We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q70GH4 (SED3_ASPFU)
Protein
Tripeptidyl-peptidase sed3
Gene
sed3
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Functioni
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
1 PublicationCatalytic activityi
- Release of an N-terminal tripeptide from a polypeptide. EC:3.4.14.10
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
pH dependencei
Optimum pH is about 6.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 285 | Charge relay systemBy similarity | 1 | |
Active sitei | 289 | Charge relay systemBy similarity | 1 | |
Active sitei | 499 | Charge relay systemBy similarity | 1 | |
Metal bindingi | 541 | CalciumBy similarity | 1 | |
Metal bindingi | 542 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 570 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 572 | CalciumBy similarity | 1 |
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- serine-type endopeptidase activity Source: InterPro
- tripeptidyl-peptidase activity Source: GO_Central
GO - Biological processi
- proteolysis Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Virulence |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.4.14.9, 508 |
Protein family/group databases
MEROPSi | S53.010 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sed3 Synonyms:sedC ORF Names:AFUA_3G08930 |
Organismi | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
Taxonomic identifieri | 330879 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:Afu3g08930 |
Subcellular locationi
Extracellular region or secreted
- extracellular space 1 Publication
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
PropeptideiPRO_0000390747 | 17 – 201 | Removed in mature formBy similarityAdd BLAST | 185 | |
ChainiPRO_5000072081 | 202 – 596 | Tripeptidyl-peptidase sed3Add BLAST | 395 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 205 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 264 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 322 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 365 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 535 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 562 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Glycoprotein, ZymogenFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 592 | Peptidase S53Add BLAST | 384 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QR6D, Eukaryota |
HOGENOMi | CLU_013783_3_0_1 |
InParanoidi | Q70GH4 |
OMAi | ESFPTEM |
OrthoDBi | 1294880at2759 |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q70GH4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPFTFLVGI LSLCICCIVL GAAAEPSYAV VEQLRNVPDG WIKHDAAPAS
60 70 80 90 100
ELIRFRLAMN QERAAEFERR VIDMSTPGHS SYGQHMKRDD VREFLRPPEE
110 120 130 140 150
VSDKVLSWLR SENVPAGSIE SHGNWVTFTV PVSQAERMLR TRFYAFQHVE
160 170 180 190 200
TSTTQVRTLA YSVPHDVHRY IQMIQPTTRF GQPARHERQP LFHGTVATKE
210 220 230 240 250
ELAANCSTTI TPNCLRELYG IYDTRAEPDP RNRLGVSGFL DQYARYDDFE
260 270 280 290 300
NFMRLYATSR TDVNFTVVSI NDGLNLQDSS LSSTEASLDV QYAYSLAYKA
310 320 330 340 350
LGTYYTTGGR GPVVPEEGQD TNVSTNEPYL DQLHYLLDLP DEELPAVLST
360 370 380 390 400
SYGEDEQSVP ESYSNATCNL FAQLGARGVS IIFSSGDSGV GSTCITNDGT
410 420 430 440 450
KTTRFLPVFP ASCPFVTAVG GTHDIQPEKA ISFSSGGFSD HFPRPSYQDS
460 470 480 490 500
SVQGYLEQLG SRWNGLYNPS GRGFPDVAAQ ATNFVVIDHG QTLRVGGTSA
510 520 530 540 550
SAPVFAAIVS RLNAARLEDG LLKLGFLNPW LYSLNQTGFT DIIDGGSSGC
560 570 580 590
YVGTSNEQLV PNASWNATPG WDPVTGLGTP IYNTLVKLAT SVSSTP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ581835 mRNA Translation: CAE46473.1 AAHF01000002 Genomic DNA Translation: EAL92685.2 |
RefSeqi | XP_754723.2, XM_749630.2 |
Genome annotation databases
EnsemblFungii | EAL92685; EAL92685; AFUA_3G08930 |
GeneIDi | 3512055 |
KEGGi | afm:AFUA_3G08930 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ581835 mRNA Translation: CAE46473.1 AAHF01000002 Genomic DNA Translation: EAL92685.2 |
RefSeqi | XP_754723.2, XM_749630.2 |
3D structure databases
SMRi | Q70GH4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 746128.CADAFUBP00003935 |
Protein family/group databases
MEROPSi | S53.010 |
Genome annotation databases
EnsemblFungii | EAL92685; EAL92685; AFUA_3G08930 |
GeneIDi | 3512055 |
KEGGi | afm:AFUA_3G08930 |
Organism-specific databases
VEuPathDBi | FungiDB:Afu3g08930 |
Phylogenomic databases
eggNOGi | ENOG502QR6D, Eukaryota |
HOGENOMi | CLU_013783_3_0_1 |
InParanoidi | Q70GH4 |
OMAi | ESFPTEM |
OrthoDBi | 1294880at2759 |
Enzyme and pathway databases
BRENDAi | 3.4.14.9, 508 |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SED3_ASPFU | |
Accessioni | Q70GH4Primary (citable) accession number: Q70GH4 Secondary accession number(s): Q4WXB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 19, 2010 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |