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UniProtKB - Q70HW3 (SAMC_HUMAN)

Entry version 139 (25 May 2022)
Sequence version 2 (28 Mar 2018)
Previous versions | rss
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Protein

S-adenosylmethionine mitochondrial carrier protein

Gene

SLC25A26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly inhibited by tannic acid and Bromocresol Purple.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • S-adenosyl-L-methionine transmembrane transporter activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q70HW3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-425393, Transport of inorganic cations/anions and amino acids/oligopeptides

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q70HW3

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.29.18.3, the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
S-adenosylmethionine mitochondrial carrier protein
Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A26
Synonyms:SAMC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20661, SLC25A26

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611037, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q70HW3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000144741

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined oxidative phosphorylation deficiency 28 (COXPD28)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive mitochondrial disorder characterized by decreased activities of respiratory chain enzymes, and variable clinical manifestations. Clinical features include episodic metabolic decompensation beginning in infancy, mild muscle weakness, cardiorespiratory insufficiency, developmental delay, or even death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076305102A → V in COXPD28; severe abrogation of S-adenosylmethionine transport. 1 PublicationCorresponds to variant dbSNP:rs869025314EnsemblClinVar.1
Natural variantiVAR_076306148V → G in COXPD28; severe abrogation of S-adenosylmethionine transport. 1 PublicationCorresponds to variant dbSNP:rs869025313EnsemblClinVar.1
Natural variantiVAR_076307199P → L in COXPD28; severe abrogation of S-adenosylmethionine transport. 1 PublicationCorresponds to variant dbSNP:rs869025315EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		115286

MalaCards human disease database

More...MalaCardsi		SLC25A26
MIMi616794, phenotype

Open Targets

More...OpenTargetsi		ENSG00000144741

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		466784, Neonatal severe cardiopulmonary failure due to mitochondrial methylation defect

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134987831

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q70HW3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC25A26

Domain mapping of disease mutations (DMDM)

More...DMDMi		74749739

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003175871 – 274S-adenosylmethionine mitochondrial carrier proteinAdd BLAST274

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q70HW3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q70HW3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q70HW3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q70HW3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q70HW3

PeptideAtlas

More...PeptideAtlasi		Q70HW3

PRoteomics IDEntifications database

More...PRIDEi		Q70HW3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30470
68552 [Q70HW3-1]
68553 [Q70HW3-2]
68554 [Q70HW3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q70HW3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q70HW3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144741, Expressed in epithelium of mammary gland and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q70HW3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q70HW3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000144741, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125423, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q70HW3, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346955

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q70HW3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q70HW3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q70HW3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 77Solcar 1Add BLAST74
Repeati86 – 168Solcar 2Add BLAST83
Repeati177 – 265Solcar 3Add BLAST89

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0768, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074950

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q70HW3

Identification of Orthologs from Complete Genome Data

More...OMAi		PRVGWIS

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q70HW3

TreeFam database of animal gene trees

More...TreeFami		TF313186

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00153, Mito_carr, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103506, SSF103506, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50920, SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q70HW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRPGFVAAL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF SKAGGFHGIY 
        60         70         80         90        100
AGVPSAAIGS FPNAAAFFIT YEYVKWFLHA DSSSYLTPMK HMLAASAGEV 
       110        120        130        140        150
VACLIRVPSE VVKQRAQVSA STRTFQIFSN ILYEEGIQGL YRGYKSTVLR 
       160        170        180        190        200
EIPFSLVQFP LWESLKALWS WRQDHVVDSW QSAVCGAFAG GFAAAVTTPL 
       210        220        230        240        250
DVAKTRITLA KAGSSTADGN VLSVLHGVWR SQGLAGLFAG VFPRMAAISL 
       260        270 
GGFIFLGAYD RTHSLLLEVG RKSP
Length:274
Mass (Da):29,354
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97315DE9CC68D19D
GO
Isoform 2 (identifier: Q70HW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:186
Mass (Da):20,116
Checksum:i8024D5D11F6CF22B
GO
Isoform 3 (identifier: Q70HW3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     152-154: IPF → EED
     155-274: Missing.

Show »
Length:66
Mass (Da):7,405
Checksum:i68F03A11822C5C3E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C430H7C430_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCZ5H0YCZ5_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF50H0YF50_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KPW2A0A8I5KPW2_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KQI7A0A8I5KQI7_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KRE2A0A8I5KRE2_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KS24A0A8I5KS24_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KTP7A0A8I5KTP7_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KW47A0A8I5KW47_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5QKW7A0A8I5QKW7_HUMAN
S-adenosylmethionine mitochondrial ...
SLC25A26
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti208T → A in BAF84562 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08024441S → N3 PublicationsCorresponds to variant dbSNP:rs146159281EnsemblClinVar.1
Natural variantiVAR_076305102A → V in COXPD28; severe abrogation of S-adenosylmethionine transport. 1 PublicationCorresponds to variant dbSNP:rs869025314EnsemblClinVar.1
Natural variantiVAR_076306148V → G in COXPD28; severe abrogation of S-adenosylmethionine transport. 1 PublicationCorresponds to variant dbSNP:rs869025313EnsemblClinVar.1
Natural variantiVAR_076307199P → L in COXPD28; severe abrogation of S-adenosylmethionine transport. 1 PublicationCorresponds to variant dbSNP:rs869025315EnsemblClinVar.1
Natural variantiVAR_058973208T → M2 PublicationsCorresponds to variant dbSNP:rs13874EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0310621 – 88Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_031063152 – 154IPF → EED in isoform 3. 1 Publication3
Alternative sequenceiVSP_031064155 – 274Missing in isoform 3. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ580932 mRNA Translation: CAE45652.1
AK092495 mRNA Translation: BAG52559.1
AK096876 mRNA Translation: BAG53388.1
AK291873 mRNA Translation: BAF84562.1
AC145425 Genomic DNA No translation available.
AC170165 Genomic DNA No translation available.
AC092034 Genomic DNA No translation available.
AC170801 Genomic DNA No translation available.
AC235952 Genomic DNA No translation available.
AEKP01024816 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65449.1
CH471055 Genomic DNA Translation: EAW65451.1
BC003399 mRNA No translation available.
BC012852 mRNA Translation: AAH12852.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2905.2 [Q70HW3-1]
CCDS54604.1 [Q70HW3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001158268.1, NM_001164796.1 [Q70HW3-2]
NP_775742.4, NM_173471.3 [Q70HW3-1]
XP_011531629.1, XM_011533327.2 [Q70HW3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000336733.10; ENSP00000336801.5; ENSG00000144741.19 [Q70HW3-2]
ENST00000354883.11; ENSP00000346955.6; ENSG00000144741.19
ENST00000632575.1; ENSP00000488865.1; ENSG00000282739.1 [Q70HW3-2]
ENST00000633701.1; ENSP00000488659.1; ENSG00000282739.1
ENST00000676754.1; ENSP00000504323.1; ENSG00000144741.19
ENST00000686511.1; ENSP00000509933.1; ENSG00000144741.19 [Q70HW3-2]
ENST00000691461.1; ENSP00000510022.1; ENSG00000144741.19 [Q70HW3-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		115286

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:115286

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000354883.11; ENSP00000346955.6; NM_001379210.1; NP_001366139.1

UCSC genome browser

More...UCSCi		uc011bfq.2, human
uc011bfs.3, human [Q70HW3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580932 mRNA Translation: CAE45652.1
AK092495 mRNA Translation: BAG52559.1
AK096876 mRNA Translation: BAG53388.1
AK291873 mRNA Translation: BAF84562.1
AC145425 Genomic DNA No translation available.
AC170165 Genomic DNA No translation available.
AC092034 Genomic DNA No translation available.
AC170801 Genomic DNA No translation available.
AC235952 Genomic DNA No translation available.
AEKP01024816 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65449.1
CH471055 Genomic DNA Translation: EAW65451.1
BC003399 mRNA No translation available.
BC012852 mRNA Translation: AAH12852.2
CCDSiCCDS2905.2 [Q70HW3-1]
CCDS54604.1 [Q70HW3-2]
RefSeqiNP_001158268.1, NM_001164796.1 [Q70HW3-2]
NP_775742.4, NM_173471.3 [Q70HW3-1]
XP_011531629.1, XM_011533327.2 [Q70HW3-2]

3D structure databases

AlphaFoldDBiQ70HW3
SMRiQ70HW3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125423, 6 interactors
IntActiQ70HW3, 1 interactor
STRINGi9606.ENSP00000346955

Protein family/group databases

TCDBi2.A.29.18.3, the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ70HW3
PhosphoSitePlusiQ70HW3

Genetic variation databases

BioMutaiSLC25A26
DMDMi74749739

Proteomic databases

EPDiQ70HW3
jPOSTiQ70HW3
MassIVEiQ70HW3
MaxQBiQ70HW3
PaxDbiQ70HW3
PeptideAtlasiQ70HW3
PRIDEiQ70HW3
ProteomicsDBi30470
68552 [Q70HW3-1]
68553 [Q70HW3-2]
68554 [Q70HW3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15419, 109 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		115286

Genome annotation databases

EnsembliENST00000336733.10; ENSP00000336801.5; ENSG00000144741.19 [Q70HW3-2]
ENST00000354883.11; ENSP00000346955.6; ENSG00000144741.19
ENST00000632575.1; ENSP00000488865.1; ENSG00000282739.1 [Q70HW3-2]
ENST00000633701.1; ENSP00000488659.1; ENSG00000282739.1
ENST00000676754.1; ENSP00000504323.1; ENSG00000144741.19
ENST00000686511.1; ENSP00000509933.1; ENSG00000144741.19 [Q70HW3-2]
ENST00000691461.1; ENSP00000510022.1; ENSG00000144741.19 [Q70HW3-2]
GeneIDi115286
KEGGihsa:115286
MANE-SelectiENST00000354883.11; ENSP00000346955.6; NM_001379210.1; NP_001366139.1
UCSCiuc011bfq.2, human
uc011bfs.3, human [Q70HW3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		115286
DisGeNETi115286

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC25A26
HGNCiHGNC:20661, SLC25A26
HPAiENSG00000144741, Low tissue specificity
MalaCardsiSLC25A26
MIMi611037, gene
616794, phenotype
neXtProtiNX_Q70HW3
OpenTargetsiENSG00000144741
Orphaneti466784, Neonatal severe cardiopulmonary failure due to mitochondrial methylation defect
PharmGKBiPA134987831
VEuPathDBiHostDB:ENSG00000144741

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0768, Eukaryota
GeneTreeiENSGT00550000074950
InParanoidiQ70HW3
OMAiPRVGWIS
PhylomeDBiQ70HW3
TreeFamiTF313186

Enzyme and pathway databases

PathwayCommonsiQ70HW3
ReactomeiR-HSA-425393, Transport of inorganic cations/anions and amino acids/oligopeptides
SignaLinkiQ70HW3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		115286, 344 hits in 1096 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC25A26, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		115286
PharosiQ70HW3, Tbio

Protein Ontology

More...PROi		PR:Q70HW3
RNActiQ70HW3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144741, Expressed in epithelium of mammary gland and 207 other tissues
ExpressionAtlasiQ70HW3, baseline and differential
GenevisibleiQ70HW3, HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153, Mito_carr, 3 hits
SUPFAMiSSF103506, SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920, SOLCAR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAMC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q70HW3
Secondary accession number(s): A8K758
, B3KRZ7, F8WAB8, Q7Z786, Q96E68
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 28, 2018
Last modified: May 25, 2022
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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