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Entry version 138 (18 Sep 2019)
Sequence version 3 (17 Apr 2007)
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Protein

Chondroitin sulfate synthase 3

Gene

CHSY3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Co2+1 Publication, Mn2+1 Publication, Cd2+1 PublicationNote: Divalent metal cations. Highest activities are measured with Co2+, Mn2+ and Cd2+.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi720Divalent metal cationSequence analysis1
Metal bindingi834Divalent metal cationSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandMetal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS11959-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.175 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022870 Chondroitin sulfate biosynthesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q70JA7

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT31 Glycosyltransferase Family 31
GT7 Glycosyltransferase Family 7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chondroitin sulfate synthase 3 (EC:2.4.1.175, EC:2.4.1.226)
Alternative name(s):
Carbohydrate synthase 2
Chondroitin glucuronyltransferase 3
Chondroitin synthase 2
Short name:
ChSy-2
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3
N-acetylgalactosaminyltransferase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHSY3
Synonyms:CHSY2, CSS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24293 CHSY3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609963 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q70JA7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini29 – 882LumenalSequence analysisAdd BLAST854

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
337876

Open Targets

More...
OpenTargetsi
ENSG00000198108

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382259

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHSY3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559453

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001895621 – 882Chondroitin sulfate synthase 3Add BLAST882

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi710N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi878N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q70JA7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q70JA7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q70JA7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q70JA7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q70JA7

PeptideAtlas

More...
PeptideAtlasi
Q70JA7

PRoteomics IDEntifications database

More...
PRIDEi
Q70JA7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68561

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q70JA7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q70JA7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected at low levels in brain, cerebral cortex, uterus and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198108 Expressed in 142 organ(s), highest expression level in tibia

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q70JA7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044612

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130623, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q70JA7, 15 interactors

Molecular INTeraction database

More...
MINTi
Q70JA7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302629

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q70JA7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi211 – 235Pro-richAdd BLAST25
Compositional biasi539 – 544Poly-Leu6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3588 Eukaryota
ENOG410XNYM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182646

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220809

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q70JA7

KEGG Orthology (KO)

More...
KOi
K13499

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMQQLFH

Database of Orthologous Groups

More...
OrthoDBi
442283at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q70JA7

TreeFam database of animal gene trees

More...
TreeFami
TF318303

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008428 Chond_GalNAc
IPR029044 Nucleotide-diphossugar_trans

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05679 CHGN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q70JA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVRSRRPWM SVALGLVLGF TAASWLIAPR VAELSERKRR GSSLCSYYGR
60 70 80 90 100
SAAGPRAGAQ QPLPQPQSRP RQEQSPPPAR QDLQGPPLPE AAPGITSFRS
110 120 130 140 150
SPWQQPPPLQ QRRRGREPEG ATGLPGAPAA EGEPEEEDGG AAGQRRDGRP
160 170 180 190 200
GSSHNGSGDG GAAAPSARPR DFLYVGVMTA QKYLGSRALA AQRTWARFIP
210 220 230 240 250
GRVEFFSSQQ PPNAGQPPPP LPVIALPGVD DSYPPQKKSF MMIKYMHDHY
260 270 280 290 300
LDKYEWFMRA DDDVYIKGDK LEEFLRSLNS SKPLYLGQTG LGNIEELGKL
310 320 330 340 350
GLEPGENFCM GGPGMIFSRE VLRRMVPHIG ECLREMYTTH EDVEVGRCVR
360 370 380 390 400
RFGGTQCVWS YEMQQLFHEN YEHNRKGYIQ DLHNSKIHAA ITLHPNKRPA
410 420 430 440 450
YQYRLHNYML SRKISELRYR TIQLHRESAL MSKLSNTEVS KEDQQLGVIP
460 470 480 490 500
SFNHFQPRER NEVIEWEFLT GKLLYSAAEN QPPRQSLSSI LRTALDDTVL
510 520 530 540 550
QVMEMINENA KSRGRLIDFK EIQYGYRRVN PMHGVEYILD LLLLYKRHKG
560 570 580 590 600
RKLTVPVRRH AYLQQLFSKP FFRETEELDV NSLVESINSE TQSFSFISNS
610 620 630 640 650
LKILSSFQGA KEMGGHNEKK VHILVPLIGR YDIFLRFMEN FENMCLIPKQ
660 670 680 690 700
NVKLVIILFS RDSGQDSSKH IELIKGYQNK YPKAEMTLIP MKGEFSRGLG
710 720 730 740 750
LEMASAQFDN DTLLLFCDVD LIFREDFLQR CRDNTIQGQQ VYYPIIFSQY
760 770 780 790 800
DPKVTNGGNP PTDDYFIFSK KTGFWRDYGY GITCIYKSDL LGAGGFDTSI
810 820 830 840 850
QGWGLEDVDL YNKVILSGLR PFRSQEVGVV HIFHPVHCDP NLDPKQYKMC
860 870 880
LGSKASTFAS TMQLAELWLE KHLGVRYNRT LS
Length:882
Mass (Da):100,284
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FE26485B2CEA515
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD43233 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173L → P in CAE17326 (Ref. 2) Curated1
Sequence conflicti195W → R in CAE17326 (Ref. 2) Curated1
Sequence conflicti202R → H in CAE17326 (Ref. 2) Curated1
Sequence conflicti268G → E in CAE17326 (Ref. 2) Curated1
Sequence conflicti337Y → H in BAC98832 (PubMed:12907687).Curated1
Sequence conflicti354 – 355GT → RA in BAC98832 (PubMed:12907687).Curated2
Sequence conflicti361 – 362YE → FQ in BAC98832 (PubMed:12907687).Curated2
Sequence conflicti856S → N in CAD43233 (Ref. 2) Curated1
Sequence conflicti856S → N in CAE17326 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027540615G → E. Corresponds to variant dbSNP:rs10068403Ensembl.1
Natural variantiVAR_021174764D → G. Corresponds to variant dbSNP:rs2015018Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB086062 mRNA Translation: BAC98832.1
AJ504664 mRNA Translation: CAD43233.1 Different initiation.
AJ578034 mRNA Translation: CAE17326.1
BC137325 mRNA Translation: AAI37326.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34223.1

NCBI Reference Sequences

More...
RefSeqi
NP_787052.3, NM_175856.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305031; ENSP00000302629; ENSG00000198108

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
337876

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:337876

UCSC genome browser

More...
UCSCi
uc003kvd.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - GTase

Chondroitin sulfate synthase 3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086062 mRNA Translation: BAC98832.1
AJ504664 mRNA Translation: CAD43233.1 Different initiation.
AJ578034 mRNA Translation: CAE17326.1
BC137325 mRNA Translation: AAI37326.1
CCDSiCCDS34223.1
RefSeqiNP_787052.3, NM_175856.4

3D structure databases

SMRiQ70JA7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi130623, 20 interactors
IntActiQ70JA7, 15 interactors
MINTiQ70JA7
STRINGi9606.ENSP00000302629

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31
GT7 Glycosyltransferase Family 7

PTM databases

iPTMnetiQ70JA7
PhosphoSitePlusiQ70JA7

Polymorphism and mutation databases

BioMutaiCHSY3
DMDMi145559453

Proteomic databases

EPDiQ70JA7
jPOSTiQ70JA7
MassIVEiQ70JA7
MaxQBiQ70JA7
PaxDbiQ70JA7
PeptideAtlasiQ70JA7
PRIDEiQ70JA7
ProteomicsDBi68561

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
337876
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305031; ENSP00000302629; ENSG00000198108
GeneIDi337876
KEGGihsa:337876
UCSCiuc003kvd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
337876
DisGeNETi337876

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHSY3
HGNCiHGNC:24293 CHSY3
HPAiHPA044612
MIMi609963 gene
neXtProtiNX_Q70JA7
OpenTargetsiENSG00000198108
PharmGKBiPA162382259

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3588 Eukaryota
ENOG410XNYM LUCA
GeneTreeiENSGT00950000182646
HOGENOMiHOG000220809
InParanoidiQ70JA7
KOiK13499
OMAiEMQQLFH
OrthoDBi442283at2759
PhylomeDBiQ70JA7
TreeFamiTF318303

Enzyme and pathway databases

BioCyciMetaCyc:HS11959-MONOMER
BRENDAi2.4.1.175 2681
ReactomeiR-HSA-2022870 Chondroitin sulfate biosynthesis
SABIO-RKiQ70JA7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CHSY3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
337876

Pharos

More...
Pharosi
Q70JA7

Protein Ontology

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PROi
PR:Q70JA7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000198108 Expressed in 142 organ(s), highest expression level in tibia
GenevisibleiQ70JA7 HS

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR008428 Chond_GalNAc
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF05679 CHGN, 1 hit
SUPFAMiSSF53448 SSF53448, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHSS3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70JA7
Secondary accession number(s): B2RP97, Q76L22, Q86Y52
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: April 17, 2007
Last modified: September 18, 2019
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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