UniProtKB - Q70IA6 (MOB2_HUMAN)
Protein
MOB kinase activator 2
Gene
MOB2
Organism
Homo sapiens (Human)
Status
Functioni
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 78 | ZincBy similarity | 1 | |
Metal bindingi | 83 | ZincBy similarity | 1 | |
Metal bindingi | 157 | ZincBy similarity | 1 | |
Metal bindingi | 162 | ZincBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- actin cytoskeleton organization Source: Ensembl
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of protein phosphorylation Source: Ensembl
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q70IA6 |
Names & Taxonomyi
Protein namesi | Recommended name: MOB kinase activator 2Alternative name(s): HCCA2 Mob2 homolog Mps one binder kinase activator-like 2 |
Gene namesi | Name:MOB2 Synonyms:HCCA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24904, MOB2 |
MIMi | 611969, gene |
neXtProti | NX_Q70IA6 |
VEuPathDBi | HostDB:ENSG00000182208.12 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- perinuclear region 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
- neuron projection terminus Source: Ensembl
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 81532 |
OpenTargetsi | ENSG00000182208 |
Miscellaneous databases
Pharosi | Q70IA6, Tbio |
Genetic variation databases
BioMutai | MOB2 |
DMDMi | 56749258 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193568 | 1 – 237 | MOB kinase activator 2Add BLAST | 237 |
Post-translational modificationi
Phosphorylated.
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q70IA6 |
jPOSTi | Q70IA6 |
MassIVEi | Q70IA6 |
MaxQBi | Q70IA6 |
PaxDbi | Q70IA6 |
PeptideAtlasi | Q70IA6 |
PRIDEi | Q70IA6 |
ProteomicsDBi | 68555 [Q70IA6-1] 68556 [Q70IA6-2] |
PTM databases
iPTMneti | Q70IA6 |
PhosphoSitePlusi | Q70IA6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182208, Expressed in lower esophagus and 210 other tissues |
ExpressionAtlasi | Q70IA6, baseline and differential |
Organism-specific databases
HPAi | ENSG00000182208, Tissue enhanced (smooth muscle, urinary bladder) |
Interactioni
Subunit structurei
Binds STK38 and STK38L.
Binary interactionsi
Hide detailsQ70IA6
Protein-protein interaction databases
BioGRIDi | 123506, 28 interactors |
IntActi | Q70IA6, 28 interactors |
STRINGi | 9606.ENSP00000328694 |
Miscellaneous databases
RNActi | Q70IA6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the MOB1/phocein family.Curated
Phylogenomic databases
eggNOGi | KOG0440, Eukaryota |
GeneTreei | ENSGT01000000214382 |
InParanoidi | Q70IA6 |
OMAi | TVKHVYR |
OrthoDBi | 1127941at2759 |
PhylomeDBi | Q70IA6 |
TreeFami | TF300789 |
Family and domain databases
Gene3Di | 1.20.140.30, 1 hit |
InterProi | View protein in InterPro IPR005301, MOB_kinase_act_fam IPR036703, MOB_kinase_act_sf |
PANTHERi | PTHR22599, PTHR22599, 1 hit |
Pfami | View protein in Pfam PF03637, Mob1_phocein, 1 hit |
SMARTi | View protein in SMART SM01388, Mob1_phocein, 1 hit |
SUPFAMi | SSF101152, SSF101152, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q70IA6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDWLMGKSKA KPNGKKPAAE ERKAYLEPEH TKARITDFQF KELVVLPREI
60 70 80 90 100
DLNEWLASNT TTFFHHINLQ YSTISEFCTG ETCQTMAVCN TQYYWYDERG
110 120 130 140 150
KKVKCTAPQY VDFVMSSVQK LVTDEDVFPT KYGREFPSSF ESLVRKICRH
160 170 180 190 200
LFHVLAHIYW AHFKETLALE LHGHLNTLYV HFILFAREFN LLDPKETAIM
210 220 230
DDLTEVLCSG AGGVHSGGSG DGAGSGGPGA QNHVKER
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WVS8 | A0A087WVS8_HUMAN | MOB kinase activator 2 | MOB2 | 234 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 49 | E → K in BAB71443 (PubMed:14702039).Curated | 1 | ||
Isoform 3 (identifier: Q70IA6-3) | |||||
Sequence conflicti | 19 | L → P in BAG59255 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044472 | 1 – 6 | MDWLMG → MLGDHCSLPEDQARPGQSLQ SGLCCKMVLQAVSKVLR in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_012298 | 133 – 142 | GREFPSSFES → ENSPAPLSPW in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_012299 | 143 – 237 | Missing in isoform 2. 1 PublicationAdd BLAST | 95 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ580639 mRNA Translation: CAE45271.1 AK057350 mRNA Translation: BAB71443.1 AK296658 mRNA Translation: BAG59255.1 AC091196 Genomic DNA No translation available. BC047291 mRNA Translation: AAH47291.1 BC067785 mRNA Translation: AAH67785.1 |
CCDSi | CCDS53591.1 [Q70IA6-3] |
RefSeqi | NP_001165694.1, NM_001172223.2 [Q70IA6-3] NP_443731.2, NM_053005.5 [Q70IA6-1] |
Genome annotation databases
Ensembli | ENST00000329957; ENSP00000328694; ENSG00000182208 [Q70IA6-3] |
GeneIDi | 81532 |
KEGGi | hsa:81532 |
UCSCi | uc010qwz.3, human [Q70IA6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ580639 mRNA Translation: CAE45271.1 AK057350 mRNA Translation: BAB71443.1 AK296658 mRNA Translation: BAG59255.1 AC091196 Genomic DNA No translation available. BC047291 mRNA Translation: AAH47291.1 BC067785 mRNA Translation: AAH67785.1 |
CCDSi | CCDS53591.1 [Q70IA6-3] |
RefSeqi | NP_001165694.1, NM_001172223.2 [Q70IA6-3] NP_443731.2, NM_053005.5 [Q70IA6-1] |
3D structure databases
SMRi | Q70IA6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123506, 28 interactors |
IntActi | Q70IA6, 28 interactors |
STRINGi | 9606.ENSP00000328694 |
PTM databases
iPTMneti | Q70IA6 |
PhosphoSitePlusi | Q70IA6 |
Genetic variation databases
BioMutai | MOB2 |
DMDMi | 56749258 |
Proteomic databases
EPDi | Q70IA6 |
jPOSTi | Q70IA6 |
MassIVEi | Q70IA6 |
MaxQBi | Q70IA6 |
PaxDbi | Q70IA6 |
PeptideAtlasi | Q70IA6 |
PRIDEi | Q70IA6 |
ProteomicsDBi | 68555 [Q70IA6-1] 68556 [Q70IA6-2] |
Protocols and materials databases
Antibodypediai | 22879, 147 antibodies |
Genome annotation databases
Ensembli | ENST00000329957; ENSP00000328694; ENSG00000182208 [Q70IA6-3] |
GeneIDi | 81532 |
KEGGi | hsa:81532 |
UCSCi | uc010qwz.3, human [Q70IA6-1] |
Organism-specific databases
CTDi | 81532 |
DisGeNETi | 81532 |
GeneCardsi | MOB2 |
HGNCi | HGNC:24904, MOB2 |
HPAi | ENSG00000182208, Tissue enhanced (smooth muscle, urinary bladder) |
MIMi | 611969, gene |
neXtProti | NX_Q70IA6 |
OpenTargetsi | ENSG00000182208 |
VEuPathDBi | HostDB:ENSG00000182208.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0440, Eukaryota |
GeneTreei | ENSGT01000000214382 |
InParanoidi | Q70IA6 |
OMAi | TVKHVYR |
OrthoDBi | 1127941at2759 |
PhylomeDBi | Q70IA6 |
TreeFami | TF300789 |
Enzyme and pathway databases
PathwayCommonsi | Q70IA6 |
Miscellaneous databases
BioGRID-ORCSi | 81532, 4 hits in 880 CRISPR screens |
ChiTaRSi | MOB2, human |
GenomeRNAii | 81532 |
Pharosi | Q70IA6, Tbio |
PROi | PR:Q70IA6 |
RNActi | Q70IA6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182208, Expressed in lower esophagus and 210 other tissues |
ExpressionAtlasi | Q70IA6, baseline and differential |
Family and domain databases
Gene3Di | 1.20.140.30, 1 hit |
InterProi | View protein in InterPro IPR005301, MOB_kinase_act_fam IPR036703, MOB_kinase_act_sf |
PANTHERi | PTHR22599, PTHR22599, 1 hit |
Pfami | View protein in Pfam PF03637, Mob1_phocein, 1 hit |
SMARTi | View protein in SMART SM01388, Mob1_phocein, 1 hit |
SUPFAMi | SSF101152, SSF101152, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MOB2_HUMAN | |
Accessioni | Q70IA6Primary (citable) accession number: Q70IA6 Secondary accession number(s): B4DKP3, Q96M67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families