLADKLPAY MIPQHYMILD SLPKTPNGKL DRKALPKPEY DRSEAGVEYV
4610 4620 4630 4640 4650
APQTPVEIML HAHWAAVLEM ETIGVHDNFF EIGGHSLLAT QLIFKVREEL
4660 4670 4680 4690 4700
QLEVPLRILF ETPTIAGMAK TIEEIIKHGL TSVSQEIDAK GLQDEVALDP
4710 4720 4730 4740 4750
AILAEQPYEG DPSQFQAALL TGATGFLGAF LLRDLLQMTD ADIYCLVRAS
4760 4770 4780 4790 4800
GEEEGLARLR KTLQLYELWD EAQAHRIIPV IGDLAQPRLG LSAGQFDALA
4810 4820 4830 4840 4850
ATVDVIYHNG ALVNFVYPYA ALKKANVIGT EEIIRLAAAK KTKPVHFVST
4860 4870 4880 4890 4900
IFTFASEEGE ESVAVREEDM PENSRILTSG YTQSKWVAEH IVNLARQRGI
4910 4920 4930 4940 4950
PTAIYRCGRM TGDSETGACQ KDDLMWRIAA GIIDLGKAPD MSGDLDMMPV
4960 4970 4980 4990 5000
DFASKGIVHL SMTEHSVNSN FHLLNPNATD YDDLIAAIEN KGFELERVTM
5010 5020 5030 5040 5050
DEWIEAVQED AKDKGMDANS AAPLGNLFSD GHSSRGSVVY VGNKTTRLLR
5060 5070 5080
QADIECPEID EEVFAKVLDY FARTGQLRVT QNTRN
Length:5,085
Mass (Da):567,458
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E0618C4AC39BF24
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ566197 Genomic DNA Translation: CAD92852.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ566197 Genomic DNA Translation: CAD92852.1

3D structure databases

SMRiQ70LM4
ModBaseiSearch...

Proteomic databases

PRIDEiQ70LM4

Family and domain databases

CDDicd05235, SDR_e1, 1 hit
Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR013120, Male_sterile_NAD-bd
IPR036291, NAD(P)-bd_dom_sf
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR010080, Thioester_reductase-like_dom
PfamiView protein in Pfam
PF00501, AMP-binding, 4 hits
PF13193, AMP-binding_C, 4 hits
PF00668, Condensation, 5 hits
PF07993, NAD_binding_4, 1 hit
PF00550, PP-binding, 4 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 4 hits
SUPFAMiSSF47336, SSF47336, 4 hits
SSF51735, SSF51735, 1 hit
TIGRFAMsiTIGR01733, AA-adenyl-dom, 4 hits
TIGR01720, NRPS-para261, 1 hit
TIGR01746, Thioester-redct, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 4 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLGRD_BREPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70LM4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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